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The map label for this gene is murC

Identifier: 15924730

GI number: 15924730

Start: 1867419

End: 1868732

Strand: Reverse

Name: murC

Synonym: SAV1740

Alternate gene names: 15924730

Gene position: 1868732-1867419 (Counterclockwise)

Preceding gene: 15924731

Following gene: 15924729

Centisome position: 64.92

GC content: 31.28

Gene sequence:

>1314_bases
ATGACACACTATCATTTTGTCGGAATTAAAGGTTCTGGCATGAGTTCATTAGCACAAATCATGCATGATTTAGGACATGA
AGTTCAAGGATCGGATATTGAGAACTACGTATTTACAGAAGTTGCTCTTAGAAATAAGGGGATAAAAATATTACCATTTG
ATGCTAATAACATAAAAGAAGATATGGTAGTTATACAAGGTAATGCATTCGCGAGTAGCCATGAAGAAATAGTACGTGCA
CATCAATTGAAATTAGATGTTGTAAGTTATAATGATTTTTTAGGACAGATTATTGATCAATATACTTCAGTAGCTGTAAC
TGGTGCACATGGTAAAACTTCTACAACAGGTTTATTATCACATGTTATGAATGGTGATAAAAAGACTTCATTTTTAATTG
GTGATGGCACAGGTATGGGATTGCCTGAAAGTGATTATTTCGCTTTTGAGGCATGTGAATATAGACGTCACTTTTTAAGT
TATAAACCTGATTACGCAATTATGACAAATATTGATTTCGATCATCCTGATTATTTTAAAGATATTAATGATGTTTTTGA
TGCATTCCAAGAAATGGCACATAATGTTAAAAAAGGTATTATTGCTTGGGGTGATGATGAACATCTACGTAAAATTGAAG
CAGATGTTCCAATTTATTATTATGGATTTAAAGATTCGGATGACATTTATGCTCAAAATATTCAAATTACGGATAAAGGT
ACTGCTTTTGATGTGTATGTGGATGGTGAGTTTTATGATCACTTCCTGTCTCCACAATATGGTGACCATACAGTTTTAAA
TGCATTAGCTGTAATTGCGATTAGTTATTTAGAGAAGCTAGATGTTACAAATATTAAAGAAGCATTAGAAACGTTTGGTG
GTGTTAAACGTCGTTTCAATGAAACTACAATTGCAAATCAAGTTATTGTAGATGATTATGCACACCATCCAAGAGAAATT
AGTGCTACAATTGAAACAGCACGAAAGAAATATCCACATAAAGAAGTTGTTGCAGTATTTCAACCACACACTTTCTCTAG
AACACAAGCATTTTTAAATGAATTTGCAGAAAGTTTAAGTAAAGCAGATCGTGTATTCTTATGTGAAATTTTTGGATCAA
TTAGAGAAAATACTGGCGCATTAACGATACAAGATTTAATTGATAAAATTGAAGGTGCATCGTTAATTAATGAAGATTCT
ATTAATGTATTAGAACAATTTGATAATGCTGTTGTTTTATTTATGGGTGCAGGTGATATTCAAAAATTACAAAATGCATA
TTTAGATAAATTAGGCATGAAAAATGCGTTTTAA

Upstream 100 bases:

>100_bases
TCGGTTATGTTTCGAGTGCTAATGGTTCAAAACCAAGGGATGTTTATGTTACGGAAGCAGATTTAAATAAAGAATAATTA
TGAGTAAGGAGTTTTATATA

Downstream 100 bases:

>100_bases
TATGTTTATAATAGAGTAGTATGGGTATTTATTATTAATGACATTATTACATGTTAATTAGGAGGCGTTTTTAATGGATT
GGATTTTACCAATTGCTGGA

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase

Number of amino acids: Translated: 437; Mature: 436

Protein sequence:

>437_residues
MTHYHFVGIKGSGMSSLAQIMHDLGHEVQGSDIENYVFTEVALRNKGIKILPFDANNIKEDMVVIQGNAFASSHEEIVRA
HQLKLDVVSYNDFLGQIIDQYTSVAVTGAHGKTSTTGLLSHVMNGDKKTSFLIGDGTGMGLPESDYFAFEACEYRRHFLS
YKPDYAIMTNIDFDHPDYFKDINDVFDAFQEMAHNVKKGIIAWGDDEHLRKIEADVPIYYYGFKDSDDIYAQNIQITDKG
TAFDVYVDGEFYDHFLSPQYGDHTVLNALAVIAISYLEKLDVTNIKEALETFGGVKRRFNETTIANQVIVDDYAHHPREI
SATIETARKKYPHKEVVAVFQPHTFSRTQAFLNEFAESLSKADRVFLCEIFGSIRENTGALTIQDLIDKIEGASLINEDS
INVLEQFDNAVVLFMGAGDIQKLQNAYLDKLGMKNAF

Sequences:

>Translated_437_residues
MTHYHFVGIKGSGMSSLAQIMHDLGHEVQGSDIENYVFTEVALRNKGIKILPFDANNIKEDMVVIQGNAFASSHEEIVRA
HQLKLDVVSYNDFLGQIIDQYTSVAVTGAHGKTSTTGLLSHVMNGDKKTSFLIGDGTGMGLPESDYFAFEACEYRRHFLS
YKPDYAIMTNIDFDHPDYFKDINDVFDAFQEMAHNVKKGIIAWGDDEHLRKIEADVPIYYYGFKDSDDIYAQNIQITDKG
TAFDVYVDGEFYDHFLSPQYGDHTVLNALAVIAISYLEKLDVTNIKEALETFGGVKRRFNETTIANQVIVDDYAHHPREI
SATIETARKKYPHKEVVAVFQPHTFSRTQAFLNEFAESLSKADRVFLCEIFGSIRENTGALTIQDLIDKIEGASLINEDS
INVLEQFDNAVVLFMGAGDIQKLQNAYLDKLGMKNAF
>Mature_436_residues
THYHFVGIKGSGMSSLAQIMHDLGHEVQGSDIENYVFTEVALRNKGIKILPFDANNIKEDMVVIQGNAFASSHEEIVRAH
QLKLDVVSYNDFLGQIIDQYTSVAVTGAHGKTSTTGLLSHVMNGDKKTSFLIGDGTGMGLPESDYFAFEACEYRRHFLSY
KPDYAIMTNIDFDHPDYFKDINDVFDAFQEMAHNVKKGIIAWGDDEHLRKIEADVPIYYYGFKDSDDIYAQNIQITDKGT
AFDVYVDGEFYDHFLSPQYGDHTVLNALAVIAISYLEKLDVTNIKEALETFGGVKRRFNETTIANQVIVDDYAHHPREIS
ATIETARKKYPHKEVVAVFQPHTFSRTQAFLNEFAESLSKADRVFLCEIFGSIRENTGALTIQDLIDKIEGASLINEDSI
NVLEQFDNAVVLFMGAGDIQKLQNAYLDKLGMKNAF

Specific function: Cell wall formation

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family

Homologues:

Organism=Escherichia coli, GI1790680, Length=387, Percent_Identity=29.4573643410853, Blast_Score=145, Evalue=7e-36,
Organism=Escherichia coli, GI1786279, Length=456, Percent_Identity=29.8245614035088, Blast_Score=144, Evalue=1e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURC_STAA1 (A7X3H5)

Other databases:

- EMBL:   AP009324
- RefSeq:   YP_001442316.1
- ProteinModelPortal:   A7X3H5
- STRING:   A7X3H5
- EnsemblBacteria:   EBSTAT00000004891
- GeneID:   5560327
- GenomeReviews:   AP009324_GR
- KEGG:   saw:SAHV_1726
- eggNOG:   COG0773
- GeneTree:   EBGT00050000023807
- HOGENOM:   HBG476594
- OMA:   YHEFLGD
- ProtClustDB:   PRK00421
- BioCyc:   SAUR418127:SAHV_1726-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00046
- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758
- Gene3D:   G3DSA:3.90.190.20
- Gene3D:   G3DSA:3.40.1190.10
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR01082

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M; SSF53244 Mur_ligase_C; SSF53623 Mur_ligase_cen

EC number: =6.3.2.8

Molecular weight: Translated: 49175; Mature: 49044

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHYHFVGIKGSGMSSLAQIMHDLGHEVQGSDIENYVFTEVALRNKGIKILPFDANNIKE
CCCEEEEEECCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCEEEECCCCCCCC
DMVVIQGNAFASSHEEIVRAHQLKLDVVSYNDFLGQIIDQYTSVAVTGAHGKTSTTGLLS
CEEEEECCCCCCHHHHHHHHHHHEEEEECHHHHHHHHHHHHHHEEEECCCCCCHHHHHHH
HVMNGDKKTSFLIGDGTGMGLPESDYFAFEACEYRRHFLSYKPDYAIMTNIDFDHPDYFK
HHHCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHH
DINDVFDAFQEMAHNVKKGIIAWGDDEHLRKIEADVPIYYYGFKDSDDIYAQNIQITDKG
HHHHHHHHHHHHHHHHHCCCEEECCHHHHHHHHCCCCEEEECCCCCCCEEEEEEEEECCC
TAFDVYVDGEFYDHFLSPQYGDHTVLNALAVIAISYLEKLDVTNIKEALETFGGVKRRFN
CEEEEEECCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHC
ETTIANQVIVDDYAHHPREISATIETARKKYPHKEVVAVFQPHTFSRTQAFLNEFAESLS
HHHHHHHHEEHHHCCCCHHHHHHHHHHHHHCCCHHEEEEECCCCHHHHHHHHHHHHHHHH
KADRVFLCEIFGSIRENTGALTIQDLIDKIEGASLINEDSINVLEQFDNAVVLFMGAGDI
HHCCEEHHHHHHHHHCCCCCEEHHHHHHHHCCCCCCCCCHHHHHHHCCCEEEEEECCCHH
QKLQNAYLDKLGMKNAF
HHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
THYHFVGIKGSGMSSLAQIMHDLGHEVQGSDIENYVFTEVALRNKGIKILPFDANNIKE
CCEEEEEECCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCEEEECCCCCCCC
DMVVIQGNAFASSHEEIVRAHQLKLDVVSYNDFLGQIIDQYTSVAVTGAHGKTSTTGLLS
CEEEEECCCCCCHHHHHHHHHHHEEEEECHHHHHHHHHHHHHHEEEECCCCCCHHHHHHH
HVMNGDKKTSFLIGDGTGMGLPESDYFAFEACEYRRHFLSYKPDYAIMTNIDFDHPDYFK
HHHCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHH
DINDVFDAFQEMAHNVKKGIIAWGDDEHLRKIEADVPIYYYGFKDSDDIYAQNIQITDKG
HHHHHHHHHHHHHHHHHCCCEEECCHHHHHHHHCCCCEEEECCCCCCCEEEEEEEEECCC
TAFDVYVDGEFYDHFLSPQYGDHTVLNALAVIAISYLEKLDVTNIKEALETFGGVKRRFN
CEEEEEECCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHC
ETTIANQVIVDDYAHHPREISATIETARKKYPHKEVVAVFQPHTFSRTQAFLNEFAESLS
HHHHHHHHEEHHHCCCCHHHHHHHHHHHHHCCCHHEEEEECCCCHHHHHHHHHHHHHHHH
KADRVFLCEIFGSIRENTGALTIQDLIDKIEGASLINEDSINVLEQFDNAVVLFMGAGDI
HHCCEEHHHHHHHHHCCCCCEEHHHHHHHHCCCCCCCCCHHHHHHHCCCEEEEEECCCHH
QKLQNAYLDKLGMKNAF
HHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA