Click here to switch to the map view.

The map label for this gene is pcoA [H]

Identifier: 159046599

GI number: 159046599

Start: 120370

End: 121764

Strand: Direct

Name: pcoA [H]

Synonym: Dshi_4061

Alternate gene names: 159046599

Gene position: 120370-121764 (Clockwise)

Preceding gene: 159046598

Following gene: 159046600

Centisome position: 95.3

GC content: 61.0

Gene sequence:

>1395_bases
ATGAGACAAACACGTCGGGATTTCTTGCGCCATGCAACACTGGCGGCCTGCGCGGCGGCCATCCCGCAGTCGGCTTTTGC
CGCGACCCCGTTCGAGGACCTGATTGCCAAGGTTGCACGTCGACAGCTTCTTCCGGACACCTACCCGGAAACAGAGATCT
GGGGCTATGACGGCCTCGTTCCGGCCCCGGAAATCAGGGTCACACAAGGCGATCGGGTGCGTCGCAGGTTTCGCAACGAG
GTACCCGATCCCAGTTCGGTTCACTGGCACGGAATCCGGATCGACAACGCGATGGATGGCGTTTCAGGGCTGACCCAAGA
GGCCGTAGCGCCGGGTGGAACCTTTGACTACGACTTCGTCGTACCGGACGCGGGCACCTATTGGTATCACGCGCATAATC
GCTCATACGAGCAAGTCGCGCGTGGTCTGCGCGGTGCCTTGATCGTCGAAGAGGTCGATGGACCGGACATCGACCGCGAG
GAAGTCATCGTTCTGGAGGACTGGTTGCTCGACCCTGAGAGCGGGCAGCTGTTCGACAATTTCGAACAGCCCATGATGAT
GAGCCACGGTGGACGTACCGGCAACTTTATCACGACCAACGGGCGCTATGACCTGACCTTGCCCGCGCAGCGCAACGAGC
GCATTCGCTTGCGGATCATCAACGCAGCAAGCGCTCGAATTTTCCCGCTGAGGCTCTCTGGATTCAGTGGCTGGACGGTG
GCCGTGGATGGAATGCCAACCGGCCAACCCCAGTCGGTTGACGGCGAGTTGATCCTCGGCCCGGCACAGCGCGTCGACTT
AATTGTGGATGTGACCGAAGACGAAGGCGGCACCGCCCAATTGCTTCGCATCGGCGATGATGATCAACTGACCCCGTTGG
TGAGTTTTCTGGTCAACGGCACAGCCAGTTCAGTACCAAGAGGCAAGCCACTGCCGTTGCCGCCGAACCCCGCGGCACAC
GCCCCGGACCTTGCCGATGCGCGTGATTTGCGACTGGTCATGTCCGGCGGGGCAATGGGGCGAATGCAGTCCGCATTGCT
TGGCGGGGAACGTCTTGGATTCCGTCAGCTTGCCCAAGCGGGCAAATTCTGGGCCCTGAATGATGTCGCCGAAATGACCT
ACACGCCACTGGCCGATCTATCCCTGAACGAGCCGGTGCGCCTGAAGATCGAGAACCAGACCGTTTTCCCACATGCGATG
CACCTGCACGGGATGCATTTCCGCGAGCTGCGCCCCGACGGCGCGTTCGGGCCGATGCGGGACACGATCCTGTTGGCCGG
CAACGAGTCCCGGGAGATCGCCTTTACGGCAGACAATCCCGGCAAGTGGCTGTTCCATTGCCACATGCTCAGCCACGCCG
CATCTGGCATGACAACCTGGATACGGGTCACATGA

Upstream 100 bases:

>100_bases
GCGCTTTTCCTGCTGAACAAGGACACGGTCGAGGCGGAGAACCCCGCGTCGAACTAACACCACGCGGGGGCAACACGCCC
CCGCTTTCTCGAGGATCGAA

Downstream 100 bases:

>100_bases
GATATCTCGTTTGGTCCCTTCCGATCACTGTCGCAGCAGCCGCCTTCACGTATTGGCTCTCGACCAGTGCATCCTCGGAT
GTCGGCAGCGCGTCCAGGGC

Product: multicopper oxidase type 3

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 464; Mature: 464

Protein sequence:

>464_residues
MRQTRRDFLRHATLAACAAAIPQSAFAATPFEDLIAKVARRQLLPDTYPETEIWGYDGLVPAPEIRVTQGDRVRRRFRNE
VPDPSSVHWHGIRIDNAMDGVSGLTQEAVAPGGTFDYDFVVPDAGTYWYHAHNRSYEQVARGLRGALIVEEVDGPDIDRE
EVIVLEDWLLDPESGQLFDNFEQPMMMSHGGRTGNFITTNGRYDLTLPAQRNERIRLRIINAASARIFPLRLSGFSGWTV
AVDGMPTGQPQSVDGELILGPAQRVDLIVDVTEDEGGTAQLLRIGDDDQLTPLVSFLVNGTASSVPRGKPLPLPPNPAAH
APDLADARDLRLVMSGGAMGRMQSALLGGERLGFRQLAQAGKFWALNDVAEMTYTPLADLSLNEPVRLKIENQTVFPHAM
HLHGMHFRELRPDGAFGPMRDTILLAGNESREIAFTADNPGKWLFHCHMLSHAASGMTTWIRVT

Sequences:

>Translated_464_residues
MRQTRRDFLRHATLAACAAAIPQSAFAATPFEDLIAKVARRQLLPDTYPETEIWGYDGLVPAPEIRVTQGDRVRRRFRNE
VPDPSSVHWHGIRIDNAMDGVSGLTQEAVAPGGTFDYDFVVPDAGTYWYHAHNRSYEQVARGLRGALIVEEVDGPDIDRE
EVIVLEDWLLDPESGQLFDNFEQPMMMSHGGRTGNFITTNGRYDLTLPAQRNERIRLRIINAASARIFPLRLSGFSGWTV
AVDGMPTGQPQSVDGELILGPAQRVDLIVDVTEDEGGTAQLLRIGDDDQLTPLVSFLVNGTASSVPRGKPLPLPPNPAAH
APDLADARDLRLVMSGGAMGRMQSALLGGERLGFRQLAQAGKFWALNDVAEMTYTPLADLSLNEPVRLKIENQTVFPHAM
HLHGMHFRELRPDGAFGPMRDTILLAGNESREIAFTADNPGKWLFHCHMLSHAASGMTTWIRVT
>Mature_464_residues
MRQTRRDFLRHATLAACAAAIPQSAFAATPFEDLIAKVARRQLLPDTYPETEIWGYDGLVPAPEIRVTQGDRVRRRFRNE
VPDPSSVHWHGIRIDNAMDGVSGLTQEAVAPGGTFDYDFVVPDAGTYWYHAHNRSYEQVARGLRGALIVEEVDGPDIDRE
EVIVLEDWLLDPESGQLFDNFEQPMMMSHGGRTGNFITTNGRYDLTLPAQRNERIRLRIINAASARIFPLRLSGFSGWTV
AVDGMPTGQPQSVDGELILGPAQRVDLIVDVTEDEGGTAQLLRIGDDDQLTPLVSFLVNGTASSVPRGKPLPLPPNPAAH
APDLADARDLRLVMSGGAMGRMQSALLGGERLGFRQLAQAGKFWALNDVAEMTYTPLADLSLNEPVRLKIENQTVFPHAM
HLHGMHFRELRPDGAFGPMRDTILLAGNESREIAFTADNPGKWLFHCHMLSHAASGMTTWIRVT

Specific function: Required for the copper-inducible expression of copper resistance. May have oxidase activity [H]

COG id: COG2132

COG function: function code Q; Putative multicopper oxidases

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multicopper oxidase family. CopA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786314, Length=526, Percent_Identity=24.3346007604563, Blast_Score=99, Evalue=8e-22,
Organism=Escherichia coli, GI1789394, Length=299, Percent_Identity=26.7558528428094, Blast_Score=78, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17539950, Length=263, Percent_Identity=27.3764258555133, Blast_Score=68, Evalue=8e-12,
Organism=Saccharomyces cerevisiae, GI6323703, Length=452, Percent_Identity=25.8849557522124, Blast_Score=115, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6321067, Length=491, Percent_Identity=24.847250509165, Blast_Score=102, Evalue=1e-22,
Organism=Drosophila melanogaster, GI18859919, Length=238, Percent_Identity=27.3109243697479, Blast_Score=75, Evalue=9e-14,
Organism=Drosophila melanogaster, GI28574104, Length=133, Percent_Identity=31.5789473684211, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24585842, Length=256, Percent_Identity=27.734375, Blast_Score=66, Evalue=6e-11,
Organism=Drosophila melanogaster, GI281360167, Length=256, Percent_Identity=27.734375, Blast_Score=66, Evalue=6e-11,
Organism=Drosophila melanogaster, GI221329998, Length=247, Percent_Identity=27.9352226720648, Blast_Score=66, Evalue=7e-11,
Organism=Drosophila melanogaster, GI221330000, Length=247, Percent_Identity=27.9352226720648, Blast_Score=65, Evalue=8e-11,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001117
- InterPro:   IPR011706
- InterPro:   IPR011707
- InterPro:   IPR006376
- InterPro:   IPR002355
- InterPro:   IPR008972
- InterPro:   IPR006311 [H]

Pfam domain/function: PF00394 Cu-oxidase; PF07731 Cu-oxidase_2; PF07732 Cu-oxidase_3 [H]

EC number: NA

Molecular weight: Translated: 51240; Mature: 51240

Theoretical pI: Translated: 5.43; Mature: 5.43

Prosite motif: PS00079 MULTICOPPER_OXIDASE1 ; PS00080 MULTICOPPER_OXIDASE2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRQTRRDFLRHATLAACAAAIPQSAFAATPFEDLIAKVARRQLLPDTYPETEIWGYDGLV
CCCHHHHHHHHHHHHHHHHHCCCHHHCCCCHHHHHHHHHHHHCCCCCCCCCEECCCCCCC
PAPEIRVTQGDRVRRRFRNEVPDPSSVHWHGIRIDNAMDGVSGLTQEAVAPGGTFDYDFV
CCCCEEECCCHHHHHHHHHCCCCCCCEEEEEEEECCHHHHHHHHHHHHCCCCCCCCEEEE
VPDAGTYWYHAHNRSYEQVARGLRGALIVEEVDGPDIDREEVIVLEDWLLDPESGQLFDN
ECCCCCEEEEECCCCHHHHHHCCCCEEEEEECCCCCCCCCCEEEEEEEECCCCCCCHHHC
FEQPMMMSHGGRTGNFITTNGRYDLTLPAQRNERIRLRIINAASARIFPLRLSGFSGWTV
CCCCHHHHCCCCCCCEEEECCEEEEEECCCCCCEEEEEEEECCCCEEEEEEECCCCCCEE
AVDGMPTGQPQSVDGELILGPAQRVDLIVDVTEDEGGTAQLLRIGDDDQLTPLVSFLVNG
EECCCCCCCCCCCCCCEEECCCCEEEEEEEEECCCCCCEEEEEECCCCCHHHHHHHHHCC
TASSVPRGKPLPLPPNPAAHAPDLADARDLRLVMSGGAMGRMQSALLGGERLGFRQLAQA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHCCCCCCHHHHHHC
GKFWALNDVAEMTYTPLADLSLNEPVRLKIENQTVFPHAMHLHGMHFRELRPDGAFGPMR
CCEEEECHHHHHHCCCCCCCCCCCCEEEEECCCEECCHHHHHCCCHHHHCCCCCCCCCCC
DTILLAGNESREIAFTADNPGKWLFHCHMLSHAASGMTTWIRVT
CEEEEECCCCCEEEEEECCCCCEEEEEEHHHHHCCCCEEEEEEC
>Mature Secondary Structure
MRQTRRDFLRHATLAACAAAIPQSAFAATPFEDLIAKVARRQLLPDTYPETEIWGYDGLV
CCCHHHHHHHHHHHHHHHHHCCCHHHCCCCHHHHHHHHHHHHCCCCCCCCCEECCCCCCC
PAPEIRVTQGDRVRRRFRNEVPDPSSVHWHGIRIDNAMDGVSGLTQEAVAPGGTFDYDFV
CCCCEEECCCHHHHHHHHHCCCCCCCEEEEEEEECCHHHHHHHHHHHHCCCCCCCCEEEE
VPDAGTYWYHAHNRSYEQVARGLRGALIVEEVDGPDIDREEVIVLEDWLLDPESGQLFDN
ECCCCCEEEEECCCCHHHHHHCCCCEEEEEECCCCCCCCCCEEEEEEEECCCCCCCHHHC
FEQPMMMSHGGRTGNFITTNGRYDLTLPAQRNERIRLRIINAASARIFPLRLSGFSGWTV
CCCCHHHHCCCCCCCEEEECCEEEEEECCCCCCEEEEEEEECCCCEEEEEEECCCCCCEE
AVDGMPTGQPQSVDGELILGPAQRVDLIVDVTEDEGGTAQLLRIGDDDQLTPLVSFLVNG
EECCCCCCCCCCCCCCEEECCCCEEEEEEEEECCCCCCEEEEEECCCCCHHHHHHHHHCC
TASSVPRGKPLPLPPNPAAHAPDLADARDLRLVMSGGAMGRMQSALLGGERLGFRQLAQA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHCCCCCCHHHHHHC
GKFWALNDVAEMTYTPLADLSLNEPVRLKIENQTVFPHAMHLHGMHFRELRPDGAFGPMR
CCEEEECHHHHHHCCCCCCCCCCCCEEEEECCCEECCHHHHHCCCHHHHCCCCCCCCCCC
DTILLAGNESREIAFTADNPGKWLFHCHMLSHAASGMTTWIRVT
CEEEEECCCCCEEEEEECCCCCEEEEEEHHHHHCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8594334 [H]