BacMap

Definition	Sulfolobus tokodaii str. 7 chromosome, complete genome.
Accession	NC_003106
Length	2,694,756

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The map label for this gene is echA8 [H]

Identifier: 15920273

GI number: 15920273

Start: 119593

End: 120324

Strand: Reverse

Name: echA8 [H]

Synonym: ST0095

Alternate gene names: 15920273

Gene position: 120324-119593 (Counterclockwise)

Preceding gene: 15920274

Following gene: 15920269

Centisome position: 4.47

GC content: 33.2

Gene sequence:

>732_bases
ATGATCTATGAAAAAAGAGGGATAGTGTCGTGGATAATATTTAATAGGCCAGAAAGGCTAAATGCTTTTGATAAAGAAAG
TTGGGATTCCTTAGCTAAATTATTAAAGAAAGCTAATGAGGATGATACAAAAGTTGTAGTCCTTATTGGAAATGGAAGAG
CATTTTCTTCTGGTGATGATATATATGCCATGTATGAATTAAAAGATGGTGATGAAGCTAAAGATTTCTTTCTCACACTT
TATTCAGCGATAGAGAACTTAGTAGAACTTGAAAAACCATTAATATGTGCTGTTAACGGTTTAGCATATGGTGGAGGATG
TGAAATATTGCTCTTCTGTGATGTCACTATAGCAGTGCAATCTGCAAAATTTTCTATCCCAGAAGCTAAATTAGGCTTAA
TACCTCCAATGGCAATAACTATAGGTCCTTTAGCATTAGGAAGAAGGATTAATCGATTAGTACTCACTGGTGAAGCTATA
ACTGCGGAAGAGGCAAAAATTCTAGGCTTGGTGGATTATGTTGTACCAGATGATAAATTAGTAGAGGAAGTTAATAGGAT
TGTGAATATGATTGATCAGCTTGATTTCTATTCTCTAAAAACTATAAAAAGATGGCTTAGAAAAGATAAGAAAATAGTTG
AAAAGGCTATAATGGAATTAGCATTATTATCTCAAACAGAGTCAGCAAAAAAGAGGATGAAAGAATTTATTGACTCAAGG
AAGAAGACTTAA

Upstream 100 bases:

>100_bases
TTAAGCTAAGATTAAAAACTTTACCCCGCCTTAAAAGGCGAGGCTTGCCCCGCGTTTTGTCAAATTAAAAATAAATAATA
AATTAGACCTATTTCAATAT

Downstream 100 bases:

>100_bases
TTGCTTTTATAATATTAAAGTAACCAGTACATCGACAAATATTTTTTATGCTATGTCTAAGTAACTCGTCATTATCCCTT
TTACCTACTCTCTTTAGATA

Product: fatty acid--CoA dehydratase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 243; Mature: 243

Protein sequence:

>243_residues
MIYEKRGIVSWIIFNRPERLNAFDKESWDSLAKLLKKANEDDTKVVVLIGNGRAFSSGDDIYAMYELKDGDEAKDFFLTL
YSAIENLVELEKPLICAVNGLAYGGGCEILLFCDVTIAVQSAKFSIPEAKLGLIPPMAITIGPLALGRRINRLVLTGEAI
TAEEAKILGLVDYVVPDDKLVEEVNRIVNMIDQLDFYSLKTIKRWLRKDKKIVEKAIMELALLSQTESAKKRMKEFIDSR
KKT

Sequences:

>Translated_243_residues
MIYEKRGIVSWIIFNRPERLNAFDKESWDSLAKLLKKANEDDTKVVVLIGNGRAFSSGDDIYAMYELKDGDEAKDFFLTL
YSAIENLVELEKPLICAVNGLAYGGGCEILLFCDVTIAVQSAKFSIPEAKLGLIPPMAITIGPLALGRRINRLVLTGEAI
TAEEAKILGLVDYVVPDDKLVEEVNRIVNMIDQLDFYSLKTIKRWLRKDKKIVEKAIMELALLSQTESAKKRMKEFIDSR
KKT
>Mature_243_residues
MIYEKRGIVSWIIFNRPERLNAFDKESWDSLAKLLKKANEDDTKVVVLIGNGRAFSSGDDIYAMYELKDGDEAKDFFLTL
YSAIENLVELEKPLICAVNGLAYGGGCEILLFCDVTIAVQSAKFSIPEAKLGLIPPMAITIGPLALGRRINRLVLTGEAI
TAEEAKILGLVDYVVPDDKLVEEVNRIVNMIDQLDFYSLKTIKRWLRKDKKIVEKAIMELALLSQTESAKKRMKEFIDSR
KKT

Specific function: Could possibly oxidize fatty acids using specific components [H]

COG id: COG1024

COG function: function code I; Enoyl-CoA hydratase/carnithine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=193, Percent_Identity=38.860103626943, Blast_Score=115, Evalue=3e-26,
Organism=Homo sapiens, GI31542718, Length=190, Percent_Identity=32.1052631578947, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI260274832, Length=208, Percent_Identity=30.2884615384615, Blast_Score=96, Evalue=2e-20,
Organism=Homo sapiens, GI45643119, Length=208, Percent_Identity=30.2884615384615, Blast_Score=96, Evalue=2e-20,
Organism=Homo sapiens, GI260275230, Length=208, Percent_Identity=30.2884615384615, Blast_Score=96, Evalue=2e-20,
Organism=Homo sapiens, GI70995211, Length=188, Percent_Identity=31.3829787234043, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI68989263, Length=167, Percent_Identity=34.1317365269461, Blast_Score=78, Evalue=7e-15,
Organism=Homo sapiens, GI221307494, Length=189, Percent_Identity=29.1005291005291, Blast_Score=75, Evalue=4e-14,
Organism=Homo sapiens, GI221136756, Length=189, Percent_Identity=29.1005291005291, Blast_Score=75, Evalue=5e-14,
Organism=Homo sapiens, GI221136753, Length=189, Percent_Identity=29.1005291005291, Blast_Score=75, Evalue=5e-14,
Organism=Homo sapiens, GI25453481, Length=189, Percent_Identity=26.984126984127, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI51538573, Length=189, Percent_Identity=26.984126984127, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI4757966, Length=189, Percent_Identity=26.984126984127, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI51538581, Length=189, Percent_Identity=26.984126984127, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI4757968, Length=189, Percent_Identity=26.984126984127, Blast_Score=75, Evalue=7e-14,
Organism=Homo sapiens, GI49355787, Length=189, Percent_Identity=26.984126984127, Blast_Score=75, Evalue=7e-14,
Organism=Homo sapiens, GI37594471, Length=186, Percent_Identity=26.3440860215054, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI37594469, Length=186, Percent_Identity=26.3440860215054, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI116235487, Length=190, Percent_Identity=28.4210526315789, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI20127408, Length=232, Percent_Identity=28.8793103448276, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1787659, Length=248, Percent_Identity=30.6451612903226, Blast_Score=116, Evalue=1e-27,
Organism=Escherichia coli, GI1787660, Length=209, Percent_Identity=35.4066985645933, Blast_Score=89, Evalue=2e-19,
Organism=Escherichia coli, GI221142681, Length=210, Percent_Identity=31.9047619047619, Blast_Score=88, Evalue=4e-19,
Organism=Escherichia coli, GI1790281, Length=179, Percent_Identity=31.2849162011173, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI87082183, Length=205, Percent_Identity=27.3170731707317, Blast_Score=68, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI25145438, Length=240, Percent_Identity=33.3333333333333, Blast_Score=105, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17554946, Length=241, Percent_Identity=31.5352697095436, Blast_Score=99, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17535521, Length=212, Percent_Identity=30.6603773584906, Blast_Score=92, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17549921, Length=214, Percent_Identity=26.6355140186916, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17560910, Length=190, Percent_Identity=31.0526315789474, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17540306, Length=203, Percent_Identity=27.0935960591133, Blast_Score=76, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17540714, Length=239, Percent_Identity=27.1966527196653, Blast_Score=74, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI25144160, Length=205, Percent_Identity=27.8048780487805, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI25144157, Length=205, Percent_Identity=27.8048780487805, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI25141363, Length=221, Percent_Identity=26.2443438914027, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17534483, Length=200, Percent_Identity=28.5, Blast_Score=68, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17536985, Length=200, Percent_Identity=26, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6320241, Length=185, Percent_Identity=29.7297297297297, Blast_Score=78, Evalue=2e-15,
Organism=Drosophila melanogaster, GI20129971, Length=203, Percent_Identity=35.4679802955665, Blast_Score=104, Evalue=5e-23,
Organism=Drosophila melanogaster, GI24653477, Length=203, Percent_Identity=35.4679802955665, Blast_Score=104, Evalue=5e-23,
Organism=Drosophila melanogaster, GI19922422, Length=197, Percent_Identity=29.4416243654822, Blast_Score=88, Evalue=6e-18,
Organism=Drosophila melanogaster, GI21357171, Length=191, Percent_Identity=30.3664921465969, Blast_Score=78, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24654903, Length=187, Percent_Identity=27.807486631016, Blast_Score=77, Evalue=8e-15,
Organism=Drosophila melanogaster, GI28571729, Length=186, Percent_Identity=29.0322580645161, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI28571730, Length=186, Percent_Identity=29.0322580645161, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24653139, Length=183, Percent_Identity=31.6939890710383, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI19920382, Length=225, Percent_Identity=25.3333333333333, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24650670, Length=179, Percent_Identity=28.4916201117318, Blast_Score=65, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.2.1.17 [H]

Molecular weight: Translated: 27366; Mature: 27366

Theoretical pI: Translated: 5.57; Mature: 5.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIYEKRGIVSWIIFNRPERLNAFDKESWDSLAKLLKKANEDDTKVVVLIGNGRAFSSGDD
CCCCCCCCEEEEEECCCHHCCCCCHHHHHHHHHHHHHCCCCCCEEEEEEECCEEECCCCC
IYAMYELKDGDEAKDFFLTLYSAIENLVELEKPLICAVNGLAYGGGCEILLFCDVTIAVQ
EEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCEEEECCEEECCCCEEEEEEEEEEEEE
SAKFSIPEAKLGLIPPMAITIGPLALGRRINRLVLTGEAITAEEAKILGLVDYVVPDDKL
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCEEEEECCCCCHHHHHHHHHHHHHCCCHHH
VEEVNRIVNMIDQLDFYSLKTIKRWLRKDKKIVEKAIMELALLSQTESAKKRMKEFIDSR
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHC
KKT
CCC
>Mature Secondary Structure
MIYEKRGIVSWIIFNRPERLNAFDKESWDSLAKLLKKANEDDTKVVVLIGNGRAFSSGDD
CCCCCCCCEEEEEECCCHHCCCCCHHHHHHHHHHHHHCCCCCCEEEEEEECCEEECCCCC
IYAMYELKDGDEAKDFFLTLYSAIENLVELEKPLICAVNGLAYGGGCEILLFCDVTIAVQ
EEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCEEEECCEEECCCCEEEEEEEEEEEEE
SAKFSIPEAKLGLIPPMAITIGPLALGRRINRLVLTGEAITAEEAKILGLVDYVVPDDKL
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCEEEEECCCCCHHHHHHHHHHHHHCCCHHH
VEEVNRIVNMIDQLDFYSLKTIKRWLRKDKKIVEKAIMELALLSQTESAKKRMKEFIDSR
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHC
KKT
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]