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The map label for this gene is yieO [C]

Identifier: 159184543

GI number: 159184543

Start: 930033

End: 931415

Strand: Direct

Name: yieO [C]

Synonym: Atu0942

Alternate gene names: 159184543

Gene position: 930033-931415 (Clockwise)

Preceding gene: 159184542

Following gene: 159184545

Centisome position: 32.73

GC content: 64.14

Gene sequence:

>1383_bases
ATGGTGGAGAAAAACGGCTGGGGCGAATTGCTGAGCGGGGCTAACCTCTCGCTTCTGACCGTCATCTCCTCCGGTATAGG
TCTGCACGCCTTTAATCAGTTTGCTGTCGTCACGGCCTTGCCCGTCGCCGTCAACGACATCGGCGGCGCGGGTTTTTATA
GCTGGGCCTATAGTCTCTATTTCGTCGGCTCCGTGGCGGGCGGCGTCACCGCGGTGCTGTTTCGCGAACGTTTCGGCGCT
CGCGCTATCCTGCTTCTGTGCTGCCTCATCTTTTCCTTCGGCTCGGTACTTTCGGCAATCGCCGGCGATTTTTTATGGGT
CGTCGTCGGCCGGGCGTTGCAGGGGGTGGCGGACGGGCTGATCGTGGCGGTGTGCTATAGTCTCATTCCCGCCGGGTTCC
GCTCCGGTTTGTTGCCCAAGGTCTTTGCCATCGAGGCGGCGATCTGGGCGGTGGCCTCCTTCATCGGTCCGCTGACTGGC
GGTTTTGCCACCCAGCACATTTCCTGGCGCGCCACCTTCCTGCTCTCGGCACCGCTGATCATCGTGCTCGTGGTCTATAC
GGTGGTTGCCGTCTCCGCCGAGCGGCCGGTGGTGGCCACGCGCAGGCCGCTGGTGCCGCTGCTGCTCTGCCTTGTTGGCG
CATTGGCCTTTTCCGCGCCTTCCGCCTTTGAGGATGCGAGCCTGCGGGCGATCTCCCTGCTGGCGGGCGCTGCCTTGCTG
TGGGCTTCCCTGCGGGCAGGCATCCAGCCTTCCTCCGGCCTGTTCCCCAGGGATTCCTTCCGGCTGAAAACGGTGCTCGG
CAGCGGCTTCTGGGTGCTGTTCCTGATGTCCTATGCCCATGCGCTGGGCAGCGTCTACCTCGCTTATGTGGCCATCAATC
TCTGGCAGCATGAACCGACTTTTGCCGGTTTCATCGTCGTCACCATGCCGCTCGCCTGGAGCTTCGTGGCGATGCTGATC
GGCAGCCTGCGCTCAAACCGCCTGCGGGAAATCTGCCTGCATTACGGCCCCTACCAGATGGTGCCGGGCTGCGTCCTGTT
GGGGCTCGGGCTTGCGACGGGCAACTGGGGAGAGATGCTGCTCGGGCAGACGTTGATCGGCTCTGCCTTCGGCATGTCCT
GGGCCGGCATCAGCCAGGCTGCCATGGAGGCGGCACCTGAAGAGGAGCGCAAGATGACTGGCGCATTGCTGCCCACGGTC
GCGACGCTGGGTTCGGCGGCCGGTGCGGGTGCCAGCGGCACTGTCGCCGCCGCGACCGATCTCGTCGTGCAGATCGATCG
TGCTGATGTGACGACGCCGATGCTTTATCTTTATGGGCTGGGTGTGGTTGTGTCGCTGCTGGCGATCATGACGGCGAGGG
GCCTGCGGGGCGAGCGCCGGTAG

Upstream 100 bases:

>100_bases
ATCGGATAAAAAAGCCCGCTTGACCTCAATGGCGCTTGAGGTTCTAGTTTGCCCGCCGTGTCGCAAAAATGGAAAGGATA
CGGCTTTGTCGAGTATGGAA

Downstream 100 bases:

>100_bases
AGCATTTCCAGAAAAAGTGAACCCGGCTTTCCGTCCATAAATGCGAAAAATCAAACGAATCGCCGCTCGCCCACCCGGTC
AGGACTGAGTAGTGGCGATG

Product: MFS permease

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 460; Mature: 460

Protein sequence:

>460_residues
MVEKNGWGELLSGANLSLLTVISSGIGLHAFNQFAVVTALPVAVNDIGGAGFYSWAYSLYFVGSVAGGVTAVLFRERFGA
RAILLLCCLIFSFGSVLSAIAGDFLWVVVGRALQGVADGLIVAVCYSLIPAGFRSGLLPKVFAIEAAIWAVASFIGPLTG
GFATQHISWRATFLLSAPLIIVLVVYTVVAVSAERPVVATRRPLVPLLLCLVGALAFSAPSAFEDASLRAISLLAGAALL
WASLRAGIQPSSGLFPRDSFRLKTVLGSGFWVLFLMSYAHALGSVYLAYVAINLWQHEPTFAGFIVVTMPLAWSFVAMLI
GSLRSNRLREICLHYGPYQMVPGCVLLGLGLATGNWGEMLLGQTLIGSAFGMSWAGISQAAMEAAPEEERKMTGALLPTV
ATLGSAAGAGASGTVAAATDLVVQIDRADVTTPMLYLYGLGVVVSLLAIMTARGLRGERR

Sequences:

>Translated_460_residues
MVEKNGWGELLSGANLSLLTVISSGIGLHAFNQFAVVTALPVAVNDIGGAGFYSWAYSLYFVGSVAGGVTAVLFRERFGA
RAILLLCCLIFSFGSVLSAIAGDFLWVVVGRALQGVADGLIVAVCYSLIPAGFRSGLLPKVFAIEAAIWAVASFIGPLTG
GFATQHISWRATFLLSAPLIIVLVVYTVVAVSAERPVVATRRPLVPLLLCLVGALAFSAPSAFEDASLRAISLLAGAALL
WASLRAGIQPSSGLFPRDSFRLKTVLGSGFWVLFLMSYAHALGSVYLAYVAINLWQHEPTFAGFIVVTMPLAWSFVAMLI
GSLRSNRLREICLHYGPYQMVPGCVLLGLGLATGNWGEMLLGQTLIGSAFGMSWAGISQAAMEAAPEEERKMTGALLPTV
ATLGSAAGAGASGTVAAATDLVVQIDRADVTTPMLYLYGLGVVVSLLAIMTARGLRGERR
>Mature_460_residues
MVEKNGWGELLSGANLSLLTVISSGIGLHAFNQFAVVTALPVAVNDIGGAGFYSWAYSLYFVGSVAGGVTAVLFRERFGA
RAILLLCCLIFSFGSVLSAIAGDFLWVVVGRALQGVADGLIVAVCYSLIPAGFRSGLLPKVFAIEAAIWAVASFIGPLTG
GFATQHISWRATFLLSAPLIIVLVVYTVVAVSAERPVVATRRPLVPLLLCLVGALAFSAPSAFEDASLRAISLLAGAALL
WASLRAGIQPSSGLFPRDSFRLKTVLGSGFWVLFLMSYAHALGSVYLAYVAINLWQHEPTFAGFIVVTMPLAWSFVAMLI
GSLRSNRLREICLHYGPYQMVPGCVLLGLGLATGNWGEMLLGQTLIGSAFGMSWAGISQAAMEAAPEEERKMTGALLPTV
ATLGSAAGAGASGTVAAATDLVVQIDRADVTTPMLYLYGLGVVVSLLAIMTARGLRGERR

Specific function: Could be involved in fluoroquinolones efflux [H]

COG id: COG0477

COG function: function code GEPR; Permeases of the major facilitator superfamily

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 48270; Mature: 48270

Theoretical pI: Translated: 8.56; Mature: 8.56

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVEKNGWGELLSGANLSLLTVISSGIGLHAFNQFAVVTALPVAVNDIGGAGFYSWAYSLY
CCCCCCCHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
FVGSVAGGVTAVLFRERFGARAILLLCCLIFSFGSVLSAIAGDFLWVVVGRALQGVADGL
HHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IVAVCYSLIPAGFRSGLLPKVFAIEAAIWAVASFIGPLTGGFATQHISWRATFLLSAPLI
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
IVLVVYTVVAVSAERPVVATRRPLVPLLLCLVGALAFSAPSAFEDASLRAISLLAGAALL
HHHHHHHHHHHCCCCCCHHCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
WASLRAGIQPSSGLFPRDSFRLKTVLGSGFWVLFLMSYAHALGSVYLAYVAINLWQHEPT
HHHHHCCCCCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
FAGFIVVTMPLAWSFVAMLIGSLRSNRLREICLHYGPYQMVPGCVLLGLGLATGNWGEML
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHH
LGQTLIGSAFGMSWAGISQAAMEAAPEEERKMTGALLPTVATLGSAAGAGASGTVAAATD
HHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHH
LVVQIDRADVTTPMLYLYGLGVVVSLLAIMTARGLRGERR
HHEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MVEKNGWGELLSGANLSLLTVISSGIGLHAFNQFAVVTALPVAVNDIGGAGFYSWAYSLY
CCCCCCCHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
FVGSVAGGVTAVLFRERFGARAILLLCCLIFSFGSVLSAIAGDFLWVVVGRALQGVADGL
HHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IVAVCYSLIPAGFRSGLLPKVFAIEAAIWAVASFIGPLTGGFATQHISWRATFLLSAPLI
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
IVLVVYTVVAVSAERPVVATRRPLVPLLLCLVGALAFSAPSAFEDASLRAISLLAGAALL
HHHHHHHHHHHCCCCCCHHCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
WASLRAGIQPSSGLFPRDSFRLKTVLGSGFWVLFLMSYAHALGSVYLAYVAINLWQHEPT
HHHHHCCCCCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
FAGFIVVTMPLAWSFVAMLIGSLRSNRLREICLHYGPYQMVPGCVLLGLGLATGNWGEML
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHH
LGQTLIGSAFGMSWAGISQAAMEAAPEEERKMTGALLPTVATLGSAAGAGASGTVAAATD
HHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHH
LVVQIDRADVTTPMLYLYGLGVVVSLLAIMTARGLRGERR
HHEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]