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The map label for this gene is mcmA2 [H]

Identifier: 15899035

GI number: 15899035

Start: 2078112

End: 2078537

Strand: Reverse

Name: mcmA2 [H]

Synonym: SSO2266

Alternate gene names: 15899035

Gene position: 2078537-2078112 (Counterclockwise)

Preceding gene: 15899037

Following gene: 15899034

Centisome position: 69.46

GC content: 36.38

Gene sequence:

>426_bases
ATGATGATTACAACAAAAAGAATTAAGGTTATTGTGGCAAAATTAGGTTTAGATGGGCACGATAGAGGGGCAAAAGTAGT
TGCAAGAGCACTAAAAGATGCGGGAATGGAGGTAGTGTATACTGGATTAAGACAAACTCCAGAACAGATAGTAAGAGCTG
CATTGCAGGAAGACGCAGACGTTATAGGAATTAGCATATTAAGCGGAGCTCATTTGGAGTTGATACCAAAAGTAGTAGAG
ATAATGAAACAAAATGGATTAAATGATGTAGGATTAATAGTTGGAGGAGTAATACCGCCAGAGGATATTAAAAAGTTAAA
AGAAATGGGAGTTGATGAAGTCTTTCTGCCTGGTAGTAGTCTTAAAGAAATAGTAGAGAAGGTTAAAAAGGTAGCAAGGG
AAAAAAGAGGTATAAGTGTTGAATAA

Upstream 100 bases:

>100_bases
TTTAATAAGCGTGATTATTAAACTTTTACCCATATTTATCGACCTTAAGGGTAAACAAAACGATTAGCAAAAAGTTTAAA
CGTTTTAAGTATTAGTAATA

Downstream 100 bases:

>100_bases
CAATTTATCAAAATTAATAGAAGAAGCATTAAATGGAAATGAATTAGCAATAGCTAGGTTATTAACAAAGATTGAGTACA
TGACCGATGAAGGAATAAGT

Product: methylmalonyl-CoA mutase, alpha-subunit, chain B (mcmA2)

Products: succinyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 141; Mature: 141

Protein sequence:

>141_residues
MMITTKRIKVIVAKLGLDGHDRGAKVVARALKDAGMEVVYTGLRQTPEQIVRAALQEDADVIGISILSGAHLELIPKVVE
IMKQNGLNDVGLIVGGVIPPEDIKKLKEMGVDEVFLPGSSLKEIVEKVKKVAREKRGISVE

Sequences:

>Translated_141_residues
MMITTKRIKVIVAKLGLDGHDRGAKVVARALKDAGMEVVYTGLRQTPEQIVRAALQEDADVIGISILSGAHLELIPKVVE
IMKQNGLNDVGLIVGGVIPPEDIKKLKEMGVDEVFLPGSSLKEIVEKVKKVAREKRGISVE
>Mature_141_residues
MMITTKRIKVIVAKLGLDGHDRGAKVVARALKDAGMEVVYTGLRQTPEQIVRAALQEDADVIGISILSGAHLELIPKVVE
IMKQNGLNDVGLIVGGVIPPEDIKKLKEMGVDEVFLPGSSLKEIVEKVKKVAREKRGISVE

Specific function: Unknown

COG id: COG2185

COG function: function code I; Methylmalonyl-CoA mutase, C-terminal domain/subunit (cobalamin-binding)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 B12-binding domain [H]

Homologues:

Organism=Homo sapiens, GI156105689, Length=135, Percent_Identity=37.037037037037, Blast_Score=102, Evalue=1e-22,
Organism=Escherichia coli, GI1789284, Length=123, Percent_Identity=43.0894308943089, Blast_Score=111, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI25144500, Length=128, Percent_Identity=42.96875, Blast_Score=103, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006159
- InterPro:   IPR016176
- InterPro:   IPR014348
- InterPro:   IPR006158
- InterPro:   IPR006099
- InterPro:   IPR006098 [H]

Pfam domain/function: PF02310 B12-binding; PF01642 MM_CoA_mutase [H]

EC number: 5.4.99.2

Molecular weight: Translated: 15259; Mature: 15259

Theoretical pI: Translated: 9.58; Mature: 9.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMITTKRIKVIVAKLGLDGHDRGAKVVARALKDAGMEVVYTGLRQTPEQIVRAALQEDAD
CCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHCCCH
VIGISILSGAHLELIPKVVEIMKQNGLNDVGLIVGGVIPPEDIKKLKEMGVDEVFLPGSS
HHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHCCCCCHHHHHHHHHCCCCEEECCCHH
LKEIVEKVKKVAREKRGISVE
HHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MMITTKRIKVIVAKLGLDGHDRGAKVVARALKDAGMEVVYTGLRQTPEQIVRAALQEDAD
CCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHCCCH
VIGISILSGAHLELIPKVVEIMKQNGLNDVGLIVGGVIPPEDIKKLKEMGVDEVFLPGSS
HHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHCCCCCHHHHHHHHHCCCCEEECCCHH
LKEIVEKVKKVAREKRGISVE
HHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (R)-methylmalonyl-CoA

Specific reaction: (R)-methylmalonyl-CoA = succinyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1355087; 9278503 [H]