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The map label for this gene is bcr [H]

Identifier: 159184948

GI number: 159184948

Start: 1834707

End: 1835915

Strand: Direct

Name: bcr [H]

Synonym: Atu1855

Alternate gene names: 159184948

Gene position: 1834707-1835915 (Clockwise)

Preceding gene: 159184947

Following gene: 15889162

Centisome position: 64.57

GC content: 60.38

Gene sequence:

>1209_bases
ATGGGGCGCACGGAATTCATTGGGCTGGCAGCAATGCTGATGGCGCTGAATGCGCTGGCCATCGACATCATGCTGCCGGG
TCTTCAGGAAATCGGCGCATCACTGGGCGTCGTCAATGAAAACCACCGCCAATACGTGATTTCGACCTATCTCCTCGGTT
TCGGTATCGCCCAGCTTCTCTACGGGCCGATTTCTGACCGTTTCGGTCGGCGCAAGCCGATGCTCGTCGGTCTGGCCATC
TACATCATCTCCGCCATTGCAGTGGTCTTCGTGCCGTCATTCACCGGCCTCCTGGTCCTGCGCTTCATTCAGGGCATCGG
TTCGGCGGCAACGCGTGTCATCACCATCTCGATCGTCCGTGACATCTATGGCGGCCGTCAGATGGCGGAAGTGATGTCGC
TGATCATGATGGTCTTCATGGTCGTTCCGGTCATCGCGCCAGGCACGGGCCAGATCGTGCTCTTCTTCGGCGACTGGCAC
CTGATCTTCGCCTTCATGGCCGGCATCGCCGCCGTCGTGACGGCCTGGATGTATTTCCGCCTGCCGGAAACCCTGCATCC
CGATGACGTCAGGCCTTTCACGGCTCGTTCGATCCTCGGCGGGTTCAAGATCGTGCTCACCAACCGTATCGCGCTCTGCT
ACACGCTTTCCAGCACCTTCATTTTCGGGGCGCTGTTCGGCTTCATCAACTCGGCTGAACAGGTTTACAAGGGCATCTAC
GGCCTTGGCGCATGGTTTGCGGCGGCCTTTGCCGGCGTGGCGCTGTTCATGGCCTTCTCGTCCTTCATCAATGCAAGGCT
GGTCGGCCGGTTCGGCATGCGCAAGCTGTCGCACGGATCGCTGCTCGGCTTCATCGCCATCACCTTCGTGTGGTTGCTGG
TGCAGATACTCGGGCCGGAGCCGATGCCCTTCGCCATCTTCATCGTGTTCTTTGCGCTCGCCATGTTCCAGTTCGGCTGG
ATCGGCTCGAACTTCAACTCGCTCGCCATGGAGCCGCTCGGCCATGTCGCCGGCACGGCCTCCTCCGTCATAGGCTTCAT
GGGAACCGTCGGCGGTTCGCTGATCGGCGCCGGCATTGGTCAGGCTTTCGACGGCACGGCGCTGCCGATGGTGGCCGGCT
TCTTTGCCGTCTCCATCATCGGCCTTATCTTCGTGCTGATCGGCGAAAAGGGCGTGTTGTTTCAGGCCCACAACAAGCCG
ACACGGTAA

Upstream 100 bases:

>100_bases
AATTTATGCCAGGCGTTGCTTCATGCAACGCCTTTGCCGTTCTTTTTGGGGCAATCCTGTGACAGAACTTTCACAATCCA
CCGCTTCGCGCGCAGGCTCG

Downstream 100 bases:

>100_bases
GTTCGGACAGACAAAAAGAAAGGGCGCGGAATTCTGTTCCGCGCCCTTTTTATTGAAAACAGCTGTTGTTCGTTCAAACC
GTAAAAATCTTCTCGCGCAG

Product: MFS permease

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: Sulfonamide resistance protein [H]

Number of amino acids: Translated: 402; Mature: 401

Protein sequence:

>402_residues
MGRTEFIGLAAMLMALNALAIDIMLPGLQEIGASLGVVNENHRQYVISTYLLGFGIAQLLYGPISDRFGRRKPMLVGLAI
YIISAIAVVFVPSFTGLLVLRFIQGIGSAATRVITISIVRDIYGGRQMAEVMSLIMMVFMVVPVIAPGTGQIVLFFGDWH
LIFAFMAGIAAVVTAWMYFRLPETLHPDDVRPFTARSILGGFKIVLTNRIALCYTLSSTFIFGALFGFINSAEQVYKGIY
GLGAWFAAAFAGVALFMAFSSFINARLVGRFGMRKLSHGSLLGFIAITFVWLLVQILGPEPMPFAIFIVFFALAMFQFGW
IGSNFNSLAMEPLGHVAGTASSVIGFMGTVGGSLIGAGIGQAFDGTALPMVAGFFAVSIIGLIFVLIGEKGVLFQAHNKP
TR

Sequences:

>Translated_402_residues
MGRTEFIGLAAMLMALNALAIDIMLPGLQEIGASLGVVNENHRQYVISTYLLGFGIAQLLYGPISDRFGRRKPMLVGLAI
YIISAIAVVFVPSFTGLLVLRFIQGIGSAATRVITISIVRDIYGGRQMAEVMSLIMMVFMVVPVIAPGTGQIVLFFGDWH
LIFAFMAGIAAVVTAWMYFRLPETLHPDDVRPFTARSILGGFKIVLTNRIALCYTLSSTFIFGALFGFINSAEQVYKGIY
GLGAWFAAAFAGVALFMAFSSFINARLVGRFGMRKLSHGSLLGFIAITFVWLLVQILGPEPMPFAIFIVFFALAMFQFGW
IGSNFNSLAMEPLGHVAGTASSVIGFMGTVGGSLIGAGIGQAFDGTALPMVAGFFAVSIIGLIFVLIGEKGVLFQAHNKP
TR
>Mature_401_residues
GRTEFIGLAAMLMALNALAIDIMLPGLQEIGASLGVVNENHRQYVISTYLLGFGIAQLLYGPISDRFGRRKPMLVGLAIY
IISAIAVVFVPSFTGLLVLRFIQGIGSAATRVITISIVRDIYGGRQMAEVMSLIMMVFMVVPVIAPGTGQIVLFFGDWHL
IFAFMAGIAAVVTAWMYFRLPETLHPDDVRPFTARSILGGFKIVLTNRIALCYTLSSTFIFGALFGFINSAEQVYKGIYG
LGAWFAAAFAGVALFMAFSSFINARLVGRFGMRKLSHGSLLGFIAITFVWLLVQILGPEPMPFAIFIVFFALAMFQFGWI
GSNFNSLAMEPLGHVAGTASSVIGFMGTVGGSLIGAGIGQAFDGTALPMVAGFFAVSIIGLIFVLIGEKGVLFQAHNKPT
R

Specific function: Involved in sulfonamide (sulfathiazole) and bicyclomycin resistance. Probable membrane translocase [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Bcr/CmlA family [H]

Homologues:

Organism=Escherichia coli, GI1788509, Length=387, Percent_Identity=31.7829457364341, Blast_Score=158, Evalue=5e-40,
Organism=Escherichia coli, GI87082312, Length=348, Percent_Identity=29.5977011494253, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI48994889, Length=166, Percent_Identity=34.3373493975904, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1790146, Length=401, Percent_Identity=27.6807980049875, Blast_Score=95, Evalue=7e-21,
Organism=Escherichia coli, GI1790794, Length=206, Percent_Identity=28.6407766990291, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI1787065, Length=162, Percent_Identity=25.3086419753086, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004812
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR004734 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 43252; Mature: 43121

Theoretical pI: Translated: 10.03; Mature: 10.03

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGRTEFIGLAAMLMALNALAIDIMLPGLQEIGASLGVVNENHRQYVISTYLLGFGIAQLL
CCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
YGPISDRFGRRKPMLVGLAIYIISAIAVVFVPSFTGLLVLRFIQGIGSAATRVITISIVR
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHH
DIYGGRQMAEVMSLIMMVFMVVPVIAPGTGQIVLFFGDWHLIFAFMAGIAAVVTAWMYFR
HHHCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHH
LPETLHPDDVRPFTARSILGGFKIVLTNRIALCYTLSSTFIFGALFGFINSAEQVYKGIY
CCCCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLGAWFAAAFAGVALFMAFSSFINARLVGRFGMRKLSHGSLLGFIAITFVWLLVQILGPE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCC
PMPFAIFIVFFALAMFQFGWIGSNFNSLAMEPLGHVAGTASSVIGFMGTVGGSLIGAGIG
CCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
QAFDGTALPMVAGFFAVSIIGLIFVLIGEKGVLFQAHNKPTR
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCC
>Mature Secondary Structure 
GRTEFIGLAAMLMALNALAIDIMLPGLQEIGASLGVVNENHRQYVISTYLLGFGIAQLL
CCCHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
YGPISDRFGRRKPMLVGLAIYIISAIAVVFVPSFTGLLVLRFIQGIGSAATRVITISIVR
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHH
DIYGGRQMAEVMSLIMMVFMVVPVIAPGTGQIVLFFGDWHLIFAFMAGIAAVVTAWMYFR
HHHCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHH
LPETLHPDDVRPFTARSILGGFKIVLTNRIALCYTLSSTFIFGALFGFINSAEQVYKGIY
CCCCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLGAWFAAAFAGVALFMAFSSFINARLVGRFGMRKLSHGSLLGFIAITFVWLLVQILGPE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCC
PMPFAIFIVFFALAMFQFGWIGSNFNSLAMEPLGHVAGTASSVIGFMGTVGGSLIGAGIG
CCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
QAFDGTALPMVAGFFAVSIIGLIFVLIGEKGVLFQAHNKPTR
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8486276; 9278503; 2694948 [H]