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The map label for this gene is panB [H]

Identifier: 15899151

GI number: 15899151

Start: 2185709

End: 2186512

Strand: Reverse

Name: panB [H]

Synonym: SSO2400

Alternate gene names: 15899151

Gene position: 2186512-2185709 (Counterclockwise)

Preceding gene: 15899152

Following gene: 15899148

Centisome position: 73.07

GC content: 37.19

Gene sequence:

>804_bases
ATGAAAAAGGTGACAATAAGGGATTTCATAAAGAAGAAATCAATGAAGGAGAAAATTACGATGTTAACAGCTTACGATTA
CCCCACAGCGAAAATAATATCTAATACTACGCTAGATTCCATACTAGTAGGAGATTCCTTAGGAATGGTTGTTCTAGGAT
ATACAAATACGCTTAACGTAACCATGAGAGACATGATCTCCCATACTAGAGCAGTAGCAAGAGCTAATCCTCCTCAGTTA
ATAGTTTCAGATATGCCGTTCCTAAGTTATGAGATAGACGTGAAAAGTGCAGTGAAGAATGCAGGTCTTTTAGTTAAGGC
TGGTAGTGACGCGGTAAAACTAGAGGGTGGAGAGGAAATTAAAGACATTATTAGAGCAATCGTAAAGGCTGGAATACCCG
TAATGGGGCATATTGGTTTAACCCCTCAAAGGTTCTTGAGGCTAGGGGGATTTAGAACTATCGGAAAAACTAAGCAGGAA
GAGGAGCAATTAATAAAGGATAGTTTAGAACTAGAAGATGCAGGGGTATTTTCAATAGTTATAGAAAATACATACGTGGA
TATAGCTAAAAGGATTACGGAAAAACTAAACGTGCCTACAATCTGTATAGGAGCAGGCCCATATTGTGATGGACAAGTGT
TAGTAATACACGATTTACTAGGGTTATCTGAGGTTACCCCTTACTTCGCTAAGTCATACGTTAATTTGAAAGAAATCATC
TCCAGCGCTATTAATCAGTATATAATTGACGTGAAAACTAATAAGTTTCCTGAAAAACAACATTATAAGGAAAGAGAAAG
TTGA

Upstream 100 bases:

>100_bases
TTGTATTATAAGGCTTCCCAGCATGAGGAAACCTTTGAGATTGCTGAAAAATTGAAAAAAATTATAAATTTAGCTAAGAG
AATAAGCTCAAGAATAAACA

Downstream 100 bases:

>100_bases
GTTAATCTGTTAGCTATAAATTTTAGTGATTCAGCTAAGATAGTTTTGTTATCATAGTTAAAGACTATTTGTTCTAGCTC
TTCTTTACTCTTAGACTTCA

Product: 3-methyl-2-oxobutanoate hydroxymethyltransferase

Products: NA

Alternate protein names: Ketopantoate hydroxymethyltransferase; KPHMT [H]

Number of amino acids: Translated: 267; Mature: 267

Protein sequence:

>267_residues
MKKVTIRDFIKKKSMKEKITMLTAYDYPTAKIISNTTLDSILVGDSLGMVVLGYTNTLNVTMRDMISHTRAVARANPPQL
IVSDMPFLSYEIDVKSAVKNAGLLVKAGSDAVKLEGGEEIKDIIRAIVKAGIPVMGHIGLTPQRFLRLGGFRTIGKTKQE
EEQLIKDSLELEDAGVFSIVIENTYVDIAKRITEKLNVPTICIGAGPYCDGQVLVIHDLLGLSEVTPYFAKSYVNLKEII
SSAINQYIIDVKTNKFPEKQHYKERES

Sequences:

>Translated_267_residues
MKKVTIRDFIKKKSMKEKITMLTAYDYPTAKIISNTTLDSILVGDSLGMVVLGYTNTLNVTMRDMISHTRAVARANPPQL
IVSDMPFLSYEIDVKSAVKNAGLLVKAGSDAVKLEGGEEIKDIIRAIVKAGIPVMGHIGLTPQRFLRLGGFRTIGKTKQE
EEQLIKDSLELEDAGVFSIVIENTYVDIAKRITEKLNVPTICIGAGPYCDGQVLVIHDLLGLSEVTPYFAKSYVNLKEII
SSAINQYIIDVKTNKFPEKQHYKERES
>Mature_267_residues
MKKVTIRDFIKKKSMKEKITMLTAYDYPTAKIISNTTLDSILVGDSLGMVVLGYTNTLNVTMRDMISHTRAVARANPPQL
IVSDMPFLSYEIDVKSAVKNAGLLVKAGSDAVKLEGGEEIKDIIRAIVKAGIPVMGHIGLTPQRFLRLGGFRTIGKTKQE
EEQLIKDSLELEDAGVFSIVIENTYVDIAKRITEKLNVPTICIGAGPYCDGQVLVIHDLLGLSEVTPYFAKSYVNLKEII
SSAINQYIIDVKTNKFPEKQHYKERES

Specific function: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate [H]

COG id: COG0413

COG function: function code H; Ketopantoate hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the panB family [H]

Homologues:

Organism=Escherichia coli, GI1786326, Length=262, Percent_Identity=40.8396946564886, Blast_Score=211, Evalue=6e-56,
Organism=Saccharomyces cerevisiae, GI6319653, Length=264, Percent_Identity=39.3939393939394, Blast_Score=181, Evalue=9e-47,

Paralogues:

None

Copy number: 1080 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003700
- InterPro:   IPR015813 [H]

Pfam domain/function: PF02548 Pantoate_transf [H]

EC number: =2.1.2.11 [H]

Molecular weight: Translated: 29624; Mature: 29624

Theoretical pI: Translated: 8.90; Mature: 8.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKVTIRDFIKKKSMKEKITMLTAYDYPTAKIISNTTLDSILVGDSLGMVVLGYTNTLNV
CCCCHHHHHHHHHHHHHHHEEEEECCCCCHHHHCCCCHHHEEECCCCCEEEEEECCEECH
TMRDMISHTRAVARANPPQLIVSDMPFLSYEIDVKSAVKNAGLLVKAGSDAVKLEGGEEI
HHHHHHHHHHHHHCCCCCEEEEECCCCEEEEEEHHHHHHCCCEEEEECCCEEEECCCHHH
KDIIRAIVKAGIPVMGHIGLTPQRFLRLGGFRTIGKTKQEEEQLIKDSLELEDAGVFSIV
HHHHHHHHHCCCCEEECCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEE
IENTYVDIAKRITEKLNVPTICIGAGPYCDGQVLVIHDLLGLSEVTPYFAKSYVNLKEII
EEHHHHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEHHHHCHHHCCHHHHHHHCCHHHHH
SSAINQYIIDVKTNKFPEKQHYKERES
HHHHHHEEEEEECCCCCCHHHHHHCCC
>Mature Secondary Structure
MKKVTIRDFIKKKSMKEKITMLTAYDYPTAKIISNTTLDSILVGDSLGMVVLGYTNTLNV
CCCCHHHHHHHHHHHHHHHEEEEECCCCCHHHHCCCCHHHEEECCCCCEEEEEECCEECH
TMRDMISHTRAVARANPPQLIVSDMPFLSYEIDVKSAVKNAGLLVKAGSDAVKLEGGEEI
HHHHHHHHHHHHHCCCCCEEEEECCCCEEEEEEHHHHHHCCCEEEEECCCEEEECCCHHH
KDIIRAIVKAGIPVMGHIGLTPQRFLRLGGFRTIGKTKQEEEQLIKDSLELEDAGVFSIV
HHHHHHHHHCCCCEEECCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEE
IENTYVDIAKRITEKLNVPTICIGAGPYCDGQVLVIHDLLGLSEVTPYFAKSYVNLKEII
EEHHHHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEHHHHCHHHCCHHHHHHHCCHHHHH
SSAINQYIIDVKTNKFPEKQHYKERES
HHHHHHEEEEEECCCCCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA