BacMap

Definition	Staphylococcus aureus subsp. aureus N315, complete genome.
Accession	NC_002745
Length	2,814,816

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The map label for this gene is butA

Identifier: 15925830

GI number: 15925830

Start: 141023

End: 141799

Strand: Direct

Name: butA

Synonym: SA0122

Alternate gene names: 15925830

Gene position: 141023-141799 (Clockwise)

Preceding gene: 15925829

Following gene: 15925832

Centisome position: 5.01

GC content: 40.93

Gene sequence:

>777_bases
ATGACAAACAACAAAGTAGCATTAGTAACTGGCGGAGCACAAGGGATTGGTTTTAAAATTGCAGAACGTTTAGTGGAAGA
TGGTTTCAAAGTAGCAGTTGTTGATTTCAATGAAGAAGGGGCAAAAGCAGCTGCACTTAAATTATCAAGTGATGGTACAA
AAGCTATTGCTATCAAAGCAGATGTATCAAACCGTGATGATGTATTTAACGCAGTAAGACAAACTGCCGCGCAATTTGGC
GATTTCCATGTCATGGTTAACAATGCCGGCCTTGGACCAACAACACCAATCGATACAATTACTGAAGAACAGTTTAAAAC
AGTATATGGCGTGAACGTTGCAGGTGTGCTATGGGGTATTCAAGCCGCACATGAACAATTTAAAAAATTCAATCATGGCG
GTAAAATTATCAATGCAACATCTCAAGCAGGCGTTGAGGGTAACCCAGGCTTGTCTTTATATTGCAGTACAAAATTCGCA
GTGCGAGGTTTAACACAAGTAGCCGCACAAGATTTAGCGTCTGAAGGTATTACTGTGAATGCATTCGCACCTGGTATCGT
TCAAACACCAATGATGGAAAGTATCGCAGTGGCAACAGCCGAAGAAGCAGGTAAACCTGAAGCATGGGGTTGGGAACAAT
TTACAAGTCAGATTGCTTTGGGCAGAGTTTCTCAACCAGAAGATGTTTCAAATGTAGTGAGCTTCTTAGCTGGTAAAGAC
TCTGATTACATTACTGGACAAACAATTATTGTAGATGGTGGTATGAGATTCCGTTAA

Upstream 100 bases:

>100_bases
ATATCTGAATATTTTGTTAAATGGAGCTACCTTTGTTGTACTATTCAAATGAAGAGGAGTAAAATGTAATTAAAGGAAAG
AAATTTGAGGAGTGATCTTT

Downstream 100 bases:

>100_bases
TAATCATGCATTAGCGATAAATAAATCCTTATTGTTAAGTTTAATCACTTAGCAGTAAGGATTTTTTAGTGCACTTAGAA
GGGATTGTATTGGTAGAAAA

Product: acetoin reductase

Products: NA

Alternate protein names: Acetoin(diacetyl) reductase; AR; Meso-2,3-butanediol dehydrogenase

Number of amino acids: Translated: 258; Mature: 257

Protein sequence:

>258_residues
MTNNKVALVTGGAQGIGFKIAERLVEDGFKVAVVDFNEEGAKAAALKLSSDGTKAIAIKADVSNRDDVFNAVRQTAAQFG
DFHVMVNNAGLGPTTPIDTITEEQFKTVYGVNVAGVLWGIQAAHEQFKKFNHGGKIINATSQAGVEGNPGLSLYCSTKFA
VRGLTQVAAQDLASEGITVNAFAPGIVQTPMMESIAVATAEEAGKPEAWGWEQFTSQIALGRVSQPEDVSNVVSFLAGKD
SDYITGQTIIVDGGMRFR

Sequences:

>Translated_258_residues
MTNNKVALVTGGAQGIGFKIAERLVEDGFKVAVVDFNEEGAKAAALKLSSDGTKAIAIKADVSNRDDVFNAVRQTAAQFG
DFHVMVNNAGLGPTTPIDTITEEQFKTVYGVNVAGVLWGIQAAHEQFKKFNHGGKIINATSQAGVEGNPGLSLYCSTKFA
VRGLTQVAAQDLASEGITVNAFAPGIVQTPMMESIAVATAEEAGKPEAWGWEQFTSQIALGRVSQPEDVSNVVSFLAGKD
SDYITGQTIIVDGGMRFR
>Mature_257_residues
TNNKVALVTGGAQGIGFKIAERLVEDGFKVAVVDFNEEGAKAAALKLSSDGTKAIAIKADVSNRDDVFNAVRQTAAQFGD
FHVMVNNAGLGPTTPIDTITEEQFKTVYGVNVAGVLWGIQAAHEQFKKFNHGGKIINATSQAGVEGNPGLSLYCSTKFAV
RGLTQVAAQDLASEGITVNAFAPGIVQTPMMESIAVATAEEAGKPEAWGWEQFTSQIALGRVSQPEDVSNVVSFLAGKDS
DYITGQTIIVDGGMRFR

Specific function: Catalyzes the irreversible reduction of 2,3-butanediol to (S)-acetoin in the presence of NADH

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family

Homologues:

Organism=Homo sapiens, GI32483357, Length=256, Percent_Identity=31.640625, Blast_Score=122, Evalue=3e-28,
Organism=Homo sapiens, GI40254992, Length=255, Percent_Identity=32.156862745098, Blast_Score=121, Evalue=5e-28,
Organism=Homo sapiens, GI15277342, Length=261, Percent_Identity=33.3333333333333, Blast_Score=121, Evalue=6e-28,
Organism=Homo sapiens, GI19923817, Length=265, Percent_Identity=30.9433962264151, Blast_Score=111, Evalue=5e-25,
Organism=Homo sapiens, GI31542939, Length=199, Percent_Identity=36.1809045226131, Blast_Score=105, Evalue=4e-23,
Organism=Homo sapiens, GI5031737, Length=254, Percent_Identity=31.1023622047244, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI4758504, Length=265, Percent_Identity=30.9433962264151, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI10190704, Length=256, Percent_Identity=28.515625, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI142976729, Length=188, Percent_Identity=30.8510638297872, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI59889578, Length=232, Percent_Identity=31.4655172413793, Blast_Score=95, Evalue=5e-20,
Organism=Homo sapiens, GI126723750, Length=257, Percent_Identity=29.1828793774319, Blast_Score=95, Evalue=6e-20,
Organism=Homo sapiens, GI210032110, Length=190, Percent_Identity=33.1578947368421, Blast_Score=93, Evalue=2e-19,
Organism=Homo sapiens, GI224922801, Length=179, Percent_Identity=34.6368715083799, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI7705925, Length=247, Percent_Identity=29.1497975708502, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI83715985, Length=265, Percent_Identity=29.0566037735849, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI223718074, Length=239, Percent_Identity=28.8702928870293, Blast_Score=82, Evalue=5e-16,
Organism=Homo sapiens, GI109715829, Length=242, Percent_Identity=28.5123966942149, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI33667109, Length=187, Percent_Identity=31.0160427807487, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI66933014, Length=223, Percent_Identity=28.2511210762332, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI40807363, Length=193, Percent_Identity=25.9067357512953, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI126723191, Length=180, Percent_Identity=30, Blast_Score=71, Evalue=9e-13,
Organism=Homo sapiens, GI310128830, Length=200, Percent_Identity=28, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI310115468, Length=200, Percent_Identity=28, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI4503817, Length=188, Percent_Identity=26.5957446808511, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI4504505, Length=218, Percent_Identity=29.8165137614679, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1787335, Length=251, Percent_Identity=33.0677290836653, Blast_Score=124, Evalue=4e-30,
Organism=Escherichia coli, GI1788459, Length=256, Percent_Identity=32.421875, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI87082100, Length=251, Percent_Identity=32.6693227091633, Blast_Score=118, Evalue=4e-28,
Organism=Escherichia coli, GI1790717, Length=248, Percent_Identity=31.0483870967742, Blast_Score=114, Evalue=5e-27,
Organism=Escherichia coli, GI1789208, Length=254, Percent_Identity=30.7086614173228, Blast_Score=107, Evalue=7e-25,
Organism=Escherichia coli, GI1786812, Length=248, Percent_Identity=29.8387096774194, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1789057, Length=255, Percent_Identity=30.1960784313725, Blast_Score=100, Evalue=8e-23,
Organism=Escherichia coli, GI2367365, Length=251, Percent_Identity=30.2788844621514, Blast_Score=99, Evalue=2e-22,
Organism=Escherichia coli, GI2367175, Length=257, Percent_Identity=31.1284046692607, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1789378, Length=255, Percent_Identity=29.0196078431373, Blast_Score=95, Evalue=6e-21,
Organism=Escherichia coli, GI1787905, Length=250, Percent_Identity=28.4, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI87082160, Length=256, Percent_Identity=25, Blast_Score=71, Evalue=8e-14,
Organism=Escherichia coli, GI1787820, Length=233, Percent_Identity=27.0386266094421, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI1787526, Length=260, Percent_Identity=24.2307692307692, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17561402, Length=256, Percent_Identity=33.59375, Blast_Score=128, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI25147288, Length=254, Percent_Identity=33.8582677165354, Blast_Score=119, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17555706, Length=255, Percent_Identity=31.3725490196078, Blast_Score=112, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI17560676, Length=256, Percent_Identity=29.296875, Blast_Score=102, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17562906, Length=261, Percent_Identity=31.8007662835249, Blast_Score=102, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17562908, Length=261, Percent_Identity=32.183908045977, Blast_Score=102, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17560150, Length=266, Percent_Identity=31.203007518797, Blast_Score=100, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI17538486, Length=261, Percent_Identity=31.8007662835249, Blast_Score=100, Evalue=7e-22,
Organism=Caenorhabditis elegans, GI17560220, Length=259, Percent_Identity=31.6602316602317, Blast_Score=100, Evalue=8e-22,
Organism=Caenorhabditis elegans, GI17531453, Length=259, Percent_Identity=31.6602316602317, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI193204405, Length=260, Percent_Identity=31.5384615384615, Blast_Score=99, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17538480, Length=268, Percent_Identity=32.8358208955224, Blast_Score=99, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI115534694, Length=251, Percent_Identity=29.0836653386454, Blast_Score=97, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI17560332, Length=268, Percent_Identity=32.089552238806, Blast_Score=96, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17538182, Length=269, Percent_Identity=28.996282527881, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17551412, Length=265, Percent_Identity=32.0754716981132, Blast_Score=95, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI17562990, Length=264, Percent_Identity=29.5454545454545, Blast_Score=92, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17562904, Length=262, Percent_Identity=29.3893129770992, Blast_Score=91, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI17567345, Length=192, Percent_Identity=30.2083333333333, Blast_Score=88, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI17565030, Length=263, Percent_Identity=32.319391634981, Blast_Score=87, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI17559104, Length=262, Percent_Identity=29.0076335877863, Blast_Score=87, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI17562910, Length=261, Percent_Identity=26.4367816091954, Blast_Score=87, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI71994604, Length=252, Percent_Identity=26.1904761904762, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI71994600, Length=253, Percent_Identity=28.8537549407115, Blast_Score=86, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17544670, Length=267, Percent_Identity=27.3408239700375, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI72000259, Length=258, Percent_Identity=28.2945736434109, Blast_Score=83, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17563726, Length=260, Percent_Identity=26.9230769230769, Blast_Score=77, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17508651, Length=261, Percent_Identity=29.8850574712644, Blast_Score=77, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI32563809, Length=214, Percent_Identity=26.6355140186916, Blast_Score=70, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17507613, Length=214, Percent_Identity=26.6355140186916, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI115534660, Length=199, Percent_Identity=28.1407035175879, Blast_Score=68, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17568967, Length=212, Percent_Identity=27.8301886792453, Blast_Score=66, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17564282, Length=195, Percent_Identity=24.6153846153846, Blast_Score=64, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6324126, Length=256, Percent_Identity=28.125, Blast_Score=75, Evalue=8e-15,
Organism=Saccharomyces cerevisiae, GI6323882, Length=192, Percent_Identity=29.6875, Blast_Score=66, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6322861, Length=199, Percent_Identity=28.1407035175879, Blast_Score=63, Evalue=5e-11,
Organism=Drosophila melanogaster, GI21355319, Length=255, Percent_Identity=33.3333333333333, Blast_Score=124, Evalue=4e-29,
Organism=Drosophila melanogaster, GI24639444, Length=254, Percent_Identity=32.6771653543307, Blast_Score=118, Evalue=4e-27,
Organism=Drosophila melanogaster, GI23397609, Length=253, Percent_Identity=34.3873517786561, Blast_Score=110, Evalue=8e-25,
Organism=Drosophila melanogaster, GI28571526, Length=256, Percent_Identity=30.46875, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI21357041, Length=256, Percent_Identity=28.90625, Blast_Score=98, Evalue=5e-21,
Organism=Drosophila melanogaster, GI24644339, Length=256, Percent_Identity=29.296875, Blast_Score=98, Evalue=5e-21,
Organism=Drosophila melanogaster, GI17737361, Length=271, Percent_Identity=29.1512915129151, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24644337, Length=257, Percent_Identity=29.9610894941634, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24640492, Length=171, Percent_Identity=32.1637426900585, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI281364892, Length=175, Percent_Identity=35.4285714285714, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24643142, Length=250, Percent_Identity=27.2, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI21355631, Length=171, Percent_Identity=29.8245614035088, Blast_Score=74, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24641388, Length=209, Percent_Identity=31.1004784688995, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24663911, Length=199, Percent_Identity=26.6331658291457, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI281364494, Length=196, Percent_Identity=29.5918367346939, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI116007236, Length=221, Percent_Identity=26.6968325791855, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24581726, Length=215, Percent_Identity=25.5813953488372, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24648693, Length=243, Percent_Identity=27.9835390946502, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI21355889, Length=243, Percent_Identity=27.9835390946502, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24665243, Length=191, Percent_Identity=26.7015706806283, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI221331218, Length=191, Percent_Identity=26.7015706806283, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24665264, Length=207, Percent_Identity=27.0531400966184, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24665247, Length=192, Percent_Identity=27.0833333333333, Blast_Score=64, Evalue=7e-11,
Organism=Drosophila melanogaster, GI221331216, Length=192, Percent_Identity=27.0833333333333, Blast_Score=64, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): BUTA_STAAC (Q5HJP2)

Other databases:

- EMBL:   CP000046
- RefSeq:   YP_185015.1
- ProteinModelPortal:   Q5HJP2
- SMR:   Q5HJP2
- STRING:   Q5HJP2
- EnsemblBacteria:   EBSTAT00000010547
- GeneID:   3236834
- GenomeReviews:   CP000046_GR
- KEGG:   sac:SACOL0111
- TIGR:   SACOL0111
- eggNOG:   COG1028
- GeneTree:   EBGT00050000023864
- HOGENOM:   HBG750976
- OMA:   ACVAYLA
- ProtClustDB:   PRK08643
- BioCyc:   SAUR93062:SACOL0111-MONOMER
- GO:   GO:0005488
- InterPro:   IPR014007
- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904
- Gene3D:   G3DSA:3.40.50.720
- PANTHER:   PTHR19410
- PRINTS:   PR00081
- PRINTS:   PR00080
- TIGRFAMs:   TIGR02415

Pfam domain/function: PF00106 adh_short

EC number: =1.1.1.304

Molecular weight: Translated: 27216; Mature: 27085

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: PS00061 ADH_SHORT

Important sites: ACT_SITE 154-154 ACT_SITE 158-158 BINDING 141-141

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNNKVALVTGGAQGIGFKIAERLVEDGFKVAVVDFNEEGAKAAALKLSSDGTKAIAIKA
CCCCEEEEEECCCCCCHHHHHHHHHHCCCEEEEEEECCCCCEEEEEEECCCCCEEEEEEE
DVSNRDDVFNAVRQTAAQFGDFHVMVNNAGLGPTTPIDTITEEQFKTVYGVNVAGVLWGI
CCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHH
QAAHEQFKKFNHGGKIINATSQAGVEGNPGLSLYCSTKFAVRGLTQVAAQDLASEGITVN
HHHHHHHHHHCCCCCEEEECCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHCCEEEE
AFAPGIVQTPMMESIAVATAEEAGKPEAWGWEQFTSQIALGRVSQPEDVSNVVSFLAGKD
ECCCCHHCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCC
SDYITGQTIIVDGGMRFR
CCEECCEEEEEECCCCCC
>Mature Secondary Structure 
TNNKVALVTGGAQGIGFKIAERLVEDGFKVAVVDFNEEGAKAAALKLSSDGTKAIAIKA
CCCEEEEEECCCCCCHHHHHHHHHHCCCEEEEEEECCCCCEEEEEEECCCCCEEEEEEE
DVSNRDDVFNAVRQTAAQFGDFHVMVNNAGLGPTTPIDTITEEQFKTVYGVNVAGVLWGI
CCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHH
QAAHEQFKKFNHGGKIINATSQAGVEGNPGLSLYCSTKFAVRGLTQVAAQDLASEGITVN
HHHHHHHHHHCCCCCEEEECCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHCCEEEE
AFAPGIVQTPMMESIAVATAEEAGKPEAWGWEQFTSQIALGRVSQPEDVSNVVSFLAGKD
ECCCCHHCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCC
SDYITGQTIIVDGGMRFR
CCEECCEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA