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The map label for this gene is fhs

Identifier: 15924722

GI number: 15924722

Start: 1856202

End: 1857869

Strand: Reverse

Name: fhs

Synonym: SAV1732

Alternate gene names: 15924722

Gene position: 1857869-1856202 (Counterclockwise)

Preceding gene: 15924723

Following gene: 15924721

Centisome position: 64.54

GC content: 36.27

Gene sequence:

>1668_bases
TTGACTCATTTATCAGATTTAGATATTGCGAATCAATCAACACTACAACCAATTAAGGATATTGCTGCATCAGTAGGTAT
TTCAGAGGATGCATTAGAACCTTATGGTCATTACAAAGCTAAAATCGACATTAATAAAATTACGCCAAGAGAAAACAAAG
GGAAAGTTGTTTTAGTAACTGCGATGAGCCCAACACCAGCTGGTGAAGGTAAATCAACGGTTACAGTTGGTTTAGCTGAT
GCATTCCATGAGTTAAATAAAAACGTTATGGTTGCATTAAGAGAGCCTGCTTTAGGACCAACATTTGGTATCAAAGGTGG
TGCGACTGGTGGTGGTTATGCGCAAGTCTTACCTATGGAAGATATCAACTTACATTTCAACGGAGATTTCCATGCGATTA
CAACTGCAAATAATGCATTGTCTGCGTTTATAGATAATCATATTCACCAAGGTAATGAATTAGGAATCGATCAAAGACGT
ATTGAATGGAAACGTGTATTAGATATGAATGATCGTGCACTTAGACATGTAAACGTTGGGTTAGGTGGACCTACAAATGG
TGTACCACGTGAAGATGGCTTTAATATTACAGTAGCGTCTGAAATTATGGCGATTTTATGTTTAAGTAGAAGTATTAAAG
ACTTAAAAGATAAAATTAGTCGTATTACTATTGGTTACACTAGAGATCGCAAGCCAGTTACAGTTGCAGATTTAAAAGTG
CAAGGTGCACTTGCAATGATTTTAAAAGATGCAATTAAACCAAACTTAGTACAATCAATTGAAGGGACACCTGCATTAGT
TCATGGTGGACCATTTGCGAATATCGCACACGGTTGTAACTCAATTTTAGCAACTGAAACAGCACGTGATTTAGCTGATA
TCGTTGTAACGGAAGCTGGATTTGGTTCAGACTTAGGCGCTGAAAAATTCATGGACATTAAAGCGCGTGAAGCAGGATTT
GATCTGGCAGCTGTCGTTGTTGTTGCGACAATTCGTGCGTTAAAAATGCATGGTGGTGTAGCGAAAGATAATTTAAAAGA
AGAAAATGTAGAAGCAGTAAAAGCAGGAATTGTTAATTTAGAGCGTCATGTTAATAATATTAAAAAATTCGGTGTAGAAC
CGGTTGTTGCAATTAATGCATTTATACATGATACCGATGCAGAAGTAGAATATGTAAAATCTTGGGCTAAAGAAAATAAC
GTACGAATTGCCTTAACTGAAGTTTGGGAAAAAGGTGGTAAAGGTGGCGTTGACTTAGCAAATGAAGTATTAGAAGTCAT
TGATCAACCTAATTCATTTAAACCTTTATATGAATTAGAATTACCATTAGAGCAAAAGATTGAAAAGATTGTGACTGAAA
TCTATGGCGGTTCAAAAGTAACGTTTAGCAGTAAAGCGCAAAAACAATTAAAACAATTTAAAGAAAATGGTTGGGATAAT
TACCCAGTATGTATGGCGAAAACACAATATTCATTCTCAGATGATCAAACGTTGTTAGGTGCACCATCAGGATTTGAAAT
TACAATTCGTGAATTAGAAGCGAAAACAGGTGCAGGATTTATCGTAGCGTTGACAGGTGCAATCATGACTATGCCTGGTT
TACCTAAAAAACCAGCAGCATTAAACATGGATGTTACTGATGATGGTCATGCAATTGGGTTATTCTAA

Upstream 100 bases:

>100_bases
GTTTTTAACAGTTCGTTATTATATGAATGTAAGTAAAAATTTCTTAGCTACAACTTACATATTATAAATGCATAAATTAA
ACAAAAAGGGGCGAAAAAAG

Downstream 100 bases:

>100_bases
TAAATCATGTCAATTGTTTAATAAAGATAAGTAAATAGTTTAATAGACCGGACTGTTGGAGATGCATTATTTCAGCAGTT
CGGTTTTTTGCTGTGCTAAA

Product: formate--tetrahydrofolate ligase

Products: NA

Alternate protein names: Formyltetrahydrofolate synthetase; FHS; FTHFS

Number of amino acids: Translated: 555; Mature: 554

Protein sequence:

>555_residues
MTHLSDLDIANQSTLQPIKDIAASVGISEDALEPYGHYKAKIDINKITPRENKGKVVLVTAMSPTPAGEGKSTVTVGLAD
AFHELNKNVMVALREPALGPTFGIKGGATGGGYAQVLPMEDINLHFNGDFHAITTANNALSAFIDNHIHQGNELGIDQRR
IEWKRVLDMNDRALRHVNVGLGGPTNGVPREDGFNITVASEIMAILCLSRSIKDLKDKISRITIGYTRDRKPVTVADLKV
QGALAMILKDAIKPNLVQSIEGTPALVHGGPFANIAHGCNSILATETARDLADIVVTEAGFGSDLGAEKFMDIKAREAGF
DLAAVVVVATIRALKMHGGVAKDNLKEENVEAVKAGIVNLERHVNNIKKFGVEPVVAINAFIHDTDAEVEYVKSWAKENN
VRIALTEVWEKGGKGGVDLANEVLEVIDQPNSFKPLYELELPLEQKIEKIVTEIYGGSKVTFSSKAQKQLKQFKENGWDN
YPVCMAKTQYSFSDDQTLLGAPSGFEITIRELEAKTGAGFIVALTGAIMTMPGLPKKPAALNMDVTDDGHAIGLF

Sequences:

>Translated_555_residues
MTHLSDLDIANQSTLQPIKDIAASVGISEDALEPYGHYKAKIDINKITPRENKGKVVLVTAMSPTPAGEGKSTVTVGLAD
AFHELNKNVMVALREPALGPTFGIKGGATGGGYAQVLPMEDINLHFNGDFHAITTANNALSAFIDNHIHQGNELGIDQRR
IEWKRVLDMNDRALRHVNVGLGGPTNGVPREDGFNITVASEIMAILCLSRSIKDLKDKISRITIGYTRDRKPVTVADLKV
QGALAMILKDAIKPNLVQSIEGTPALVHGGPFANIAHGCNSILATETARDLADIVVTEAGFGSDLGAEKFMDIKAREAGF
DLAAVVVVATIRALKMHGGVAKDNLKEENVEAVKAGIVNLERHVNNIKKFGVEPVVAINAFIHDTDAEVEYVKSWAKENN
VRIALTEVWEKGGKGGVDLANEVLEVIDQPNSFKPLYELELPLEQKIEKIVTEIYGGSKVTFSSKAQKQLKQFKENGWDN
YPVCMAKTQYSFSDDQTLLGAPSGFEITIRELEAKTGAGFIVALTGAIMTMPGLPKKPAALNMDVTDDGHAIGLF
>Mature_554_residues
THLSDLDIANQSTLQPIKDIAASVGISEDALEPYGHYKAKIDINKITPRENKGKVVLVTAMSPTPAGEGKSTVTVGLADA
FHELNKNVMVALREPALGPTFGIKGGATGGGYAQVLPMEDINLHFNGDFHAITTANNALSAFIDNHIHQGNELGIDQRRI
EWKRVLDMNDRALRHVNVGLGGPTNGVPREDGFNITVASEIMAILCLSRSIKDLKDKISRITIGYTRDRKPVTVADLKVQ
GALAMILKDAIKPNLVQSIEGTPALVHGGPFANIAHGCNSILATETARDLADIVVTEAGFGSDLGAEKFMDIKAREAGFD
LAAVVVVATIRALKMHGGVAKDNLKEENVEAVKAGIVNLERHVNNIKKFGVEPVVAINAFIHDTDAEVEYVKSWAKENNV
RIALTEVWEKGGKGGVDLANEVLEVIDQPNSFKPLYELELPLEQKIEKIVTEIYGGSKVTFSSKAQKQLKQFKENGWDNY
PVCMAKTQYSFSDDQTLLGAPSGFEITIRELEAKTGAGFIVALTGAIMTMPGLPKKPAALNMDVTDDGHAIGLF

Specific function: Unknown

COG id: COG2759

COG function: function code F; Formyltetrahydrofolate synthetase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the formate--tetrahydrofolate ligase family

Homologues:

Organism=Homo sapiens, GI222136639, Length=619, Percent_Identity=40.3877221324717, Blast_Score=437, Evalue=1e-123,
Organism=Homo sapiens, GI36796743, Length=618, Percent_Identity=41.5857605177994, Blast_Score=431, Evalue=1e-120,
Organism=Homo sapiens, GI310124614, Length=86, Percent_Identity=37.2093023255814, Blast_Score=69, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17568737, Length=612, Percent_Identity=42.8104575163399, Blast_Score=440, Evalue=1e-123,
Organism=Caenorhabditis elegans, GI17568739, Length=612, Percent_Identity=42.8104575163399, Blast_Score=440, Evalue=1e-123,
Organism=Saccharomyces cerevisiae, GI6319558, Length=631, Percent_Identity=42.1553090332805, Blast_Score=447, Evalue=1e-126,
Organism=Saccharomyces cerevisiae, GI6321643, Length=626, Percent_Identity=41.6932907348243, Blast_Score=439, Evalue=1e-124,
Organism=Drosophila melanogaster, GI24645718, Length=619, Percent_Identity=43.4571890145396, Blast_Score=465, Evalue=1e-131,
Organism=Drosophila melanogaster, GI17137370, Length=619, Percent_Identity=43.4571890145396, Blast_Score=465, Evalue=1e-131,
Organism=Drosophila melanogaster, GI62472483, Length=619, Percent_Identity=43.4571890145396, Blast_Score=464, Evalue=1e-131,
Organism=Drosophila melanogaster, GI45551871, Length=619, Percent_Identity=43.4571890145396, Blast_Score=464, Evalue=1e-131,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FTHS_STAA1 (A7X3G5)

Other databases:

- EMBL:   AP009324
- RefSeq:   YP_001442308.1
- ProteinModelPortal:   A7X3G5
- SMR:   A7X3G5
- STRING:   A7X3G5
- EnsemblBacteria:   EBSTAT00000004367
- GeneID:   5560476
- GenomeReviews:   AP009324_GR
- KEGG:   saw:SAHV_1718
- eggNOG:   COG2759
- GeneTree:   EBGT00050000024933
- HOGENOM:   HBG677721
- OMA:   EIMAVLC
- ProtClustDB:   PRK13505
- BioCyc:   SAUR418127:SAHV_1718-MONOMER
- HAMAP:   MF_01543
- InterPro:   IPR000559
- InterPro:   IPR020628

Pfam domain/function: PF01268 FTHFS

EC number: =6.3.4.3

Molecular weight: Translated: 59872; Mature: 59741

Theoretical pI: Translated: 5.91; Mature: 5.91

Prosite motif: PS00721 FTHFS_1; PS00722 FTHFS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHLSDLDIANQSTLQPIKDIAASVGISEDALEPYGHYKAKIDINKITPRENKGKVVLVT
CCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHCCCCCCEEEEEEEEECCCCCCCCCEEEEE
AMSPTPAGEGKSTVTVGLADAFHELNKNVMVALREPALGPTFGIKGGATGGGYAQVLPME
ECCCCCCCCCCCEEEEEHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCCEEEEEEC
DINLHFNGDFHAITTANNALSAFIDNHIHQGNELGIDQRRIEWKRVLDMNDRALRHVNVG
CCEEEECCCEEEEEECCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCEEEEEEEC
LGGPTNGVPREDGFNITVASEIMAILCLSRSIKDLKDKISRITIGYTRDRKPVTVADLKV
CCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCEEEEEEEE
QGALAMILKDAIKPNLVQSIEGTPALVHGGPFANIAHGCNSILATETARDLADIVVTEAG
HHHHHHHHHHHCCCHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHEECCC
FGSDLGAEKFMDIKAREAGFDLAAVVVVATIRALKMHGGVAKDNLKEENVEAVKAGIVNL
CCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHH
ERHVNNIKKFGVEPVVAINAFIHDTDAEVEYVKSWAKENNVRIALTEVWEKGGKGGVDLA
HHHHHHHHHHCCCCEEEEEEEEECCCCHHHHHHHHHHCCCCEEEEEHHHHCCCCCCHHHH
NEVLEVIDQPNSFKPLYELELPLEQKIEKIVTEIYGGSKVTFSSKAQKQLKQFKENGWDN
HHHHHHHCCCCCCCCEEEECCCHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHCCCCC
YPVCMAKTQYSFSDDQTLLGAPSGFEITIRELEAKTGAGFIVALTGAIMTMPGLPKKPAA
CCEEEEEEECCCCCCCEEEECCCCCEEEEEEECCCCCCCEEEEEHHHHHHCCCCCCCCCE
LNMDVTDDGHAIGLF
EEEEECCCCCEECCC
>Mature Secondary Structure 
THLSDLDIANQSTLQPIKDIAASVGISEDALEPYGHYKAKIDINKITPRENKGKVVLVT
CCCCCCCCCCCHHHHHHHHHHHHCCCCHHHCCCCCCEEEEEEEEECCCCCCCCCEEEEE
AMSPTPAGEGKSTVTVGLADAFHELNKNVMVALREPALGPTFGIKGGATGGGYAQVLPME
ECCCCCCCCCCCEEEEEHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCCEEEEEEC
DINLHFNGDFHAITTANNALSAFIDNHIHQGNELGIDQRRIEWKRVLDMNDRALRHVNVG
CCEEEECCCEEEEEECCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCEEEEEEEC
LGGPTNGVPREDGFNITVASEIMAILCLSRSIKDLKDKISRITIGYTRDRKPVTVADLKV
CCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCEEEEEEEE
QGALAMILKDAIKPNLVQSIEGTPALVHGGPFANIAHGCNSILATETARDLADIVVTEAG
HHHHHHHHHHHCCCHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHEECCC
FGSDLGAEKFMDIKAREAGFDLAAVVVVATIRALKMHGGVAKDNLKEENVEAVKAGIVNL
CCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHH
ERHVNNIKKFGVEPVVAINAFIHDTDAEVEYVKSWAKENNVRIALTEVWEKGGKGGVDLA
HHHHHHHHHHCCCCEEEEEEEEECCCCHHHHHHHHHHCCCCEEEEEHHHHCCCCCCHHHH
NEVLEVIDQPNSFKPLYELELPLEQKIEKIVTEIYGGSKVTFSSKAQKQLKQFKENGWDN
HHHHHHHCCCCCCCCEEEECCCHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHCCCCC
YPVCMAKTQYSFSDDQTLLGAPSGFEITIRELEAKTGAGFIVALTGAIMTMPGLPKKPAA
CCEEEEEEECCCCCCCEEEECCCCCEEEEEEECCCCCCCEEEEEHHHHHHCCCCCCCCCE
LNMDVTDDGHAIGLF
EEEEECCCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA