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The map label for this gene is apeH-2

Identifier: 15898924

GI number: 15898924

Start: 1968668

End: 1970377

Strand: Reverse

Name: apeH-2

Synonym: SSO2141

Alternate gene names: NA

Gene position: 1970377-1968668 (Counterclockwise)

Preceding gene: 15898925

Following gene: 15898921

Centisome position: 65.85

GC content: 36.49

Gene sequence:

>1710_bases
TTGCAAATACAATTCCACTATATGGAGTACTCAGAACTAATAAAGCTGTTAGAGGAAACGGTAAGAATTCCATTTTATGC
CATATTAGGTAAGTTAAAGAATAATTTAATATATTTGGCAACATCTGAGGGAGAAATAAGCATCTATGCTCTAATAGGTG
GAAAGAATGTAAAGTTAACAAAATCGCCAATAGCAATTTCAACTAGACCAAAATCAAGCCTAGACTTTATACCCTTTGCA
AGAGACGTTGAAAAGGGGAAAGAAATTCATGCAATACATATAGCAAATTTGAAAGGAGAGGAATTTCAGATTGAATCGCC
AAGGGTTAGAATTTCATCACTGACCTACGATGATAAGCGAATAGTATTCACTGGCTCTTCACAAAATGAAACCTCATTAT
ATGTTATTGAAAATGGGAAATTAAGTAAACTGACTACCATACCACCCTTCTCATTTGTTACCGATGTCAATGAAAAATAT
ATTATAGGTTCAGGGGTATTGAAGGGAAATCCAAGATCACAGGAGTTCTTCATAGCAGATTTTAGTGGGAATATTGAGAT
ATTAACACCAAAGGAAGGAAGTGTAACCAACGCTTACTATCTAATGGGAAATAAAGTTTACTTAATAAGCGATTACGAAA
CACCAGGGGAATCTTACTGGATTTACATATATGATATAGAGAGTAAGAAGTACGATAGAGTTGAGATCCCTGGATTCGAA
TTTAAGGCAATAGAAATATATTATGACCCTGAGGATTTGTTAATAATAGCAAAGAAGGATGGTGAATCCAGACTATTTGA
CAACGGTAAAGAAATTAACACCCCTAAAGGTACAATTAGTGGCGCTACCAGAATTGGCGACGAAATATACTTTTCCCATT
CCTCCTTAGTGTCGCCACATAAGATATACAAGGTAAGTAGATATGGGAAGATTGAGGTGGTTGTAGATAATAGGAAGGTT
GATGTGGGTGAGGTAGAGTATGTTAAGGTAAAGACGGATGTTGAAGTACCTACTTGGGTTATAAAGAGGAAAATTCCGGG
TAATACAATAATTTATATTCATGGAGGCCCTTGGTCTGAGGTTGATAATAGCTGGAATTTACTAATTGCACCTCTAGTAT
TAGCTGGATATAATGTAATTGCACCTAACTATAGGGGATCGACGGGATATGGGAGTAAATTCATGTTCATGAATATTGGA
GATGCTGGAGGCGGTGATTTAAGAGACGTGGTAAAGGTAAGGGATTACGCAATAGAGACTGGAATTACAAATAAAGTAGG
AATAATGGGTTATAGTTATGGTGGATATATGACTTTATTGGCAGTAGGAAAAGAACCAGATAAGTGGGATTTCGGTATTG
CTGGTGCGGCTGTAGCGGATTGGGTTGAGATGTATGATCTCTCTGATTCCTTGTTTAGGGGGTTCATGGAGATACTATTT
AATGGTAAGAATATTGATTTAATGAAGGAAAGGTCTCCTATCACCTATGTTAGGAACGTCAAAGTACCCCTATGCATAAT
TCACTCTCAAAACGATACTAGAACTCCATTAAATCCAGTAATGAGATATATACAAGAATTGCAAAGAACCGGCAAGACTT
ACGAATTTCATGTGATACCGAACCTCGGCCACGCTATATATAAGGTAAGTGACGCAATAGATATATTACTTCCGGCCTTA
ATATTCCTTAAGAAACTAGAGGAACAATAA

Upstream 100 bases:

>100_bases
TTGGAAAAGTTCTTAGACTATGATCTAGTGGTATATCCTTTGCCTAAAGCTATAAACTTTCTGAAAGCATTAGTGTTATA
AAAAGATATTAATATATATA

Downstream 100 bases:

>100_bases
AAGTGTGCTACTTTGCTTGTACCTTGGTTCTCAAAATATACCATGAACCTATAGCCTTAGCACCCAATTTCCCGTCTGCG
TCCTTAAACTCTATTTCGAC

Product: acylaminoacyl-peptidase

Products: NA

Alternate protein names: AARE; Acyl-peptide hydrolase; APH; Acylaminoacyl-peptidase [H]

Number of amino acids: Translated: 569; Mature: 569

Protein sequence:

>569_residues
MQIQFHYMEYSELIKLLEETVRIPFYAILGKLKNNLIYLATSEGEISIYALIGGKNVKLTKSPIAISTRPKSSLDFIPFA
RDVEKGKEIHAIHIANLKGEEFQIESPRVRISSLTYDDKRIVFTGSSQNETSLYVIENGKLSKLTTIPPFSFVTDVNEKY
IIGSGVLKGNPRSQEFFIADFSGNIEILTPKEGSVTNAYYLMGNKVYLISDYETPGESYWIYIYDIESKKYDRVEIPGFE
FKAIEIYYDPEDLLIIAKKDGESRLFDNGKEINTPKGTISGATRIGDEIYFSHSSLVSPHKIYKVSRYGKIEVVVDNRKV
DVGEVEYVKVKTDVEVPTWVIKRKIPGNTIIYIHGGPWSEVDNSWNLLIAPLVLAGYNVIAPNYRGSTGYGSKFMFMNIG
DAGGGDLRDVVKVRDYAIETGITNKVGIMGYSYGGYMTLLAVGKEPDKWDFGIAGAAVADWVEMYDLSDSLFRGFMEILF
NGKNIDLMKERSPITYVRNVKVPLCIIHSQNDTRTPLNPVMRYIQELQRTGKTYEFHVIPNLGHAIYKVSDAIDILLPAL
IFLKKLEEQ

Sequences:

>Translated_569_residues
MQIQFHYMEYSELIKLLEETVRIPFYAILGKLKNNLIYLATSEGEISIYALIGGKNVKLTKSPIAISTRPKSSLDFIPFA
RDVEKGKEIHAIHIANLKGEEFQIESPRVRISSLTYDDKRIVFTGSSQNETSLYVIENGKLSKLTTIPPFSFVTDVNEKY
IIGSGVLKGNPRSQEFFIADFSGNIEILTPKEGSVTNAYYLMGNKVYLISDYETPGESYWIYIYDIESKKYDRVEIPGFE
FKAIEIYYDPEDLLIIAKKDGESRLFDNGKEINTPKGTISGATRIGDEIYFSHSSLVSPHKIYKVSRYGKIEVVVDNRKV
DVGEVEYVKVKTDVEVPTWVIKRKIPGNTIIYIHGGPWSEVDNSWNLLIAPLVLAGYNVIAPNYRGSTGYGSKFMFMNIG
DAGGGDLRDVVKVRDYAIETGITNKVGIMGYSYGGYMTLLAVGKEPDKWDFGIAGAAVADWVEMYDLSDSLFRGFMEILF
NGKNIDLMKERSPITYVRNVKVPLCIIHSQNDTRTPLNPVMRYIQELQRTGKTYEFHVIPNLGHAIYKVSDAIDILLPAL
IFLKKLEEQ
>Mature_569_residues
MQIQFHYMEYSELIKLLEETVRIPFYAILGKLKNNLIYLATSEGEISIYALIGGKNVKLTKSPIAISTRPKSSLDFIPFA
RDVEKGKEIHAIHIANLKGEEFQIESPRVRISSLTYDDKRIVFTGSSQNETSLYVIENGKLSKLTTIPPFSFVTDVNEKY
IIGSGVLKGNPRSQEFFIADFSGNIEILTPKEGSVTNAYYLMGNKVYLISDYETPGESYWIYIYDIESKKYDRVEIPGFE
FKAIEIYYDPEDLLIIAKKDGESRLFDNGKEINTPKGTISGATRIGDEIYFSHSSLVSPHKIYKVSRYGKIEVVVDNRKV
DVGEVEYVKVKTDVEVPTWVIKRKIPGNTIIYIHGGPWSEVDNSWNLLIAPLVLAGYNVIAPNYRGSTGYGSKFMFMNIG
DAGGGDLRDVVKVRDYAIETGITNKVGIMGYSYGGYMTLLAVGKEPDKWDFGIAGAAVADWVEMYDLSDSLFRGFMEILF
NGKNIDLMKERSPITYVRNVKVPLCIIHSQNDTRTPLNPVMRYIQELQRTGKTYEFHVIPNLGHAIYKVSDAIDILLPAL
IFLKKLEEQ

Specific function: This enzyme catalyzes the hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate an N- acetylated amino acid and a peptide with a free N-terminus [H]

COG id: COG1506

COG function: function code E; Dipeptidyl aminopeptidases/acylaminoacyl-peptidases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S9C family [H]

Homologues:

Organism=Homo sapiens, GI23510451, Length=237, Percent_Identity=27.8481012658228, Blast_Score=95, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI25144537, Length=220, Percent_Identity=25.9090909090909, Blast_Score=93, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI25144540, Length=220, Percent_Identity=25.9090909090909, Blast_Score=93, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17552908, Length=275, Percent_Identity=24.7272727272727, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI25144543, Length=111, Percent_Identity=34.2342342342342, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI45550825, Length=229, Percent_Identity=28.82096069869, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI45553511, Length=229, Percent_Identity=28.82096069869, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI45551969, Length=229, Percent_Identity=28.82096069869, Blast_Score=70, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011042
- InterPro:   IPR001375
- InterPro:   IPR004106 [H]

Pfam domain/function: PF00326 Peptidase_S9 [H]

EC number: =3.4.19.1 [H]

Molecular weight: Translated: 64284; Mature: 64284

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQIQFHYMEYSELIKLLEETVRIPFYAILGKLKNNLIYLATSEGEISIYALIGGKNVKLT
CEEEEEECCHHHHHHHHHHHHCCCHHHHHHHHCCCEEEEEECCCCEEEEEEECCCEEEEE
KSPIAISTRPKSSLDFIPFARDVEKGKEIHAIHIANLKGEEFQIESPRVRISSLTYDDKR
CCCEEEEECCCCCCCCCCCHHHHHCCCEEEEEEEECCCCCEEEECCCCEEEEEEEECCCE
IVFTGSSQNETSLYVIENGKLSKLTTIPPFSFVTDVNEKYIIGSGVLKGNPRSQEFFIAD
EEEECCCCCCEEEEEEECCCEEEEEECCCCHHEECCCCCEEEECCEECCCCCCCEEEEEE
FSGNIEILTPKEGSVTNAYYLMGNKVYLISDYETPGESYWIYIYDIESKKYDRVEIPGFE
ECCCEEEEECCCCCCEEEEEEECCEEEEEECCCCCCCEEEEEEEEECCCCCCEEECCCCE
FKAIEIYYDPEDLLIIAKKDGESRLFDNGKEINTPKGTISGATRIGDEIYFSHSSLVSPH
EEEEEEEECCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHCCCEEEECCCCCCCCH
KIYKVSRYGKIEVVVDNRKVDVGEVEYVKVKTDVEVPTWVIKRKIPGNTIIYIHGGPWSE
HEEEEECCCEEEEEECCCEECCCCEEEEEEEECCCCCEEEEEEECCCCEEEEEECCCCCC
VDNSWNLLIAPLVLAGYNVIAPNYRGSTGYGSKFMFMNIGDAGGGDLRDVVKVRDYAIET
CCCCCCEEEEEHHHCCCEEECCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHEEEC
GITNKVGIMGYSYGGYMTLLAVGKEPDKWDFGIAGAAVADWVEMYDLSDSLFRGFMEILF
CCCCCEEEEEEECCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHC
NGKNIDLMKERSPITYVRNVKVPLCIIHSQNDTRTPLNPVMRYIQELQRTGKTYEFHVIP
CCCCEEEEECCCCEEEEECCCEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCEEEEEEEC
NLGHAIYKVSDAIDILLPALIFLKKLEEQ
CCCCEEEEHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQIQFHYMEYSELIKLLEETVRIPFYAILGKLKNNLIYLATSEGEISIYALIGGKNVKLT
CEEEEEECCHHHHHHHHHHHHCCCHHHHHHHHCCCEEEEEECCCCEEEEEEECCCEEEEE
KSPIAISTRPKSSLDFIPFARDVEKGKEIHAIHIANLKGEEFQIESPRVRISSLTYDDKR
CCCEEEEECCCCCCCCCCCHHHHHCCCEEEEEEEECCCCCEEEECCCCEEEEEEEECCCE
IVFTGSSQNETSLYVIENGKLSKLTTIPPFSFVTDVNEKYIIGSGVLKGNPRSQEFFIAD
EEEECCCCCCEEEEEEECCCEEEEEECCCCHHEECCCCCEEEECCEECCCCCCCEEEEEE
FSGNIEILTPKEGSVTNAYYLMGNKVYLISDYETPGESYWIYIYDIESKKYDRVEIPGFE
ECCCEEEEECCCCCCEEEEEEECCEEEEEECCCCCCCEEEEEEEEECCCCCCEEECCCCE
FKAIEIYYDPEDLLIIAKKDGESRLFDNGKEINTPKGTISGATRIGDEIYFSHSSLVSPH
EEEEEEEECCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHCCCEEEECCCCCCCCH
KIYKVSRYGKIEVVVDNRKVDVGEVEYVKVKTDVEVPTWVIKRKIPGNTIIYIHGGPWSE
HEEEEECCCEEEEEECCCEECCCCEEEEEEEECCCCCEEEEEEECCCCEEEEEECCCCCC
VDNSWNLLIAPLVLAGYNVIAPNYRGSTGYGSKFMFMNIGDAGGGDLRDVVKVRDYAIET
CCCCCCEEEEEHHHCCCEEECCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHEEEC
GITNKVGIMGYSYGGYMTLLAVGKEPDKWDFGIAGAAVADWVEMYDLSDSLFRGFMEILF
CCCCCEEEEEEECCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHC
NGKNIDLMKERSPITYVRNVKVPLCIIHSQNDTRTPLNPVMRYIQELQRTGKTYEFHVIP
CCCCEEEEECCCCEEEEECCCEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCEEEEEEEC
NLGHAIYKVSDAIDILLPALIFLKKLEEQ
CCCCEEEEHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10382966; 12037315 [H]