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The map label for this gene is fumC [H]

Identifier: 15924841

GI number: 15924841

Start: 1983314

End: 1984699

Strand: Reverse

Name: fumC [H]

Synonym: SAV1851

Alternate gene names: 15924841

Gene position: 1984699-1983314 (Counterclockwise)

Preceding gene: 15924842

Following gene: 15924839

Centisome position: 68.95

GC content: 34.92

Gene sequence:

>1386_bases
ATGTCAGTAAGAATTGAACATGATACTTTTGGAGAAATAGAAGTACCTGCAGATAAATATTGGGGTGCTCAAACAGAAAG
AAGTAAACGCAATTTCCCAGTTGGTAAAGAGCGTATGCCAATCGAAGTAGTTTATGGTTTTGCACAACTAAAGCGTGCAG
CAGCATTAGCTAATTTTGATTTAGGAAAATTAAGCGAGGCAAAGAAAGATGCCATTGTATACGCATGTGATCAAATTTTA
TCAGGTGAATTAGATGAACACTTCCCACTAGTTGTATGGCAAACAGGAAGCGGTACACAAAGTAATATGAATGTGAACGA
AGTAGTAAGTTATGTTGCTAATATGTATTTAAAAGATCATCAAATTGATGAAAGTATCCACCCAAATGATGATGTAAATG
AATCACAAAGTTCGAATGATACATTCCCAACTGCTATGCACGTTGCATTATATCAAGAGGTTGAAACAAAATTAGAACCT
GCATTAAAACTTTTAAGAAATACTTTGAAAGAAAAAGAAGACAAATTTGAATCAATTATTAAAATTGGTCGTACACATTT
ACAAGATGCAACGCCGATCAAACTAGGACAAGAGATTAGTGGCTGGCGTTATATGCTTGACCGTTGCGAAATAATGTTAT
CTGAATCTAAGAAGCACATTTTAAATCTTGCCATCGGTGGTACGGCTGTTGGTACTGGTATTAATGCGCATCCTGAATTT
GGTGATAAGGTGGCACATTATATTTCAGAAAATACGGGTTATCCATTTGTATCTTCTGAAAATAAATTCCACGCACTTAC
AGCGCATGATGAAGTTGTTCAATTGCACGGAACATTGAAGGCATTAGCTGGAGATTTAATGAAAATTGCTAATGATGTGA
GATGGTTGGCTTCAGGTCCACGAGCTGGTTTGGCAGAAATTTCCATCCCTGAAAATGAACCAGGTTCATCAATTATGCCT
GGTAAAGTTAATCCTACACAATGTGAAATGTTAACAATGGTTGCAGTCCAAGTAATGGGTAATGATACAGTTGTTGGCTT
CGCAAGTTCACAAGGTAACTTTGAATTGAATGTTTATAAACCAGTTATTATGCATAATACACTACAATCAATTTACCTTT
TAGCTGATGGTATGGAAACATTTAATAACAATTGTGCAGTGGGCATTGAGCCAATCGAAGAGAATATTGATAATTATTTA
AATCAATCATTAATGTTAGTTACTGCATTAAATCCACATATTGGTTATGAAAAAGCAGCTCAAATTGCTAAGAAAGCCCA
TAAAGAAGGTTTAACTTTAAAAGAATCTGCAATTCAAACTGGATATGTTACAGAAGAACAATTTGAAGCATGGATTAAAC
CAGAAGATATGGTAGATCCTCATTAA

Upstream 100 bases:

>100_bases
TTTATTTCAAATTATGAAAACGTTTTAATCATAAATTGCTCAATTAAATTATTTAATGATATACTACAGTTAAATAAACA
GTGATAAGGGGAGAAATTGA

Downstream 100 bases:

>100_bases
TTAAATATTAATATAAAATAAAGTTTGGGCATTATAGTGTTCAAGCTTTATTTTTTGTCTATGTCAAATTGAACTTATAA
GTCCGATTTGATATAGAGCC

Product: fumarate hydratase

Products: NA

Alternate protein names: Fumarase C [H]

Number of amino acids: Translated: 461; Mature: 460

Protein sequence:

>461_residues
MSVRIEHDTFGEIEVPADKYWGAQTERSKRNFPVGKERMPIEVVYGFAQLKRAAALANFDLGKLSEAKKDAIVYACDQIL
SGELDEHFPLVVWQTGSGTQSNMNVNEVVSYVANMYLKDHQIDESIHPNDDVNESQSSNDTFPTAMHVALYQEVETKLEP
ALKLLRNTLKEKEDKFESIIKIGRTHLQDATPIKLGQEISGWRYMLDRCEIMLSESKKHILNLAIGGTAVGTGINAHPEF
GDKVAHYISENTGYPFVSSENKFHALTAHDEVVQLHGTLKALAGDLMKIANDVRWLASGPRAGLAEISIPENEPGSSIMP
GKVNPTQCEMLTMVAVQVMGNDTVVGFASSQGNFELNVYKPVIMHNTLQSIYLLADGMETFNNNCAVGIEPIEENIDNYL
NQSLMLVTALNPHIGYEKAAQIAKKAHKEGLTLKESAIQTGYVTEEQFEAWIKPEDMVDPH

Sequences:

>Translated_461_residues
MSVRIEHDTFGEIEVPADKYWGAQTERSKRNFPVGKERMPIEVVYGFAQLKRAAALANFDLGKLSEAKKDAIVYACDQIL
SGELDEHFPLVVWQTGSGTQSNMNVNEVVSYVANMYLKDHQIDESIHPNDDVNESQSSNDTFPTAMHVALYQEVETKLEP
ALKLLRNTLKEKEDKFESIIKIGRTHLQDATPIKLGQEISGWRYMLDRCEIMLSESKKHILNLAIGGTAVGTGINAHPEF
GDKVAHYISENTGYPFVSSENKFHALTAHDEVVQLHGTLKALAGDLMKIANDVRWLASGPRAGLAEISIPENEPGSSIMP
GKVNPTQCEMLTMVAVQVMGNDTVVGFASSQGNFELNVYKPVIMHNTLQSIYLLADGMETFNNNCAVGIEPIEENIDNYL
NQSLMLVTALNPHIGYEKAAQIAKKAHKEGLTLKESAIQTGYVTEEQFEAWIKPEDMVDPH
>Mature_460_residues
SVRIEHDTFGEIEVPADKYWGAQTERSKRNFPVGKERMPIEVVYGFAQLKRAAALANFDLGKLSEAKKDAIVYACDQILS
GELDEHFPLVVWQTGSGTQSNMNVNEVVSYVANMYLKDHQIDESIHPNDDVNESQSSNDTFPTAMHVALYQEVETKLEPA
LKLLRNTLKEKEDKFESIIKIGRTHLQDATPIKLGQEISGWRYMLDRCEIMLSESKKHILNLAIGGTAVGTGINAHPEFG
DKVAHYISENTGYPFVSSENKFHALTAHDEVVQLHGTLKALAGDLMKIANDVRWLASGPRAGLAEISIPENEPGSSIMPG
KVNPTQCEMLTMVAVQVMGNDTVVGFASSQGNFELNVYKPVIMHNTLQSIYLLADGMETFNNNCAVGIEPIEENIDNYLN
QSLMLVTALNPHIGYEKAAQIAKKAHKEGLTLKESAIQTGYVTEEQFEAWIKPEDMVDPH

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19743875, Length=462, Percent_Identity=56.4935064935065, Blast_Score=510, Evalue=1e-144,
Organism=Escherichia coli, GI1787896, Length=458, Percent_Identity=60.0436681222707, Blast_Score=565, Evalue=1e-162,
Organism=Escherichia coli, GI87082375, Length=464, Percent_Identity=37.2844827586207, Blast_Score=310, Evalue=1e-85,
Organism=Caenorhabditis elegans, GI17553882, Length=461, Percent_Identity=57.4837310195228, Blast_Score=540, Evalue=1e-154,
Organism=Caenorhabditis elegans, GI32565146, Length=326, Percent_Identity=57.361963190184, Blast_Score=392, Evalue=1e-109,
Organism=Saccharomyces cerevisiae, GI6324993, Length=461, Percent_Identity=54.2299349240781, Blast_Score=504, Evalue=1e-143,
Organism=Drosophila melanogaster, GI24640179, Length=461, Percent_Identity=56.6160520607375, Blast_Score=528, Evalue=1e-150,
Organism=Drosophila melanogaster, GI24640177, Length=461, Percent_Identity=56.6160520607375, Blast_Score=528, Evalue=1e-150,
Organism=Drosophila melanogaster, GI78710009, Length=462, Percent_Identity=56.0606060606061, Blast_Score=517, Evalue=1e-147,
Organism=Drosophila melanogaster, GI24662684, Length=462, Percent_Identity=51.5151515151515, Blast_Score=471, Evalue=1e-133,
Organism=Drosophila melanogaster, GI24583245, Length=462, Percent_Identity=46.1038961038961, Blast_Score=424, Evalue=1e-119,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003031
- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1 [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 51162; Mature: 51030

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVRIEHDTFGEIEVPADKYWGAQTERSKRNFPVGKERMPIEVVYGFAQLKRAAALANFD
CCEEECCCCCCCEECCHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCC
LGKLSEAKKDAIVYACDQILSGELDEHFPLVVWQTGSGTQSNMNVNEVVSYVANMYLKDH
CHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHC
QIDESIHPNDDVNESQSSNDTFPTAMHVALYQEVETKLEPALKLLRNTLKEKEDKFESII
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KIGRTHLQDATPIKLGQEISGWRYMLDRCEIMLSESKKHILNLAIGGTAVGTGINAHPEF
HHHHHHCCCCCCHHCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCEEECCCCCCCCCH
GDKVAHYISENTGYPFVSSENKFHALTAHDEVVQLHGTLKALAGDLMKIANDVRWLASGP
HHHHHHHHHCCCCCCEECCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
RAGLAEISIPENEPGSSIMPGKVNPTQCEMLTMVAVQVMGNDTVVGFASSQGNFELNVYK
CCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCEEEEEEC
PVIMHNTLQSIYLLADGMETFNNNCAVGIEPIEENIDNYLNQSLMLVTALNPHIGYEKAA
HHHHHHHHHHHHHHHCCHHHHCCCCEEECCHHHHHHHHHHCCCEEEEEECCCCCCHHHHH
QIAKKAHKEGLTLKESAIQTGYVTEEQFEAWIKPEDMVDPH
HHHHHHHHCCCCCHHHHHHCCCCCHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
SVRIEHDTFGEIEVPADKYWGAQTERSKRNFPVGKERMPIEVVYGFAQLKRAAALANFD
CEEECCCCCCCEECCHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCC
LGKLSEAKKDAIVYACDQILSGELDEHFPLVVWQTGSGTQSNMNVNEVVSYVANMYLKDH
CHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHC
QIDESIHPNDDVNESQSSNDTFPTAMHVALYQEVETKLEPALKLLRNTLKEKEDKFESII
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KIGRTHLQDATPIKLGQEISGWRYMLDRCEIMLSESKKHILNLAIGGTAVGTGINAHPEF
HHHHHHCCCCCCHHCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCEEECCCCCCCCCH
GDKVAHYISENTGYPFVSSENKFHALTAHDEVVQLHGTLKALAGDLMKIANDVRWLASGP
HHHHHHHHHCCCCCCEECCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
RAGLAEISIPENEPGSSIMPGKVNPTQCEMLTMVAVQVMGNDTVVGFASSQGNFELNVYK
CCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCEEEEEEC
PVIMHNTLQSIYLLADGMETFNNNCAVGIEPIEENIDNYLNQSLMLVTALNPHIGYEKAA
HHHHHHHHHHHHHHHCCHHHHCCCCEEECCHHHHHHHHHHCCCEEEEEECCCCCCHHHHH
QIAKKAHKEGLTLKESAIQTGYVTEEQFEAWIKPEDMVDPH
HHHHHHHHCCCCCHHHHHHCCCCCHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA