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The map label for this gene is coaBC [H]

Identifier: 15920445

GI number: 15920445

Start: 274352

End: 275590

Strand: Reverse

Name: coaBC [H]

Synonym: ST0257

Alternate gene names: 15920445

Gene position: 275590-274352 (Counterclockwise)

Preceding gene: 15920447

Following gene: 15920444

Centisome position: 10.23

GC content: 31.88

Gene sequence:

>1239_bases
ATGGTTATTCATCCCTCGAAGAAAATTATAGGCGAGATCTCATCAGAACTTTTGAATAAGAAAATTTTAGTAGGAGTCAC
AGGTAGTGTATCCATTTATAAGACTATTGACTTAGTGAGAAGCTTAATGAGGTTAGGTGCAGAAGTCCAAGTTATTATGA
GTAAAGACGCTTCAAAATTAGTCTCTCCTACAATGTTTGAATGGGCAACTGGTAATCCAGTGATAACAAAAATTTCTGGC
GGGATAGAACATGTTACATTAGCTGAAGATTATGACGCATATGTTGTAGCACCAGCTACAGCAAATACTATAAGCAAAAT
TGTTAATGGAATTGCAGATACTCCAATAACAGTTACTGCTCTTAATTTTATTGGTCTAAAAAAACCTCTAATCTTAGTTC
CAGCGATGCATTTACCAATGTATTTTACACCTCAAATGATAAATAATATAAATAAACTAAATGAGATAGGAGTAATTGTT
GTAGAACCTTTTCTTGTAAGAGATGTTGCTCATTATCCAGATATAGAATATTTATCAAATTATATTTCAACCTTACTTCT
TAGGGGTAAGGATTTAGAAGGATTGAAAATTGTCGTTACAGCTGGCCCTACAAGAGAGCATTTAGACCCAGTGAGATTTA
TTTCAAATCCTAGTAGTGGGACTATGGGAGTTGCAATAGCAAACGAGGCATATTTTAGAGGTGCTGATGTTGTTTTAGTT
CATGGTCCTTTAAGTACTCATATAAAGCCTTATGTTAAAAAGAAAGTTCAGGTAGAAACAACTGATGAAATGGCTAATGA
AGTGAAGAAATTTGTAGAAACTGGATATAATATTGTGATTTTAGCTGGAGCACCAGCAGATTATAAGTTTAAAAACATTG
CTTCTTCAAAGATTGATAGTCATACAGAAACTCCTACAGTAGAACTTGAAAAAACAGTAAAGATCTCAAGTATAATAAGG
AAATATAATGTTTTCTTAGTAGGTTTTGCTGCAGAGACTGTAAAAGATGACAATGAATTAATAGAAAAAGGTAAAATAAA
GAAGGAGAGGCATGGCTTTGATTTGCTAATAGCGAATAATGCTTCTAGAAAAGATATAGCATTTTCATCAGATTTTAATG
AAGTTATAGTAATCGGAAACAATTTTATAAAGAAAATAAATAAAAATTATAAAACAGTTATAGCTAGAGAAATACTTGAC
ATAGTTAAGCAAGAGTATAAGGTTCAAAAACATGGGTAA

Upstream 100 bases:

>100_bases
TCTGTTAACCTTGCATTTCTTATTCTATATTCTTTTCCCTTTTTTGCTTCAGCAAACTCCATAATATAAGGTTTTTATTC
GAAGTTTAAATTTATGTCTG

Downstream 100 bases:

>100_bases
GCTTAAAAAATTGGAAGTTAGAAATAATAATGGGATTGGCTCGGGTAGCTCAGCCTGGTTAGAGCGACGGGCTGTGGACC
CGTAGGTCCCGGGTTCAAGT

Product: hypothetical protein

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 412; Mature: 412

Protein sequence:

>412_residues
MVIHPSKKIIGEISSELLNKKILVGVTGSVSIYKTIDLVRSLMRLGAEVQVIMSKDASKLVSPTMFEWATGNPVITKISG
GIEHVTLAEDYDAYVVAPATANTISKIVNGIADTPITVTALNFIGLKKPLILVPAMHLPMYFTPQMINNINKLNEIGVIV
VEPFLVRDVAHYPDIEYLSNYISTLLLRGKDLEGLKIVVTAGPTREHLDPVRFISNPSSGTMGVAIANEAYFRGADVVLV
HGPLSTHIKPYVKKKVQVETTDEMANEVKKFVETGYNIVILAGAPADYKFKNIASSKIDSHTETPTVELEKTVKISSIIR
KYNVFLVGFAAETVKDDNELIEKGKIKKERHGFDLLIANNASRKDIAFSSDFNEVIVIGNNFIKKINKNYKTVIAREILD
IVKQEYKVQKHG

Sequences:

>Translated_412_residues
MVIHPSKKIIGEISSELLNKKILVGVTGSVSIYKTIDLVRSLMRLGAEVQVIMSKDASKLVSPTMFEWATGNPVITKISG
GIEHVTLAEDYDAYVVAPATANTISKIVNGIADTPITVTALNFIGLKKPLILVPAMHLPMYFTPQMINNINKLNEIGVIV
VEPFLVRDVAHYPDIEYLSNYISTLLLRGKDLEGLKIVVTAGPTREHLDPVRFISNPSSGTMGVAIANEAYFRGADVVLV
HGPLSTHIKPYVKKKVQVETTDEMANEVKKFVETGYNIVILAGAPADYKFKNIASSKIDSHTETPTVELEKTVKISSIIR
KYNVFLVGFAAETVKDDNELIEKGKIKKERHGFDLLIANNASRKDIAFSSDFNEVIVIGNNFIKKINKNYKTVIAREILD
IVKQEYKVQKHG
>Mature_412_residues
MVIHPSKKIIGEISSELLNKKILVGVTGSVSIYKTIDLVRSLMRLGAEVQVIMSKDASKLVSPTMFEWATGNPVITKISG
GIEHVTLAEDYDAYVVAPATANTISKIVNGIADTPITVTALNFIGLKKPLILVPAMHLPMYFTPQMINNINKLNEIGVIV
VEPFLVRDVAHYPDIEYLSNYISTLLLRGKDLEGLKIVVTAGPTREHLDPVRFISNPSSGTMGVAIANEAYFRGADVVLV
HGPLSTHIKPYVKKKVQVETTDEMANEVKKFVETGYNIVILAGAPADYKFKNIASSKIDSHTETPTVELEKTVKISSIIR
KYNVFLVGFAAETVKDDNELIEKGKIKKERHGFDLLIANNASRKDIAFSSDFNEVIVIGNNFIKKINKNYKTVIAREILD
IVKQEYKVQKHG

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=154, Percent_Identity=31.1688311688312, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI87082301, Length=421, Percent_Identity=32.0665083135392, Blast_Score=171, Evalue=6e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 45518; Mature: 45518

Theoretical pI: Translated: 9.44; Mature: 9.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVIHPSKKIIGEISSELLNKKILVGVTGSVSIYKTIDLVRSLMRLGAEVQVIMSKDASKL
CEECCCHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHCCCEEEEEECCCHHHH
VSPTMFEWATGNPVITKISGGIEHVTLAEDYDAYVVAPATANTISKIVNGIADTPITVTA
CCCCEEEECCCCCEEEEECCCCEEEEEECCCCEEEEECCCHHHHHHHHHHHCCCCEEEEE
LNFIGLKKPLILVPAMHLPMYFTPQMINNINKLNEIGVIVVEPFLVRDVAHYPDIEYLSN
EHHHCCCCCEEEEEHHHCCEEECHHHHHHHHHHHHCCEEEECHHHHHHHHHCCCHHHHHH
YISTLLLRGKDLEGLKIVVTAGPTREHLDPVRFISNPSSGTMGVAIANEAYFRGADVVLV
HHHHHHHCCCCCCCEEEEEECCCCHHHCCHHHHHCCCCCCCEEEEEECCCEECCCCEEEE
HGPLSTHIKPYVKKKVQVETTDEMANEVKKFVETGYNIVILAGAPADYKFKNIASSKIDS
ECCHHHCCCHHHHHEEEEECHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHCCC
HTETPTVELEKTVKISSIIRKYNVFLVGFAAETVKDDNELIEKGKIKKERHGFDLLIANN
CCCCCCEEHHHHHHHHHHHHHHCEEEEEEEHHHHCCCHHHHHHCCCCHHHCCEEEEEECC
ASRKDIAFSSDFNEVIVIGNNFIKKINKNYKTVIAREILDIVKQEYKVQKHG
CCCCCEEECCCCCEEEEECCHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MVIHPSKKIIGEISSELLNKKILVGVTGSVSIYKTIDLVRSLMRLGAEVQVIMSKDASKL
CEECCCHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHCCCEEEEEECCCHHHH
VSPTMFEWATGNPVITKISGGIEHVTLAEDYDAYVVAPATANTISKIVNGIADTPITVTA
CCCCEEEECCCCCEEEEECCCCEEEEEECCCCEEEEECCCHHHHHHHHHHHCCCCEEEEE
LNFIGLKKPLILVPAMHLPMYFTPQMINNINKLNEIGVIVVEPFLVRDVAHYPDIEYLSN
EHHHCCCCCEEEEEHHHCCEEECHHHHHHHHHHHHCCEEEECHHHHHHHHHCCCHHHHHH
YISTLLLRGKDLEGLKIVVTAGPTREHLDPVRFISNPSSGTMGVAIANEAYFRGADVVLV
HHHHHHHCCCCCCCEEEEEECCCCHHHCCHHHHHCCCCCCCEEEEEECCCEECCCCEEEE
HGPLSTHIKPYVKKKVQVETTDEMANEVKKFVETGYNIVILAGAPADYKFKNIASSKIDS
ECCHHHCCCHHHHHEEEEECHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHCCC
HTETPTVELEKTVKISSIIRKYNVFLVGFAAETVKDDNELIEKGKIKKERHGFDLLIANN
CCCCCCEEHHHHHHHHHHHHHHCEEEEEEEHHHHCCCHHHHHHCCCCHHHCCEEEEEECC
ASRKDIAFSSDFNEVIVIGNNFIKKINKNYKTVIAREILDIVKQEYKVQKHG
CCCCCEEECCCCCEEEEECCHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]