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The map label for this gene is icdA [H]

Identifier: 159184957

GI number: 159184957

Start: 1848284

End: 1849498

Strand: Direct

Name: icdA [H]

Synonym: Atu1870

Alternate gene names: 159184957

Gene position: 1848284-1849498 (Clockwise)

Preceding gene: 15889162

Following gene: 15889171

Centisome position: 65.04

GC content: 60.58

Gene sequence:

>1215_bases
ATGGCAAAGATCAAGGTAGCCAATCCAGTCGTCGATCTCGACGGCGACGAAATGACCCGTATCATCTGGCAGCTCATCAA
GGACAAGCTGATCCTGCCATACCTCGATCTCGACATCGAATATTACGACCTCTCGGTTGAAAACCGCGATGCCACCAACG
ACCAGGTCACCGTCGATGCGGCACACGCCATCAAGAAGCATGGCGTCGGCATCAAGTGCGCGACGATCACGCCGGACGAG
CAGCGCGTCGAGGAATTCGGCCTGAAGCAGATGTGGAAGAGCCCGAACGGCACGATCCGCAACATTCTCGGCGGCGTCAT
CTTCCGCGAGCCGATCATCTGCAAGAACGTTCCGCGCCTCGTTCCCGGCTGGACCAAGCCGATCGTCGTCGGCCGTCACG
CCTTTGGCGACCAGTACAAGGCAACCGATTTCAAGTTCCCCGGCAAGGGCAAGCTGACGATCAAGTTCGTCGGTGAAGAC
GGCACGGTCATCGAAAAGGACGTCTTCGACGCCCCGAGCGCCGGCGTGGCACTCGCCATGTACAACCTCGACGAATCCAT
CCGCGAATTCGCCCGCGCCTCGATGATGTATGGCCTGATGCGCAAGTGGCCGGTTTACCTCTCCACCAAGAACACCATCC
TCAAGGCCTATGACGGCCGCTTCAAGGATATCTTCGAAGAAGTCTACCAGACCGAGTTCAAGGCAAAGTTCGACGAAGTC
GGCATCACCTACGAACACCGCCTGATCGACGACATGGTTGCCTCGGCGCTGAAGTGGTCCGGCGGCTACGTCTGGGCCTG
CAAGAACTACGATGGCGACGTGCAGTCCGACACGGTTGCCCAGGGCTTCGGCTCGCTCGGCCTGATGACCTCGGTTCTGC
TGTCGCCGGATGGCCGCACCGTCGAAGCCGAAGCGGCGCACGGCACGGTGACGCGTCACTACCGCCAGCACCAGAAGGGT
CAGGAAACCTCGACCAACTCGATCGCCTCGATCTTCGCCTGGACCCGTGGCCTCGCCCACCGCGCCAAGCTGGATGACAA
TGCGGAACTGGCAAAGTTCGCGACGACGCTCGAAACCGTCTGCGTCGACACCGTCGAAAGCGGCTTCATGACCAAGGATC
TGGCCCTCCTCATCGGACCGGACCAGCCCTGGCTCTCCACCACCGCCTTCCTCGACAAGATCGACGAAAACCTCAAGACG
GCGATGGCGGCCTGA

Upstream 100 bases:

>100_bases
CCATGGCTTTGCCTCAGACGCTCGCGATGCTATAGCCCGACCGGATATTTTTCCGACTATTGGCGTCAACAGGCGCCACA
GCTTCGAAGGTGAGGAATTC

Downstream 100 bases:

>100_bases
AATCAGGAGGGCAATGCCCGTCCGAAATGGTGAAACAGGAAAACCCGGCGGCAACGCCGGGTTTCTTTTTTGTTCACAGT
ATCTTGATTAGCCGTTGTAC

Product: isocitrate dehydrogenase

Products: NA

Alternate protein names: IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 404; Mature: 403

Protein sequence:

>404_residues
MAKIKVANPVVDLDGDEMTRIIWQLIKDKLILPYLDLDIEYYDLSVENRDATNDQVTVDAAHAIKKHGVGIKCATITPDE
QRVEEFGLKQMWKSPNGTIRNILGGVIFREPIICKNVPRLVPGWTKPIVVGRHAFGDQYKATDFKFPGKGKLTIKFVGED
GTVIEKDVFDAPSAGVALAMYNLDESIREFARASMMYGLMRKWPVYLSTKNTILKAYDGRFKDIFEEVYQTEFKAKFDEV
GITYEHRLIDDMVASALKWSGGYVWACKNYDGDVQSDTVAQGFGSLGLMTSVLLSPDGRTVEAEAAHGTVTRHYRQHQKG
QETSTNSIASIFAWTRGLAHRAKLDDNAELAKFATTLETVCVDTVESGFMTKDLALLIGPDQPWLSTTAFLDKIDENLKT
AMAA

Sequences:

>Translated_404_residues
MAKIKVANPVVDLDGDEMTRIIWQLIKDKLILPYLDLDIEYYDLSVENRDATNDQVTVDAAHAIKKHGVGIKCATITPDE
QRVEEFGLKQMWKSPNGTIRNILGGVIFREPIICKNVPRLVPGWTKPIVVGRHAFGDQYKATDFKFPGKGKLTIKFVGED
GTVIEKDVFDAPSAGVALAMYNLDESIREFARASMMYGLMRKWPVYLSTKNTILKAYDGRFKDIFEEVYQTEFKAKFDEV
GITYEHRLIDDMVASALKWSGGYVWACKNYDGDVQSDTVAQGFGSLGLMTSVLLSPDGRTVEAEAAHGTVTRHYRQHQKG
QETSTNSIASIFAWTRGLAHRAKLDDNAELAKFATTLETVCVDTVESGFMTKDLALLIGPDQPWLSTTAFLDKIDENLKT
AMAA
>Mature_403_residues
AKIKVANPVVDLDGDEMTRIIWQLIKDKLILPYLDLDIEYYDLSVENRDATNDQVTVDAAHAIKKHGVGIKCATITPDEQ
RVEEFGLKQMWKSPNGTIRNILGGVIFREPIICKNVPRLVPGWTKPIVVGRHAFGDQYKATDFKFPGKGKLTIKFVGEDG
TVIEKDVFDAPSAGVALAMYNLDESIREFARASMMYGLMRKWPVYLSTKNTILKAYDGRFKDIFEEVYQTEFKAKFDEVG
ITYEHRLIDDMVASALKWSGGYVWACKNYDGDVQSDTVAQGFGSLGLMTSVLLSPDGRTVEAEAAHGTVTRHYRQHQKGQ
ETSTNSIASIFAWTRGLAHRAKLDDNAELAKFATTLETVCVDTVESGFMTKDLALLIGPDQPWLSTTAFLDKIDENLKTA
MAA

Specific function: Unknown

COG id: COG0538

COG function: function code C; Isocitrate dehydrogenases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI28178825, Length=412, Percent_Identity=66.504854368932, Blast_Score=574, Evalue=1e-164,
Organism=Homo sapiens, GI28178832, Length=408, Percent_Identity=66.1764705882353, Blast_Score=568, Evalue=1e-162,
Organism=Caenorhabditis elegans, GI17540874, Length=402, Percent_Identity=68.1592039800995, Blast_Score=574, Evalue=1e-164,
Organism=Caenorhabditis elegans, GI17550822, Length=407, Percent_Identity=66.8304668304668, Blast_Score=568, Evalue=1e-162,
Organism=Saccharomyces cerevisiae, GI6323203, Length=409, Percent_Identity=63.5696821515892, Blast_Score=542, Evalue=1e-155,
Organism=Saccharomyces cerevisiae, GI6320137, Length=405, Percent_Identity=63.4567901234568, Blast_Score=539, Evalue=1e-154,
Organism=Saccharomyces cerevisiae, GI6324319, Length=409, Percent_Identity=59.9022004889976, Blast_Score=527, Evalue=1e-150,
Organism=Drosophila melanogaster, GI21356561, Length=409, Percent_Identity=66.0146699266504, Blast_Score=565, Evalue=1e-161,
Organism=Drosophila melanogaster, GI221330987, Length=409, Percent_Identity=66.0146699266504, Blast_Score=563, Evalue=1e-161,
Organism=Drosophila melanogaster, GI221330985, Length=409, Percent_Identity=66.0146699266504, Blast_Score=563, Evalue=1e-161,
Organism=Drosophila melanogaster, GI28574947, Length=409, Percent_Identity=66.0146699266504, Blast_Score=563, Evalue=1e-161,
Organism=Drosophila melanogaster, GI24660849, Length=409, Percent_Identity=66.0146699266504, Blast_Score=563, Evalue=1e-161,
Organism=Drosophila melanogaster, GI221330983, Length=409, Percent_Identity=66.0146699266504, Blast_Score=563, Evalue=1e-161,
Organism=Drosophila melanogaster, GI24660856, Length=409, Percent_Identity=66.0146699266504, Blast_Score=563, Evalue=1e-161,
Organism=Drosophila melanogaster, GI24660868, Length=409, Percent_Identity=66.0146699266504, Blast_Score=562, Evalue=1e-160,
Organism=Drosophila melanogaster, GI24660860, Length=409, Percent_Identity=66.0146699266504, Blast_Score=562, Evalue=1e-160,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR004790 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 45068; Mature: 44937

Theoretical pI: Translated: 5.70; Mature: 5.70

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKIKVANPVVDLDGDEMTRIIWQLIKDKLILPYLDLDIEYYDLSVENRDATNDQVTVDA
CCEEEECCCEEECCCHHHHHHHHHHHHCCEECEEEECEEEEEEEEECCCCCCCCEEEEHH
AHAIKKHGVGIKCATITPDEQRVEEFGLKQMWKSPNGTIRNILGGVIFREPIICKNVPRL
HHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHCCCCCC
VPGWTKPIVVGRHAFGDQYKATDFKFPGKGKLTIKFVGEDGTVIEKDVFDAPSAGVALAM
CCCCCCCEEEECCCCCCCCCCCCCCCCCCCEEEEEEECCCCCEEEHHCCCCCCCCEEEEE
YNLDESIREFARASMMYGLMRKWPVYLSTKNTILKAYDGRFKDIFEEVYQTEFKAKFDEV
ECCHHHHHHHHHHHHHHHHHHHCCEEEECCCCEEEHHCCHHHHHHHHHHHHHHHHHHHHC
GITYEHRLIDDMVASALKWSGGYVWACKNYDGDVQSDTVAQGFGSLGLMTSVLLSPDGRT
CCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCE
VEAEAAHGTVTRHYRQHQKGQETSTNSIASIFAWTRGLAHRAKLDDNAELAKFATTLETV
EEECCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
CVDTVESGFMTKDLALLIGPDQPWLSTTAFLDKIDENLKTAMAA
HHHHHHCCCCEECEEEEECCCCCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AKIKVANPVVDLDGDEMTRIIWQLIKDKLILPYLDLDIEYYDLSVENRDATNDQVTVDA
CEEEECCCEEECCCHHHHHHHHHHHHCCEECEEEECEEEEEEEEECCCCCCCCEEEEHH
AHAIKKHGVGIKCATITPDEQRVEEFGLKQMWKSPNGTIRNILGGVIFREPIICKNVPRL
HHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHCCCCCC
VPGWTKPIVVGRHAFGDQYKATDFKFPGKGKLTIKFVGEDGTVIEKDVFDAPSAGVALAM
CCCCCCCEEEECCCCCCCCCCCCCCCCCCCEEEEEEECCCCCEEEHHCCCCCCCCEEEEE
YNLDESIREFARASMMYGLMRKWPVYLSTKNTILKAYDGRFKDIFEEVYQTEFKAKFDEV
ECCHHHHHHHHHHHHHHHHHHHCCEEEECCCCEEEHHCCHHHHHHHHHHHHHHHHHHHHC
GITYEHRLIDDMVASALKWSGGYVWACKNYDGDVQSDTVAQGFGSLGLMTSVLLSPDGRT
CCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCE
VEAEAAHGTVTRHYRQHQKGQETSTNSIASIFAWTRGLAHRAKLDDNAELAKFATTLETV
EEECCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
CVDTVESGFMTKDLALLIGPDQPWLSTTAFLDKIDENLKTAMAA
HHHHHHCCCCEECEEEEECCCCCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8626059 [H]