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The map label for this gene is flpA [H]

Identifier: 15921530

GI number: 15921530

Start: 1266637

End: 1267347

Strand: Direct

Name: flpA [H]

Synonym: ST1266

Alternate gene names: 15921530

Gene position: 1266637-1267347 (Clockwise)

Preceding gene: 15921529

Following gene: 15921531

Centisome position: 47.0

GC content: 32.63

Gene sequence:

>711_bases
ATGAAATTTATGTCAGAATTAGTTAAGATTTCAAAAACACAGTTTGAAAATGTGTTTCAATGTGAATTTAATGATGGCAC
AGTAAGGCTTTGTACTAAAAACTTAGCTCCAGGGTTTAGTGTTTATGGCGAGAGGCTATTTAAAGTAGAAGGGGTAGAGT
ATAGAGAATGGAATGCTTTTAGAAGTAAATTAGGCGGTGCTATTCTAAAGGGTTTAAAACAGAATCCTATTGTAAAAGGA
ACTAAAGTACTTTATTTGGGTGCAGCTTCTGGAACTACTCCAAGTCATGTTTCTGATATCGTAGAATTAGAAGGAAAAGT
ATACGGAGTGGAGTTTTCTCCTAGAGTAGTTAGGGAATTTTTACTTGTCGCTCAGCATAGACCTAATTTATTTCCAATTT
TAGCAGATGCTAGATTTCCGCAATATTATAGGACTCTTGTAGAAGATGTTGACGTATTATATGTAGATATTGCCCAGCCA
GATGAAACAGATATAGCAATCTATAATGCTAAATTTTTCCTTAAAAATGGTGGATATATGATGATGGCAATAAAAGCTAG
AAGTATTGATGTTACAAAAGAACCTACTGAAATCTATGAAATGGAAGTTAATAAGTTAAAAGAAAACAACTTTGATGTTA
TCCAAGTTATTCAGTTAGATCCTTATGATAAAGACCATGCAATGGTGTTAGCAAAATATAAGGGAAAATAA

Upstream 100 bases:

>100_bases
AATACGCTCAACCTCCACCAAGGAAGCCACAAGAACAAAAGAGAAAAGAAGAAGAAAGAAAAGGTAAAAAAGGAGGAAGA
GAAAAAAGAAAAGGTAGGAG

Downstream 100 bases:

>100_bases
ATGATAGATAAAATTTTTGAGATAGGATTAAAGAATTTTTTAAGTTTTTATCCTCAAGACTTAGTAAGTATTCGTGAAGC
TCTTGATGGGAAATTAAATA

Product: fibrillarin

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 236; Mature: 236

Protein sequence:

>236_residues
MKFMSELVKISKTQFENVFQCEFNDGTVRLCTKNLAPGFSVYGERLFKVEGVEYREWNAFRSKLGGAILKGLKQNPIVKG
TKVLYLGAASGTTPSHVSDIVELEGKVYGVEFSPRVVREFLLVAQHRPNLFPILADARFPQYYRTLVEDVDVLYVDIAQP
DETDIAIYNAKFFLKNGGYMMMAIKARSIDVTKEPTEIYEMEVNKLKENNFDVIQVIQLDPYDKDHAMVLAKYKGK

Sequences:

>Translated_236_residues
MKFMSELVKISKTQFENVFQCEFNDGTVRLCTKNLAPGFSVYGERLFKVEGVEYREWNAFRSKLGGAILKGLKQNPIVKG
TKVLYLGAASGTTPSHVSDIVELEGKVYGVEFSPRVVREFLLVAQHRPNLFPILADARFPQYYRTLVEDVDVLYVDIAQP
DETDIAIYNAKFFLKNGGYMMMAIKARSIDVTKEPTEIYEMEVNKLKENNFDVIQVIQLDPYDKDHAMVLAKYKGK
>Mature_236_residues
MKFMSELVKISKTQFENVFQCEFNDGTVRLCTKNLAPGFSVYGERLFKVEGVEYREWNAFRSKLGGAILKGLKQNPIVKG
TKVLYLGAASGTTPSHVSDIVELEGKVYGVEFSPRVVREFLLVAQHRPNLFPILADARFPQYYRTLVEDVDVLYVDIAQP
DETDIAIYNAKFFLKNGGYMMMAIKARSIDVTKEPTEIYEMEVNKLKENNFDVIQVIQLDPYDKDHAMVLAKYKGK

Specific function: Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the sub

COG id: COG1889

COG function: function code J; Fibrillarin-like rRNA methylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. Fibrillarin family [H]

Homologues:

Organism=Homo sapiens, GI12056465, Length=231, Percent_Identity=47.6190476190476, Blast_Score=213, Evalue=2e-55,
Organism=Caenorhabditis elegans, GI17563672, Length=209, Percent_Identity=52.6315789473684, Blast_Score=220, Evalue=5e-58,
Organism=Saccharomyces cerevisiae, GI6320190, Length=215, Percent_Identity=47.906976744186, Blast_Score=202, Evalue=3e-53,
Organism=Drosophila melanogaster, GI17647425, Length=231, Percent_Identity=46.3203463203463, Blast_Score=208, Evalue=2e-54,
Organism=Drosophila melanogaster, GI24646406, Length=212, Percent_Identity=31.1320754716981, Blast_Score=108, Evalue=3e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000692
- InterPro:   IPR020813 [H]

Pfam domain/function: PF01269 Fibrillarin [H]

EC number: NA

Molecular weight: Translated: 26914; Mature: 26914

Theoretical pI: Translated: 7.49; Mature: 7.49

Prosite motif: PS00566 FIBRILLARIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFMSELVKISKTQFENVFQCEFNDGTVRLCTKNLAPGFSVYGERLFKVEGVEYREWNAF
CCHHHHHHHHHHHHCCCEEEEEECCCEEEEEECCCCCCHHHHCCEEEEECCCCCHHHHHH
RSKLGGAILKGLKQNPIVKGTKVLYLGAASGTTPSHVSDIVELEGKVYGVEFSPRVVREF
HHHHCHHHHHCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHCCEEEEEECCHHHHHHH
LLVAQHRPNLFPILADARFPQYYRTLVEDVDVLYVDIAQPDETDIAIYNAKFFLKNGGYM
HHHHHCCCCEEEEEECCCCHHHHHHHHCCCEEEEEEECCCCCCCEEEEEEEEEEECCCEE
MMAIKARSIDVTKEPTEIYEMEVNKLKENNFDVIQVIQLDPYDKDHAMVLAKYKGK
EEEEEEEEECCCCCCHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCEEEEEEECCC
>Mature Secondary Structure
MKFMSELVKISKTQFENVFQCEFNDGTVRLCTKNLAPGFSVYGERLFKVEGVEYREWNAF
CCHHHHHHHHHHHHCCCEEEEEECCCEEEEEECCCCCCHHHHCCEEEEECCCCCHHHHHH
RSKLGGAILKGLKQNPIVKGTKVLYLGAASGTTPSHVSDIVELEGKVYGVEFSPRVVREF
HHHHCHHHHHCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHCCEEEEEECCHHHHHHH
LLVAQHRPNLFPILADARFPQYYRTLVEDVDVLYVDIAQPDETDIAIYNAKFFLKNGGYM
HHHHHCCCCEEEEEECCCCHHHHHHHHCCCEEEEEEECCCCCCCEEEEEEEEEEECCCEE
MMAIKARSIDVTKEPTEIYEMEVNKLKENNFDVIQVIQLDPYDKDHAMVLAKYKGK
EEEEEEEEECCCCCCHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11572479 [H]