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The map label for this gene is mcmA1 [H]

Identifier: 15899174

GI number: 15899174

Start: 2203577

End: 2205262

Strand: Reverse

Name: mcmA1 [H]

Synonym: SSO2425

Alternate gene names: 15899174

Gene position: 2205262-2203577 (Counterclockwise)

Preceding gene: 15899177

Following gene: 15899171

Centisome position: 73.7

GC content: 39.15

Gene sequence:

>1686_bases
GTGTTTATAAGATTTAAACATATTATGGATGTTGAAGATAGAATTAAGGAATGGGAAGAAAAGGTCTATTCAAGTTGGGT
AAAGAAGAGGGGAGAGAGGAAAAAAGAATTCAAAACGTTTTCTGGAATACATATTAAACCAGTTTATACACCATTGGATG
TCAAGGGCAATTATATGGAAAAATTAGGATTACCAGGTGAGTATCCATTTACAAGGGGAATCTATCCTAATATGTATAGA
GGAAGAATTTGGACAATTAGACAATATGCAGGATTTGGATCTGCAGAAGAGACGAATTCTAGATTTAGGAAATTATTGGA
AGCTGGGCAAACTGGCTTAAGTATGGCCTTTGATTTGCCTACTCAATTGGGATTAGATCCAGATCATGAATTAGCTTATA
CAGAGATTGGAGTTGTTGGAGTATCGATGTTCCATTGGAAGGAAATGGATATTGTAATGTCCGGAATACCGCTCGATAAA
GTTACCACTTCAATGACTATAAATGCCACCGCTATGGAATTACTCTCAATGCTGATTGCCACTTCCGAAAGTAGAAATAT
TAACAAGAGCGTTTTGGATGGGACAGTTCAGAACGATATCTTAAAGGAGTATATAGCTAGGAAGAACTTCATATATCCTC
CTTCGCCCTCGATGAGATATGCTATCGACATTATAGAATACTCCGCAAAGTATTTACCGAAATGGCACCCAATAAGTATA
AGTGGCTATCACATAAGGGAAGCTGGAGCGGACGCAGTATTAGAAGTGGCATTTACGTTAGCTGACGGTATGGAGTATGT
CAGAAAAACAATGGAGAGAGGAATTAACGTAGATGAATTTGCACCACACTTATCCTTCTTCTTTGCAGCTTACTCAGATA
TATTCGAGGAAGTTGCTAAATTTAGAGCTGCTAGGAGAATGTGGGCGAAAATAATGAAAGAAGTATTCAACGCTAAGAAA
CCAGAGTCAATGATGTTAAGGTTCCATACTCAAACAGGTGGCGCTGAATTGACCGCGCAACAGCCAGAGATAAACATCAT
AAGAACTACATTACAAGCTTTAGCGGCCGTATTGGGCGGAACCCAGAGTTTACACGTTAATTCTTATGATGAAGCGTTAG
CATTACCTACTGAAAAGGCTGCTAAAATAGCTATAAGGGTCCAGCAGATAATAGCGAACGAGAGTGGAGCGGCTGATGTA
GTAGATCCATTAGGAGGTTCATATTACATAGAGTGGCTAACAGATGAAATAGAGGAGAGGGCATGGAAAATTATAGACCA
AGTAGAAAAGATGGGTGGTATGATAAAAGCCATAGAAAACGGGTATCCCCAAGCGCAGATAGCTGAAAGCGCCTATAAGA
TACAGAAAAGAATAGAGGAAGGTGACCTAGGAAAAGTTGGCGTTAATATGTATTATGAACCAGAATGGATTGGAACAACT
GAAATATTTAGAGTCAATCCGGAGGTTAGGGAAAGGGTAATTTCAAGGTTAAAGAAGTATAAACAAGAGAGAGATGAGAT
GAAACTTAGGGAGAGTCTCAATAATCTCCGGAAAATTGCTGAGAAGGAGAATGAGAATTTATTCCCATACATGATTGATG
CCATAAGGGCAGGGGCAACAGTAGGGGAGACCAGTGGCGTTTTAAGAGATATTTGGGGAGAGTATAAAGAACCTTCTATT
TTCTGA

Upstream 100 bases:

>100_bases
ATTCCCAACTACTATCCCAATATGATCTAGATTTTCTATCTGCATTAAATGATCGTATTGTTTAATCTTAAAAGTTTTGC
CCTGAAGAAAAAGTTTTATA

Downstream 100 bases:

>100_bases
TCTTTAATAATTGATTATACAAGTTTAAGAATCTCTCCTTTTTGTCAACTGGAACATTACTATTTTCCCTAACAACATCC
CACTTATCCCACGGGAAAAT

Product: methylmalonyl-CoA mutase, alpha-subunit, chain A (mcmA1)

Products: NA

Alternate protein names: MCM [H]

Number of amino acids: Translated: 561; Mature: 561

Protein sequence:

>561_residues
MFIRFKHIMDVEDRIKEWEEKVYSSWVKKRGERKKEFKTFSGIHIKPVYTPLDVKGNYMEKLGLPGEYPFTRGIYPNMYR
GRIWTIRQYAGFGSAEETNSRFRKLLEAGQTGLSMAFDLPTQLGLDPDHELAYTEIGVVGVSMFHWKEMDIVMSGIPLDK
VTTSMTINATAMELLSMLIATSESRNINKSVLDGTVQNDILKEYIARKNFIYPPSPSMRYAIDIIEYSAKYLPKWHPISI
SGYHIREAGADAVLEVAFTLADGMEYVRKTMERGINVDEFAPHLSFFFAAYSDIFEEVAKFRAARRMWAKIMKEVFNAKK
PESMMLRFHTQTGGAELTAQQPEINIIRTTLQALAAVLGGTQSLHVNSYDEALALPTEKAAKIAIRVQQIIANESGAADV
VDPLGGSYYIEWLTDEIEERAWKIIDQVEKMGGMIKAIENGYPQAQIAESAYKIQKRIEEGDLGKVGVNMYYEPEWIGTT
EIFRVNPEVRERVISRLKKYKQERDEMKLRESLNNLRKIAEKENENLFPYMIDAIRAGATVGETSGVLRDIWGEYKEPSI
F

Sequences:

>Translated_561_residues
MFIRFKHIMDVEDRIKEWEEKVYSSWVKKRGERKKEFKTFSGIHIKPVYTPLDVKGNYMEKLGLPGEYPFTRGIYPNMYR
GRIWTIRQYAGFGSAEETNSRFRKLLEAGQTGLSMAFDLPTQLGLDPDHELAYTEIGVVGVSMFHWKEMDIVMSGIPLDK
VTTSMTINATAMELLSMLIATSESRNINKSVLDGTVQNDILKEYIARKNFIYPPSPSMRYAIDIIEYSAKYLPKWHPISI
SGYHIREAGADAVLEVAFTLADGMEYVRKTMERGINVDEFAPHLSFFFAAYSDIFEEVAKFRAARRMWAKIMKEVFNAKK
PESMMLRFHTQTGGAELTAQQPEINIIRTTLQALAAVLGGTQSLHVNSYDEALALPTEKAAKIAIRVQQIIANESGAADV
VDPLGGSYYIEWLTDEIEERAWKIIDQVEKMGGMIKAIENGYPQAQIAESAYKIQKRIEEGDLGKVGVNMYYEPEWIGTT
EIFRVNPEVRERVISRLKKYKQERDEMKLRESLNNLRKIAEKENENLFPYMIDAIRAGATVGETSGVLRDIWGEYKEPSI
F
>Mature_561_residues
MFIRFKHIMDVEDRIKEWEEKVYSSWVKKRGERKKEFKTFSGIHIKPVYTPLDVKGNYMEKLGLPGEYPFTRGIYPNMYR
GRIWTIRQYAGFGSAEETNSRFRKLLEAGQTGLSMAFDLPTQLGLDPDHELAYTEIGVVGVSMFHWKEMDIVMSGIPLDK
VTTSMTINATAMELLSMLIATSESRNINKSVLDGTVQNDILKEYIARKNFIYPPSPSMRYAIDIIEYSAKYLPKWHPISI
SGYHIREAGADAVLEVAFTLADGMEYVRKTMERGINVDEFAPHLSFFFAAYSDIFEEVAKFRAARRMWAKIMKEVFNAKK
PESMMLRFHTQTGGAELTAQQPEINIIRTTLQALAAVLGGTQSLHVNSYDEALALPTEKAAKIAIRVQQIIANESGAADV
VDPLGGSYYIEWLTDEIEERAWKIIDQVEKMGGMIKAIENGYPQAQIAESAYKIQKRIEEGDLGKVGVNMYYEPEWIGTT
EIFRVNPEVRERVISRLKKYKQERDEMKLRESLNNLRKIAEKENENLFPYMIDAIRAGATVGETSGVLRDIWGEYKEPSI
F

Specific function: Catalyzes the interconversion of succinyl-CoA and methylmalonyl-CoA during the polyhydroxyalkanoate degradation pathway [H]

COG id: COG1884

COG function: function code I; Methylmalonyl-CoA mutase, N-terminal domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 B12-binding domain [H]

Homologues:

Organism=Homo sapiens, GI156105689, Length=554, Percent_Identity=44.5848375451264, Blast_Score=483, Evalue=1e-136,
Organism=Escherichia coli, GI1789284, Length=555, Percent_Identity=44.3243243243243, Blast_Score=437, Evalue=1e-124,
Organism=Caenorhabditis elegans, GI25144500, Length=523, Percent_Identity=45.5066921606119, Blast_Score=470, Evalue=1e-132,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006159
- InterPro:   IPR016176
- InterPro:   IPR014348
- InterPro:   IPR006158
- InterPro:   IPR006099
- InterPro:   IPR006098 [H]

Pfam domain/function: PF02310 B12-binding; PF01642 MM_CoA_mutase [H]

EC number: =5.4.99.2 [H]

Molecular weight: Translated: 64122; Mature: 64122

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFIRFKHIMDVEDRIKEWEEKVYSSWVKKRGERKKEFKTFSGIHIKPVYTPLDVKGNYME
CEEEEHHHCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCEEEEECCCCCCCCCHHH
KLGLPGEYPFTRGIYPNMYRGRIWTIRQYAGFGSAEETNSRFRKLLEAGQTGLSMAFDLP
HCCCCCCCCCCCCCCCCCCCCCEEEEHHHCCCCCCHHHHHHHHHHHHHCCCCCEEEECCC
TQLGLDPDHELAYTEIGVVGVSMFHWKEMDIVMSGIPLDKVTTSMTINATAMELLSMLIA
HHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCEEECHHHHHHHHHHHH
TSESRNINKSVLDGTVQNDILKEYIARKNFIYPPSPSMRYAIDIIEYSAKYLPKWHPISI
CCCCCCCCHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEE
SGYHIREAGADAVLEVAFTLADGMEYVRKTMERGINVDEFAPHLSFFFAAYSDIFEEVAK
CCCEEHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
FRAARRMWAKIMKEVFNAKKPESMMLRFHTQTGGAELTAQQPEINIIRTTLQALAAVLGG
HHHHHHHHHHHHHHHHCCCCCHHHEEEEEECCCCCEEEECCCCHHHHHHHHHHHHHHHCC
TQSLHVNSYDEALALPTEKAAKIAIRVQQIIANESGAADVVDPLGGSYYIEWLTDEIEER
CCEEECCCCHHHHCCCCHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCEEHHHHHHHHHHH
AWKIIDQVEKMGGMIKAIENGYPQAQIAESAYKIQKRIEEGDLGKVGVNMYYEPEWIGTT
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCC
EIFRVNPEVRERVISRLKKYKQERDEMKLRESLNNLRKIAEKENENLFPYMIDAIRAGAT
EEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCC
VGETSGVLRDIWGEYKEPSIF
CCHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MFIRFKHIMDVEDRIKEWEEKVYSSWVKKRGERKKEFKTFSGIHIKPVYTPLDVKGNYME
CEEEEHHHCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCEEEEECCCCCCCCCHHH
KLGLPGEYPFTRGIYPNMYRGRIWTIRQYAGFGSAEETNSRFRKLLEAGQTGLSMAFDLP
HCCCCCCCCCCCCCCCCCCCCCEEEEHHHCCCCCCHHHHHHHHHHHHHCCCCCEEEECCC
TQLGLDPDHELAYTEIGVVGVSMFHWKEMDIVMSGIPLDKVTTSMTINATAMELLSMLIA
HHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCEEECHHHHHHHHHHHH
TSESRNINKSVLDGTVQNDILKEYIARKNFIYPPSPSMRYAIDIIEYSAKYLPKWHPISI
CCCCCCCCHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEE
SGYHIREAGADAVLEVAFTLADGMEYVRKTMERGINVDEFAPHLSFFFAAYSDIFEEVAK
CCCEEHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
FRAARRMWAKIMKEVFNAKKPESMMLRFHTQTGGAELTAQQPEINIIRTTLQALAAVLGG
HHHHHHHHHHHHHHHHCCCCCHHHEEEEEECCCCCEEEECCCCHHHHHHHHHHHHHHHCC
TQSLHVNSYDEALALPTEKAAKIAIRVQQIIANESGAADVVDPLGGSYYIEWLTDEIEER
CCEEECCCCHHHHCCCCHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCEEHHHHHHHHHHH
AWKIIDQVEKMGGMIKAIENGYPQAQIAESAYKIQKRIEEGDLGKVGVNMYYEPEWIGTT
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCC
EIFRVNPEVRERVISRLKKYKQERDEMKLRESLNNLRKIAEKENENLFPYMIDAIRAGAT
EEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCC
VGETSGVLRDIWGEYKEPSIF
CCHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9889346; 11481431 [H]