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The map label for this gene is livH [H]

Identifier: 159184625

GI number: 159184625

Start: 1115058

End: 1115954

Strand: Direct

Name: livH [H]

Synonym: Atu1125

Alternate gene names: 159184625

Gene position: 1115058-1115954 (Clockwise)

Preceding gene: 15888460

Following gene: 15888468

Centisome position: 39.24

GC content: 62.54

Gene sequence:

>897_bases
TTGGCTTATTTCCTGCAACAATTGCTGAATGCCGTGCCGGTCGCAGCCCTCTATGCGGTTCTGGCCTTCGGCTACGCCAT
CGCCTTCTCGGTCACGAAACGCGCCGATGTGACCTATGGCGCCATCTTTGCCTTCGCCGGGCAGACTTGCCTGCTTTTTG
CTGACTTCGGCTGGAACCGGCTGTGGCTGGTTCTGCCGGCAACATTGGCGCTGGGGGCAGGGGCCGGCCTGTTCGGCGGG
CTTTGGGCCGCGGGTCTCATCGGTAGGGCGGTCATGCGGCCGCTGGCAAAGGCCTCTCCCAACGCGGTGACCGTGGCCTC
CATCGGCGTGCTGATTGCGCTCACGGAAAGCGCAAGGCTCGCCGCCGATACAAGGCAATTATGGCTGCCGCCGCTTTTGT
CGCAGCCAGTACGTTTCTGGATCGAGGGCGGCTTTGCCGTCACCCTGACACCGATTCAGATGTTGAATACAGCCGTCTTC
TGCCTTCTCATTCTCACAGGTTCGCTTTATCTCGGCCGTTCCGCTTTCGGCAGGCGCTGGAAGGCCGTGTCGGACGATGC
CTTTGCCGCCTCGCTCCTGGGGGTGAACGCGAGCAGGATATTTCTGCTGTCCTATTGCGCGGCGGGTCTCGTGGCAGCCA
TCGCCGGCGTGCTCGCCACGTTTTATTACGGCACCATGGATTTTGGCGCCGGTCTCGTTTTTGGCCTGAAAGTCGTGCTG
ATCTCGGCGGCGGGCGGATATGCCAGCCCGCTCATCTGCGGCCTGGGGGCGGCAGCCATCGGTTTTGCGGAAACATTCTG
GGTCGGTTACGGCCCCGTCGCCTGGCGGGATGCGGCGGTTCTTGCCTTGCTGGTTGGCTGGCTCATCGTCATGCGCAGCC
GGGTTGAAGCAGCTTAG

Upstream 100 bases:

>100_bases
CTCCCCCTGCGAAACGATGTTCTGTCCAGCGAAATGTCATATACATATTATAACTGGTAAAAAGCATTTTAACAGTTATA
ATTCCGGCAGGAGGACGGGC

Downstream 100 bases:

>100_bases
GGGGAAAAATGGGCCCCGGTTTTCCGCCCGGAAATGCGATAAGACAAAAGCGCTATCGCCACTTGTCCCTGGCCGTATCG
TCGGTAGCCTTCGCTGCCAC

Product: ABC transporter, membrane spanning protein

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein H [H]

Number of amino acids: Translated: 298; Mature: 297

Protein sequence:

>298_residues
MAYFLQQLLNAVPVAALYAVLAFGYAIAFSVTKRADVTYGAIFAFAGQTCLLFADFGWNRLWLVLPATLALGAGAGLFGG
LWAAGLIGRAVMRPLAKASPNAVTVASIGVLIALTESARLAADTRQLWLPPLLSQPVRFWIEGGFAVTLTPIQMLNTAVF
CLLILTGSLYLGRSAFGRRWKAVSDDAFAASLLGVNASRIFLLSYCAAGLVAAIAGVLATFYYGTMDFGAGLVFGLKVVL
ISAAGGYASPLICGLGAAAIGFAETFWVGYGPVAWRDAAVLALLVGWLIVMRSRVEAA

Sequences:

>Translated_298_residues
MAYFLQQLLNAVPVAALYAVLAFGYAIAFSVTKRADVTYGAIFAFAGQTCLLFADFGWNRLWLVLPATLALGAGAGLFGG
LWAAGLIGRAVMRPLAKASPNAVTVASIGVLIALTESARLAADTRQLWLPPLLSQPVRFWIEGGFAVTLTPIQMLNTAVF
CLLILTGSLYLGRSAFGRRWKAVSDDAFAASLLGVNASRIFLLSYCAAGLVAAIAGVLATFYYGTMDFGAGLVFGLKVVL
ISAAGGYASPLICGLGAAAIGFAETFWVGYGPVAWRDAAVLALLVGWLIVMRSRVEAA
>Mature_297_residues
AYFLQQLLNAVPVAALYAVLAFGYAIAFSVTKRADVTYGAIFAFAGQTCLLFADFGWNRLWLVLPATLALGAGAGLFGGL
WAAGLIGRAVMRPLAKASPNAVTVASIGVLIALTESARLAADTRQLWLPPLLSQPVRFWIEGGFAVTLTPIQMLNTAVFC
LLILTGSLYLGRSAFGRRWKAVSDDAFAASLLGVNASRIFLLSYCAAGLVAAIAGVLATFYYGTMDFGAGLVFGLKVVLI
SAAGGYASPLICGLGAAAIGFAETFWVGYGPVAWRDAAVLALLVGWLIVMRSRVEAA

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: COG0559

COG function: function code E; Branched-chain amino acid ABC-type transport system, permease components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789866, Length=316, Percent_Identity=26.2658227848101, Blast_Score=87, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851 [H]

Pfam domain/function: PF02653 BPD_transp_2 [H]

EC number: NA

Molecular weight: Translated: 31217; Mature: 31086

Theoretical pI: Translated: 9.55; Mature: 9.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAYFLQQLLNAVPVAALYAVLAFGYAIAFSVTKRADVTYGAIFAFAGQTCLLFADFGWNR
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCEEEEEEECCCCE
LWLVLPATLALGAGAGLFGGLWAAGLIGRAVMRPLAKASPNAVTVASIGVLIALTESARL
EEEHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHEEECCCHHH
AADTRQLWLPPLLSQPVRFWIEGGFAVTLTPIQMLNTAVFCLLILTGSLYLGRSAFGRRW
HHHHHHHCCCHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHCCHHHCHHHHCCCC
KAVSDDAFAASLLGVNASRIFLLSYCAAGLVAAIAGVLATFYYGTMDFGAGLVFGLKVVL
CCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ISAAGGYASPLICGLGAAAIGFAETFWVGYGPVAWRDAAVLALLVGWLIVMRSRVEAA
HCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AYFLQQLLNAVPVAALYAVLAFGYAIAFSVTKRADVTYGAIFAFAGQTCLLFADFGWNR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCEEEEEEECCCCE
LWLVLPATLALGAGAGLFGGLWAAGLIGRAVMRPLAKASPNAVTVASIGVLIALTESARL
EEEHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHEEECCCHHH
AADTRQLWLPPLLSQPVRFWIEGGFAVTLTPIQMLNTAVFCLLILTGSLYLGRSAFGRRW
HHHHHHHCCCHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHCCHHHCHHHHCCCC
KAVSDDAFAASLLGVNASRIFLLSYCAAGLVAAIAGVLATFYYGTMDFGAGLVFGLKVVL
CCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ISAAGGYASPLICGLGAAAIGFAETFWVGYGPVAWRDAAVLALLVGWLIVMRSRVEAA
HCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]