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The map label for this gene is adh [C]

Identifier: 159185076

GI number: 159185076

Start: 2115801

End: 2116844

Strand: Direct

Name: adh [C]

Synonym: Atu2151

Alternate gene names: 159185076

Gene position: 2115801-2116844 (Clockwise)

Preceding gene: 15889431

Following gene: 15889434

Centisome position: 74.46

GC content: 63.98

Gene sequence:

>1044_bases
ATGCGCGCGCTTTATTACGAACGATTCGGCGAGACCCCTGTAGTCGCGTCCCTGCCTGATCCGGCACCGAGCGATGGCGG
CGTGGTGATTGCGGTGAAGGCAACCGGCCTCTGCCGCAGCGACTGGCATGGCTGGATGGGACATGACACGGATATCCGTC
TGCCGCATGTGCCCGGCCACGAGTTCGCCGGCGTCATCTCCGCAGTCGGCAGAAACGTCACCCGCTTCAAGACGGGTGAT
CGCGTTACCGTGCCTTTCGTCTCCGGCTGCGGCCATTGCCATGAGTGCCGCTCCGGCAATCAGCAGGTCTGCGAAACGCA
GTTCCAGCCCGGCTTCACCCATTGGGGTTCCTTCGCCGAATATGTCGCCATCGACTATGCCGATCAGAACCTCGTGCACC
TGCCGGAATCGATGAGTTACGCCACCGCCGCCGGCCTCGGTTGCCGTTTCGCCACCTCCTTCCGGGCGGTGACGGATCAG
GGACGCCTGAAGGGCGGCGAATGGCTGGCTGTCCATGGCTGCGGCGGTGTCGGTCTCTCCGCCATCATGATCGGCGCCGG
CCTCGGCGCACAGGTCGTCGCCATCGATATTGCCGAAGACAAGCTCGAACTCGCCCGGCAACTGGGTGCAACCGCAACCA
TCAACAGCCGCTCCGTTGCCGATGTCGCCGAAGCGGTGCGCGACATCACCGGTGGCGGCGCGCATGTGTCGGTGGATGCG
CTTGGCCATCCGCAGACCTGCTGCAATTCCATCAGCAACCTGCGCCGGCGCGGACGCCATGTGCAGGTGGGGCTGATGCT
GGCAGACCATGCCATGCCGGCCATTCCCATGGCCCGGGTGATCGCTCATGAGCTGGAGATCTATGGCAGCCACGGCATGC
AGGCATGGCGTTACGAGGACATGCTGGCCATGATCGAAAGCGGCAGGCTTGCGCCGGAAAAGCTGATTGGCCGCCATATC
TCGCTGACCGAAGCGGCCGTCGCCCTGCCCGGAATGGATAGGTTCCAGGAGAGCGGCATCAGCATCATCGACCGGTTCGA
ATAG

Upstream 100 bases:

>100_bases
GACTGAAGCGCTTCCCCAGACGTAAAACGGCTTCGCACTTTTGCTGAAAATGCTCTAGAGCAGGTTCGGATTGAACCTGC
GGACCAATGATGAGGCCATG

Downstream 100 bases:

>100_bases
TACCGGTCGCAGCCATTCGGTTTCGCTTCACTTGGTCCTGCGCCCAAAAGCCCGGGCCGTGCCGCCTGTCGGGGGTGAGG
CCTCCACCGGCGGGGGCGCC

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: ADH-HT [H]

Number of amino acids: Translated: 347; Mature: 347

Protein sequence:

>347_residues
MRALYYERFGETPVVASLPDPAPSDGGVVIAVKATGLCRSDWHGWMGHDTDIRLPHVPGHEFAGVISAVGRNVTRFKTGD
RVTVPFVSGCGHCHECRSGNQQVCETQFQPGFTHWGSFAEYVAIDYADQNLVHLPESMSYATAAGLGCRFATSFRAVTDQ
GRLKGGEWLAVHGCGGVGLSAIMIGAGLGAQVVAIDIAEDKLELARQLGATATINSRSVADVAEAVRDITGGGAHVSVDA
LGHPQTCCNSISNLRRRGRHVQVGLMLADHAMPAIPMARVIAHELEIYGSHGMQAWRYEDMLAMIESGRLAPEKLIGRHI
SLTEAAVALPGMDRFQESGISIIDRFE

Sequences:

>Translated_347_residues
MRALYYERFGETPVVASLPDPAPSDGGVVIAVKATGLCRSDWHGWMGHDTDIRLPHVPGHEFAGVISAVGRNVTRFKTGD
RVTVPFVSGCGHCHECRSGNQQVCETQFQPGFTHWGSFAEYVAIDYADQNLVHLPESMSYATAAGLGCRFATSFRAVTDQ
GRLKGGEWLAVHGCGGVGLSAIMIGAGLGAQVVAIDIAEDKLELARQLGATATINSRSVADVAEAVRDITGGGAHVSVDA
LGHPQTCCNSISNLRRRGRHVQVGLMLADHAMPAIPMARVIAHELEIYGSHGMQAWRYEDMLAMIESGRLAPEKLIGRHI
SLTEAAVALPGMDRFQESGISIIDRFE
>Mature_347_residues
MRALYYERFGETPVVASLPDPAPSDGGVVIAVKATGLCRSDWHGWMGHDTDIRLPHVPGHEFAGVISAVGRNVTRFKTGD
RVTVPFVSGCGHCHECRSGNQQVCETQFQPGFTHWGSFAEYVAIDYADQNLVHLPESMSYATAAGLGCRFATSFRAVTDQ
GRLKGGEWLAVHGCGGVGLSAIMIGAGLGAQVVAIDIAEDKLELARQLGATATINSRSVADVAEAVRDITGGGAHVSVDA
LGHPQTCCNSISNLRRRGRHVQVGLMLADHAMPAIPMARVIAHELEIYGSHGMQAWRYEDMLAMIESGRLAPEKLIGRHI
SLTEAAVALPGMDRFQESGISIIDRFE

Specific function: Thermophilic NAD(+)-dependent alcohol dehydrogenase. Bears mainly an ethanol-dehydrogenase activity [H]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI71743840, Length=278, Percent_Identity=28.7769784172662, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI262073058, Length=278, Percent_Identity=28.7769784172662, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI4501933, Length=250, Percent_Identity=30, Blast_Score=109, Evalue=4e-24,
Organism=Homo sapiens, GI34577061, Length=284, Percent_Identity=28.8732394366197, Blast_Score=109, Evalue=5e-24,
Organism=Homo sapiens, GI4501929, Length=247, Percent_Identity=29.5546558704453, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI71565154, Length=244, Percent_Identity=30.327868852459, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI156523966, Length=244, Percent_Identity=28.2786885245902, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI4501939, Length=244, Percent_Identity=28.2786885245902, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI71565152, Length=246, Percent_Identity=29.2682926829268, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI194239674, Length=269, Percent_Identity=29.7397769516729, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI13236495, Length=269, Percent_Identity=29.7397769516729, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI194239676, Length=224, Percent_Identity=32.1428571428571, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI156627571, Length=334, Percent_Identity=23.9520958083832, Blast_Score=73, Evalue=5e-13,
Organism=Escherichia coli, GI1787863, Length=349, Percent_Identity=28.080229226361, Blast_Score=121, Evalue=8e-29,
Organism=Escherichia coli, GI87082125, Length=320, Percent_Identity=28.4375, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI87081918, Length=295, Percent_Identity=31.5254237288136, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI1790045, Length=330, Percent_Identity=29.6969696969697, Blast_Score=111, Evalue=6e-26,
Organism=Escherichia coli, GI1786825, Length=383, Percent_Identity=25.5874673629243, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1788073, Length=311, Percent_Identity=27.3311897106109, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI226510992, Length=249, Percent_Identity=33.3333333333333, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI1786552, Length=283, Percent_Identity=30.0353356890459, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI1788075, Length=341, Percent_Identity=25.8064516129032, Blast_Score=91, Evalue=8e-20,
Organism=Escherichia coli, GI1788407, Length=318, Percent_Identity=27.0440251572327, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1786518, Length=275, Percent_Identity=28, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1790718, Length=335, Percent_Identity=23.8805970149254, Blast_Score=75, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI71988145, Length=292, Percent_Identity=29.4520547945205, Blast_Score=125, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI17562582, Length=266, Percent_Identity=28.1954887218045, Blast_Score=108, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI17562584, Length=290, Percent_Identity=26.8965517241379, Blast_Score=105, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17565904, Length=207, Percent_Identity=31.8840579710145, Blast_Score=101, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI25146526, Length=219, Percent_Identity=31.0502283105023, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI71997431, Length=214, Percent_Identity=31.3084112149533, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17562878, Length=320, Percent_Identity=28.75, Blast_Score=98, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI17562876, Length=324, Percent_Identity=28.3950617283951, Blast_Score=97, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6324486, Length=265, Percent_Identity=32.4528301886792, Blast_Score=130, Evalue=4e-31,
Organism=Saccharomyces cerevisiae, GI6323961, Length=265, Percent_Identity=32.8301886792453, Blast_Score=125, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6319621, Length=266, Percent_Identity=30.8270676691729, Blast_Score=125, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6323729, Length=350, Percent_Identity=28.2857142857143, Blast_Score=124, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6320033, Length=288, Percent_Identity=28.125, Blast_Score=107, Evalue=4e-24,
Organism=Saccharomyces cerevisiae, GI6319258, Length=347, Percent_Identity=28.8184438040346, Blast_Score=101, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6319955, Length=340, Percent_Identity=28.2352941176471, Blast_Score=100, Evalue=5e-22,
Organism=Saccharomyces cerevisiae, GI6322619, Length=340, Percent_Identity=28.2352941176471, Blast_Score=100, Evalue=6e-22,
Organism=Saccharomyces cerevisiae, GI6323980, Length=220, Percent_Identity=29.5454545454545, Blast_Score=72, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6319949, Length=206, Percent_Identity=30.5825242718447, Blast_Score=67, Evalue=4e-12,
Organism=Drosophila melanogaster, GI17737895, Length=334, Percent_Identity=26.9461077844311, Blast_Score=118, Evalue=6e-27,
Organism=Drosophila melanogaster, GI17137530, Length=324, Percent_Identity=27.1604938271605, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI17737897, Length=321, Percent_Identity=26.4797507788162, Blast_Score=98, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 37198; Mature: 37198

Theoretical pI: Translated: 6.50; Mature: 6.50

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRALYYERFGETPVVASLPDPAPSDGGVVIAVKATGLCRSDWHGWMGHDTDIRLPHVPGH
CCCCCHHHCCCCCEEEECCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCEECCCCCCH
EFAGVISAVGRNVTRFKTGDRVTVPFVSGCGHCHECRSGNQQVCETQFQPGFTHWGSFAE
HHHHHHHHHCCCCEEEECCCEEEEEHHCCCCCHHHHCCCCHHHHHHCCCCCCHHHCCHHH
YVAIDYADQNLVHLPESMSYATAAGLGCRFATSFRAVTDQGRLKGGEWLAVHGCGGVGLS
EEEEECCCCCEEECCCCCCHHHHHCCCHHHHHHHHHHCCCCCCCCCCEEEEECCCCHHHH
AIMIGAGLGAQVVAIDIAEDKLELARQLGATATINSRSVADVAEAVRDITGGGAHVSVDA
HHHHHCCCCCEEEEEEECHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHCCCCCEEEEEC
LGHPQTCCNSISNLRRRGRHVQVGLMLADHAMPAIPMARVIAHELEIYGSHGMQAWRYED
CCCHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHH
MLAMIESGRLAPEKLIGRHISLTEAAVALPGMDRFQESGISIIDRFE
HHHHHHCCCCCHHHHHCCCCCHHHHHHHCCCHHHHHHCCCCCEECCC
>Mature Secondary Structure
MRALYYERFGETPVVASLPDPAPSDGGVVIAVKATGLCRSDWHGWMGHDTDIRLPHVPGH
CCCCCHHHCCCCCEEEECCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCEECCCCCCH
EFAGVISAVGRNVTRFKTGDRVTVPFVSGCGHCHECRSGNQQVCETQFQPGFTHWGSFAE
HHHHHHHHHCCCCEEEECCCEEEEEHHCCCCCHHHHCCCCHHHHHHCCCCCCHHHCCHHH
YVAIDYADQNLVHLPESMSYATAAGLGCRFATSFRAVTDQGRLKGGEWLAVHGCGGVGLS
EEEEECCCCCEEECCCCCCHHHHHCCCHHHHHHHHHHCCCCCCCCCCEEEEECCCCHHHH
AIMIGAGLGAQVVAIDIAEDKLELARQLGATATINSRSVADVAEAVRDITGGGAHVSVDA
HHHHHCCCCCEEEEEEECHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHCCCCCEEEEEC
LGHPQTCCNSISNLRRRGRHVQVGLMLADHAMPAIPMARVIAHELEIYGSHGMQAWRYED
CCCHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHH
MLAMIESGRLAPEKLIGRHISLTEAAVALPGMDRFQESGISIIDRFE
HHHHHHCCCCCHHHHHCCCCCHHHHHHHCCCHHHHHHCCCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8020473 [H]