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The map label for this gene is cysO [H]

Identifier: 15921669

GI number: 15921669

Start: 1385123

End: 1386025

Strand: Direct

Name: cysO [H]

Synonym: ST1380

Alternate gene names: 15921669

Gene position: 1385123-1386025 (Clockwise)

Preceding gene: 15921668

Following gene: 15921670

Centisome position: 51.4

GC content: 33.11

Gene sequence:

>903_bases
GTGTCATCAAAAGAGGTACATGTTTTCGAAAATGCCATAGATTTAATGCAAGGGATGTGGCCTACTCCATTATTAAAGTT
AAATATAGGTAATGATGTATGGGCTAAATTAGAGTTCTATAACCCTTTCAGTCATAGTATTAAGGATAGAACTGCTCTAT
TCTTATTTAAAGAAGCAATCAAGCAAAACGCTAAATCAATAGTTGAGGCAACTTCTGGCAATACTGGAATAGCTCTTTCT
GCACTCTCTTCTATATTTAAAATAAATTTTACAGTGTTTATACCATCTACTGCTCCTTCATCATTCAAAGTCTTAATGAA
AATTTTAGGCGCAAACGTCATTTCAGCAGGAAATTCTACAACTGAGCTCTTACCTTTAGTGAAGAAACTAAGTGAATTTA
ATGGGTATACTCATCTGGATCAGTTTCATAATGAGATTAATGTTTTAGCTCATTATGAAACTACAGCTAAAGAAATTGAT
GAGCAAACTAAAGTTTCTGGTATTAAAGTTAAAAGGATAATAGCTACTATGGGAACTGCTGGACATATTGTAGGTATAGC
TAAGTATTTTAAAGAGAAATATGGTGATGACGTAGAAATTATAGGTGTTGAACCTGCGCAAGGAGAGCGTATACCTGGAA
TAAAAAGAGTTACAGATGATAAGGATAATAAGTTTCTTAAAATTGCTAAGATTGATAGGATAATAGAGATTAAGTTTAAG
GAGGCTGTAGAGGGAGTAATAGATGTTGCTAGAAATGATGGTATTTTAATAGGTTTAAGCTCTGGTGCCACTGTTTCTGC
ATACAAAAAAGTGATAAGAGAAAGTAAGGATGAAGGTGCTACTATTTTAATATTCCCAGATGACGCATTTAAGTACGTTA
ATGAGTTAGAGGAGTATGTATAA

Upstream 100 bases:

>100_bases
GGTTGGGAGAAAGAAGGGAATAAATATGTTATTAAAATGAAGAAAGGAAAATAATACTTTTAAGTTATTAGTTACTAAAA
GTAGTTAGGCGGTCAATATT

Downstream 100 bases:

>100_bases
TTAATTTTTTAAAGGTTTATTAAAGTAAGATATATTTCGTGGCTACAGAGGTAATAGTTATTTTTAATAAGAATGGAGAT
ATATTGGATTTTTCTCCAAG

Product: cysteine synthase

Products: NA

Alternate protein names: Cystathionine beta-synthase; Cysteine synthase; O-acetylserine sulfhydrylase; O-phosphoserine sulfhydrylase; Serine sulfhydrase [H]

Number of amino acids: Translated: 300; Mature: 299

Protein sequence:

>300_residues
MSSKEVHVFENAIDLMQGMWPTPLLKLNIGNDVWAKLEFYNPFSHSIKDRTALFLFKEAIKQNAKSIVEATSGNTGIALS
ALSSIFKINFTVFIPSTAPSSFKVLMKILGANVISAGNSTTELLPLVKKLSEFNGYTHLDQFHNEINVLAHYETTAKEID
EQTKVSGIKVKRIIATMGTAGHIVGIAKYFKEKYGDDVEIIGVEPAQGERIPGIKRVTDDKDNKFLKIAKIDRIIEIKFK
EAVEGVIDVARNDGILIGLSSGATVSAYKKVIRESKDEGATILIFPDDAFKYVNELEEYV

Sequences:

>Translated_300_residues
MSSKEVHVFENAIDLMQGMWPTPLLKLNIGNDVWAKLEFYNPFSHSIKDRTALFLFKEAIKQNAKSIVEATSGNTGIALS
ALSSIFKINFTVFIPSTAPSSFKVLMKILGANVISAGNSTTELLPLVKKLSEFNGYTHLDQFHNEINVLAHYETTAKEID
EQTKVSGIKVKRIIATMGTAGHIVGIAKYFKEKYGDDVEIIGVEPAQGERIPGIKRVTDDKDNKFLKIAKIDRIIEIKFK
EAVEGVIDVARNDGILIGLSSGATVSAYKKVIRESKDEGATILIFPDDAFKYVNELEEYV
>Mature_299_residues
SSKEVHVFENAIDLMQGMWPTPLLKLNIGNDVWAKLEFYNPFSHSIKDRTALFLFKEAIKQNAKSIVEATSGNTGIALSA
LSSIFKINFTVFIPSTAPSSFKVLMKILGANVISAGNSTTELLPLVKKLSEFNGYTHLDQFHNEINVLAHYETTAKEIDE
QTKVSGIKVKRIIATMGTAGHIVGIAKYFKEKYGDDVEIIGVEPAQGERIPGIKRVTDDKDNKFLKIAKIDRIIEIKFKE
AVEGVIDVARNDGILIGLSSGATVSAYKKVIRESKDEGATILIFPDDAFKYVNELEEYV

Specific function: Cysteine synthase that can also catalyze the synthesis of S-sulfo-L-cysteine from thiosulfate and O(3)-acetyl-L-serine, as well as the sulfhydrylation of L-serine by sulfide [H]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=312, Percent_Identity=28.525641025641, Blast_Score=108, Evalue=7e-24,
Organism=Homo sapiens, GI295821200, Length=312, Percent_Identity=28.525641025641, Blast_Score=108, Evalue=7e-24,
Organism=Homo sapiens, GI4557415, Length=312, Percent_Identity=28.525641025641, Blast_Score=108, Evalue=7e-24,
Organism=Escherichia coli, GI2367138, Length=291, Percent_Identity=30.9278350515464, Blast_Score=137, Evalue=6e-34,
Organism=Escherichia coli, GI1788754, Length=302, Percent_Identity=32.4503311258278, Blast_Score=85, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI32566674, Length=285, Percent_Identity=31.9298245614035, Blast_Score=98, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI17562970, Length=285, Percent_Identity=31.9298245614035, Blast_Score=98, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI17535051, Length=284, Percent_Identity=30.2816901408451, Blast_Score=97, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI115535073, Length=307, Percent_Identity=27.3615635179153, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17561720, Length=284, Percent_Identity=29.9295774647887, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17534315, Length=309, Percent_Identity=26.2135922330097, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI32566672, Length=203, Percent_Identity=29.5566502463054, Blast_Score=67, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI25147552, Length=319, Percent_Identity=26.6457680250784, Blast_Score=65, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6321594, Length=332, Percent_Identity=31.9277108433735, Blast_Score=114, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6321449, Length=321, Percent_Identity=26.1682242990654, Blast_Score=67, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24643623, Length=201, Percent_Identity=34.3283582089552, Blast_Score=91, Evalue=9e-19,
Organism=Drosophila melanogaster, GI20129101, Length=201, Percent_Identity=34.3283582089552, Blast_Score=91, Evalue=9e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.1.22; =2.5.1.47; =2.5.1.65 [H]

Molecular weight: Translated: 33218; Mature: 33086

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSKEVHVFENAIDLMQGMWPTPLLKLNIGNDVWAKLEFYNPFSHSIKDRTALFLFKEAI
CCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCEEEEEEECCCHHHHHHHHHHHHHHHHHH
KQNAKSIVEATSGNTGIALSALSSIFKINFTVFIPSTAPSSFKVLMKILGANVISAGNST
HHHHHHHHHHCCCCCCHHHHHHHHHHEEEEEEEECCCCCHHHHHHHHHHCCHHCCCCCCH
TELLPLVKKLSEFNGYTHLDQFHNEINVLAHYETTAKEIDEQTKVSGIKVKRIIATMGTA
HHHHHHHHHHHHCCCCCHHHHHHHHHEEEEECCHHHHHHHHHHHHCCHHHHHHHHHCCCC
GHIVGIAKYFKEKYGDDVEIIGVEPAQGERIPGIKRVTDDKDNKFLKIAKIDRIIEIKFK
HHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCEEEEEECCHHEEEHHH
EAVEGVIDVARNDGILIGLSSGATVSAYKKVIRESKDEGATILIFPDDAFKYVNELEEYV
HHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHCCCCCCCEEEEECCHHHHHHHHHHHCC
>Mature Secondary Structure 
SSKEVHVFENAIDLMQGMWPTPLLKLNIGNDVWAKLEFYNPFSHSIKDRTALFLFKEAI
CCCCCHHHHHHHHHHHCCCCCCEEEEECCCCEEEEEEECCCHHHHHHHHHHHHHHHHHH
KQNAKSIVEATSGNTGIALSALSSIFKINFTVFIPSTAPSSFKVLMKILGANVISAGNST
HHHHHHHHHHCCCCCCHHHHHHHHHHEEEEEEEECCCCCHHHHHHHHHHCCHHCCCCCCH
TELLPLVKKLSEFNGYTHLDQFHNEINVLAHYETTAKEIDEQTKVSGIKVKRIIATMGTA
HHHHHHHHHHHHCCCCCHHHHHHHHHEEEEECCHHHHHHHHHHHHCCHHHHHHHHHCCCC
GHIVGIAKYFKEKYGDDVEIIGVEPAQGERIPGIKRVTDDKDNKFLKIAKIDRIIEIKFK
HHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCEEEEEECCHHEEEHHH
EAVEGVIDVARNDGILIGLSSGATVSAYKKVIRESKDEGATILIFPDDAFKYVNELEEYV
HHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHCCCCCCCEEEEECCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10382966; 12644499 [H]