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The map label for this gene is hemH

Identifier: 15924823

GI number: 15924823

Start: 1963089

End: 1964012

Strand: Reverse

Name: hemH

Synonym: SAV1833

Alternate gene names: 15924823

Gene position: 1964012-1963089 (Counterclockwise)

Preceding gene: 15924824

Following gene: 15924822

Centisome position: 68.23

GC content: 33.33

Gene sequence:

>924_bases
ATGACTAAAAAAATGGGGTTATTAGTTATGGCTTATGGCACACCTTATAAAGAAAGTGACATAGAGCCATATTATACAGA
TATTAGACATGGTAAACGTCCATCTGAAGAAGAACTTCAAGATTTGAAAGATAGATATGAATTTATAGGTGGTTTATCAC
CATTAGCAGGTACAACAGATGACCAAGCTGATGCACTAGTTTCAGCATTAAATAAAGCATATGCAGATGTTGAATTTAAA
CTATACTTAGGATTAAAACACATTTCACCATTTATCGAAGATGCGGTTGAACAAATGCACAATGATGGTATTACTGAAGC
AATCACGGTAGTACTAGCACCACATTATTCTTCATTTTCAGTAGGATCATATGACAAACGTGCTGATGAAGAAGCTGCAA
AATATGGTATTCAACTTACACATGTGAAACATTATTATGAACAACCTAAATTTATTGAATATTGGACGAATAAAGTCAAC
GAAACATTAGCTCAAATACCGGAAGAGGAACATAAAGACACGGTATTAGTTGTTTCGGCACATAGTTTGCCAAAAGGTTT
AATCGAAAAGAATAATGATCCATATCCACAAGAACTAGAACATACTGCGCTTTTAATTAAAGAACAATCTAATATTGAAC
ATATCGCGATTGGTTGGCAATCTGAAGGTAATACAGGTACACCTTGGTTAGGGCCAGATGTACAAGATTTAACACGTGAT
TTATATGAAAAACATCAGTATAAAAACTTTATATATACGCCAGTAGGTTTTGTATGTGAGCATTTAGAGGTGCTTTATGA
CAATGATTATGAATGTAAAGTTGTTTGCGATGATATTGGTGCGAATTATTATCGTCCAAAAATGCCGAATACACATCCAT
TATTTATCGGTGCAATTGTTGATGAAATCAAGTCTATATTTTAA

Upstream 100 bases:

>100_bases
ACGTAAAGTAAGCGAATTCGTACACACATATACACAAAGATAATCATAGTATTACATTGAAGCACATGAAAGATAATTCA
TTTAAAGGAAGGTATTATCA

Downstream 100 bases:

>100_bases
TGACGAAAGAAGCGTGAAACGTTGTGACTAAATCAGTGGCTATTATAGGAGCGGGGATAACAGGTTTATCAAGTGCATAT
TTTTTAAAACAGCAAGATCC

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase

Number of amino acids: Translated: 307; Mature: 306

Protein sequence:

>307_residues
MTKKMGLLVMAYGTPYKESDIEPYYTDIRHGKRPSEEELQDLKDRYEFIGGLSPLAGTTDDQADALVSALNKAYADVEFK
LYLGLKHISPFIEDAVEQMHNDGITEAITVVLAPHYSSFSVGSYDKRADEEAAKYGIQLTHVKHYYEQPKFIEYWTNKVN
ETLAQIPEEEHKDTVLVVSAHSLPKGLIEKNNDPYPQELEHTALLIKEQSNIEHIAIGWQSEGNTGTPWLGPDVQDLTRD
LYEKHQYKNFIYTPVGFVCEHLEVLYDNDYECKVVCDDIGANYYRPKMPNTHPLFIGAIVDEIKSIF

Sequences:

>Translated_307_residues
MTKKMGLLVMAYGTPYKESDIEPYYTDIRHGKRPSEEELQDLKDRYEFIGGLSPLAGTTDDQADALVSALNKAYADVEFK
LYLGLKHISPFIEDAVEQMHNDGITEAITVVLAPHYSSFSVGSYDKRADEEAAKYGIQLTHVKHYYEQPKFIEYWTNKVN
ETLAQIPEEEHKDTVLVVSAHSLPKGLIEKNNDPYPQELEHTALLIKEQSNIEHIAIGWQSEGNTGTPWLGPDVQDLTRD
LYEKHQYKNFIYTPVGFVCEHLEVLYDNDYECKVVCDDIGANYYRPKMPNTHPLFIGAIVDEIKSIF
>Mature_306_residues
TKKMGLLVMAYGTPYKESDIEPYYTDIRHGKRPSEEELQDLKDRYEFIGGLSPLAGTTDDQADALVSALNKAYADVEFKL
YLGLKHISPFIEDAVEQMHNDGITEAITVVLAPHYSSFSVGSYDKRADEEAAKYGIQLTHVKHYYEQPKFIEYWTNKVNE
TLAQIPEEEHKDTVLVVSAHSLPKGLIEKNNDPYPQELEHTALLIKEQSNIEHIAIGWQSEGNTGTPWLGPDVQDLTRDL
YEKHQYKNFIYTPVGFVCEHLEVLYDNDYECKVVCDDIGANYYRPKMPNTHPLFIGAIVDEIKSIF

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family

Homologues:

Organism=Homo sapiens, GI60499021, Length=274, Percent_Identity=28.8321167883212, Blast_Score=122, Evalue=5e-28,
Organism=Homo sapiens, GI60499025, Length=274, Percent_Identity=28.8321167883212, Blast_Score=122, Evalue=5e-28,
Organism=Saccharomyces cerevisiae, GI6324750, Length=278, Percent_Identity=24.8201438848921, Blast_Score=84, Evalue=3e-17,
Organism=Drosophila melanogaster, GI17864156, Length=325, Percent_Identity=25.2307692307692, Blast_Score=114, Evalue=6e-26,
Organism=Drosophila melanogaster, GI45552018, Length=170, Percent_Identity=30.5882352941176, Blast_Score=89, Evalue=5e-18,
Organism=Drosophila melanogaster, GI24651774, Length=256, Percent_Identity=21.875, Blast_Score=73, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEMH_STAAC (Q5HEU3)

Other databases:

- EMBL:   CP000046
- RefSeq:   YP_186714.1
- ProteinModelPortal:   Q5HEU3
- SMR:   Q5HEU3
- STRING:   Q5HEU3
- EnsemblBacteria:   EBSTAT00000010918
- GeneID:   3236274
- GenomeReviews:   CP000046_GR
- KEGG:   sac:SACOL1888
- TIGR:   SACOL1888
- eggNOG:   COG0276
- GeneTree:   EBGT00050000024369
- HOGENOM:   HBG697135
- OMA:   LAPHFST
- ProtClustDB:   PRK12435
- BioCyc:   SAUR93062:SACOL1888-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00323
- InterPro:   IPR001015
- InterPro:   IPR019772
- PANTHER:   PTHR11108
- TIGRFAMs:   TIGR00109

Pfam domain/function: PF00762 Ferrochelatase

EC number: =4.99.1.1

Molecular weight: Translated: 35057; Mature: 34925

Theoretical pI: Translated: 4.63; Mature: 4.63

Prosite motif: PS00534 FERROCHELATASE; PS00435 PEROXIDASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKKMGLLVMAYGTPYKESDIEPYYTDIRHGKRPSEEELQDLKDRYEFIGGLSPLAGTTD
CCCCCEEEEEEECCCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCC
DQADALVSALNKAYADVEFKLYLGLKHISPFIEDAVEQMHNDGITEAITVVLAPHYSSFS
HHHHHHHHHHHHHHHCEEEEEEECHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCC
VGSYDKRADEEAAKYGIQLTHVKHYYEQPKFIEYWTNKVNETLAQIPEEEHKDTVLVVSA
CCCCHHHHHHHHHHHCEEHEEHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEC
HSLPKGLIEKNNDPYPQELEHTALLIKEQSNIEHIAIGWQSEGNTGTPWLGPDVQDLTRD
CCCCHHHHHCCCCCCHHHHHHHHEEEECCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHH
LYEKHQYKNFIYTPVGFVCEHLEVLYDNDYECKVVCDDIGANYYRPKMPNTHPLFIGAIV
HHHHHHHCCEEECCHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCCHHHHHH
DEIKSIF
HHHHHCC
>Mature Secondary Structure 
TKKMGLLVMAYGTPYKESDIEPYYTDIRHGKRPSEEELQDLKDRYEFIGGLSPLAGTTD
CCCCEEEEEEECCCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCC
DQADALVSALNKAYADVEFKLYLGLKHISPFIEDAVEQMHNDGITEAITVVLAPHYSSFS
HHHHHHHHHHHHHHHCEEEEEEECHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCC
VGSYDKRADEEAAKYGIQLTHVKHYYEQPKFIEYWTNKVNETLAQIPEEEHKDTVLVVSA
CCCCHHHHHHHHHHHCEEHEEHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEC
HSLPKGLIEKNNDPYPQELEHTALLIKEQSNIEHIAIGWQSEGNTGTPWLGPDVQDLTRD
CCCCHHHHHCCCCCCHHHHHHHHEEEECCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHH
LYEKHQYKNFIYTPVGFVCEHLEVLYDNDYECKVVCDDIGANYYRPKMPNTHPLFIGAIV
HHHHHHHCCEEECCHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCCHHHHHH
DEIKSIF
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA