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The map label for this gene is gbpR [H]

Identifier: 159185168

GI number: 159185168

Start: 2327065

End: 2327979

Strand: Direct

Name: gbpR [H]

Synonym: Atu2350

Alternate gene names: 159185168

Gene position: 2327065-2327979 (Clockwise)

Preceding gene: 159185167

Following gene: 15889627

Centisome position: 81.89

GC content: 62.62

Gene sequence:

>915_bases
ATGAGCCACCTGCGCATGCTCGTGATGATCGAGGAGCACGGACAGGTCAGCGCCGCCGCGGCAGCCATGAACATGACGCA
GCCGGCAGCCTCGCGCATGCTCTCGGAAATGGAAGCAATCGTCAAATCACCGCTTTGTCAGAGAGCCTCGCGCGGCGTGG
TGCTGACGAAATTCGGCGAGGCGCTGGCGCGCCGCGCCCGCACCATATTGCTGGAACTGCGCGAAGCTAGCCGTGAACTC
AACCAGATGAAGTCGGGCAGCGGCGGTTCGGTCTATATCGGCGCCGTCACCGCCCCGGCGATCAGCCTCGTCGTTCCCGC
CATCAGGCGCGCCATGGACACCTATCCCGGCATCGAAATCAACGTGCAGGTGGAGAGCAGCAACGTGCTGGCCCGGGAAC
TGCTGGCGGCGCGTCACGATTTCATCATCGGCCGCATTCCCGATGACTTCGATCCCGGCCTCTTCTCCATCCACGAAATC
GGCATCGAGCGCGCCTGTCTGGTGGTGCGCGAAGGCCACCCGCTGATGCGCGGCGAGCCCGTGACCCTGCAGGATCTCTC
CGGTTACGACTGGGTCTTCCAGCCACCCGGCGCGCTTTTGCGCAGAACGATGGAGGATGTCTTCCTCACCCATGGCGTCG
CCATGCCGCGCAACGTCATCAACACGCCATCCGTGGTGCTCACCCTTGCCCTCGTCTGCAATACCAATGCCATCGCCCCC
ATCGCGCAGGACATGGCCGAATTTGTTGCGGGGCAGCAGGCAGATATCGGCCGAACCCGCATTTTGCCAACGGATTTCGA
ACTCGTGGTCAAGCCTTACAGCATCATTACCACCAAAGGCCGGGTCCTGCCGCCCAGCGCCCGCCTGCTTTATGATCTGG
TGCTGGATGAAAGCCGTAAGCTGACCAACACCTGA

Upstream 100 bases:

>100_bases
AAAATCAAGGATGAGCAACCAAAAAGTGTATGAGCAGGCGCAAACAACAGAGGCTCTTTTCGTCTTTGAAGACAACCCTC
TGCTGCGGGCCGGATTAAAG

Downstream 100 bases:

>100_bases
CGACGGCAAGCCCGACTCCACCTTCACCCTTTATAGAAGCCGGATCATTGAGGCCGGCGCAGGGAACAGCCGCATGCTCT
TCGGACAATCCGTCTTCCAG

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: Galactose-binding protein regulator; GBP regulator [H]

Number of amino acids: Translated: 304; Mature: 303

Protein sequence:

>304_residues
MSHLRMLVMIEEHGQVSAAAAAMNMTQPAASRMLSEMEAIVKSPLCQRASRGVVLTKFGEALARRARTILLELREASREL
NQMKSGSGGSVYIGAVTAPAISLVVPAIRRAMDTYPGIEINVQVESSNVLARELLAARHDFIIGRIPDDFDPGLFSIHEI
GIERACLVVREGHPLMRGEPVTLQDLSGYDWVFQPPGALLRRTMEDVFLTHGVAMPRNVINTPSVVLTLALVCNTNAIAP
IAQDMAEFVAGQQADIGRTRILPTDFELVVKPYSIITTKGRVLPPSARLLYDLVLDESRKLTNT

Sequences:

>Translated_304_residues
MSHLRMLVMIEEHGQVSAAAAAMNMTQPAASRMLSEMEAIVKSPLCQRASRGVVLTKFGEALARRARTILLELREASREL
NQMKSGSGGSVYIGAVTAPAISLVVPAIRRAMDTYPGIEINVQVESSNVLARELLAARHDFIIGRIPDDFDPGLFSIHEI
GIERACLVVREGHPLMRGEPVTLQDLSGYDWVFQPPGALLRRTMEDVFLTHGVAMPRNVINTPSVVLTLALVCNTNAIAP
IAQDMAEFVAGQQADIGRTRILPTDFELVVKPYSIITTKGRVLPPSARLLYDLVLDESRKLTNT
>Mature_303_residues
SHLRMLVMIEEHGQVSAAAAAMNMTQPAASRMLSEMEAIVKSPLCQRASRGVVLTKFGEALARRARTILLELREASRELN
QMKSGSGGSVYIGAVTAPAISLVVPAIRRAMDTYPGIEINVQVESSNVLARELLAARHDFIIGRIPDDFDPGLFSIHEIG
IERACLVVREGHPLMRGEPVTLQDLSGYDWVFQPPGALLRRTMEDVFLTHGVAMPRNVINTPSVVLTLALVCNTNAIAPI
AQDMAEFVAGQQADIGRTRILPTDFELVVKPYSIITTKGRVLPPSARLLYDLVLDESRKLTNT

Specific function: Activator of the expression of chvE when bound to its inducer and represses its expression in the absence of inducer (L- arabinose, D-fucose or D-galactose). Negatively regulates its own expression [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787601, Length=249, Percent_Identity=23.2931726907631, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI87081904, Length=239, Percent_Identity=26.7782426778243, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI145693105, Length=194, Percent_Identity=26.8041237113402, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1789506, Length=298, Percent_Identity=23.1543624161074, Blast_Score=68, Evalue=8e-13,
Organism=Escherichia coli, GI1789440, Length=235, Percent_Identity=25.531914893617, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI157672245, Length=234, Percent_Identity=26.4957264957265, Blast_Score=64, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33234; Mature: 33103

Theoretical pI: Translated: 7.13; Mature: 7.13

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHLRMLVMIEEHGQVSAAAAAMNMTQPAASRMLSEMEAIVKSPLCQRASRGVVLTKFGE
CCCCEEEEEEECCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHCHHHHHHHCCEEEEHHHH
ALARRARTILLELREASRELNQMKSGSGGSVYIGAVTAPAISLVVPAIRRAMDTYPGIEI
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHHHHHCCCCCEE
NVQVESSNVLARELLAARHDFIIGRIPDDFDPGLFSIHEIGIERACLVVREGHPLMRGEP
EEEECCCCHHHHHHHHHHHCEEEECCCCCCCCCHHHHHHHCHHHEEEEEECCCCCCCCCC
VTLQDLSGYDWVFQPPGALLRRTMEDVFLTHGVAMPRNVINTPSVVLTLALVCNTNAIAP
CEEECCCCCCCEECCCHHHHHHHHHHHHHHCCCCCCHHHCCCCHHHHHHHHHHCCCCCHH
IAQDMAEFVAGQQADIGRTRILPTDFELVVKPYSIITTKGRVLPPSARLLYDLVLDESRK
HHHHHHHHHCCCCCCCCCCEECCCCHHHEECCHHEEEECCCCCCCHHHHHHHHHHCCCCC
LTNT
CCCC
>Mature Secondary Structure 
SHLRMLVMIEEHGQVSAAAAAMNMTQPAASRMLSEMEAIVKSPLCQRASRGVVLTKFGE
CCCEEEEEEECCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHCHHHHHHHCCEEEEHHHH
ALARRARTILLELREASRELNQMKSGSGGSVYIGAVTAPAISLVVPAIRRAMDTYPGIEI
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHHHHHCCCCCEE
NVQVESSNVLARELLAARHDFIIGRIPDDFDPGLFSIHEIGIERACLVVREGHPLMRGEP
EEEECCCCHHHHHHHHHHHCEEEECCCCCCCCCHHHHHHHCHHHEEEEEECCCCCCCCCC
VTLQDLSGYDWVFQPPGALLRRTMEDVFLTHGVAMPRNVINTPSVVLTLALVCNTNAIAP
CEEECCCCCCCEECCCHHHHHHHHHHHHHHCCCCCCHHHCCCCHHHHHHHHHHCCCCCHH
IAQDMAEFVAGQQADIGRTRILPTDFELVVKPYSIITTKGRVLPPSARLLYDLVLDESRK
HHHHHHHHHCCCCCCCCCCEECCCCHHHEECCHHEEEECCCCCCCHHHHHHHHHHCCCCC
LTNT
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8253677; 2156804 [H]