Click here to switch to the map view.

The map label for this gene is menE

Identifier: 15924787

GI number: 15924787

Start: 1927096

End: 1928574

Strand: Reverse

Name: menE

Synonym: SAV1797

Alternate gene names: 15924787

Gene position: 1928574-1927096 (Counterclockwise)

Preceding gene: 15924788

Following gene: 15924786

Centisome position: 67.0

GC content: 36.11

Gene sequence:

>1479_bases
ATGGACTTTTGGTTATATAAACAAGCACAACAAAATGGACATCATATTGCGATAACAGACGGTCAAGAATCTTATACTTA
TCAAAATTTATACTGTGAAGCGAGTCTATTGGCTAAAAGACTCAAGGCTTATCAACAATCTCGTGTCGGGCTATACATAG
ATAATTCGATTCAATCGATCATTTTAATACATGCATGTTGGTTGGCAAATATTGAAATTGCGATGATTAATACAAGGTTG
ACACCTAATGAGATGACGAATCAGATGAGGTCAATCGATGTACAATTGATTTTTTGTACCTTGCCACTGGAATTGCGAGG
GTTTCAAATTGTATCGCTGGATGATATTGAATTCGCTGGAAGGGATATTACAACGAACGGTTTGTTGGACAACACAATGG
GTATCCAATATGATACATCGAATGAAACTGTGGTGCCGAAAGAGTCGCCGTCCAACATATTAAATACATCATTTAATTTA
GATGACATTGCATCAATTATGTTTACATCAGGGACAACGGGCCCTCAAAAAGCGGTGCCACAAACGTTTCGTAATCATTA
TGCCAGTGCAATCGGATGTAAAGAGAGCTTGGGATTTGATCGTGACACTAATTGGCTATCTGTCTTGCCGATTTATCATA
TTTCGGGTCTCAGTGTACTTTTAAGAGCTGTTATTGAAGGTTTTACTGTGCGCATTGTTGATAAATTCAATGCCGAACAA
ATTTTAACGATGATTAAAAATGAACGAATCACGCACATTTCGCTTGTGCCACAAACTTTAAATTGGCTTATGCAACAAGG
TTTACATGAACCTTATAATTTACAAAAAATATTACTCGGCGGTGCTAAATTATCTGCCACTATGATAGAGACGGCATTAC
AATATAACCTGCCAATTTATAATTCATTTGGTATGACTGAGACATGTTCGCAATTTTTAACAGCAACACCGGAAATGTTG
CATGCACGTCCTGACACTGTAGGGATGCCAAGTGCCAATGTTGACGTTAAAATTAAAAATCCTAATAAAGAAGGTCATGG
AGAATTAATGATTAAAGGTGCCAATGTGATGAATGGATATTTGTATCCAACAGATTTAACGGGTACGTTTGAAAATGGTT
ATTTTAATACAGGTGACATTGCTGAAATAGATCATGAAGGTTATGTTATGATTTATGACCGACGTAAAGATTTAATTATT
AGTGGCGGTGAAAATATTTATCCATATCAAATTGAAACGGTAGCGAAGCAATTTCCAGGTATCAGTGACGCAGTATGTGT
AGGGCATCCTGATGATACTTGGGGCCAAGTGCCTAAATTATATTTTGTCAGTGAAAGTGACATTTCAAAGGCACAATTGA
TTGCATATTTATCAAAACATTTAGCGAAATATAAAGTACCGAAACACTTTGAAAAGGTTGATACTTTACCTTATACATCA
ACGGGTAAATTACAGAGAAATAAGTTGTATAGAGGATGA

Upstream 100 bases:

>100_bases
AATCAATTCGTCTACTTTTTTATATTTTTAAACATAACCACTGCTAGAATGTCATAAAATCGTTATAATTATAATGTAAA
TGATTTTGGAGGAATAACGC

Downstream 100 bases:

>100_bases
TTTGATGAAGTTGACAGCTTTGCATTTTTATAAATATAGTGAGCCATTTAAGTCACAAATTGTAACACCGAAAGTCACTT
TAACGCATCGTGATTGTTTG

Product: O-succinylbenzoic acid-CoA ligase

Products: NA

Alternate protein names: OSB-CoA synthetase; o-succinylbenzoyl-CoA synthetase

Number of amino acids: Translated: 492; Mature: 492

Protein sequence:

>492_residues
MDFWLYKQAQQNGHHIAITDGQESYTYQNLYCEASLLAKRLKAYQQSRVGLYIDNSIQSIILIHACWLANIEIAMINTRL
TPNEMTNQMRSIDVQLIFCTLPLELRGFQIVSLDDIEFAGRDITTNGLLDNTMGIQYDTSNETVVPKESPSNILNTSFNL
DDIASIMFTSGTTGPQKAVPQTFRNHYASAIGCKESLGFDRDTNWLSVLPIYHISGLSVLLRAVIEGFTVRIVDKFNAEQ
ILTMIKNERITHISLVPQTLNWLMQQGLHEPYNLQKILLGGAKLSATMIETALQYNLPIYNSFGMTETCSQFLTATPEML
HARPDTVGMPSANVDVKIKNPNKEGHGELMIKGANVMNGYLYPTDLTGTFENGYFNTGDIAEIDHEGYVMIYDRRKDLII
SGGENIYPYQIETVAKQFPGISDAVCVGHPDDTWGQVPKLYFVSESDISKAQLIAYLSKHLAKYKVPKHFEKVDTLPYTS
TGKLQRNKLYRG

Sequences:

>Translated_492_residues
MDFWLYKQAQQNGHHIAITDGQESYTYQNLYCEASLLAKRLKAYQQSRVGLYIDNSIQSIILIHACWLANIEIAMINTRL
TPNEMTNQMRSIDVQLIFCTLPLELRGFQIVSLDDIEFAGRDITTNGLLDNTMGIQYDTSNETVVPKESPSNILNTSFNL
DDIASIMFTSGTTGPQKAVPQTFRNHYASAIGCKESLGFDRDTNWLSVLPIYHISGLSVLLRAVIEGFTVRIVDKFNAEQ
ILTMIKNERITHISLVPQTLNWLMQQGLHEPYNLQKILLGGAKLSATMIETALQYNLPIYNSFGMTETCSQFLTATPEML
HARPDTVGMPSANVDVKIKNPNKEGHGELMIKGANVMNGYLYPTDLTGTFENGYFNTGDIAEIDHEGYVMIYDRRKDLII
SGGENIYPYQIETVAKQFPGISDAVCVGHPDDTWGQVPKLYFVSESDISKAQLIAYLSKHLAKYKVPKHFEKVDTLPYTS
TGKLQRNKLYRG
>Mature_492_residues
MDFWLYKQAQQNGHHIAITDGQESYTYQNLYCEASLLAKRLKAYQQSRVGLYIDNSIQSIILIHACWLANIEIAMINTRL
TPNEMTNQMRSIDVQLIFCTLPLELRGFQIVSLDDIEFAGRDITTNGLLDNTMGIQYDTSNETVVPKESPSNILNTSFNL
DDIASIMFTSGTTGPQKAVPQTFRNHYASAIGCKESLGFDRDTNWLSVLPIYHISGLSVLLRAVIEGFTVRIVDKFNAEQ
ILTMIKNERITHISLVPQTLNWLMQQGLHEPYNLQKILLGGAKLSATMIETALQYNLPIYNSFGMTETCSQFLTATPEML
HARPDTVGMPSANVDVKIKNPNKEGHGELMIKGANVMNGYLYPTDLTGTFENGYFNTGDIAEIDHEGYVMIYDRRKDLII
SGGENIYPYQIETVAKQFPGISDAVCVGHPDDTWGQVPKLYFVSESDISKAQLIAYLSKHLAKYKVPKHFEKVDTLPYTS
TGKLQRNKLYRG

Specific function: Converts 2-succinylbenzoate (OSB) to 2-succinylbenzoyl- CoA (OSB-CoA)

COG id: COG0318

COG function: function code IQ; Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II

Gene ontology:

Cell location: Partially Membrane-Associated [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family. MenE subfamily

Homologues:

Organism=Homo sapiens, GI42544132, Length=362, Percent_Identity=25.9668508287293, Blast_Score=106, Evalue=5e-23,
Organism=Homo sapiens, GI115511026, Length=380, Percent_Identity=26.8421052631579, Blast_Score=102, Evalue=7e-22,
Organism=Homo sapiens, GI38505220, Length=362, Percent_Identity=27.6243093922652, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI187761345, Length=551, Percent_Identity=23.4119782214156, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI187761343, Length=551, Percent_Identity=23.4119782214156, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI156151445, Length=354, Percent_Identity=25.4237288135593, Blast_Score=99, Evalue=8e-21,
Organism=Homo sapiens, GI157311624, Length=361, Percent_Identity=26.8698060941828, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI157311622, Length=361, Percent_Identity=26.8698060941828, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI58082049, Length=361, Percent_Identity=26.5927977839335, Blast_Score=93, Evalue=6e-19,
Organism=Homo sapiens, GI122937307, Length=268, Percent_Identity=27.9850746268657, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI27477105, Length=158, Percent_Identity=33.5443037974684, Blast_Score=78, Evalue=2e-14,
Organism=Escherichia coli, GI1788107, Length=503, Percent_Identity=26.441351888668, Blast_Score=142, Evalue=6e-35,
Organism=Escherichia coli, GI145693145, Length=530, Percent_Identity=25.2830188679245, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI1786810, Length=349, Percent_Identity=27.7936962750716, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI1788595, Length=309, Percent_Identity=29.4498381877023, Blast_Score=123, Evalue=3e-29,
Organism=Escherichia coli, GI221142682, Length=467, Percent_Identity=26.1241970021413, Blast_Score=111, Evalue=1e-25,
Organism=Escherichia coli, GI1789201, Length=489, Percent_Identity=23.721881390593, Blast_Score=103, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI17538037, Length=372, Percent_Identity=28.494623655914, Blast_Score=138, Evalue=8e-33,
Organism=Caenorhabditis elegans, GI17557194, Length=372, Percent_Identity=28.2258064516129, Blast_Score=137, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI17559526, Length=362, Percent_Identity=27.6243093922652, Blast_Score=134, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17560308, Length=513, Percent_Identity=25.1461988304094, Blast_Score=122, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI32563687, Length=341, Percent_Identity=29.3255131964809, Blast_Score=119, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI17558820, Length=473, Percent_Identity=27.061310782241, Blast_Score=117, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI71996755, Length=466, Percent_Identity=25.1072961373391, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17531443, Length=466, Percent_Identity=26.8240343347639, Blast_Score=111, Evalue=8e-25,
Organism=Caenorhabditis elegans, GI71994690, Length=348, Percent_Identity=25.8620689655172, Blast_Score=106, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI71994694, Length=348, Percent_Identity=25.8620689655172, Blast_Score=106, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI71994703, Length=348, Percent_Identity=25.8620689655172, Blast_Score=105, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI17560140, Length=528, Percent_Identity=22.3484848484848, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI71985884, Length=346, Percent_Identity=26.878612716763, Blast_Score=99, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI25141359, Length=466, Percent_Identity=24.8927038626609, Blast_Score=95, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI115534440, Length=526, Percent_Identity=24.3346007604563, Blast_Score=82, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17556356, Length=260, Percent_Identity=25.3846153846154, Blast_Score=72, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17556552, Length=221, Percent_Identity=27.6018099547511, Blast_Score=70, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6319699, Length=338, Percent_Identity=30.4733727810651, Blast_Score=133, Evalue=6e-32,
Organism=Saccharomyces cerevisiae, GI6319264, Length=554, Percent_Identity=20.7581227436823, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24581924, Length=353, Percent_Identity=29.1784702549575, Blast_Score=111, Evalue=9e-25,
Organism=Drosophila melanogaster, GI21355181, Length=509, Percent_Identity=23.3791748526523, Blast_Score=111, Evalue=1e-24,
Organism=Drosophila melanogaster, GI18859661, Length=512, Percent_Identity=25.390625, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI20130357, Length=475, Percent_Identity=24.4210526315789, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI21356947, Length=358, Percent_Identity=25.4189944134078, Blast_Score=89, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24648260, Length=348, Percent_Identity=26.1494252873563, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24648257, Length=452, Percent_Identity=22.5663716814159, Blast_Score=83, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24656500, Length=478, Percent_Identity=22.5941422594142, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI17933690, Length=140, Percent_Identity=35, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24653035, Length=475, Percent_Identity=23.3684210526316, Blast_Score=79, Evalue=7e-15,
Organism=Drosophila melanogaster, GI19921316, Length=161, Percent_Identity=32.2981366459627, Blast_Score=76, Evalue=4e-14,
Organism=Drosophila melanogaster, GI161076582, Length=482, Percent_Identity=23.0290456431535, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI21358303, Length=498, Percent_Identity=21.4859437751004, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MENE_STAA1 (A7X3P0)

Other databases:

- EMBL:   AP009324
- RefSeq:   YP_001442372.1
- ProteinModelPortal:   A7X3P0
- SMR:   A7X3P0
- STRING:   A7X3P0
- EnsemblBacteria:   EBSTAT00000004507
- GeneID:   5560248
- GenomeReviews:   AP009324_GR
- KEGG:   saw:SAHV_1782
- eggNOG:   COG0318
- GeneTree:   EBGT00050000024490
- HOGENOM:   HBG547964
- OMA:   ERIASIM
- ProtClustDB:   CLSK885565
- BioCyc:   SAUR418127:SAHV_1782-MONOMER
- HAMAP:   MF_00731
- InterPro:   IPR000873
- InterPro:   IPR010192
- InterPro:   IPR023015
- TIGRFAMs:   TIGR01923

Pfam domain/function: PF00501 AMP-binding

EC number: =6.2.1.26

Molecular weight: Translated: 55358; Mature: 55358

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFWLYKQAQQNGHHIAITDGQESYTYQNLYCEASLLAKRLKAYQQSRVGLYIDNSIQSI
CCCEEEEHHHCCCCEEEEECCCCCCEEEHEEECHHHHHHHHHHHHHCCCEEEECCCHHHH
ILIHACWLANIEIAMINTRLTPNEMTNQMRSIDVQLIFCTLPLELRGFQIVSLDDIEFAG
HHHHHHHHCCEEEEEEEECCCHHHHHHHHHHCEEEEEEEECCEEECCEEEEEECCCHHCC
RDITTNGLLDNTMGIQYDTSNETVVPKESPSNILNTSFNLDDIASIMFTSGTTGPQKAVP
CEEECCCCCCCCCCEEECCCCCEECCCCCCCCHHCCCCCHHHHHHHHEECCCCCCHHHHH
QTFRNHYASAIGCKESLGFDRDTNWLSVLPIYHISGLSVLLRAVIEGFTVRIVDKFNAEQ
HHHHHHHHHHCCCHHHCCCCCCCCEEEEEEEHHHHHHHHHHHHHHCCCEEEEEECCCHHH
ILTMIKNERITHISLVPQTLNWLMQQGLHEPYNLQKILLGGAKLSATMIETALQYNLPIY
HHHHHHCCCEEEEEECHHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHHHHCCCEE
NSFGMTETCSQFLTATPEMLHARPDTVGMPSANVDVKIKNPNKEGHGELMIKGANVMNGY
ECCCCHHHHHHHHHCCHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCEEEEEECCEECCE
LYPTDLTGTFENGYFNTGDIAEIDHEGYVMIYDRRKDLIISGGENIYPYQIETVAKQFPG
EEECCCCCCCCCCCCCCCCCEEECCCCEEEEEECCCEEEEECCCEECCCHHHHHHHHCCC
ISDAVCVGHPDDTWGQVPKLYFVSESDISKAQLIAYLSKHLAKYKVPKHFEKVDTLPYTS
CCCEEEECCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCC
TGKLQRNKLYRG
CCCHHCCCCCCC
>Mature Secondary Structure
MDFWLYKQAQQNGHHIAITDGQESYTYQNLYCEASLLAKRLKAYQQSRVGLYIDNSIQSI
CCCEEEEHHHCCCCEEEEECCCCCCEEEHEEECHHHHHHHHHHHHHCCCEEEECCCHHHH
ILIHACWLANIEIAMINTRLTPNEMTNQMRSIDVQLIFCTLPLELRGFQIVSLDDIEFAG
HHHHHHHHCCEEEEEEEECCCHHHHHHHHHHCEEEEEEEECCEEECCEEEEEECCCHHCC
RDITTNGLLDNTMGIQYDTSNETVVPKESPSNILNTSFNLDDIASIMFTSGTTGPQKAVP
CEEECCCCCCCCCCEEECCCCCEECCCCCCCCHHCCCCCHHHHHHHHEECCCCCCHHHHH
QTFRNHYASAIGCKESLGFDRDTNWLSVLPIYHISGLSVLLRAVIEGFTVRIVDKFNAEQ
HHHHHHHHHHCCCHHHCCCCCCCCEEEEEEEHHHHHHHHHHHHHHCCCEEEEEECCCHHH
ILTMIKNERITHISLVPQTLNWLMQQGLHEPYNLQKILLGGAKLSATMIETALQYNLPIY
HHHHHHCCCEEEEEECHHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHHHHCCCEE
NSFGMTETCSQFLTATPEMLHARPDTVGMPSANVDVKIKNPNKEGHGELMIKGANVMNGY
ECCCCHHHHHHHHHCCHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCEEEEEECCEECCE
LYPTDLTGTFENGYFNTGDIAEIDHEGYVMIYDRRKDLIISGGENIYPYQIETVAKQFPG
EEECCCCCCCCCCCCCCCCCEEECCCCEEEEEECCCEEEEECCCEECCCHHHHHHHHCCC
ISDAVCVGHPDDTWGQVPKLYFVSESDISKAQLIAYLSKHLAKYKVPKHFEKVDTLPYTS
CCCEEEECCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCC
TGKLQRNKLYRG
CCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA