Click here to switch to the map view.

The map label for this gene is tdk

Identifier: 159185140

GI number: 159185140

Start: 2254496

End: 2254987

Strand: Direct

Name: tdk

Synonym: Atu2282

Alternate gene names: 159185140

Gene position: 2254496-2254987 (Clockwise)

Preceding gene: 15889552

Following gene: 159185141

Centisome position: 79.34

GC content: 60.57

Gene sequence:

>492_bases
ATGCGCACTCTGATCTTCACGGCCGCCTTTGACGATCGGGCCGGCGTTGGCCGCGTTGCCTCGCGTATCGGCCTGTCCTC
CGAAGCCCGGACCTTCGATGAAAATACCGACCTGTTCGCCGAGGTAGCGGCATTGCACGCGCAGGCACCTGTCGCCTGCG
TCTTCGTCGATGAAGCCAATTTCCTCTCCGAGCACCATGTCTGGCAACTTGCCAACATTGCCGACCGGCTGAACATTCCG
GTCATGACCTATGGCCTGCGGACGGATTTCCAGGGCAAGCTCTTCCCGGCCTCGAAGGAACTGCTCGCCATTGCCGACGA
GCTTCGCGAAATCCGCACCATCTGCCATTGCGGCCGCAAGGCGACGATGGTGGCCCGCTTCGACAGCGAAGGAAAGGTCG
TGACCGAAGGCGCCCAGATCGAAGTTGGCGGCAACGGGAAATACGTTTCCTTCTGCCGCCGCCACTGGGTGGAAACATTT
AACTGCAGTTGA

Upstream 100 bases:

>100_bases
GGAGTGGATCATGGCAAAACTCTATTTCAATTATTCGACGATGAATGCCGGCAAATCGACCATGTTGTTGCAGGCGTCCT
ATAATTATCAGGAACGCGGC

Downstream 100 bases:

>100_bases
CCCGCTGCGTCCGGTTGCCGCATTTGATTTTTCGCAAAGATGGCCTGTCCGCTCCTGCGCTAAGACGACGGGGACACATT
CGCGTGGATGTGCTTTCTCT

Product: thymidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 163; Mature: 163

Protein sequence:

>163_residues
MRTLIFTAAFDDRAGVGRVASRIGLSSEARTFDENTDLFAEVAALHAQAPVACVFVDEANFLSEHHVWQLANIADRLNIP
VMTYGLRTDFQGKLFPASKELLAIADELREIRTICHCGRKATMVARFDSEGKVVTEGAQIEVGGNGKYVSFCRRHWVETF
NCS

Sequences:

>Translated_163_residues
MRTLIFTAAFDDRAGVGRVASRIGLSSEARTFDENTDLFAEVAALHAQAPVACVFVDEANFLSEHHVWQLANIADRLNIP
VMTYGLRTDFQGKLFPASKELLAIADELREIRTICHCGRKATMVARFDSEGKVVTEGAQIEVGGNGKYVSFCRRHWVETF
NCS
>Mature_163_residues
MRTLIFTAAFDDRAGVGRVASRIGLSSEARTFDENTDLFAEVAALHAQAPVACVFVDEANFLSEHHVWQLANIADRLNIP
VMTYGLRTDFQGKLFPASKELLAIADELREIRTICHCGRKATMVARFDSEGKVVTEGAQIEVGGNGKYVSFCRRHWVETF
NCS

Specific function: Phosphorylates Both Thymidine And Deoxyuridine. [C]

COG id: COG1435

COG function: function code F; Thymidine kinase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidine kinase family

Homologues:

Organism=Escherichia coli, GI1787490, Length=161, Percent_Identity=52.1739130434783, Blast_Score=191, Evalue=2e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KITH_AGRT5 (Q7CXF9)

Other databases:

- EMBL:   AE007869
- PIR:   AI2856
- PIR:   G97633
- RefSeq:   NP_355239.2
- ProteinModelPortal:   Q7CXF9
- SMR:   Q7CXF9
- STRING:   Q7CXF9
- GeneID:   1134320
- GenomeReviews:   AE007869_GR
- KEGG:   atu:Atu2282
- eggNOG:   COG1435
- HOGENOM:   HBG522108
- OMA:   FRYGAMN
- PhylomeDB:   Q7CXF9
- ProtClustDB:   PRK04296
- BioCyc:   ATUM176299-1:ATU2282-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00124
- InterPro:   IPR001267
- InterPro:   IPR020634
- PANTHER:   PTHR11441
- PIRSF:   PIRSF035805

Pfam domain/function: PF00265 TK

EC number: =2.7.1.21

Molecular weight: Translated: 18084; Mature: 18084

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: PS00603 TK_CELLULAR_TYPE

Important sites: ACT_SITE 88-88

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.1 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
3.1 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTLIFTAAFDDRAGVGRVASRIGLSSEARTFDENTDLFAEVAALHAQAPVACVFVDEAN
CCEEEEEEECCCCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCH
FLSEHHVWQLANIADRLNIPVMTYGLRTDFQGKLFPASKELLAIADELREIRTICHCGRK
HHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCC
ATMVARFDSEGKVVTEGAQIEVGGNGKYVSFCRRHWVETFNCS
EEEEEEECCCCCEEECCCEEEECCCCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MRTLIFTAAFDDRAGVGRVASRIGLSSEARTFDENTDLFAEVAALHAQAPVACVFVDEAN
CCEEEEEEECCCCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCH
FLSEHHVWQLANIADRLNIPVMTYGLRTDFQGKLFPASKELLAIADELREIRTICHCGRK
HHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCC
ATMVARFDSEGKVVTEGAQIEVGGNGKYVSFCRRHWVETFNCS
EEEEEEECCCCCEEECCCEEEECCCCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194