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The map label for this gene is msrA

Identifier: 159184170

GI number: 159184170

Start: 129114

End: 129764

Strand: Direct

Name: msrA

Synonym: Atu0125

Alternate gene names: 159184170

Gene position: 129114-129764 (Clockwise)

Preceding gene: 159184169

Following gene: 159184171

Centisome position: 4.54

GC content: 58.68

Gene sequence:

>651_bases
ATGTTCCTGTTCGATACGCTTTCAAAAAAGACGACGATGCCGACCGAGGAAACGGCTCTGCCCGGCCGTGAAGAGGCACT
TGCAGTGCCGGAAACCCATTTCGTGAATGGCCGGCCTTTGAAGGGGCCTTATCCCGATGGTTTGGAAATCATCTATCTCG
GCATGGGCTGCTTCTGGGGCGCAGAGCGGCTGTTCTGGAAAACGCCGGGCGTATGGGTGACGGCGGTTGGATATGCCGGC
GGCTTTACCCGCAACCCGACCTACCACGAAACAACGACCGGCCAGACGGGCCACGCCGAAGTGGTGAAGGTGGTCTACGA
TCCGGCCGTGATCTCACTGTCGGGCCTGCTCAAGATATTCTTCGAGGAGCACGATCCGACTCAAGGCATGCGACAGGGCA
ACGATGTCGGTACGACCTATCGTTCCGCCATTTATGCGACGACGGAAGGCCAACTGCAGCAGGCGCAGAAGGCGCGGGAT
GCTTTCCAGCAGGCTCTGGATGAGGCCGGCCACGGCCACGCCATCACCACCGAAATCGGCCCGCTTGAAACATTTTATTA
TGCCGAGGACTATCATCAGCAATATCTTGCCAAGAACCCGGGCGGCTACTGCGGGCTGCGGGGAACCGGCGTAAGCTGTA
ATATAGGCTAG

Upstream 100 bases:

>100_bases
CAAAGTGATGAGACGCTCGTCAGTCTGACAAGGTGAAAAGCCAGCGCCTCGCAGATGTGAACCCTTGAGACGCGGCGGAA
CCGGCCGCACGGAGGACCGA

Downstream 100 bases:

>100_bases
ATTTTTTGCAGCTAGCCCGGTGGAAAGGCTAAAAAAGCGCCAGATCAAAGTTTTTCCACCGGGTCAAAAAAACCGGATGA
ATTTTTCATTGAGCCATGCA

Product: methionine sulfoxide reductase A

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase

Number of amino acids: Translated: 216; Mature: 216

Protein sequence:

>216_residues
MFLFDTLSKKTTMPTEETALPGREEALAVPETHFVNGRPLKGPYPDGLEIIYLGMGCFWGAERLFWKTPGVWVTAVGYAG
GFTRNPTYHETTTGQTGHAEVVKVVYDPAVISLSGLLKIFFEEHDPTQGMRQGNDVGTTYRSAIYATTEGQLQQAQKARD
AFQQALDEAGHGHAITTEIGPLETFYYAEDYHQQYLAKNPGGYCGLRGTGVSCNIG

Sequences:

>Translated_216_residues
MFLFDTLSKKTTMPTEETALPGREEALAVPETHFVNGRPLKGPYPDGLEIIYLGMGCFWGAERLFWKTPGVWVTAVGYAG
GFTRNPTYHETTTGQTGHAEVVKVVYDPAVISLSGLLKIFFEEHDPTQGMRQGNDVGTTYRSAIYATTEGQLQQAQKARD
AFQQALDEAGHGHAITTEIGPLETFYYAEDYHQQYLAKNPGGYCGLRGTGVSCNIG
>Mature_216_residues
MFLFDTLSKKTTMPTEETALPGREEALAVPETHFVNGRPLKGPYPDGLEIIYLGMGCFWGAERLFWKTPGVWVTAVGYAG
GFTRNPTYHETTTGQTGHAEVVKVVYDPAVISLSGLLKIFFEEHDPTQGMRQGNDVGTTYRSAIYATTEGQLQQAQKARD
AFQQALDEAGHGHAITTEIGPLETFYYAEDYHQQYLAKNPGGYCGLRGTGVSCNIG

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family

Homologues:

Organism=Homo sapiens, GI6912516, Length=206, Percent_Identity=56.7961165048544, Blast_Score=244, Evalue=5e-65,
Organism=Homo sapiens, GI208609995, Length=184, Percent_Identity=59.7826086956522, Blast_Score=230, Evalue=5e-61,
Organism=Homo sapiens, GI208609993, Length=206, Percent_Identity=45.1456310679612, Blast_Score=167, Evalue=7e-42,
Organism=Escherichia coli, GI1790665, Length=200, Percent_Identity=54.5, Blast_Score=214, Evalue=5e-57,
Organism=Caenorhabditis elegans, GI17533973, Length=148, Percent_Identity=39.1891891891892, Blast_Score=94, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6320881, Length=167, Percent_Identity=38.9221556886228, Blast_Score=114, Evalue=9e-27,
Organism=Drosophila melanogaster, GI24664627, Length=143, Percent_Identity=41.958041958042, Blast_Score=91, Evalue=6e-19,
Organism=Drosophila melanogaster, GI45553131, Length=141, Percent_Identity=41.8439716312057, Blast_Score=87, Evalue=6e-18,
Organism=Drosophila melanogaster, GI24664631, Length=146, Percent_Identity=41.7808219178082, Blast_Score=87, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MSRA_AGRT5 (Q7D255)

Other databases:

- EMBL:   AE007869
- RefSeq:   NP_353160.2
- HSSP:   P54149
- ProteinModelPortal:   Q7D255
- SMR:   Q7D255
- STRING:   Q7D255
- GeneID:   1132163
- GenomeReviews:   AE007869_GR
- KEGG:   atu:Atu0125
- eggNOG:   COG0225
- HOGENOM:   HBG748152
- OMA:   VYFAEAY
- ProtClustDB:   PRK00058
- HAMAP:   MF_01401
- InterPro:   IPR002569
- Gene3D:   G3DSA:3.30.1060.10
- TIGRFAMs:   TIGR00401

Pfam domain/function: PF01625 PMSR; SSF55068 MsrA

EC number: =1.8.4.11

Molecular weight: Translated: 23694; Mature: 23694

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: NA

Important sites: ACT_SITE 57-57

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFLFDTLSKKTTMPTEETALPGREEALAVPETHFVNGRPLKGPYPDGLEIIYLGMGCFWG
CCCCCCCCCCCCCCCHHHCCCCCCCEEECCCEECCCCCCCCCCCCCCCEEEEEECCHHHC
AERLFWKTPGVWVTAVGYAGGFTRNPTYHETTTGQTGHAEVVKVVYDPAVISLSGLLKIF
CCEEEEECCCEEEEEEECCCCCCCCCCCCCCCCCCCCHHHEEEEEECCHHHHHHHHHHHH
FEEHDPTQGMRQGNDVGTTYRSAIYATTEGQLQQAQKARDAFQQALDEAGHGHAITTEIG
HHCCCCHHHHHCCCCCCCHHHHEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCEEEECCC
PLETFYYAEDYHQQYLAKNPGGYCGLRGTGVSCNIG
CCEEEEEHHHHHHHHHHCCCCCEECCCCCCEEEECC
>Mature Secondary Structure
MFLFDTLSKKTTMPTEETALPGREEALAVPETHFVNGRPLKGPYPDGLEIIYLGMGCFWG
CCCCCCCCCCCCCCCHHHCCCCCCCEEECCCEECCCCCCCCCCCCCCCEEEEEECCHHHC
AERLFWKTPGVWVTAVGYAGGFTRNPTYHETTTGQTGHAEVVKVVYDPAVISLSGLLKIF
CCEEEEECCCEEEEEEECCCCCCCCCCCCCCCCCCCCHHHEEEEEECCHHHHHHHHHHHH
FEEHDPTQGMRQGNDVGTTYRSAIYATTEGQLQQAQKARDAFQQALDEAGHGHAITTEIG
HHCCCCHHHHHCCCCCCCHHHHEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCEEEECCC
PLETFYYAEDYHQQYLAKNPGGYCGLRGTGVSCNIG
CCEEEEEHHHHHHHHHHCCCCCEECCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194