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The map label for this gene is macA [H]

Identifier: 159184930

GI number: 159184930

Start: 1795033

End: 1796331

Strand: Direct

Name: macA [H]

Synonym: Atu1815

Alternate gene names: 159184930

Gene position: 1795033-1796331 (Clockwise)

Preceding gene: 15889115

Following gene: 15889119

Centisome position: 63.17

GC content: 60.59

Gene sequence:

>1299_bases
ATGAATGACGCCAACGGCAATGGCCGCGATACACCAGACAGCCAGCCCGATCTGCGTGAGATTCTGGGAACGAACAGAAA
CGGCCGCAAGAAGAAATCGCGTCGGTTTCTTTATATCGCGGCGGCCATTGTGCTGATTGGCGGCGGCCTTGGATATTATT
ATCAGTCGCGCGCGGCGGGTGTTGCCTACAACTATACCACGGAACCTGCACGTCAGGGCGATCTTTCCGTCATCGTCACC
TCTACCGGCTCGGTGCAGCCGACGGATCAGGTCGATATATCGAGTGAATTGTCCGGCACGGTGCGCAAGGTCAACGTCAC
CTACAATACCCCGGTAAAATCAGGCGATATTCTGGCGGAGCTCGATACCAACAAGCTCGAAGCCGATGTGCAGAGCGCCC
GCGCCAAACTCGCCTCCGCCAAGGCCAACGTGCTGAAGGCGCGCGCCGATCTCGGCTCGGCAAAGACATCCATGGAGCGC
CTGCGGTCGCTGGTGCAGAGCCGGGTGTCCAGCCAGCAGGATCTGGATGCCGCACAGTTCACCCACGATGCGGCGGCCGC
GACGTTGCAGGTCAACGAGGCAACCGTGCTTTCGGCGGAAGCGGATCTGCGGCTGGCCGAGGTCAATCTCGGCAAAGCCA
AGATCGTCTCGCCCATCGATGGCGTCATCCTCACCCGCAGCGTCGATCCCGGCGCCACCGTCGCCTCCTCGCTCAACGCC
CCTGTTCTGTTCACGATCGCCGGCGATCTGCGTCATATGGAATTGCAGGTTTCGGTGGATGAGGCGGATGTCGGCAAGGT
CGAAACCGGGCAAAAAGCGACGTTTAATGTCGATGCCTATCCCGACCGCAGTTTCCCAGCCGAAATAGAGACGGTTCGTT
TCGCCTCGGAAACCGTATCCAATGTGGTGACCTATAAGGGCATATTGACTGTCGATAATGCCGAACTGCTGCTGCGCCCG
GGCATGACGGCAACGGCCAATATCATCGTCGAGGAAATCAAGGACACACTGCTGGTGCCTAATTCCGCGCTTCGATACAC
GCCACCGCGCGAATCCGCTTCCCGTGGCGGCGGGTTGATGAGCCTTTTCCGCCCGCCCCGCATGGGCCGCTCGCAGAACC
GCGACGCCGGACAGGCCGCAACAGGCAAAAGAACGGTCTGGGTGCTGCGCAATAACGCGCCCGTCGCCGTCGCCATCGAA
ACCGGCTCCACCGACGGCCAGCACACCGTGGTCAAATCGGGAGAGCTGAAAGCCGATGACCAGGTGATTACCGACGCTAC
GACCCGCAACGCTGGCTGA

Upstream 100 bases:

>100_bases
CACTTCCCACAATCAGAGGAATACACAGCGACGGACGGATGGACAAACCGCAGAGCGGAAACAACCCTCTGTGGTATTTT
GAATTTTGCGGGTGAAGAGA

Downstream 100 bases:

>100_bases
CGGGAGAGAACCGCATGCAACAGCCGCCGCTCATCGAATTCCGCAATGTCGTCAAGCAATATGGCCGCGGCGAAGCGACG
ATCCGCGCGCTCGATGGTGT

Product: HlyD family secretion protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 432; Mature: 432

Protein sequence:

>432_residues
MNDANGNGRDTPDSQPDLREILGTNRNGRKKKSRRFLYIAAAIVLIGGGLGYYYQSRAAGVAYNYTTEPARQGDLSVIVT
STGSVQPTDQVDISSELSGTVRKVNVTYNTPVKSGDILAELDTNKLEADVQSARAKLASAKANVLKARADLGSAKTSMER
LRSLVQSRVSSQQDLDAAQFTHDAAAATLQVNEATVLSAEADLRLAEVNLGKAKIVSPIDGVILTRSVDPGATVASSLNA
PVLFTIAGDLRHMELQVSVDEADVGKVETGQKATFNVDAYPDRSFPAEIETVRFASETVSNVVTYKGILTVDNAELLLRP
GMTATANIIVEEIKDTLLVPNSALRYTPPRESASRGGGLMSLFRPPRMGRSQNRDAGQAATGKRTVWVLRNNAPVAVAIE
TGSTDGQHTVVKSGELKADDQVITDATTRNAG

Sequences:

>Translated_432_residues
MNDANGNGRDTPDSQPDLREILGTNRNGRKKKSRRFLYIAAAIVLIGGGLGYYYQSRAAGVAYNYTTEPARQGDLSVIVT
STGSVQPTDQVDISSELSGTVRKVNVTYNTPVKSGDILAELDTNKLEADVQSARAKLASAKANVLKARADLGSAKTSMER
LRSLVQSRVSSQQDLDAAQFTHDAAAATLQVNEATVLSAEADLRLAEVNLGKAKIVSPIDGVILTRSVDPGATVASSLNA
PVLFTIAGDLRHMELQVSVDEADVGKVETGQKATFNVDAYPDRSFPAEIETVRFASETVSNVVTYKGILTVDNAELLLRP
GMTATANIIVEEIKDTLLVPNSALRYTPPRESASRGGGLMSLFRPPRMGRSQNRDAGQAATGKRTVWVLRNNAPVAVAIE
TGSTDGQHTVVKSGELKADDQVITDATTRNAG
>Mature_432_residues
MNDANGNGRDTPDSQPDLREILGTNRNGRKKKSRRFLYIAAAIVLIGGGLGYYYQSRAAGVAYNYTTEPARQGDLSVIVT
STGSVQPTDQVDISSELSGTVRKVNVTYNTPVKSGDILAELDTNKLEADVQSARAKLASAKANVLKARADLGSAKTSMER
LRSLVQSRVSSQQDLDAAQFTHDAAAATLQVNEATVLSAEADLRLAEVNLGKAKIVSPIDGVILTRSVDPGATVASSLNA
PVLFTIAGDLRHMELQVSVDEADVGKVETGQKATFNVDAYPDRSFPAEIETVRFASETVSNVVTYKGILTVDNAELLLRP
GMTATANIIVEEIKDTLLVPNSALRYTPPRESASRGGGLMSLFRPPRMGRSQNRDAGQAATGKRTVWVLRNNAPVAVAIE
TGSTDGQHTVVKSGELKADDQVITDATTRNAG

Specific function: Efflux transporter for macrolide antibiotics [H]

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87081796, Length=316, Percent_Identity=30.0632911392405, Blast_Score=132, Evalue=4e-32,
Organism=Escherichia coli, GI87082036, Length=357, Percent_Identity=23.8095238095238, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1789929, Length=370, Percent_Identity=26.7567567567568, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI1790519, Length=244, Percent_Identity=25.8196721311475, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1787013, Length=285, Percent_Identity=24.5614035087719, Blast_Score=66, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 45985; Mature: 45985

Theoretical pI: Translated: 6.83; Mature: 6.83

Prosite motif: PS00583 PFKB_KINASES_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDANGNGRDTPDSQPDLREILGTNRNGRKKKSRRFLYIAAAIVLIGGGLGYYYQSRAAG
CCCCCCCCCCCCCCCHHHHHHHCCCCCCCCHHHCEEEHEEEEHHHHCCCHHHHHHCCCCC
VAYNYTTEPARQGDLSVIVTSTGSVQPTDQVDISSELSGTVRKVNVTYNTPVKSGDILAE
EEEECCCCCCCCCCEEEEEECCCCCCCCCCCCCCHHCCCEEEEEEEEECCCCCCCCEEEE
LDTNKLEADVQSARAKLASAKANVLKARADLGSAKTSMERLRSLVQSRVSSQQDLDAAQF
ECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHCCCHHHH
THDAAAATLQVNEATVLSAEADLRLAEVNLGKAKIVSPIDGVILTRSVDPGATVASSLNA
HHCHHEEEEEECCEEEEECCCCEEEEEECCCCEEECCCCCCEEEEECCCCCCHHHHCCCC
PVLFTIAGDLRHMELQVSVDEADVGKVETGQKATFNVDAYPDRSFPAEIETVRFASETVS
CEEEEEECCCEEEEEEEEECCCCCCCCCCCCCEEEEEECCCCCCCCCCHHEEEHHHHHHH
NVVTYKGILTVDNAELLLRPGMTATANIIVEEIKDTLLVPNSALRYTPPRESASRGGGLM
HHEEEEEEEEECCCEEEEECCCCHHHHHHHHHHHHHEECCCCCEECCCCCCHHHCCCCEE
SLFRPPRMGRSQNRDAGQAATGKRTVWVLRNNAPVAVAIETGSTDGQHTVVKSGELKADD
ECCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCEEEEEECCCCCCCEEEEECCCCCCCC
QVITDATTRNAG
EEEECCCCCCCC
>Mature Secondary Structure
MNDANGNGRDTPDSQPDLREILGTNRNGRKKKSRRFLYIAAAIVLIGGGLGYYYQSRAAG
CCCCCCCCCCCCCCCHHHHHHHCCCCCCCCHHHCEEEHEEEEHHHHCCCHHHHHHCCCCC
VAYNYTTEPARQGDLSVIVTSTGSVQPTDQVDISSELSGTVRKVNVTYNTPVKSGDILAE
EEEECCCCCCCCCCEEEEEECCCCCCCCCCCCCCHHCCCEEEEEEEEECCCCCCCCEEEE
LDTNKLEADVQSARAKLASAKANVLKARADLGSAKTSMERLRSLVQSRVSSQQDLDAAQF
ECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHCCCHHHH
THDAAAATLQVNEATVLSAEADLRLAEVNLGKAKIVSPIDGVILTRSVDPGATVASSLNA
HHCHHEEEEEECCEEEEECCCCEEEEEECCCCEEECCCCCCEEEEECCCCCCHHHHCCCC
PVLFTIAGDLRHMELQVSVDEADVGKVETGQKATFNVDAYPDRSFPAEIETVRFASETVS
CEEEEEECCCEEEEEEEEECCCCCCCCCCCCCEEEEEECCCCCCCCCCHHEEEHHHHHHH
NVVTYKGILTVDNAELLLRPGMTATANIIVEEIKDTLLVPNSALRYTPPRESASRGGGLM
HHEEEEEEEEECCCEEEEECCCCHHHHHHHHHHHHHEECCCCCEECCCCCCHHHCCCCEE
SLFRPPRMGRSQNRDAGQAATGKRTVWVLRNNAPVAVAIETGSTDGQHTVVKSGELKADD
ECCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCEEEEEECCCCCCCEEEEECCCCCCCC
QVITDATTRNAG
EEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]