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The map label for this gene is acsA [H]

Identifier: 15921453

GI number: 15921453

Start: 1192241

End: 1193734

Strand: Direct

Name: acsA [H]

Synonym: ST1190

Alternate gene names: 15921453

Gene position: 1192241-1193734 (Clockwise)

Preceding gene: 15921447

Following gene: 15921454

Centisome position: 44.24

GC content: 36.41

Gene sequence:

>1494_bases
ATGGTAAGTTATTATGAGGTTGTAAGAAGTTTTAGCTGGAAGGAGATCGAAAAAACAATAGATATTTCATCACTAGTAGA
CCATGAGGGGGTAGCTGTAATTAGATTTAGTAAAGAAGGAAAAGAACAAATTACTTTCCAAGAACTTAAAGATAAAGCGT
TAAGGCTTGCTTCTTATCTGAAGCATATAGCTGGTGTTAAGAAGGGAGATGTAATATCAGTTTTAGCTTCTAAGAAAATT
GAGCAAGTTATAGTCCTCTTAGCCAGTCTCTATATAGGAGCTTTGTATCAGCCCTTATTTACAGCCTTTGGACCTAAGGC
TATAGAAATTAGGACTAGAGATAAAAAACCTAAAGTGTTATTTTATCAAGATGATCAAAAAGAGAAGGTAAGTGAAGGAG
TACCACTTTCAAAGCTTGATGAGTTAACATCTTACGGGAGATTAGAAGAGATAGAAAGGCTAAGCTGGAACGATCCAATT
ATTTTACTTTATACTTCTGGGAGTACTGGTTTACCTAAAGGAGCATTAATATCTAAGAGGCTTTTACTTAACACATACGT
ATATATGAAATACGGAATTGGGTTAAGAGAGAATGATATTTTCTGGAATGGTGCTGATCCTGGCTGGGCATATGGTCTCT
ATTATGGAATTATAGGCCCATTGCTTTTCGGCAAGACTGTAATATTCCTAGATGAGCCTTTCGATGCAGAAAGAACAATG
GAGTTTCTTGAAGAAAACAAAATAACAAATTTCGCATGGGCACCTACTACATATAGGATTATATCGAGGTCTGTGAAAAG
GAAGTACGATTTAAGGCTTGAAAGAGCTAGCTCTGCAGGAGAACCCCTTAATCCAGAGGTAATAAAGTGGTTTAAAGATA
ATTATAATGTGATTGTGAAAGACCATTATGGTCAGACTGAAGTAGGGATGGTAGTGTATAATGGTTGGGGTTATGATTAT
GAGTTAAAGATAGGTAGTATGGGGTTACCAGCACCAGGTTATGAGGTGGATATTATAGAAGAGAATATAGCTGTAAAGAA
GACTTCTCCAGGATTTCATTTTCTAGGATATTTGAATAATCCTGAGAAAACGCAAGAAGCTTTCAGAGGAGATTGGTATT
TAACTGGTGATGTAGCATCTAAAGATCAAGACGGATACTTCTGGTTTATTGGTAGAAAGGATGATGTAACTAAGGTGTCT
GGATATAGGATTGGACCTTTTGAAGTAGAGAGTGTGCTATTAGAGCATCCAGCTATCCTTGAATCTGCAGTAGTTGCTGA
TGAAGATCCTATTAGGGGGCACGTTCTCCACGCATATATAGTTCTTAAACCCGGATATACTCCAAGTGAAGAGCTAAAAA
AGGAGATAATAGAGTTTGTTAAGAGTCGTTACTCTAAGACTGTGCATTTAGAGAGGGTGGATTTCATCGATAAATTACCG
AAAACCGAAAGTGGAAAAATACAAAGGTATTTACTTAAGAAAAAGATAAGTTAA

Upstream 100 bases:

>100_bases
CACCCTACGGTATAAAGATTATAAAATAAGAACAGATTGAGATATTAATAAATAACGTAATTTATGAAAGCTTAATTATT
TCTCTTTTTATTTTTATTTT

Downstream 100 bases:

>100_bases
TTGTTAACCTTATGTTTAGTATAAAAAGTGTGCAAAATAGTAAAAGATGCTTAAGCTCGTATTATAATTAATATCAATAT
CATTTTTTAATTTTTATAAA

Product: acetyl-CoA synthetase

Products: NA

Alternate protein names: Acetate--CoA ligase; Acetyl-CoA synthase; Acyl-activating enzyme [H]

Number of amino acids: Translated: 497; Mature: 497

Protein sequence:

>497_residues
MVSYYEVVRSFSWKEIEKTIDISSLVDHEGVAVIRFSKEGKEQITFQELKDKALRLASYLKHIAGVKKGDVISVLASKKI
EQVIVLLASLYIGALYQPLFTAFGPKAIEIRTRDKKPKVLFYQDDQKEKVSEGVPLSKLDELTSYGRLEEIERLSWNDPI
ILLYTSGSTGLPKGALISKRLLLNTYVYMKYGIGLRENDIFWNGADPGWAYGLYYGIIGPLLFGKTVIFLDEPFDAERTM
EFLEENKITNFAWAPTTYRIISRSVKRKYDLRLERASSAGEPLNPEVIKWFKDNYNVIVKDHYGQTEVGMVVYNGWGYDY
ELKIGSMGLPAPGYEVDIIEENIAVKKTSPGFHFLGYLNNPEKTQEAFRGDWYLTGDVASKDQDGYFWFIGRKDDVTKVS
GYRIGPFEVESVLLEHPAILESAVVADEDPIRGHVLHAYIVLKPGYTPSEELKKEIIEFVKSRYSKTVHLERVDFIDKLP
KTESGKIQRYLLKKKIS

Sequences:

>Translated_497_residues
MVSYYEVVRSFSWKEIEKTIDISSLVDHEGVAVIRFSKEGKEQITFQELKDKALRLASYLKHIAGVKKGDVISVLASKKI
EQVIVLLASLYIGALYQPLFTAFGPKAIEIRTRDKKPKVLFYQDDQKEKVSEGVPLSKLDELTSYGRLEEIERLSWNDPI
ILLYTSGSTGLPKGALISKRLLLNTYVYMKYGIGLRENDIFWNGADPGWAYGLYYGIIGPLLFGKTVIFLDEPFDAERTM
EFLEENKITNFAWAPTTYRIISRSVKRKYDLRLERASSAGEPLNPEVIKWFKDNYNVIVKDHYGQTEVGMVVYNGWGYDY
ELKIGSMGLPAPGYEVDIIEENIAVKKTSPGFHFLGYLNNPEKTQEAFRGDWYLTGDVASKDQDGYFWFIGRKDDVTKVS
GYRIGPFEVESVLLEHPAILESAVVADEDPIRGHVLHAYIVLKPGYTPSEELKKEIIEFVKSRYSKTVHLERVDFIDKLP
KTESGKIQRYLLKKKIS
>Mature_497_residues
MVSYYEVVRSFSWKEIEKTIDISSLVDHEGVAVIRFSKEGKEQITFQELKDKALRLASYLKHIAGVKKGDVISVLASKKI
EQVIVLLASLYIGALYQPLFTAFGPKAIEIRTRDKKPKVLFYQDDQKEKVSEGVPLSKLDELTSYGRLEEIERLSWNDPI
ILLYTSGSTGLPKGALISKRLLLNTYVYMKYGIGLRENDIFWNGADPGWAYGLYYGIIGPLLFGKTVIFLDEPFDAERTM
EFLEENKITNFAWAPTTYRIISRSVKRKYDLRLERASSAGEPLNPEVIKWFKDNYNVIVKDHYGQTEVGMVVYNGWGYDY
ELKIGSMGLPAPGYEVDIIEENIAVKKTSPGFHFLGYLNNPEKTQEAFRGDWYLTGDVASKDQDGYFWFIGRKDDVTKVS
GYRIGPFEVESVLLEHPAILESAVVADEDPIRGHVLHAYIVLKPGYTPSEELKKEIIEFVKSRYSKTVHLERVDFIDKLP
KTESGKIQRYLLKKKIS

Specific function: Has a role in growth and sporulation on acetate [H]

COG id: COG0365

COG function: function code I; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI42544132, Length=499, Percent_Identity=33.0661322645291, Blast_Score=253, Evalue=3e-67,
Organism=Homo sapiens, GI122937307, Length=490, Percent_Identity=34.4897959183673, Blast_Score=247, Evalue=2e-65,
Organism=Homo sapiens, GI38505220, Length=488, Percent_Identity=33.6065573770492, Blast_Score=246, Evalue=3e-65,
Organism=Homo sapiens, GI58082049, Length=496, Percent_Identity=31.25, Blast_Score=224, Evalue=2e-58,
Organism=Homo sapiens, GI115511026, Length=490, Percent_Identity=30.6122448979592, Blast_Score=220, Evalue=2e-57,
Organism=Homo sapiens, GI157311624, Length=495, Percent_Identity=30.1010101010101, Blast_Score=216, Evalue=3e-56,
Organism=Homo sapiens, GI157311622, Length=495, Percent_Identity=30.1010101010101, Blast_Score=216, Evalue=3e-56,
Organism=Homo sapiens, GI8923896, Length=550, Percent_Identity=28.9090909090909, Blast_Score=193, Evalue=3e-49,
Organism=Homo sapiens, GI13375727, Length=526, Percent_Identity=30.4182509505703, Blast_Score=190, Evalue=2e-48,
Organism=Homo sapiens, GI253970489, Length=563, Percent_Identity=28.2415630550622, Blast_Score=188, Evalue=8e-48,
Organism=Homo sapiens, GI28416953, Length=550, Percent_Identity=28.9090909090909, Blast_Score=176, Evalue=6e-44,
Organism=Homo sapiens, GI187761345, Length=511, Percent_Identity=27.2015655577299, Blast_Score=149, Evalue=6e-36,
Organism=Homo sapiens, GI187761343, Length=511, Percent_Identity=27.2015655577299, Blast_Score=149, Evalue=6e-36,
Organism=Homo sapiens, GI156151445, Length=517, Percent_Identity=28.0464216634429, Blast_Score=133, Evalue=3e-31,
Organism=Homo sapiens, GI42544134, Length=358, Percent_Identity=25.6983240223464, Blast_Score=113, Evalue=5e-25,
Organism=Homo sapiens, GI195947378, Length=421, Percent_Identity=24.4655581947743, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI62865631, Length=477, Percent_Identity=23.2704402515723, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI13325055, Length=477, Percent_Identity=23.2704402515723, Blast_Score=84, Evalue=3e-16,
Organism=Escherichia coli, GI1790505, Length=515, Percent_Identity=29.7087378640777, Blast_Score=209, Evalue=2e-55,
Organism=Escherichia coli, GI1786529, Length=542, Percent_Identity=29.1512915129151, Blast_Score=162, Evalue=4e-41,
Organism=Escherichia coli, GI145693145, Length=522, Percent_Identity=27.2030651340996, Blast_Score=152, Evalue=6e-38,
Organism=Escherichia coli, GI1788107, Length=538, Percent_Identity=24.5353159851301, Blast_Score=124, Evalue=2e-29,
Organism=Escherichia coli, GI221142682, Length=512, Percent_Identity=23.046875, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1786801, Length=412, Percent_Identity=24.5145631067961, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1786810, Length=527, Percent_Identity=22.5806451612903, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1789201, Length=357, Percent_Identity=23.5294117647059, Blast_Score=72, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI32563687, Length=464, Percent_Identity=28.0172413793103, Blast_Score=164, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI71983001, Length=525, Percent_Identity=27.4285714285714, Blast_Score=161, Evalue=7e-40,
Organism=Caenorhabditis elegans, GI71982997, Length=525, Percent_Identity=27.4285714285714, Blast_Score=161, Evalue=9e-40,
Organism=Caenorhabditis elegans, GI17558820, Length=488, Percent_Identity=27.2540983606557, Blast_Score=153, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17559526, Length=509, Percent_Identity=25.5402750491159, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17560140, Length=355, Percent_Identity=26.7605633802817, Blast_Score=104, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17557194, Length=490, Percent_Identity=26.9387755102041, Blast_Score=102, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI17531443, Length=520, Percent_Identity=23.4615384615385, Blast_Score=100, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI71994703, Length=527, Percent_Identity=24.2884250474383, Blast_Score=99, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI71994694, Length=527, Percent_Identity=24.2884250474383, Blast_Score=99, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI71994690, Length=527, Percent_Identity=24.2884250474383, Blast_Score=99, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI71996755, Length=482, Percent_Identity=25.3112033195021, Blast_Score=98, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17538037, Length=534, Percent_Identity=25.0936329588015, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17560308, Length=518, Percent_Identity=22.7799227799228, Blast_Score=95, Evalue=8e-20,
Organism=Caenorhabditis elegans, GI71985884, Length=364, Percent_Identity=26.6483516483516, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI25141359, Length=350, Percent_Identity=21.7142857142857, Blast_Score=69, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6319264, Length=522, Percent_Identity=30.2681992337165, Blast_Score=204, Evalue=3e-53,
Organism=Saccharomyces cerevisiae, GI6323182, Length=532, Percent_Identity=30.0751879699248, Blast_Score=189, Evalue=8e-49,
Organism=Saccharomyces cerevisiae, GI6319699, Length=259, Percent_Identity=28.957528957529, Blast_Score=98, Evalue=3e-21,
Organism=Drosophila melanogaster, GI62472339, Length=526, Percent_Identity=29.467680608365, Blast_Score=195, Evalue=6e-50,
Organism=Drosophila melanogaster, GI24667955, Length=526, Percent_Identity=29.467680608365, Blast_Score=194, Evalue=1e-49,
Organism=Drosophila melanogaster, GI24667959, Length=490, Percent_Identity=29.3877551020408, Blast_Score=176, Evalue=3e-44,
Organism=Drosophila melanogaster, GI21355225, Length=520, Percent_Identity=27.1153846153846, Blast_Score=160, Evalue=2e-39,
Organism=Drosophila melanogaster, GI18859661, Length=506, Percent_Identity=26.8774703557312, Blast_Score=122, Evalue=5e-28,
Organism=Drosophila melanogaster, GI21356947, Length=507, Percent_Identity=24.4575936883629, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI19922652, Length=507, Percent_Identity=24.0631163708087, Blast_Score=115, Evalue=5e-26,
Organism=Drosophila melanogaster, GI21358303, Length=480, Percent_Identity=22.9166666666667, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI20130357, Length=501, Percent_Identity=25.1497005988024, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI21355181, Length=486, Percent_Identity=24.8971193415638, Blast_Score=110, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24656500, Length=496, Percent_Identity=23.1854838709677, Blast_Score=109, Evalue=5e-24,
Organism=Drosophila melanogaster, GI24581924, Length=372, Percent_Identity=26.0752688172043, Blast_Score=108, Evalue=8e-24,
Organism=Drosophila melanogaster, GI24653035, Length=505, Percent_Identity=23.7623762376238, Blast_Score=108, Evalue=1e-23,
Organism=Drosophila melanogaster, GI281365686, Length=486, Percent_Identity=22.4279835390947, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24648260, Length=508, Percent_Identity=24.8031496062992, Blast_Score=106, Evalue=4e-23,
Organism=Drosophila melanogaster, GI24648255, Length=482, Percent_Identity=25.3112033195021, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24648257, Length=497, Percent_Identity=22.9376257545272, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI161076582, Length=518, Percent_Identity=22.5868725868726, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24583465, Length=439, Percent_Identity=23.4624145785877, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24583463, Length=439, Percent_Identity=23.4624145785877, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI281364798, Length=439, Percent_Identity=23.4624145785877, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24648676, Length=509, Percent_Identity=23.3791748526523, Blast_Score=75, Evalue=9e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.1 [H]

Molecular weight: Translated: 56793; Mature: 56793

Theoretical pI: Translated: 6.98; Mature: 6.98

Prosite motif: PS00455 AMP_BINDING ; PS00213 LIPOCALIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSYYEVVRSFSWKEIEKTIDISSLVDHEGVAVIRFSKEGKEQITFQELKDKALRLASYL
CCCHHHHHHCCCHHHHHHHHCHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHH
KHIAGVKKGDVISVLASKKIEQVIVLLASLYIGALYQPLFTAFGPKAIEIRTRDKKPKVL
HHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCEE
FYQDDQKEKVSEGVPLSKLDELTSYGRLEEIERLSWNDPIILLYTSGSTGLPKGALISKR
EEECCCHHHHHCCCCHHHHHHHHHCCCHHHHHHCCCCCCEEEEEECCCCCCCCCHHHHHH
LLLNTYVYMKYGIGLRENDIFWNGADPGWAYGLYYGIIGPLLFGKTVIFLDEPFDAERTM
HHHHHEEEEEECCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHCCEEEEEECCCCHHHHH
EFLEENKITNFAWAPTTYRIISRSVKRKYDLRLERASSAGEPLNPEVIKWFKDNYNVIVK
HHHHHCCCCEEEECCHHHHHHHHHHHHHHHHEEECCCCCCCCCCHHHHHHHHCCCEEEEE
DHYGQTEVGMVVYNGWGYDYELKIGSMGLPAPGYEVDIIEENIAVKKTSPGFHFLGYLNN
CCCCCCEEEEEEECCCCEEEEEEECCCCCCCCCCEEEEEECCEEEEECCCCEEEEEECCC
PEKTQEAFRGDWYLTGDVASKDQDGYFWFIGRKDDVTKVSGYRIGPFEVESVLLEHPAIL
CHHHHHHHCCCEEEECCCCCCCCCCEEEEEECCCCCEEECCEEECCHHHHHHHHHCCHHH
ESAVVADEDPIRGHVLHAYIVLKPGYTPSEELKKEIIEFVKSRYSKTVHLERVDFIDKLP
HHHHCCCCCCCCCEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHCCEEEEHHHHHHHHCC
KTESGKIQRYLLKKKIS
CCCCCHHHHHHHHHCCC
>Mature Secondary Structure
MVSYYEVVRSFSWKEIEKTIDISSLVDHEGVAVIRFSKEGKEQITFQELKDKALRLASYL
CCCHHHHHHCCCHHHHHHHHCHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHH
KHIAGVKKGDVISVLASKKIEQVIVLLASLYIGALYQPLFTAFGPKAIEIRTRDKKPKVL
HHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCEE
FYQDDQKEKVSEGVPLSKLDELTSYGRLEEIERLSWNDPIILLYTSGSTGLPKGALISKR
EEECCCHHHHHCCCCHHHHHHHHHCCCHHHHHHCCCCCCEEEEEECCCCCCCCCHHHHHH
LLLNTYVYMKYGIGLRENDIFWNGADPGWAYGLYYGIIGPLLFGKTVIFLDEPFDAERTM
HHHHHEEEEEECCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHCCEEEEEECCCCHHHHH
EFLEENKITNFAWAPTTYRIISRSVKRKYDLRLERASSAGEPLNPEVIKWFKDNYNVIVK
HHHHHCCCCEEEECCHHHHHHHHHHHHHHHHEEECCCCCCCCCCHHHHHHHHCCCEEEEE
DHYGQTEVGMVVYNGWGYDYELKIGSMGLPAPGYEVDIIEENIAVKKTSPGFHFLGYLNN
CCCCCCEEEEEEECCCCEEEEEEECCCCCCCCCCEEEEEECCEEEEECCCCEEEEEECCC
PEKTQEAFRGDWYLTGDVASKDQDGYFWFIGRKDDVTKVSGYRIGPFEVESVLLEHPAIL
CHHHHHHHCCCEEEECCCCCCCCCCEEEEEECCCCCEEECCEEECCHHHHHHHHHCCHHH
ESAVVADEDPIRGHVLHAYIVLKPGYTPSEELKKEIIEFVKSRYSKTVHLERVDFIDKLP
HHHHCCCCCCCCCEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHCCEEEEHHHHHHHHCC
KTESGKIQRYLLKKKIS
CCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7934817; 9387221; 9384377 [H]