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The map label for this gene is hom [H]

Identifier: 159184828

GI number: 159184828

Start: 1570331

End: 1571641

Strand: Reverse

Name: hom [H]

Synonym: Atu1588

Alternate gene names: 159184828

Gene position: 1571641-1570331 (Counterclockwise)

Preceding gene: 159184829

Following gene: 15888900

Centisome position: 55.31

GC content: 60.87

Gene sequence:

>1311_bases
ATGGCAGATTCATTGAGAATCGGCATAGCGGGGCTCGGCACTGTCGGCGCTTCGCTCGTGCGCATCCTCCAGCAGAGAAG
CAACGAACTTGCGATTACCTGCGGACGCGCGATTGAGATTATTGCGGTGAGCGCGCGCGACCGTTCGCGCGACCGCGGCA
TCGATCTCAAGGGTATTACCTGGTTCGACACGCCCGAGCAGATGGCGAGCGAAGCCGATATCGATGTGTTCGTCGAACTG
GTCGGCGGTGCTTCCGGACAGGCAGAAAATGCGGTGCGGGCAGCGCTTTCGCGTGGTCTCCATGTAGTGACAGCCAACAA
GGCACTGCTTGCCAAGCATGGCGTCGAACTGGCGACCATTGCCGAGGACAAGGGCGCGCTGCTCAATTTCGAGGCGGCGG
TGGCTGGCGGTATCCCGGTCATCAAGGCGCTGCGTGAATCCTTGACCGGCAACCATGTGTCGCGCATCTACGGCATCATG
AACGGCACCTGCAACTACATCCTCACCAAGATGGAGAAGGAAGGCCTGTCGTTCGAGGTGTGCCTGAAGGAAGCGCAGCG
GCTCGGTTATGCCGAAGCGGATCCGGCCTTCGATATCGAAGGCAACGACACCGCGCACAAGCTCTCGATTCTGACCACGC
TTGCCTTCGGCAATAAGATCGCTGCCGACGACATCTATCTCGAAGGCATCACCAATATCTCCATCGAGGATATTCAGGCG
GCTGCCGAGCTTGGTTACCGCATCAAGCTTCTCGGCGTGGCGCAGGTGACGGACTCCGGCATCGAACAGCGCGTGCACCC
GACCATGGTGCCGCTCGACTCCGTTATCGCCCAGGTGGATGGCGTGACCAATGCGGTGGCGATCGAATCCGACATTCTCG
GCGAATTGCTGATGGTCGGCCCGGGTGCCGGCGGCAACGCCACGGCGTCTGCCGTACTTGGTGACATCGCCGATATCGCC
AAGAGCCGTCCAGGCACCCAGCAGGTGCCCGTACTCGGCCGTCCGGCCAAGTCGCTGACGGAGTACCGCCGCGCCAAGAT
GAAGAGCCATGAGGGCGGTTATTTCATCCGTCTGACGGTGAAGGATCAGGCGGGCGTCTTCGCCTCCATCGCCACCCGCA
TGGCTGACAATAACATCTCGCTGGAATCCATCGTGCAGCGCCAGCGCGTGCATGTGGAAGGCGCGCCGCAGACCATCATC
CTGGTCACCCATGCGACGATGGAAGATGCGATCCGCAAGGCCGTGAAGGCGATCAAGAACGAGAAATATCTCGTCAGCGA
ACCGCAGGTCATCCGCATCGAGCGGACCTGA

Upstream 100 bases:

>100_bases
ACGATGCACAATGTCGTTTCGCTCAACGCCCACAGATAAGGGCAACCGAAGGCGGCCGGGCCTCGGCCGCCACCATCACC
AGCAAATCAGGAACATACCC

Downstream 100 bases:

>100_bases
AACGCCTGACGATTTGTCCAAAGCCGAGGGCCGTGCTTCCGTAGGGATGCGCGGCCTTTTTTCATCATGAAACCTCGCGG
GGATATCAAAAACTATTTAG

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 436; Mature: 435

Protein sequence:

>436_residues
MADSLRIGIAGLGTVGASLVRILQQRSNELAITCGRAIEIIAVSARDRSRDRGIDLKGITWFDTPEQMASEADIDVFVEL
VGGASGQAENAVRAALSRGLHVVTANKALLAKHGVELATIAEDKGALLNFEAAVAGGIPVIKALRESLTGNHVSRIYGIM
NGTCNYILTKMEKEGLSFEVCLKEAQRLGYAEADPAFDIEGNDTAHKLSILTTLAFGNKIAADDIYLEGITNISIEDIQA
AAELGYRIKLLGVAQVTDSGIEQRVHPTMVPLDSVIAQVDGVTNAVAIESDILGELLMVGPGAGGNATASAVLGDIADIA
KSRPGTQQVPVLGRPAKSLTEYRRAKMKSHEGGYFIRLTVKDQAGVFASIATRMADNNISLESIVQRQRVHVEGAPQTII
LVTHATMEDAIRKAVKAIKNEKYLVSEPQVIRIERT

Sequences:

>Translated_436_residues
MADSLRIGIAGLGTVGASLVRILQQRSNELAITCGRAIEIIAVSARDRSRDRGIDLKGITWFDTPEQMASEADIDVFVEL
VGGASGQAENAVRAALSRGLHVVTANKALLAKHGVELATIAEDKGALLNFEAAVAGGIPVIKALRESLTGNHVSRIYGIM
NGTCNYILTKMEKEGLSFEVCLKEAQRLGYAEADPAFDIEGNDTAHKLSILTTLAFGNKIAADDIYLEGITNISIEDIQA
AAELGYRIKLLGVAQVTDSGIEQRVHPTMVPLDSVIAQVDGVTNAVAIESDILGELLMVGPGAGGNATASAVLGDIADIA
KSRPGTQQVPVLGRPAKSLTEYRRAKMKSHEGGYFIRLTVKDQAGVFASIATRMADNNISLESIVQRQRVHVEGAPQTII
LVTHATMEDAIRKAVKAIKNEKYLVSEPQVIRIERT
>Mature_435_residues
ADSLRIGIAGLGTVGASLVRILQQRSNELAITCGRAIEIIAVSARDRSRDRGIDLKGITWFDTPEQMASEADIDVFVELV
GGASGQAENAVRAALSRGLHVVTANKALLAKHGVELATIAEDKGALLNFEAAVAGGIPVIKALRESLTGNHVSRIYGIMN
GTCNYILTKMEKEGLSFEVCLKEAQRLGYAEADPAFDIEGNDTAHKLSILTTLAFGNKIAADDIYLEGITNISIEDIQAA
AELGYRIKLLGVAQVTDSGIEQRVHPTMVPLDSVIAQVDGVTNAVAIESDILGELLMVGPGAGGNATASAVLGDIADIAK
SRPGTQQVPVLGRPAKSLTEYRRAKMKSHEGGYFIRLTVKDQAGVFASIATRMADNNISLESIVQRQRVHVEGAPQTIIL
VTHATMEDAIRKAVKAIKNEKYLVSEPQVIRIERT

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=248, Percent_Identity=30.241935483871, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1790376, Length=251, Percent_Identity=27.8884462151394, Blast_Score=72, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6322599, Length=120, Percent_Identity=32.5, Blast_Score=68, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR005106
- InterPro:   IPR016204
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 46482; Mature: 46351

Theoretical pI: Translated: 5.92; Mature: 5.92

Prosite motif: PS01042 HOMOSER_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADSLRIGIAGLGTVGASLVRILQQRSNELAITCGRAIEIIAVSARDRSRDRGIDLKGIT
CCCCEEEEEEEHHHHHHHHHHHHHHCCCCEEEEECCEEEEEEEECCCCCHHCCCCCCCEE
WFDTPEQMASEADIDVFVELVGGASGQAENAVRAALSRGLHVVTANKALLAKHGVELATI
ECCCHHHHHCCCCHHHHHHHHCCCCCCHHHHHHHHHHCCEEEEECCCHHHHHCCCEEEEE
AEDKGALLNFEAAVAGGIPVIKALRESLTGNHVSRIYGIMNGTCNYILTKMEKEGLSFEV
ECCCCCEEEEHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHCCCHHHHEEHHHHCCCHHHH
CLKEAQRLGYAEADPAFDIEGNDTAHKLSILTTLAFGNKIAADDIYLEGITNISIEDIQA
HHHHHHHCCCCCCCCCEECCCCCCHHHHHHHHHHHCCCEECCCCEEEECCCCCCHHHHHH
AAELGYRIKLLGVAQVTDSGIEQRVHPTMVPLDSVIAQVDGVTNAVAIESDILGELLMVG
HHHCCCEEEEEEEEHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCEEEECHHHHHHEEEEC
PGAGGNATASAVLGDIADIAKSRPGTQQVPVLGRPAKSLTEYRRAKMKSHEGGYFIRLTV
CCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEE
KDQAGVFASIATRMADNNISLESIVQRQRVHVEGAPQTIILVTHATMEDAIRKAVKAIKN
CCCCCHHHHHHHHHCCCCCCHHHHHHHHHEEECCCCCEEEEEEECHHHHHHHHHHHHHCC
EKYLVSEPQVIRIERT
CCEEECCCCEEEEECC
>Mature Secondary Structure 
ADSLRIGIAGLGTVGASLVRILQQRSNELAITCGRAIEIIAVSARDRSRDRGIDLKGIT
CCCEEEEEEEHHHHHHHHHHHHHHCCCCEEEEECCEEEEEEEECCCCCHHCCCCCCCEE
WFDTPEQMASEADIDVFVELVGGASGQAENAVRAALSRGLHVVTANKALLAKHGVELATI
ECCCHHHHHCCCCHHHHHHHHCCCCCCHHHHHHHHHHCCEEEEECCCHHHHHCCCEEEEE
AEDKGALLNFEAAVAGGIPVIKALRESLTGNHVSRIYGIMNGTCNYILTKMEKEGLSFEV
ECCCCCEEEEHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHCCCHHHHEEHHHHCCCHHHH
CLKEAQRLGYAEADPAFDIEGNDTAHKLSILTTLAFGNKIAADDIYLEGITNISIEDIQA
HHHHHHHCCCCCCCCCEECCCCCCHHHHHHHHHHHCCCEECCCCEEEECCCCCCHHHHHH
AAELGYRIKLLGVAQVTDSGIEQRVHPTMVPLDSVIAQVDGVTNAVAIESDILGELLMVG
HHHCCCEEEEEEEEHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCEEEECHHHHHHEEEEC
PGAGGNATASAVLGDIADIAKSRPGTQQVPVLGRPAKSLTEYRRAKMKSHEGGYFIRLTV
CCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEE
KDQAGVFASIATRMADNNISLESIVQRQRVHVEGAPQTIILVTHATMEDAIRKAVKAIKN
CCCCCHHHHHHHHHCCCCCCHHHHHHHHHEEECCCCCEEEEEEECHHHHHHHHHHHHHCC
EKYLVSEPQVIRIERT
CCEEECCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1333566; 10984043 [H]