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The map label for this gene is tdcB [H]

Identifier: 15920487

GI number: 15920487

Start: 314606

End: 315820

Strand: Reverse

Name: tdcB [H]

Synonym: ST0295

Alternate gene names: 15920487

Gene position: 315820-314606 (Counterclockwise)

Preceding gene: 15920488

Following gene: 15920486

Centisome position: 11.72

GC content: 33.0

Gene sequence:

>1215_bases
ATGTCTTATACAAAATATTTTGATGAAATAGTAAAAATTCAAGATAGAATTAAACAATATATTCATGAGACGCCTATTGA
TTACTCAAAAACCTTTTCTGATATGATTGGAGCTCAAATATATTTAAAGCTTGAAAATTTGCAGAAAACAGGTTCTTTTA
AGGTAAGAGGAGCTTTTTCAAAATTGACAAGCCTAGCCGAAGAAGAAAGGAAAAAAGGTGTTATAGCGGTTTCCGCGGGT
AATCATGCTCAAGGTGTTGCATATGCTGCAAAAGTTTTAGGAATTAAAGCAACTATAGTAATGCCAGAAACTGCTCCAAT
CTCAAAATATCAAGCTACAAAGTCATACGGTGCTCAAGTTATTTTGTATGGGAAATTTCTTCATGAGAGTATGAAAAAAG
CTGAGGAGATTATAAGAGAAGAAGGAAGTATTCTTGTTCATCCTTACGGAGATCTTGATGTAATTTTGGGTCAAGGTACA
TTAGGACTAGAACTTTTGCCATATAATCCAGATATTGTTGTTGTTCCTATAGGAGGGGGAGGACTAATATCAGGAATATC
TATAGCATTAAAAGCAAAAAATCCAAAAACCAAAATAATAGGTGTACAATCTTCAGCTTCTCCTTCATTAAAGGTCTCAA
AAGATCTTCATAGGCTAGTAGAGATTGAGCCCTCTTTTTCGATAGCAGATGGAATTCTAGTAAAATCTCCCTCTGAAATA
ACGTTTAGCATAATAGATGAATTAGTGGATGATATTGTTCTTGTTGATGATGAAGAAATAGCAAATGCTATAGTATATTT
ATTAGAAAGAAATAAAACATTAGTAGAAGGAGCAGCTGCTGCTTCATTAGCAGCACTTTTATCTGGAAAGATTAAAGTTG
CTTATAATCATAAAGCTATTCCGGTTCTAAGTGGGGGCAATATAGATCTTTCAATGTTATCCAGAATTATAGATAAGATG
CTTTTCAAGAATAAACGAATAGTCAAAGTGAAGGTAATAGTACCAGATAAACCTGGATATCTTAATAAAGTATTAAGTAG
AGTAGCACAAATAAGAGGGAACGTTATCGATGTAGTTCATGATAGAACAAGCAGTGATGTTAAACCTGGTTATACTAAAA
TTTATGTAATGTTTGAAGTACCTAGTGGTGATGCTCTTTCAGATTTCATGTACAACTTAGCTTTAGATGGTATTGAGGCT
AAATTAGTAGAATAG

Upstream 100 bases:

>100_bases
TTTTAGAAGATACCTATAATAAATTAAAGCCAGAAATAGAAAAGATAATTAATGAGGAAGCCCTCGATCTCTGAAAAGTG
ATGACTGCAGGGTTTTCCTG

Downstream 100 bases:

>100_bases
TTTATATATAGGAAAAAAGTTAAATTATTGATCCAAATGGAATTTACTATTTAGGTCCCAAAGGAAGTTTCACTAATGAG
GTTGCTGAAATTTTTGAAGG

Product: threonine dehydratase

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 404; Mature: 403

Protein sequence:

>404_residues
MSYTKYFDEIVKIQDRIKQYIHETPIDYSKTFSDMIGAQIYLKLENLQKTGSFKVRGAFSKLTSLAEEERKKGVIAVSAG
NHAQGVAYAAKVLGIKATIVMPETAPISKYQATKSYGAQVILYGKFLHESMKKAEEIIREEGSILVHPYGDLDVILGQGT
LGLELLPYNPDIVVVPIGGGGLISGISIALKAKNPKTKIIGVQSSASPSLKVSKDLHRLVEIEPSFSIADGILVKSPSEI
TFSIIDELVDDIVLVDDEEIANAIVYLLERNKTLVEGAAAASLAALLSGKIKVAYNHKAIPVLSGGNIDLSMLSRIIDKM
LFKNKRIVKVKVIVPDKPGYLNKVLSRVAQIRGNVIDVVHDRTSSDVKPGYTKIYVMFEVPSGDALSDFMYNLALDGIEA
KLVE

Sequences:

>Translated_404_residues
MSYTKYFDEIVKIQDRIKQYIHETPIDYSKTFSDMIGAQIYLKLENLQKTGSFKVRGAFSKLTSLAEEERKKGVIAVSAG
NHAQGVAYAAKVLGIKATIVMPETAPISKYQATKSYGAQVILYGKFLHESMKKAEEIIREEGSILVHPYGDLDVILGQGT
LGLELLPYNPDIVVVPIGGGGLISGISIALKAKNPKTKIIGVQSSASPSLKVSKDLHRLVEIEPSFSIADGILVKSPSEI
TFSIIDELVDDIVLVDDEEIANAIVYLLERNKTLVEGAAAASLAALLSGKIKVAYNHKAIPVLSGGNIDLSMLSRIIDKM
LFKNKRIVKVKVIVPDKPGYLNKVLSRVAQIRGNVIDVVHDRTSSDVKPGYTKIYVMFEVPSGDALSDFMYNLALDGIEA
KLVE
>Mature_403_residues
SYTKYFDEIVKIQDRIKQYIHETPIDYSKTFSDMIGAQIYLKLENLQKTGSFKVRGAFSKLTSLAEEERKKGVIAVSAGN
HAQGVAYAAKVLGIKATIVMPETAPISKYQATKSYGAQVILYGKFLHESMKKAEEIIREEGSILVHPYGDLDVILGQGTL
GLELLPYNPDIVVVPIGGGGLISGISIALKAKNPKTKIIGVQSSASPSLKVSKDLHRLVEIEPSFSIADGILVKSPSEIT
FSIIDELVDDIVLVDDEEIANAIVYLLERNKTLVEGAAAASLAALLSGKIKVAYNHKAIPVLSGGNIDLSMLSRIIDKML
FKNKRIVKVKVIVPDKPGYLNKVLSRVAQIRGNVIDVVHDRTSSDVKPGYTKIYVMFEVPSGDALSDFMYNLALDGIEAK
LVE

Specific function: Acts on both serine and threonine, and properly considered as a hydroxy amino acid deaminase [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=319, Percent_Identity=41.0658307210031, Blast_Score=195, Evalue=6e-50,
Organism=Homo sapiens, GI19923959, Length=299, Percent_Identity=29.4314381270903, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI33469958, Length=320, Percent_Identity=28.125, Blast_Score=79, Evalue=5e-15,
Organism=Escherichia coli, GI1789505, Length=312, Percent_Identity=46.7948717948718, Blast_Score=247, Evalue=1e-66,
Organism=Escherichia coli, GI1790207, Length=329, Percent_Identity=34.3465045592705, Blast_Score=166, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI71991565, Length=365, Percent_Identity=37.8082191780822, Blast_Score=215, Evalue=3e-56,
Organism=Caenorhabditis elegans, GI17537387, Length=358, Percent_Identity=36.5921787709497, Blast_Score=189, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI17508781, Length=321, Percent_Identity=28.0373831775701, Blast_Score=130, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6322631, Length=313, Percent_Identity=40.8945686900958, Blast_Score=209, Evalue=8e-55,
Organism=Saccharomyces cerevisiae, GI6320930, Length=334, Percent_Identity=35.9281437125749, Blast_Score=175, Evalue=1e-44,
Organism=Saccharomyces cerevisiae, GI6319788, Length=289, Percent_Identity=25.6055363321799, Blast_Score=77, Evalue=4e-15,
Organism=Drosophila melanogaster, GI21355833, Length=358, Percent_Identity=39.9441340782123, Blast_Score=195, Evalue=4e-50,
Organism=Drosophila melanogaster, GI24645328, Length=264, Percent_Identity=38.6363636363636, Blast_Score=125, Evalue=7e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR005789 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 44035; Mature: 43904

Theoretical pI: Translated: 8.87; Mature: 8.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYTKYFDEIVKIQDRIKQYIHETPIDYSKTFSDMIGAQIYLKLENLQKTGSFKVRGAFS
CCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCEEEEEEEECCCCCCCEEEEHHHH
KLTSLAEEERKKGVIAVSAGNHAQGVAYAAKVLGIKATIVMPETAPISKYQATKSYGAQV
HHHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHCEEEEEEECCCCCCCHHHHHHHCCCEE
ILYGKFLHESMKKAEEIIREEGSILVHPYGDLDVILGQGTLGLELLPYNPDIVVVPIGGG
EEEHHHHHHHHHHHHHHHHCCCCEEEEECCCEEEEEECCCCCEEEECCCCCEEEEECCCC
GLISGISIALKAKNPKTKIIGVQSSASPSLKVSKDLHRLVEIEPSFSIADGILVKSPSEI
CCCCCEEEEEECCCCCEEEEEEECCCCCCCCHHHHHHHHEECCCCCCCCCCEEEECCCHH
TFSIIDELVDDIVLVDDEEIANAIVYLLERNKTLVEGAAAASLAALLSGKIKVAYNHKAI
HHHHHHHHHHCEEEECCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCEEEEECCCEE
PVLSGGNIDLSMLSRIIDKMLFKNKRIVKVKVIVPDKPGYLNKVLSRVAQIRGNVIDVVH
EEEECCCCCHHHHHHHHHHHHHCCCCEEEEEEEECCCCCHHHHHHHHHHHHCCCEEEEEE
DRTSSDVKPGYTKIYVMFEVPSGDALSDFMYNLALDGIEAKLVE
CCCCCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHCCCEEEECC
>Mature Secondary Structure 
SYTKYFDEIVKIQDRIKQYIHETPIDYSKTFSDMIGAQIYLKLENLQKTGSFKVRGAFS
CHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCEEEEEEEECCCCCCCEEEEHHHH
KLTSLAEEERKKGVIAVSAGNHAQGVAYAAKVLGIKATIVMPETAPISKYQATKSYGAQV
HHHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHCEEEEEEECCCCCCCHHHHHHHCCCEE
ILYGKFLHESMKKAEEIIREEGSILVHPYGDLDVILGQGTLGLELLPYNPDIVVVPIGGG
EEEHHHHHHHHHHHHHHHHCCCCEEEEECCCEEEEEECCCCCEEEECCCCCEEEEECCCC
GLISGISIALKAKNPKTKIIGVQSSASPSLKVSKDLHRLVEIEPSFSIADGILVKSPSEI
CCCCCEEEEEECCCCCEEEEEEECCCCCCCCHHHHHHHHEECCCCCCCCCCEEEECCCHH
TFSIIDELVDDIVLVDDEEIANAIVYLLERNKTLVEGAAAASLAALLSGKIKVAYNHKAI
HHHHHHHHHHCEEEECCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCEEEEECCCEE
PVLSGGNIDLSMLSRIIDKMLFKNKRIVKVKVIVPDKPGYLNKVLSRVAQIRGNVIDVVH
EEEECCCCCHHHHHHHHHHHHHCCCCEEEEEEEECCCCCHHHHHHHHHHHHCCCEEEEEE
DRTSSDVKPGYTKIYVMFEVPSGDALSDFMYNLALDGIEAKLVE
CCCCCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA