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The map label for this gene is mutL

Identifier: 159184423

GI number: 159184423

Start: 697138

End: 698958

Strand: Reverse

Name: mutL

Synonym: Atu0699

Alternate gene names: 159184423

Gene position: 698958-697138 (Counterclockwise)

Preceding gene: 159184424

Following gene: 159184422

Centisome position: 24.6

GC content: 63.54

Gene sequence:

>1821_bases
ATGGCCATCAAGCAGCTTTCAGAAACCCTCATCAACCAGATCGCCGCCGGCGAGGTCATCGAAAGACCGTCCAGCGCCAC
GAAGGAGCTTGTCGAAAACGCCATCGACGCGGGCGCTACGCGGATCGAGATCGCCACGGCGGGCGGTGGCAAGGGGCTGG
TGCGGATTACCGATAACGGCTCCGGCATGTCACCCGCCGATCTGGAGCTTGCGGTCAGGCGTCATTGCACCTCGAAAATT
TCTACGACGCTGGATGACATCCGCACGCTCGGATTTCGCGGCGAGGCCCTGCCCTCCATCGGCTCGGTCGCAAAGCTGAC
GATCACCAGCCGGCAACAGGGGGCAGAACAGGGTTCGGTGATTTCGGTTACCGGCGGCAAGGTGTCTGACGTGCGACCGG
CAGCTTCGAATGCCGGCACCATCGTCGAGGTGCGCGACCTGTTCTTCGCCACACCGGCGCGGCTGAAATTCCTGAAGACG
GAACGGGCGGAAGCGGCCGCCATCACCGAAGTCGTCAAACGGATGGCGATCGCCTTTCCGCATATCCGCTTCGTGCTCTC
GGGCACCGACCGTTCGACGCTCGAAATTCCCTCGACCGGCGACGACCACCTTGCCCGCATGGCGCAAATTCTCGGCGCGG
AGTTCAAGGATAACGCGATCGAAATCGATGCCGGGCGCGAGGACGTGACGCTGACAGGCTTTGCCGGCGTGCCGACCTTC
AACCGTGGCAACTCGTCGCATCAATATGTCTTCGTTAATGGCCGCCCGGTGCAGGACAAGCTGCTTTTATCGGCCATTCG
CGGCGCCTATGCCGAGACCGTGCCGCATGGGCGCTATCCGGTCGCGGTGCTGTCCATCACGCTCGACCCTGCCTTTGTTG
ATGTAAATGTGCATCCGGCGAAATCCGACGTGCGGTTTCGCGATCCCGGACTCATTCGCGGGCTGATCGTCGGCGCGATC
CGCCAGGCGCTGACGCGTGACGGCGACAGGGCGGCAACGACGGGCGCCAGCCAGATGATGAACGCCTTCCGCCCCGGCTA
CAGCCCGTCCGGTCTAAGACCCTCCCCCTCCGCGACATGGTCCGCCGCCACCTCGCCGTCGCGGCCGCTCGCCGTTTCCG
GGGACATGCAATTTGCCGAAGCGGCGCAATCGCGCTTCTCCGACATCACCATGCCGACCGCACGGGCGGAACCTCGCGAG
GCTTATGAAGCTTCCCAGAGCCCTTCGCCGGAACCGGTGCTTTATCCGCTTGGAGCGGCACGGGCGCAACTGCACGAGAA
CTACATCATCGCGCAGACGGAAAACGGCCTCGTCATCGTCGACCAGCATGCCGCGCATGAGCGGCTGGTGTTCGAGGAAA
TGCGCAATGCCCTGCATTCGAGGCGTCCGCCCTCACAGGTGCTGCTCATCCCTGAAATCATCGACCTGCCCGAGGAAGAT
TGCGACCGGTTGATGGATCACGCAGCCGGTTTCGACGCGCTTGGCCTCGTCATCGAACGTTTCGGGCCGGGCGCAATCGC
GGTGCGGGAAACGCCGGCCATGCTCGGCGAAGTCAACGTGCAGGGGCTGGTGCGCCAGCTAGCCGATGAGATCGCCGAAT
GGGACGCCGCTTCCACGCTTGCCAACAAGCTGGAATATGTGGCTGCGACCATGGCCTGCCACGGCTCGGTGCGCTCCGGC
CGGCGCATGCGGCCGGAGGAGATGAACGCGCTTCTGCGGCAGATGGAAAACACGCCGGGTTCGGGCCAATGCAATCACGG
CCGACCGACCTATATCGAACTGAAACTTTCCGATATAGAACGGCTCTTCGGCCGCAGCTGA

Upstream 100 bases:

>100_bases
GAAATGATCAAATGCCCGGAAACCTGCAAAACATGTGCAAATGTCCGCCACCCCGGTTTTTTGCTTTCGAAGCTGCAGCG
AATCCGCGAAAATGACGATC

Downstream 100 bases:

>100_bases
CGCCTACATTGAATGGCAAGGCAGGCGGGGGTGGCCTTGCGCCGCGCCGAGCTATATAAATTTGGGACATTGGAGCATCC
GGATTGTTCAGGAAAACGCT

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 606; Mature: 605

Protein sequence:

>606_residues
MAIKQLSETLINQIAAGEVIERPSSATKELVENAIDAGATRIEIATAGGGKGLVRITDNGSGMSPADLELAVRRHCTSKI
STTLDDIRTLGFRGEALPSIGSVAKLTITSRQQGAEQGSVISVTGGKVSDVRPAASNAGTIVEVRDLFFATPARLKFLKT
ERAEAAAITEVVKRMAIAFPHIRFVLSGTDRSTLEIPSTGDDHLARMAQILGAEFKDNAIEIDAGREDVTLTGFAGVPTF
NRGNSSHQYVFVNGRPVQDKLLLSAIRGAYAETVPHGRYPVAVLSITLDPAFVDVNVHPAKSDVRFRDPGLIRGLIVGAI
RQALTRDGDRAATTGASQMMNAFRPGYSPSGLRPSPSATWSAATSPSRPLAVSGDMQFAEAAQSRFSDITMPTARAEPRE
AYEASQSPSPEPVLYPLGAARAQLHENYIIAQTENGLVIVDQHAAHERLVFEEMRNALHSRRPPSQVLLIPEIIDLPEED
CDRLMDHAAGFDALGLVIERFGPGAIAVRETPAMLGEVNVQGLVRQLADEIAEWDAASTLANKLEYVAATMACHGSVRSG
RRMRPEEMNALLRQMENTPGSGQCNHGRPTYIELKLSDIERLFGRS

Sequences:

>Translated_606_residues
MAIKQLSETLINQIAAGEVIERPSSATKELVENAIDAGATRIEIATAGGGKGLVRITDNGSGMSPADLELAVRRHCTSKI
STTLDDIRTLGFRGEALPSIGSVAKLTITSRQQGAEQGSVISVTGGKVSDVRPAASNAGTIVEVRDLFFATPARLKFLKT
ERAEAAAITEVVKRMAIAFPHIRFVLSGTDRSTLEIPSTGDDHLARMAQILGAEFKDNAIEIDAGREDVTLTGFAGVPTF
NRGNSSHQYVFVNGRPVQDKLLLSAIRGAYAETVPHGRYPVAVLSITLDPAFVDVNVHPAKSDVRFRDPGLIRGLIVGAI
RQALTRDGDRAATTGASQMMNAFRPGYSPSGLRPSPSATWSAATSPSRPLAVSGDMQFAEAAQSRFSDITMPTARAEPRE
AYEASQSPSPEPVLYPLGAARAQLHENYIIAQTENGLVIVDQHAAHERLVFEEMRNALHSRRPPSQVLLIPEIIDLPEED
CDRLMDHAAGFDALGLVIERFGPGAIAVRETPAMLGEVNVQGLVRQLADEIAEWDAASTLANKLEYVAATMACHGSVRSG
RRMRPEEMNALLRQMENTPGSGQCNHGRPTYIELKLSDIERLFGRS
>Mature_605_residues
AIKQLSETLINQIAAGEVIERPSSATKELVENAIDAGATRIEIATAGGGKGLVRITDNGSGMSPADLELAVRRHCTSKIS
TTLDDIRTLGFRGEALPSIGSVAKLTITSRQQGAEQGSVISVTGGKVSDVRPAASNAGTIVEVRDLFFATPARLKFLKTE
RAEAAAITEVVKRMAIAFPHIRFVLSGTDRSTLEIPSTGDDHLARMAQILGAEFKDNAIEIDAGREDVTLTGFAGVPTFN
RGNSSHQYVFVNGRPVQDKLLLSAIRGAYAETVPHGRYPVAVLSITLDPAFVDVNVHPAKSDVRFRDPGLIRGLIVGAIR
QALTRDGDRAATTGASQMMNAFRPGYSPSGLRPSPSATWSAATSPSRPLAVSGDMQFAEAAQSRFSDITMPTARAEPREA
YEASQSPSPEPVLYPLGAARAQLHENYIIAQTENGLVIVDQHAAHERLVFEEMRNALHSRRPPSQVLLIPEIIDLPEEDC
DRLMDHAAGFDALGLVIERFGPGAIAVRETPAMLGEVNVQGLVRQLADEIAEWDAASTLANKLEYVAATMACHGSVRSGR
RMRPEEMNALLRQMENTPGSGQCNHGRPTYIELKLSDIERLFGRS

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family

Homologues:

Organism=Homo sapiens, GI4557757, Length=316, Percent_Identity=38.2911392405063, Blast_Score=182, Evalue=5e-46,
Organism=Homo sapiens, GI4505913, Length=343, Percent_Identity=30.3206997084548, Blast_Score=130, Evalue=3e-30,
Organism=Homo sapiens, GI310128478, Length=343, Percent_Identity=30.3206997084548, Blast_Score=130, Evalue=4e-30,
Organism=Homo sapiens, GI4505911, Length=324, Percent_Identity=28.7037037037037, Blast_Score=130, Evalue=5e-30,
Organism=Homo sapiens, GI189458898, Length=324, Percent_Identity=28.7037037037037, Blast_Score=129, Evalue=7e-30,
Organism=Homo sapiens, GI189458896, Length=322, Percent_Identity=28.2608695652174, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI263191589, Length=222, Percent_Identity=34.6846846846847, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI91992160, Length=361, Percent_Identity=26.5927977839335, Blast_Score=90, Evalue=6e-18,
Organism=Homo sapiens, GI91992162, Length=361, Percent_Identity=26.5927977839335, Blast_Score=90, Evalue=7e-18,
Organism=Escherichia coli, GI1790612, Length=340, Percent_Identity=43.8235294117647, Blast_Score=239, Evalue=3e-64,
Organism=Caenorhabditis elegans, GI71991825, Length=319, Percent_Identity=33.5423197492163, Blast_Score=163, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI17562796, Length=397, Percent_Identity=25.9445843828715, Blast_Score=134, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6323819, Length=317, Percent_Identity=38.4858044164038, Blast_Score=185, Evalue=2e-47,
Organism=Saccharomyces cerevisiae, GI6324247, Length=339, Percent_Identity=28.023598820059, Blast_Score=125, Evalue=2e-29,
Organism=Drosophila melanogaster, GI17136968, Length=326, Percent_Identity=34.6625766871166, Blast_Score=186, Evalue=3e-47,
Organism=Drosophila melanogaster, GI17136970, Length=352, Percent_Identity=26.7045454545455, Blast_Score=110, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MUTL_AGRT5 (Q8UHI3)

Other databases:

- EMBL:   AE007869
- PIR:   AE2662
- PIR:   D97444
- RefSeq:   NP_353724.2
- ProteinModelPortal:   Q8UHI3
- SMR:   Q8UHI3
- STRING:   Q8UHI3
- GeneID:   1132737
- GenomeReviews:   AE007869_GR
- KEGG:   atu:Atu0699
- eggNOG:   COG0323
- HOGENOM:   HBG520262
- OMA:   FLFINNR
- PhylomeDB:   Q8UHI3
- ProtClustDB:   PRK00095
- BioCyc:   ATUM176299-1:ATU0699-MONOMER
- HAMAP:   MF_00149
- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721
- Gene3D:   G3DSA:3.30.565.10
- Gene3D:   G3DSA:3.30.230.10
- PANTHER:   PTHR10073
- SMART:   SM00387
- SMART:   SM00853
- TIGRFAMs:   TIGR00585

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C; SSF55874 ATP_bd_ATPase; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: NA

Molecular weight: Translated: 65194; Mature: 65062

Theoretical pI: Translated: 6.22; Mature: 6.22

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIKQLSETLINQIAAGEVIERPSSATKELVENAIDAGATRIEIATAGGGKGLVRITDNG
CCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCEEEEEEECCCCCEEEEEECCC
SGMSPADLELAVRRHCTSKISTTLDDIRTLGFRGEALPSIGSVAKLTITSRQQGAEQGSV
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECHHCCCCCCCE
ISVTGGKVSDVRPAASNAGTIVEVRDLFFATPARLKFLKTERAEAAAITEVVKRMAIAFP
EEECCCCCCCCCCCCCCCCCEEEEHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
HIRFVLSGTDRSTLEIPSTGDDHLARMAQILGAEFKDNAIEIDAGREDVTLTGFAGVPTF
CEEEEEECCCCCEEECCCCCHHHHHHHHHHHCCCCCCCCEEEECCCCCEEEEEECCCCCC
NRGNSSHQYVFVNGRPVQDKLLLSAIRGAYAETVPHGRYPVAVLSITLDPAFVDVNVHPA
CCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCEEEEEEECCC
KSDVRFRDPGLIRGLIVGAIRQALTRDGDRAATTGASQMMNAFRPGYSPSGLRPSPSATW
CCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHCCHHHHHHHHCCCCCCCCCCCCCCCCC
SAATSPSRPLAVSGDMQFAEAAQSRFSDITMPTARAEPREAYEASQSPSPEPVLYPLGAA
CCCCCCCCCEEECCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCCCCCCCEEEECCHH
RAQLHENYIIAQTENGLVIVDQHAAHERLVFEEMRNALHSRRPPSQVLLIPEIIDLPEED
HHHHHCCEEEEECCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCCEEECHHHHCCCHHH
CDRLMDHAAGFDALGLVIERFGPGAIAVRETPAMLGEVNVQGLVRQLADEIAEWDAASTL
HHHHHHHHCCHHHHHHHHHHCCCCEEEEECCCHHHHCCCHHHHHHHHHHHHHHHHHHHHH
ANKLEYVAATMACHGSVRSGRRMRPEEMNALLRQMENTPGSGQCNHGRPTYIELKLSDIE
HHHHHHHHHHHHHCCCHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEHHHHH
RLFGRS
HHHCCC
>Mature Secondary Structure 
AIKQLSETLINQIAAGEVIERPSSATKELVENAIDAGATRIEIATAGGGKGLVRITDNG
CHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCEEEEEEECCCCCEEEEEECCC
SGMSPADLELAVRRHCTSKISTTLDDIRTLGFRGEALPSIGSVAKLTITSRQQGAEQGSV
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECHHCCCCCCCE
ISVTGGKVSDVRPAASNAGTIVEVRDLFFATPARLKFLKTERAEAAAITEVVKRMAIAFP
EEECCCCCCCCCCCCCCCCCEEEEHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
HIRFVLSGTDRSTLEIPSTGDDHLARMAQILGAEFKDNAIEIDAGREDVTLTGFAGVPTF
CEEEEEECCCCCEEECCCCCHHHHHHHHHHHCCCCCCCCEEEECCCCCEEEEEECCCCCC
NRGNSSHQYVFVNGRPVQDKLLLSAIRGAYAETVPHGRYPVAVLSITLDPAFVDVNVHPA
CCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCEEEEEEECCC
KSDVRFRDPGLIRGLIVGAIRQALTRDGDRAATTGASQMMNAFRPGYSPSGLRPSPSATW
CCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHCCHHHHHHHHCCCCCCCCCCCCCCCCC
SAATSPSRPLAVSGDMQFAEAAQSRFSDITMPTARAEPREAYEASQSPSPEPVLYPLGAA
CCCCCCCCCEEECCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCCCCCCCEEEECCHH
RAQLHENYIIAQTENGLVIVDQHAAHERLVFEEMRNALHSRRPPSQVLLIPEIIDLPEED
HHHHHCCEEEEECCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCCEEECHHHHCCCHHH
CDRLMDHAAGFDALGLVIERFGPGAIAVRETPAMLGEVNVQGLVRQLADEIAEWDAASTL
HHHHHHHHCCHHHHHHHHHHCCCCEEEEECCCHHHHCCCHHHHHHHHHHHHHHHHHHHHH
ANKLEYVAATMACHGSVRSGRRMRPEEMNALLRQMENTPGSGQCNHGRPTYIELKLSDIE
HHHHHHHHHHHHHCCCHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEHHHHH
RLFGRS
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194