BacMap

Definition	Staphylococcus aureus subsp. aureus Mu50, complete genome.
Accession	NC_002758
Length	2,878,529

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The map label for this gene is yvgN [H]

Identifier: 15924778

GI number: 15924778

Start: 1918933

End: 1919766

Strand: Reverse

Name: yvgN [H]

Synonym: SAV1788

Alternate gene names: 15924778

Gene position: 1919766-1918933 (Counterclockwise)

Preceding gene: 15924779

Following gene: 15924771

Centisome position: 66.69

GC content: 34.53

Gene sequence:

>834_bases
ATGGAGGTTAAAACATTTTATAATGGAAACACGATGCCACAAATTGGTTTAGGGACATTTCGTGTGGAAAATGATGAAAA
TTGCATGGAAAGTGTTAAGTATGCCATTGAACAAGGATATCGTAGTATTGATACCGCAAAAGTTTATGGGAATGAAGAAC
AAGTAGGTGCTGGCATTCGTGCCGGATTGGAGTCAACTGGTATTGCTAGAGAAGACTTATTTATTACTTCAAAATTATAT
TTTGAGGATTTCGGTCGTGAAAATGTAGCAGCTGCTTACGAAGCTAGTTTATCTAGATTAGGTTTAAAATACTTAGATTT
GTATCTAGTACATTGGCCAGGCACGAACGAAGCCGTAATGGTTGATACATGGAAAGGTATGGAAGATTTATATAAAAATA
ATAAAGCTAAAAATATAGGTGTCAGCAATTTTGAACCTGAACATTTGGAAGCTTTGTTGGCACAAGTGTCAATTAAACCT
GTAATTAATCAAGTTGAATATCATCCATATTTAACGCAACATAAATTGAAATTATATTTGGCAGCACAACATATCGTGAT
GGAATCTTGGTCACCATTGATGAATGCACAAATTTTAAATGATGAGACAATTAAAGACATTGCTCAAGAATTAGGAAAGT
CACCTGCCCAAGTTGTTTTAAGATGGAATGTGCAGCATGGTGTGGTTATAATCCCTAAATCGGTAACACCAAACAGAATC
TCTGAAAACTTCCAAATATTTGATTTCGAATTATCAGATGAACAAATGACGCGAATTGATGGTTTAAATCAAGATAAGAG
AATTGGACCTGATCCAAAAACTTTTGAAGGATAG

Upstream 100 bases:

>100_bases
ATTTTAGTGGTTGATTGCTCTAAGTGTTTTTTCTCATGTATTCAACTCAGATTTGTTATGATAACAGGGTATAATACATC
AAAAAGGTGAGGCGATATTT

Downstream 100 bases:

>100_bases
ATTAAAATCACTCAACTGATGAAAAGGTTAGATGAATTGTCAGGGCTTGGGACATTAAGTTCTTAGGCAATGTAAAAAAG
TTGATTTCTATTAATTATTT

Product: 2,5-didehydrogluconate reductase

Products: NA

Alternate protein names: GR; Methylglyoxal reductase [H]

Number of amino acids: Translated: 277; Mature: 277

Protein sequence:

>277_residues
MEVKTFYNGNTMPQIGLGTFRVENDENCMESVKYAIEQGYRSIDTAKVYGNEEQVGAGIRAGLESTGIAREDLFITSKLY
FEDFGRENVAAAYEASLSRLGLKYLDLYLVHWPGTNEAVMVDTWKGMEDLYKNNKAKNIGVSNFEPEHLEALLAQVSIKP
VINQVEYHPYLTQHKLKLYLAAQHIVMESWSPLMNAQILNDETIKDIAQELGKSPAQVVLRWNVQHGVVIIPKSVTPNRI
SENFQIFDFELSDEQMTRIDGLNQDKRIGPDPKTFEG

Sequences:

>Translated_277_residues
MEVKTFYNGNTMPQIGLGTFRVENDENCMESVKYAIEQGYRSIDTAKVYGNEEQVGAGIRAGLESTGIAREDLFITSKLY
FEDFGRENVAAAYEASLSRLGLKYLDLYLVHWPGTNEAVMVDTWKGMEDLYKNNKAKNIGVSNFEPEHLEALLAQVSIKP
VINQVEYHPYLTQHKLKLYLAAQHIVMESWSPLMNAQILNDETIKDIAQELGKSPAQVVLRWNVQHGVVIIPKSVTPNRI
SENFQIFDFELSDEQMTRIDGLNQDKRIGPDPKTFEG
>Mature_277_residues
MEVKTFYNGNTMPQIGLGTFRVENDENCMESVKYAIEQGYRSIDTAKVYGNEEQVGAGIRAGLESTGIAREDLFITSKLY
FEDFGRENVAAAYEASLSRLGLKYLDLYLVHWPGTNEAVMVDTWKGMEDLYKNNKAKNIGVSNFEPEHLEALLAQVSIKP
VINQVEYHPYLTQHKLKLYLAAQHIVMESWSPLMNAQILNDETIKDIAQELGKSPAQVVLRWNVQHGVVIIPKSVTPNRI
SENFQIFDFELSDEQMTRIDGLNQDKRIGPDPKTFEG

Specific function: Reduces glyoxal and methylglyoxal. Is not involved in the vitamin B6 biosynthesis [H]

COG id: COG0656

COG function: function code R; Aldo/keto reductases, related to diketogulonate reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldo/keto reductase family [H]

Homologues:

Organism=Homo sapiens, GI223468663, Length=286, Percent_Identity=41.958041958042, Blast_Score=212, Evalue=4e-55,
Organism=Homo sapiens, GI93277124, Length=306, Percent_Identity=38.2352941176471, Blast_Score=205, Evalue=4e-53,
Organism=Homo sapiens, GI24497577, Length=291, Percent_Identity=36.0824742268041, Blast_Score=200, Evalue=1e-51,
Organism=Homo sapiens, GI5174391, Length=291, Percent_Identity=36.0824742268041, Blast_Score=200, Evalue=1e-51,
Organism=Homo sapiens, GI291291012, Length=268, Percent_Identity=39.9253731343284, Blast_Score=191, Evalue=5e-49,
Organism=Homo sapiens, GI45446745, Length=293, Percent_Identity=37.8839590443686, Blast_Score=190, Evalue=1e-48,
Organism=Homo sapiens, GI4503285, Length=293, Percent_Identity=37.8839590443686, Blast_Score=190, Evalue=1e-48,
Organism=Homo sapiens, GI5453543, Length=293, Percent_Identity=37.2013651877133, Blast_Score=189, Evalue=2e-48,
Organism=Homo sapiens, GI310109920, Length=293, Percent_Identity=37.542662116041, Blast_Score=189, Evalue=2e-48,
Organism=Homo sapiens, GI24497585, Length=293, Percent_Identity=38.2252559726962, Blast_Score=188, Evalue=5e-48,
Organism=Homo sapiens, GI5174695, Length=295, Percent_Identity=37.2881355932203, Blast_Score=188, Evalue=6e-48,
Organism=Homo sapiens, GI310109922, Length=275, Percent_Identity=38.9090909090909, Blast_Score=187, Evalue=7e-48,
Organism=Homo sapiens, GI4502049, Length=291, Percent_Identity=40.5498281786942, Blast_Score=184, Evalue=6e-47,
Organism=Homo sapiens, GI24497583, Length=291, Percent_Identity=36.7697594501718, Blast_Score=179, Evalue=2e-45,
Organism=Homo sapiens, GI300116273, Length=273, Percent_Identity=36.2637362637363, Blast_Score=165, Evalue=5e-41,
Organism=Homo sapiens, GI300116271, Length=275, Percent_Identity=35.2727272727273, Blast_Score=155, Evalue=3e-38,
Organism=Homo sapiens, GI310109924, Length=154, Percent_Identity=37.6623376623377, Blast_Score=103, Evalue=1e-22,
Organism=Homo sapiens, GI207028673, Length=121, Percent_Identity=43.801652892562, Blast_Score=99, Evalue=3e-21,
Organism=Homo sapiens, GI310109926, Length=121, Percent_Identity=42.9752066115703, Blast_Score=99, Evalue=5e-21,
Organism=Escherichia coli, GI87082198, Length=277, Percent_Identity=44.7653429602888, Blast_Score=246, Evalue=2e-66,
Organism=Escherichia coli, GI1786400, Length=260, Percent_Identity=33.0769230769231, Blast_Score=152, Evalue=2e-38,
Organism=Escherichia coli, GI1788081, Length=285, Percent_Identity=31.2280701754386, Blast_Score=111, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI17537077, Length=290, Percent_Identity=37.5862068965517, Blast_Score=190, Evalue=8e-49,
Organism=Caenorhabditis elegans, GI17564128, Length=294, Percent_Identity=34.0136054421769, Blast_Score=183, Evalue=7e-47,
Organism=Caenorhabditis elegans, GI17537075, Length=296, Percent_Identity=36.8243243243243, Blast_Score=183, Evalue=9e-47,
Organism=Caenorhabditis elegans, GI17538386, Length=269, Percent_Identity=36.4312267657993, Blast_Score=181, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI71998625, Length=267, Percent_Identity=38.5767790262172, Blast_Score=180, Evalue=6e-46,
Organism=Caenorhabditis elegans, GI17552492, Length=280, Percent_Identity=32.8571428571429, Blast_Score=175, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI17550248, Length=289, Percent_Identity=34.6020761245675, Blast_Score=167, Evalue=8e-42,
Organism=Caenorhabditis elegans, GI17561298, Length=269, Percent_Identity=33.8289962825279, Blast_Score=161, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI17561300, Length=271, Percent_Identity=35.0553505535055, Blast_Score=159, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI17566692, Length=293, Percent_Identity=32.7645051194539, Blast_Score=157, Evalue=5e-39,
Organism=Caenorhabditis elegans, GI17562292, Length=276, Percent_Identity=31.5217391304348, Blast_Score=154, Evalue=4e-38,
Organism=Caenorhabditis elegans, GI17537079, Length=298, Percent_Identity=30.2013422818792, Blast_Score=149, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17550246, Length=75, Percent_Identity=44, Blast_Score=68, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6324694, Length=296, Percent_Identity=37.8378378378378, Blast_Score=181, Evalue=1e-46,
Organism=Saccharomyces cerevisiae, GI6320576, Length=291, Percent_Identity=36.426116838488, Blast_Score=179, Evalue=6e-46,
Organism=Saccharomyces cerevisiae, GI6322556, Length=266, Percent_Identity=34.9624060150376, Blast_Score=174, Evalue=2e-44,
Organism=Saccharomyces cerevisiae, GI6321896, Length=315, Percent_Identity=32.0634920634921, Blast_Score=159, Evalue=5e-40,
Organism=Saccharomyces cerevisiae, GI6319625, Length=272, Percent_Identity=33.0882352941176, Blast_Score=144, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6320079, Length=283, Percent_Identity=33.5689045936396, Blast_Score=143, Evalue=3e-35,
Organism=Drosophila melanogaster, GI24657054, Length=289, Percent_Identity=39.7923875432526, Blast_Score=197, Evalue=6e-51,
Organism=Drosophila melanogaster, GI21356425, Length=290, Percent_Identity=38.6206896551724, Blast_Score=189, Evalue=1e-48,
Organism=Drosophila melanogaster, GI24663317, Length=290, Percent_Identity=38.6206896551724, Blast_Score=188, Evalue=3e-48,
Organism=Drosophila melanogaster, GI24662789, Length=292, Percent_Identity=37.3287671232877, Blast_Score=187, Evalue=5e-48,
Organism=Drosophila melanogaster, GI24644950, Length=300, Percent_Identity=37.6666666666667, Blast_Score=187, Evalue=9e-48,
Organism=Drosophila melanogaster, GI20129731, Length=285, Percent_Identity=37.5438596491228, Blast_Score=182, Evalue=2e-46,
Organism=Drosophila melanogaster, GI24662785, Length=292, Percent_Identity=43.1506849315069, Blast_Score=181, Evalue=6e-46,
Organism=Drosophila melanogaster, GI221378297, Length=320, Percent_Identity=35.3125, Blast_Score=179, Evalue=2e-45,
Organism=Drosophila melanogaster, GI24662781, Length=294, Percent_Identity=42.8571428571429, Blast_Score=178, Evalue=4e-45,
Organism=Drosophila melanogaster, GI45553081, Length=287, Percent_Identity=33.1010452961672, Blast_Score=156, Evalue=1e-38,
Organism=Drosophila melanogaster, GI281366140, Length=256, Percent_Identity=32.421875, Blast_Score=134, Evalue=9e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001395
- InterPro:   IPR018170
- InterPro:   IPR020471
- InterPro:   IPR023210 [H]

Pfam domain/function: PF00248 Aldo_ket_red [H]

EC number: =1.1.1.283 [H]

Molecular weight: Translated: 31410; Mature: 31410

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: PS00798 ALDOKETO_REDUCTASE_1 ; PS00062 ALDOKETO_REDUCTASE_2 ; PS00063 ALDOKETO_REDUCTASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEVKTFYNGNTMPQIGLGTFRVENDENCMESVKYAIEQGYRSIDTAKVYGNEEQVGAGIR
CCEEEEECCCCCCEECCEEEEECCCHHHHHHHHHHHHHCCCCCCCEEECCCHHHHCCHHH
AGLESTGIAREDLFITSKLYFEDFGRENVAAAYEASLSRLGLKYLDLYLVHWPGTNEAVM
CCCHHCCCCHHHEEEEHHHHHHHCCCCHHHHHHHHHHHHHCCEEEEEEEEECCCCCCEEE
VDTWKGMEDLYKNNKAKNIGVSNFEPEHLEALLAQVSIKPVINQVEYHPYLTQHKLKLYL
EECCCCHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHEEEEH
AAQHIVMESWSPLMNAQILNDETIKDIAQELGKSPAQVVLRWNVQHGVVIIPKSVTPNRI
HHHHHHHHCCCHHHCEEECCCHHHHHHHHHHCCCCEEEEEEEECCCCEEEEECCCCCCHH
SENFQIFDFELSDEQMTRIDGLNQDKRIGPDPKTFEG
CCCCEEEEEEECCHHHHHHCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MEVKTFYNGNTMPQIGLGTFRVENDENCMESVKYAIEQGYRSIDTAKVYGNEEQVGAGIR
CCEEEEECCCCCCEECCEEEEECCCHHHHHHHHHHHHHCCCCCCCEEECCCHHHHCCHHH
AGLESTGIAREDLFITSKLYFEDFGRENVAAAYEASLSRLGLKYLDLYLVHWPGTNEAVM
CCCHHCCCCHHHEEEEHHHHHHHCCCCHHHHHHHHHHHHHCCEEEEEEEEECCCCCCEEE
VDTWKGMEDLYKNNKAKNIGVSNFEPEHLEALLAQVSIKPVINQVEYHPYLTQHKLKLYL
EECCCCHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHEEEEH
AAQHIVMESWSPLMNAQILNDETIKDIAQELGKSPAQVVLRWNVQHGVVIIPKSVTPNRI
HHHHHHHHCCCHHHCEEECCCHHHHHHHHHHCCCCEEEEEEEECCCCEEEEECCCCCCHH
SENFQIFDFELSDEQMTRIDGLNQDKRIGPDPKTFEG
CCCCEEEEEEECCHHHHHHCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9639930; 9384377 [H]