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The map label for this gene is hexR [H]

Identifier: 159185286

GI number: 159185286

Start: 2577218

End: 2578081

Strand: Reverse

Name: hexR [H]

Synonym: Atu2598

Alternate gene names: 159185286

Gene position: 2578081-2577218 (Counterclockwise)

Preceding gene: 15889857

Following gene: 159185285

Centisome position: 90.73

GC content: 57.99

Gene sequence:

>864_bases
ATGGATATTTTTGCAAGGATACAGGACGACAAGGGGCAGTTCTCGCAGTCAGAACGGCGGATTGCCGATATTCTGGTTTC
GGACTTCGAATTCGCCGTCAATGCGTCTATTATCGAGCTTGCAGCCCGCGCAGAAGTCTCGCCGCCGACGGTGACGCGGT
TCTGCCGTCGTCTCGGTTGCCAGAGCTTTTCGGACTTCAAGGTCAGCCTTGCCAAGACGGCCTATGTAGGTGTCCGGTAT
CTCACATCAGAACCTTCCAGCACCGGCCCTTCCGATGTCGCGGAAGAGGTGCTGGCAAAGGCGCAGGAAGCGCTGTTCCT
GCTGCACAAAACACTCGATCCCGCGCTCGCTGATGAAGCGGCGGTCAAGATTGCCAATAGCGGCATGATCTATGCCTTCG
GCGCCGGCGGCAATTCCTCGATGATCGCTTCGGAAATCCAGAACCGGCTGTTTCGGCTGGGTTTGCGTGTTTCGACCAGC
GCCGATCACAGCATGCAGCTGATGATGACGGCAGCGGCGCGCAAGGAAGACGTGATTATCGGTTCGTCTTTTTCCGGTCG
CAACATGGAACTGGTGAAGTGTTTCAGGCTGGCGCGGGAAATGGGGGTCACCACCATCGCGCTTACCCAGAGCGACACGC
CTGTCGCTGCCGCGGCCGATATGGTGGTGGCCGTTAATGTGCCCGAAGGGAACAATATCTTCCGCCCTACCTCATCACGT
TACGCCTATCTGGCCGCCGTCGATATTCTTGCGACGCTCGCTGCCTATCAGCAGCGGCAGAGATCGATGGTGACGCTGCG
TCACATCAAGCAGCAGCTGGTGGAGCATCGTGACCCGGACGACAAGCAATTGCTCGGTGACTGA

Upstream 100 bases:

>100_bases
GATCGATTCGTGGGTCTATGCGGTTGACGGGCGCGCTTTATTAGGGTGCATCGGCAAAGGGGCCAAGCATTAAGTTTTGG
CGGAACGGAGACCGGTGAGC

Downstream 100 bases:

>100_bases
GGGCGAGAAAAAATACAGGCGGTTTCGCCTGAGGCCCCTGTGGTGGGTCGGAAAGTTTTAAGGGAGTTGTAAAGGTGATG
AACGACAGGAAAGACCAGCT

Product: RpiR family transcriptional regulator

Products: NA

Alternate protein names: Hex regulon repressor [H]

Number of amino acids: Translated: 287; Mature: 287

Protein sequence:

>287_residues
MDIFARIQDDKGQFSQSERRIADILVSDFEFAVNASIIELAARAEVSPPTVTRFCRRLGCQSFSDFKVSLAKTAYVGVRY
LTSEPSSTGPSDVAEEVLAKAQEALFLLHKTLDPALADEAAVKIANSGMIYAFGAGGNSSMIASEIQNRLFRLGLRVSTS
ADHSMQLMMTAAARKEDVIIGSSFSGRNMELVKCFRLAREMGVTTIALTQSDTPVAAAADMVVAVNVPEGNNIFRPTSSR
YAYLAAVDILATLAAYQQRQRSMVTLRHIKQQLVEHRDPDDKQLLGD

Sequences:

>Translated_287_residues
MDIFARIQDDKGQFSQSERRIADILVSDFEFAVNASIIELAARAEVSPPTVTRFCRRLGCQSFSDFKVSLAKTAYVGVRY
LTSEPSSTGPSDVAEEVLAKAQEALFLLHKTLDPALADEAAVKIANSGMIYAFGAGGNSSMIASEIQNRLFRLGLRVSTS
ADHSMQLMMTAAARKEDVIIGSSFSGRNMELVKCFRLAREMGVTTIALTQSDTPVAAAADMVVAVNVPEGNNIFRPTSSR
YAYLAAVDILATLAAYQQRQRSMVTLRHIKQQLVEHRDPDDKQLLGD
>Mature_287_residues
MDIFARIQDDKGQFSQSERRIADILVSDFEFAVNASIIELAARAEVSPPTVTRFCRRLGCQSFSDFKVSLAKTAYVGVRY
LTSEPSSTGPSDVAEEVLAKAQEALFLLHKTLDPALADEAAVKIANSGMIYAFGAGGNSSMIASEIQNRLFRLGLRVSTS
ADHSMQLMMTAAARKEDVIIGSSFSGRNMELVKCFRLAREMGVTTIALTQSDTPVAAAADMVVAVNVPEGNNIFRPTSSR
YAYLAAVDILATLAAYQQRQRSMVTLRHIKQQLVEHRDPDDKQLLGD

Specific function: Represses the expression of the hex regulon (zwf, eda, glp and gap) [H]

COG id: COG1737

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 SIS domain [H]

Homologues:

Organism=Escherichia coli, GI1788159, Length=293, Percent_Identity=32.4232081911263, Blast_Score=142, Evalue=4e-35,
Organism=Escherichia coli, GI1788767, Length=262, Percent_Identity=27.8625954198473, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI87082369, Length=236, Percent_Identity=23.3050847457627, Blast_Score=66, Evalue=3e-12,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000281
- InterPro:   IPR001347
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01418 HTH_6; PF01380 SIS [H]

EC number: NA

Molecular weight: Translated: 31332; Mature: 31332

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: PS00356 HTH_LACI_1 ; PS51071 HTH_RPIR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIFARIQDDKGQFSQSERRIADILVSDFEFAVNASIIELAARAEVSPPTVTRFCRRLGC
CCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCC
QSFSDFKVSLAKTAYVGVRYLTSEPSSTGPSDVAEEVLAKAQEALFLLHKTLDPALADEA
CCCCHHHHHHHHHHHHHEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
AVKIANSGMIYAFGAGGNSSMIASEIQNRLFRLGLRVSTSADHSMQLMMTAAARKEDVII
HHEEECCCEEEEEECCCCCHHHHHHHHHHHHHHCCEEECCCCCHHHHHHHHHCCCCCEEE
GSSFSGRNMELVKCFRLAREMGVTTIALTQSDTPVAAAADMVVAVNVPEGNNIFRPTSSR
ECCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCHHHHCCEEEEEECCCCCCEECCCCCC
YAYLAAVDILATLAAYQQRQRSMVTLRHIKQQLVEHRDPDDKQLLGD
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCC
>Mature Secondary Structure
MDIFARIQDDKGQFSQSERRIADILVSDFEFAVNASIIELAARAEVSPPTVTRFCRRLGC
CCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCC
QSFSDFKVSLAKTAYVGVRYLTSEPSSTGPSDVAEEVLAKAQEALFLLHKTLDPALADEA
CCCCHHHHHHHHHHHHHEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
AVKIANSGMIYAFGAGGNSSMIASEIQNRLFRLGLRVSTSADHSMQLMMTAAARKEDVII
HHEEECCCEEEEEECCCCCHHHHHHHHHHHHHHCCEEECCCCCHHHHHHHHHCCCCCEEE
GSSFSGRNMELVKCFRLAREMGVTTIALTQSDTPVAAAADMVVAVNVPEGNNIFRPTSSR
ECCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCHHHHCCEEEEEECCCCCCEECCCCCC
YAYLAAVDILATLAAYQQRQRSMVTLRHIKQQLVEHRDPDDKQLLGD
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]