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The map label for this gene is nupC [H]

Identifier: 15923303

GI number: 15923303

Start: 356872

End: 358092

Strand: Direct

Name: nupC [H]

Synonym: SAV0313

Alternate gene names: 15923303

Gene position: 356872-358092 (Clockwise)

Preceding gene: 15923302

Following gene: 15923306

Centisome position: 12.4

GC content: 32.84

Gene sequence:

>1221_bases
ATGAATATTTTATTCGCTATCACAGGGATAGCATTTGCACTATTTGTTGCGTTTTTATTCAGTTTTGATCGTAAAAACAT
AGACTTCAAAAAGACGTTAATAATGATATTTATTCAAGTGTTGATTGTGTTATTTATGATGAACACAACGATTGGTTTAA
CAATCTTAACTGCATTAGGCTCATTTTTTGAAGGGTTAATAAATGTTAGTAAAGCAGGTATAAACTTTGTTTTTGGAGAT
ATACAAAATAAAAATGGCTTTACGTTCTTTTTAAATGTGTTACTGCCATTAGTGTTCATTTCTGTATTAATAGGCATTTT
TAATTATATTAAGGTATTACCATTTATTATCAAATATGTAGGTATCGCTATTAATAAAATAACGAGAATGGGGCGCTTAG
AAAGTTACTTTGCTATTTCAACAGCAATGTTTGGACAACCAGAAGTATATTTAACAATAAAAGATATTATTCCAAGATTA
TCTAGAGCGAAATTATATACAATTGCGACGTCTGGTATGAGTGCTGTTAGTATGGCAATGTTGGGTTCATATATGCAGAT
GATTGAGCCCAAGTTCGTAGTTACAGCTGTAATGTTAAATATTTTTAGTGCGCTTATCATCGCTAGTGTAATCAATCCCT
ATAAATCTGATGATAGTGATGTTGAGATTGATAATTTAACTAAATCAACGGAAACGAAATCAGTGAATGGAAAAACAGGA
AAACCTAAGAAAGTTGCCTTCTTCCAAATGATAGGTGATAGTGCGATGGATGGATTTAAAATCGCTGTTGTAGTAGCCGT
AATGTTGTTAGCATTTATTTCATTAATGGAAGCAATTAATATCATGTTTGGTAGTGTTGGTTTGAACTTTAAACAGCTTA
TTGGCTATGTGTTTGCACCAATCGCATTCTTAATGGGGATTCCATGGAGCGAAGCTGTTCCAGCTGGCTCTTTAATGGCG
ACTAAATTAATTACAAATGAGTTTGTAGCAATGCTTGATTTTAAAAATGTCCTGGGTGATGTATCTGCTCGAACACAAGG
TATCATTTCAGTTTACTTAGTAAGCTTCGCTAATTTTGGTACGGTTGGTATCATCGTAGGTTCAATTAAAGGCATTAGTG
ATAAACAAGGAGAAAAAGTTTCATCCTTTGCAATGAGGCTGTTACTTGGTTCAACTCTAGCTTCAATCATTTCAGGATCA
ATCATTGGCTTAGTATTGTAA

Upstream 100 bases:

>100_bases
GGTAAAAGTTTAGCAGCAAATATAAAACTTGTTGAAAACAATGCGGCGTTGGGTGCTAAAATTGCTGTCGCTGTTAATAA
ATTATTGTAGGTGATGATAC

Downstream 100 bases:

>100_bases
ATTAATCGAAGTATCTAAATTAAATTCATGGCAAAGCTAAACCCCATCACCAAGTTGGCGCAACAGCGCATCATAACTTG
GTGATGGGATTTTATCATAA

Product: pyrimidine nucleoside transporter

Products: uridine [Cytoplasm]; thymidine [Cytoplasm]; inosine [Cytoplasm]; Deoxyuridine [Cytoplasm]; deoxyinosine [Cytoplasm]; deoxycytidine [Cytoplasm]; deoxyadenosine [Cytoplasm]; cytidine [Cytoplasm]; Proton [Cytoplasm]; adenosine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 406; Mature: 406

Protein sequence:

>406_residues
MNILFAITGIAFALFVAFLFSFDRKNIDFKKTLIMIFIQVLIVLFMMNTTIGLTILTALGSFFEGLINVSKAGINFVFGD
IQNKNGFTFFLNVLLPLVFISVLIGIFNYIKVLPFIIKYVGIAINKITRMGRLESYFAISTAMFGQPEVYLTIKDIIPRL
SRAKLYTIATSGMSAVSMAMLGSYMQMIEPKFVVTAVMLNIFSALIIASVINPYKSDDSDVEIDNLTKSTETKSVNGKTG
KPKKVAFFQMIGDSAMDGFKIAVVVAVMLLAFISLMEAINIMFGSVGLNFKQLIGYVFAPIAFLMGIPWSEAVPAGSLMA
TKLITNEFVAMLDFKNVLGDVSARTQGIISVYLVSFANFGTVGIIVGSIKGISDKQGEKVSSFAMRLLLGSTLASIISGS
IIGLVL

Sequences:

>Translated_406_residues
MNILFAITGIAFALFVAFLFSFDRKNIDFKKTLIMIFIQVLIVLFMMNTTIGLTILTALGSFFEGLINVSKAGINFVFGD
IQNKNGFTFFLNVLLPLVFISVLIGIFNYIKVLPFIIKYVGIAINKITRMGRLESYFAISTAMFGQPEVYLTIKDIIPRL
SRAKLYTIATSGMSAVSMAMLGSYMQMIEPKFVVTAVMLNIFSALIIASVINPYKSDDSDVEIDNLTKSTETKSVNGKTG
KPKKVAFFQMIGDSAMDGFKIAVVVAVMLLAFISLMEAINIMFGSVGLNFKQLIGYVFAPIAFLMGIPWSEAVPAGSLMA
TKLITNEFVAMLDFKNVLGDVSARTQGIISVYLVSFANFGTVGIIVGSIKGISDKQGEKVSSFAMRLLLGSTLASIISGS
IIGLVL
>Mature_406_residues
MNILFAITGIAFALFVAFLFSFDRKNIDFKKTLIMIFIQVLIVLFMMNTTIGLTILTALGSFFEGLINVSKAGINFVFGD
IQNKNGFTFFLNVLLPLVFISVLIGIFNYIKVLPFIIKYVGIAINKITRMGRLESYFAISTAMFGQPEVYLTIKDIIPRL
SRAKLYTIATSGMSAVSMAMLGSYMQMIEPKFVVTAVMLNIFSALIIASVINPYKSDDSDVEIDNLTKSTETKSVNGKTG
KPKKVAFFQMIGDSAMDGFKIAVVVAVMLLAFISLMEAINIMFGSVGLNFKQLIGYVFAPIAFLMGIPWSEAVPAGSLMA
TKLITNEFVAMLDFKNVLGDVSARTQGIISVYLVSFANFGTVGIIVGSIKGISDKQGEKVSSFAMRLLLGSTLASIISGS
IIGLVL

Specific function: Transports Nucleosides With A High Affinity Except Guanosine And Deoxyguanosine. Driven By A Proton Motive Force. [C]

COG id: COG1972

COG function: function code F; Nucleoside permease

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family [H]

Homologues:

Organism=Homo sapiens, GI11545853, Length=411, Percent_Identity=25.5474452554745, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI42542381, Length=422, Percent_Identity=22.7488151658768, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI227116277, Length=427, Percent_Identity=24.1217798594848, Blast_Score=106, Evalue=4e-23,
Organism=Escherichia coli, GI1788737, Length=411, Percent_Identity=43.5523114355231, Blast_Score=352, Evalue=2e-98,
Organism=Escherichia coli, GI1788485, Length=422, Percent_Identity=30.0947867298578, Blast_Score=186, Evalue=3e-48,
Organism=Escherichia coli, GI1788488, Length=424, Percent_Identity=30.4245283018868, Blast_Score=185, Evalue=5e-48,
Organism=Caenorhabditis elegans, GI17560276, Length=403, Percent_Identity=20.5955334987593, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI71991794, Length=406, Percent_Identity=22.1674876847291, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI45552517, Length=415, Percent_Identity=25.3012048192771, Blast_Score=111, Evalue=8e-25,
Organism=Drosophila melanogaster, GI45552519, Length=415, Percent_Identity=25.3012048192771, Blast_Score=111, Evalue=8e-25,
Organism=Drosophila melanogaster, GI19921868, Length=415, Percent_Identity=25.3012048192771, Blast_Score=111, Evalue=8e-25,
Organism=Drosophila melanogaster, GI281360430, Length=362, Percent_Identity=25.1381215469613, Blast_Score=100, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008276
- InterPro:   IPR018270
- InterPro:   IPR011657
- InterPro:   IPR002668 [H]

Pfam domain/function: PF07662 Nucleos_tra2_C; PF01773 Nucleos_tra2_N [H]

EC number: NA

Molecular weight: Translated: 44168; Mature: 44168

Theoretical pI: Translated: 10.05; Mature: 10.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNILFAITGIAFALFVAFLFSFDRKNIDFKKTLIMIFIQVLIVLFMMNTTIGLTILTALG
CCEEHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SFFEGLINVSKAGINFVFGDIQNKNGFTFFLNVLLPLVFISVLIGIFNYIKVLPFIIKYV
HHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GIAINKITRMGRLESYFAISTAMFGQPEVYLTIKDIIPRLSRAKLYTIATSGMSAVSMAM
HHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHCEEEEEECCCHHHHHHHH
LGSYMQMIEPKFVVTAVMLNIFSALIIASVINPYKSDDSDVEIDNLTKSTETKSVNGKTG
HHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCCCCCCCCCCCCC
KPKKVAFFQMIGDSAMDGFKIAVVVAVMLLAFISLMEAINIMFGSVGLNFKQLIGYVFAP
CCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
IAFLMGIPWSEAVPAGSLMATKLITNEFVAMLDFKNVLGDVSARTQGIISVYLVSFANFG
HHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
TVGIIVGSIKGISDKQGEKVSSFAMRLLLGSTLASIISGSIIGLVL
HHHHEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHCC
>Mature Secondary Structure
MNILFAITGIAFALFVAFLFSFDRKNIDFKKTLIMIFIQVLIVLFMMNTTIGLTILTALG
CCEEHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SFFEGLINVSKAGINFVFGDIQNKNGFTFFLNVLLPLVFISVLIGIFNYIKVLPFIIKYV
HHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GIAINKITRMGRLESYFAISTAMFGQPEVYLTIKDIIPRLSRAKLYTIATSGMSAVSMAM
HHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHCEEEEEECCCHHHHHHHH
LGSYMQMIEPKFVVTAVMLNIFSALIIASVINPYKSDDSDVEIDNLTKSTETKSVNGKTG
HHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCCCCCCCCCCCCC
KPKKVAFFQMIGDSAMDGFKIAVVVAVMLLAFISLMEAINIMFGSVGLNFKQLIGYVFAP
CCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
IAFLMGIPWSEAVPAGSLMATKLITNEFVAMLDFKNVLGDVSARTQGIISVYLVSFANFG
HHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
TVGIIVGSIKGISDKQGEKVSSFAMRLLLGSTLASIISGSIIGLVL
HHHHEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: uridine [Periplasm]; thymidine [Periplasm]; inosine [Periplasm]; Deoxyuridine [Periplasm]; deoxyinosine [Periplasm]; deoxycytidine [Periplasm]; deoxyadenosine [Periplasm]; cytidine [Periplasm]; Proton [Periplasm]; adenosine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + uridine [Periplasm] = Proton [Cytoplasm] + uridine [Cytoplasm] Proton [Periplasm] + thymidine [Periplasm] = Proton [Cytoplasm] + thymidine [Cytoplasm] Proton [Periplasm] + inosine [Periplasm] = Proton [Cytoplasm] + inosine [Cytoplasm]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8550462; 8867804; 9384377 [H]