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The map label for this gene is bcr [C]

Identifier: 159185315

GI number: 159185315

Start: 2650002

End: 2651180

Strand: Direct

Name: bcr [C]

Synonym: Atu2666

Alternate gene names: 159185315

Gene position: 2650002-2651180 (Clockwise)

Preceding gene: 15889921

Following gene: 159185317

Centisome position: 93.26

GC content: 61.58

Gene sequence:

>1179_bases
ATGTCGACAAAACGCACGGCCATTCTCGGCGCGTTGCTGACGGCGCTGGCGCCGATTTCCATGGCGATCTATACGCCGGC
CATGCCGGAACTGACGCGGGTTTTCGCCACGAATGAATCCGCGATAAAGCTCAGCCTCTCGCTTTATTTCGCCGGTTTCG
CCCTGGCGCAGCTGCTCGCCGGCCCTGCTTCCGATGCCTTTGGCCGGCGCAGGGCGAGCCTCGTTTTCCTGTCAGTCTTT
CTGGGCGGCGGACTGCTGGCGATTTTTGCCCCGACGATAGAAGTGCTGCTCCTCGCGCGGCTCATTCAGGGCATCGGCGC
CTCCGTCGGCATGACGGTGGCACGCGCTATCGTACGCGACCAGTTTACTGGCGCGGAAGCCTCCAGCATCATGAACCTCA
TCGGCATCATGCTGGCAGTCGGCCCCGCCCTCGGACCAACGATCGGTGGGCTTTCGCTTGCGGCTTTCGGCTGGAAATCG
GTGTTTTTCCTCATGGCCGGTCTCGGCGCCGCCGCCATCTTCTCCGTCGTGATTTTTCTGCGCGAAACAACGGTCCCGGA
CAAAAGCCTTATCCGCCCCCGTCGCCTCCTGTCGGCCTACGGCAACTTGCTGACCGAACCACGCTTTCTTCTGGCCGCCC
TCGTGCTCGGCGGTTCCATCGGCGCACTTTATGCGCAGGCCACCATGCTGACCTTCATTCTCATCAACACGGTTGGCATG
ACACCCACCGCCTTCGGCATCGGCATGCTGATGCAGACCGGCGCTTATTTCTTCGGCTCCATCGCCCTGCGGTACATCGC
ACCGCGACTGGGTGATCGCCGTTCGGTCATGCTCGGCCTCTGTTTTTCGGGAACAGGCGGTCTGCTCATCCTGCTGTCGG
TCTTCCTGATACCGCCGTCCTTCTTTTCCATCATGGGACCCGTGGCGGTCGCAACGGTCGGTATCGCCTTGCTGACACCC
TCAATGGTAACGGCAGCGCTTGCACCCTTCCCCCATATTGCCGGCTCGGCCTCGGCGATGATGGGCTTCATCCAGATGGG
ATCGGGTTTTGCGGGCGGCACCGCTGCCTCGCTCATCGGTTCACCCTTGACAGGCTTCGGCATCGTCATCCCGGTGATGG
AATTCACCGCTGTTGCCAGCTACATCGGCTTCCGCATCGTCTCCAGAAGCAAGACATGA

Upstream 100 bases:

>100_bases
AAGTTGCGCTTTTCCGCAGCTTCCTGCAGACGCTTCGCGACAATCTCCAGCCTGAACAGCCGGGCCAGAGCTGCTGACCA
CAATGCCGCCAGAACCGATC

Downstream 100 bases:

>100_bases
AAAAACCCGCCGGCGTCACCGCCCGCGGGTTTCATAATCTTTACGTCAGCTGAATTACTTGTTGAGGTTACGCTTGGCGA
GCGTGCGAAGACGCAGCGCA

Product: MFS permease

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 392; Mature: 391

Protein sequence:

>392_residues
MSTKRTAILGALLTALAPISMAIYTPAMPELTRVFATNESAIKLSLSLYFAGFALAQLLAGPASDAFGRRRASLVFLSVF
LGGGLLAIFAPTIEVLLLARLIQGIGASVGMTVARAIVRDQFTGAEASSIMNLIGIMLAVGPALGPTIGGLSLAAFGWKS
VFFLMAGLGAAAIFSVVIFLRETTVPDKSLIRPRRLLSAYGNLLTEPRFLLAALVLGGSIGALYAQATMLTFILINTVGM
TPTAFGIGMLMQTGAYFFGSIALRYIAPRLGDRRSVMLGLCFSGTGGLLILLSVFLIPPSFFSIMGPVAVATVGIALLTP
SMVTAALAPFPHIAGSASAMMGFIQMGSGFAGGTAASLIGSPLTGFGIVIPVMEFTAVASYIGFRIVSRSKT

Sequences:

>Translated_392_residues
MSTKRTAILGALLTALAPISMAIYTPAMPELTRVFATNESAIKLSLSLYFAGFALAQLLAGPASDAFGRRRASLVFLSVF
LGGGLLAIFAPTIEVLLLARLIQGIGASVGMTVARAIVRDQFTGAEASSIMNLIGIMLAVGPALGPTIGGLSLAAFGWKS
VFFLMAGLGAAAIFSVVIFLRETTVPDKSLIRPRRLLSAYGNLLTEPRFLLAALVLGGSIGALYAQATMLTFILINTVGM
TPTAFGIGMLMQTGAYFFGSIALRYIAPRLGDRRSVMLGLCFSGTGGLLILLSVFLIPPSFFSIMGPVAVATVGIALLTP
SMVTAALAPFPHIAGSASAMMGFIQMGSGFAGGTAASLIGSPLTGFGIVIPVMEFTAVASYIGFRIVSRSKT
>Mature_391_residues
STKRTAILGALLTALAPISMAIYTPAMPELTRVFATNESAIKLSLSLYFAGFALAQLLAGPASDAFGRRRASLVFLSVFL
GGGLLAIFAPTIEVLLLARLIQGIGASVGMTVARAIVRDQFTGAEASSIMNLIGIMLAVGPALGPTIGGLSLAAFGWKSV
FFLMAGLGAAAIFSVVIFLRETTVPDKSLIRPRRLLSAYGNLLTEPRFLLAALVLGGSIGALYAQATMLTFILINTVGMT
PTAFGIGMLMQTGAYFFGSIALRYIAPRLGDRRSVMLGLCFSGTGGLLILLSVFLIPPSFFSIMGPVAVATVGIALLTPS
MVTAALAPFPHIAGSASAMMGFIQMGSGFAGGTAASLIGSPLTGFGIVIPVMEFTAVASYIGFRIVSRSKT

Specific function: Involved In Sulfonamide (Sulfathiazole) And Bicyclomycin Resistance. Probable Membrane Translocase. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Bcr/CmlA family [H]

Homologues:

Organism=Escherichia coli, GI1788509, Length=358, Percent_Identity=26.8156424581006, Blast_Score=115, Evalue=4e-27,
Organism=Escherichia coli, GI48994889, Length=363, Percent_Identity=27.2727272727273, Blast_Score=115, Evalue=4e-27,
Organism=Escherichia coli, GI87082312, Length=360, Percent_Identity=28.6111111111111, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1790146, Length=206, Percent_Identity=28.6407766990291, Blast_Score=85, Evalue=8e-18,
Organism=Escherichia coli, GI1787065, Length=326, Percent_Identity=26.3803680981595, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1790794, Length=230, Percent_Identity=24.3478260869565, Blast_Score=62, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6324264, Length=179, Percent_Identity=25.6983240223464, Blast_Score=64, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004812
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 40540; Mature: 40409

Theoretical pI: Translated: 11.21; Mature: 11.21

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTKRTAILGALLTALAPISMAIYTPAMPELTRVFATNESAIKLSLSLYFAGFALAQLLA
CCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHC
GPASDAFGRRRASLVFLSVFLGGGLLAIFAPTIEVLLLARLIQGIGASVGMTVARAIVRD
CCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
QFTGAEASSIMNLIGIMLAVGPALGPTIGGLSLAAFGWKSVFFLMAGLGAAAIFSVVIFL
HCCCCHHHHHHHHHHHHHHHCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RETTVPDKSLIRPRRLLSAYGNLLTEPRFLLAALVLGGSIGALYAQATMLTFILINTVGM
HHCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCC
TPTAFGIGMLMQTGAYFFGSIALRYIAPRLGDRRSVMLGLCFSGTGGLLILLSVFLIPPS
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHHHCHH
FFSIMGPVAVATVGIALLTPSMVTAALAPFPHIAGSASAMMGFIQMGSGFAGGTAASLIG
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHC
SPLTGFGIVIPVMEFTAVASYIGFRIVSRSKT
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
STKRTAILGALLTALAPISMAIYTPAMPELTRVFATNESAIKLSLSLYFAGFALAQLLA
CCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHC
GPASDAFGRRRASLVFLSVFLGGGLLAIFAPTIEVLLLARLIQGIGASVGMTVARAIVRD
CCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
QFTGAEASSIMNLIGIMLAVGPALGPTIGGLSLAAFGWKSVFFLMAGLGAAAIFSVVIFL
HCCCCHHHHHHHHHHHHHHHCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RETTVPDKSLIRPRRLLSAYGNLLTEPRFLLAALVLGGSIGALYAQATMLTFILINTVGM
HHCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCC
TPTAFGIGMLMQTGAYFFGSIALRYIAPRLGDRRSVMLGLCFSGTGGLLILLSVFLIPPS
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHHHCHH
FFSIMGPVAVATVGIALLTPSMVTAALAPFPHIAGSASAMMGFIQMGSGFAGGTAASLIG
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHC
SPLTGFGIVIPVMEFTAVASYIGFRIVSRSKT
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA