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The map label for this gene is lytR

Identifier: 15923251

GI number: 15923251

Start: 306219

End: 306959

Strand: Direct

Name: lytR

Synonym: SAV0261

Alternate gene names: 15923251

Gene position: 306219-306959 (Clockwise)

Preceding gene: 15923250

Following gene: 15923252

Centisome position: 10.64

GC content: 32.39

Gene sequence:

>741_bases
ATGAAAGCATTAATCATAGATGATGAGCCATTAGCACGTAATGAATTAACATATTTATTAAATGAAATTGGTGGTTTTGA
AGAAATTAATGAGGCAGAAAATGTAAAAGAAACATTGGAAGCACTACTGATCAATCAATATGACATTATATTTTTAGATG
TCAATTTAATGGATGAAAATGGGATCGAATTAGGAGCTAAGATTCAAAAGATGAAAGAGCCACCTGCGATTATTTTTGCA
ACTGCACATGACCAATACGCAGTACAGGCATTTGAATTAAATGCGACAGACTATATTTTGAAACCGTTTGGTCAAAAACG
TATTGAACAAGCAGTCAATAAAGTGCGTGCGACTAAAGCCAAAGATGATAATAACGCAAGTGCAATTGCGAATGATATGT
CGGCGAATTTTGATCAAAGCTTACCTGTTGAAATTGACGATAAAATTCACATGTTAAAGCAACAAAATATTATTGGGATT
GGCACACATAATGGTATTACAACCATACATACAACGAATCATAAATACGAAACAACAGAGCCATTGAATCGTTATGAAAA
ACGATTGAATCCCACTTATTTTATACGTATTCATCGTTCATATATTATTAACACGAAACACATTAAAGAAGTGCAACAAT
GGTTTAACTACACTTATATGGTAATATTGACAAATGGTGTCAAGATGCAAGTTGGACGTTCATTTATGAAAGATTTTAAA
GCGTCGATAGGATTACTTTAA

Upstream 100 bases:

>100_bases
GATTATTTGGAAAATCCGCAGCATTACAATTTGAATCGACATCGAGCGGTACCACTTTTTGGTGTGTACTTCCTTATGAA
AGACAAGAGGAGGAATAAAT

Downstream 100 bases:

>100_bases
CAGTAATCCTTTTTTTTATGCATTTTACCTATGATATTTTGTATTTCGGACTAAAAATCACGCAAATCGAAGTGAGCCAT
CTATACTTTAGTTAAATCAA

Product: two-component response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 246; Mature: 246

Protein sequence:

>246_residues
MKALIIDDEPLARNELTYLLNEIGGFEEINEAENVKETLEALLINQYDIIFLDVNLMDENGIELGAKIQKMKEPPAIIFA
TAHDQYAVQAFELNATDYILKPFGQKRIEQAVNKVRATKAKDDNNASAIANDMSANFDQSLPVEIDDKIHMLKQQNIIGI
GTHNGITTIHTTNHKYETTEPLNRYEKRLNPTYFIRIHRSYIINTKHIKEVQQWFNYTYMVILTNGVKMQVGRSFMKDFK
ASIGLL

Sequences:

>Translated_246_residues
MKALIIDDEPLARNELTYLLNEIGGFEEINEAENVKETLEALLINQYDIIFLDVNLMDENGIELGAKIQKMKEPPAIIFA
TAHDQYAVQAFELNATDYILKPFGQKRIEQAVNKVRATKAKDDNNASAIANDMSANFDQSLPVEIDDKIHMLKQQNIIGI
GTHNGITTIHTTNHKYETTEPLNRYEKRLNPTYFIRIHRSYIINTKHIKEVQQWFNYTYMVILTNGVKMQVGRSFMKDFK
ASIGLL
>Mature_246_residues
MKALIIDDEPLARNELTYLLNEIGGFEEINEAENVKETLEALLINQYDIIFLDVNLMDENGIELGAKIQKMKEPPAIIFA
TAHDQYAVQAFELNATDYILKPFGQKRIEQAVNKVRATKAKDDNNASAIANDMSANFDQSLPVEIDDKIHMLKQQNIIGI
GTHNGITTIHTTNHKYETTEPLNRYEKRLNPTYFIRIHRSYIINTKHIKEVQQWFNYTYMVILTNGVKMQVGRSFMKDFK
ASIGLL

Specific function: Member of the two-component regulatory system lytR/lytS that regulates genes involved in autolysis and cell wall metabolism. Regulates the activity of the cell wall-associated murein hydrolase through regulation of lrgA and lrgB

COG id: COG3279

COG function: function code KT; Response regulator of the LytR/AlgR family

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain

Homologues:

Organism=Escherichia coli, GI1788724, Length=246, Percent_Identity=31.3008130081301, Blast_Score=136, Evalue=2e-33,
Organism=Escherichia coli, GI87082052, Length=248, Percent_Identity=31.0483870967742, Blast_Score=129, Evalue=2e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LYTR_STAA3 (Q2FK09)

Other databases:

- EMBL:   CP000255
- RefSeq:   YP_492969.1
- ProteinModelPortal:   Q2FK09
- STRING:   Q2FK09
- EnsemblBacteria:   EBSTAT00000037852
- GeneID:   3914555
- GenomeReviews:   CP000255_GR
- KEGG:   saa:SAUSA300_0255
- eggNOG:   COG3279
- GeneTree:   EBGT00050000024060
- HOGENOM:   HBG753323
- OMA:   KDDNSAN
- ProtClustDB:   PRK14084
- GO:   GO:0005737
- GO:   GO:0006350
- InterPro:   IPR011006
- InterPro:   IPR007492
- InterPro:   IPR001789
- SMART:   SM00850
- SMART:   SM00448

Pfam domain/function: PF04397 LytTR; PF00072 Response_reg; SSF52172 CheY_like

EC number: NA

Molecular weight: Translated: 28222; Mature: 28222

Theoretical pI: Translated: 5.91; Mature: 5.91

Prosite motif: PS50930 HTH_LYTTR; PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKALIIDDEPLARNELTYLLNEIGGFEEINEAENVKETLEALLINQYDIIFLDVNLMDEN
CCEEEECCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEECCC
GIELGAKIQKMKEPPAIIFATAHDQYAVQAFELNATDYILKPFGQKRIEQAVNKVRATKA
CCCHHHHHHHCCCCCEEEEEECCCCEEEEEEEECCCHHHHCCCCHHHHHHHHHHHHHHCC
KDDNNASAIANDMSANFDQSLPVEIDDKIHMLKQQNIIGIGTHNGITTIHTTNHKYETTE
CCCCCHHHHHHHHCCCCCCCCCEEECHHHHHHHHCCEEEEECCCCEEEEEECCCCCCCCC
PLNRYEKRLNPTYFIRIHRSYIINTKHIKEVQQWFNYTYMVILTNGVKMQVGRSFMKDFK
HHHHHHHHCCCEEEEEEEEHEEECHHHHHHHHHHHCEEEEEEEECCCEEHHHHHHHHHHH
ASIGLL
HHHCCC
>Mature Secondary Structure
MKALIIDDEPLARNELTYLLNEIGGFEEINEAENVKETLEALLINQYDIIFLDVNLMDEN
CCEEEECCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEECCC
GIELGAKIQKMKEPPAIIFATAHDQYAVQAFELNATDYILKPFGQKRIEQAVNKVRATKA
CCCHHHHHHHCCCCCEEEEEECCCCEEEEEEEECCCHHHHCCCCHHHHHHHHHHHHHHCC
KDDNNASAIANDMSANFDQSLPVEIDDKIHMLKQQNIIGIGTHNGITTIHTTNHKYETTE
CCCCCHHHHHHHHCCCCCCCCCEEECHHHHHHHHCCEEEEECCCCEEEEEECCCCCCCCC
PLNRYEKRLNPTYFIRIHRSYIINTKHIKEVQQWFNYTYMVILTNGVKMQVGRSFMKDFK
HHHHHHHHCCCEEEEEEEEHEEECHHHHHHHHHHHCEEEEEEEECCCEEHHHHHHHHHHH
ASIGLL
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA