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The map label for this gene is hemE

Identifier: 15890080

GI number: 15890080

Start: 2840340

End: 2841374

Strand: Reverse

Name: hemE

Synonym: Atu2835

Alternate gene names: 15890080

Gene position: 2841374-2840340 (Counterclockwise)

Preceding gene: NA

Following gene: 159185405

Centisome position: 99.99

GC content: 59.42

Gene sequence:

>1035_bases
ATGAGCGAACGCAAGGTTATGACTGTTTTGAACGGGAAGACGGTTACGCCGCCGCCAATATGGCTGATGCGCCAGGCTGG
GCGTTATCTTCCGGAGTATCGGGAAACGCGTAAGAGTGCCGGAAGTTTCCTGGATCTCTGTTATAATCCCGAGCTGGCGA
GCGAAGTGACCCTTCAGCCCATTCGCCGGTTCGGGCTGGATGCGGCCATCCTCTTTTCCGATATTCTTGTCATTCCCGAC
GCGCTTCATCGCAATGTGTCCTTCAGCGAAGGCAAGGGCCCGGCCATGGATCCGATCGATATTAGCGGTATCGAAAAGCT
TGATGCATCTGATGTCATGGCGCATCTTTCGCCCGTTTTCGAAACGGTGTCGCGGCTGCGCACCTCATTGCCGGATGAAA
CGACGCTTCTCGGTTTTTGCGGTGCGCCTTGGACAGTTGCGACCTATATGATCGCCGGGCATGGGACGCCGGACCAGGCG
CCGGCGCGGCTGTTCGGTTATCAGGAACCGGCCGCGATGGAAAAGCTGCTGGCTCTCCTCGCTGAGGTCTCAGCCGATTA
TCTGGTGGCGCAGATCGATGCCGGCGCCGACGCGGTTCAGATCTTCGATTCCTGGGCTGGCGTGCTCGGCGAAAAGGAAT
TCGAGGAATATGCGATCAAGCCGGTCGCCAGGATTATCGCGTCTGTGCGCGCCCGCCGACCTTCGGCAAAGATCATCGCT
TTCGCCAAGGGCGCTGGTTATCTGCTGAGGGATTATCGCCGCAAGACGGGTGCTAACGCCATTGGCCTCGATTGGTCCGT
GCCGTTGAGCTTCGCCCGGGATTTGCAGAAGGAAGGCCCGGTGCAGGGTAATCTTGACCCGATGCTGATGGTGGCCGGTG
GCAAAGCCTTGCAGGATGGCATCGATGCTGTGCTGCAGTCGCTTGGGCAGGGTCCGCTGATCTTCAATCTCGGCCATGGC
ATCACCCCGCAAGCAGACCCGGAAAACGTCACCCGGCTGGTGCAGCGGGTGCGCTCGGTTGGGGGTGCTGGATGA

Upstream 100 bases:

>100_bases
CATTTCGACTGGAATGATTTTAATCCTTGCTACCCACAGACTCTAAGAAATAGAAAATCTTTTAAATCTCTTTGTTTTTA
TTTTTTAGAAGCTGGGTGCC

Downstream 100 bases:

>100_bases
GCGAGGAAAAACAGACCTCGGCCCGCTCCGGAAACAAGGCGGCCTTGCGTGCTGGCGTCGCACTCGGCGTCTTTGCCGCT
TTCATCGCGCTGCTGTTTTA

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D

Number of amino acids: Translated: 344; Mature: 343

Protein sequence:

>344_residues
MSERKVMTVLNGKTVTPPPIWLMRQAGRYLPEYRETRKSAGSFLDLCYNPELASEVTLQPIRRFGLDAAILFSDILVIPD
ALHRNVSFSEGKGPAMDPIDISGIEKLDASDVMAHLSPVFETVSRLRTSLPDETTLLGFCGAPWTVATYMIAGHGTPDQA
PARLFGYQEPAAMEKLLALLAEVSADYLVAQIDAGADAVQIFDSWAGVLGEKEFEEYAIKPVARIIASVRARRPSAKIIA
FAKGAGYLLRDYRRKTGANAIGLDWSVPLSFARDLQKEGPVQGNLDPMLMVAGGKALQDGIDAVLQSLGQGPLIFNLGHG
ITPQADPENVTRLVQRVRSVGGAG

Sequences:

>Translated_344_residues
MSERKVMTVLNGKTVTPPPIWLMRQAGRYLPEYRETRKSAGSFLDLCYNPELASEVTLQPIRRFGLDAAILFSDILVIPD
ALHRNVSFSEGKGPAMDPIDISGIEKLDASDVMAHLSPVFETVSRLRTSLPDETTLLGFCGAPWTVATYMIAGHGTPDQA
PARLFGYQEPAAMEKLLALLAEVSADYLVAQIDAGADAVQIFDSWAGVLGEKEFEEYAIKPVARIIASVRARRPSAKIIA
FAKGAGYLLRDYRRKTGANAIGLDWSVPLSFARDLQKEGPVQGNLDPMLMVAGGKALQDGIDAVLQSLGQGPLIFNLGHG
ITPQADPENVTRLVQRVRSVGGAG
>Mature_343_residues
SERKVMTVLNGKTVTPPPIWLMRQAGRYLPEYRETRKSAGSFLDLCYNPELASEVTLQPIRRFGLDAAILFSDILVIPDA
LHRNVSFSEGKGPAMDPIDISGIEKLDASDVMAHLSPVFETVSRLRTSLPDETTLLGFCGAPWTVATYMIAGHGTPDQAP
ARLFGYQEPAAMEKLLALLAEVSADYLVAQIDAGADAVQIFDSWAGVLGEKEFEEYAIKPVARIIASVRARRPSAKIIAF
AKGAGYLLRDYRRKTGANAIGLDWSVPLSFARDLQKEGPVQGNLDPMLMVAGGKALQDGIDAVLQSLGQGPLIFNLGHGI
TPQADPENVTRLVQRVRSVGGAG

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family

Homologues:

Organism=Homo sapiens, GI71051616, Length=337, Percent_Identity=40.9495548961424, Blast_Score=234, Evalue=7e-62,
Organism=Escherichia coli, GI2367337, Length=328, Percent_Identity=39.9390243902439, Blast_Score=237, Evalue=9e-64,
Organism=Saccharomyces cerevisiae, GI6320252, Length=354, Percent_Identity=35.8757062146893, Blast_Score=212, Evalue=6e-56,
Organism=Drosophila melanogaster, GI221330099, Length=338, Percent_Identity=39.3491124260355, Blast_Score=222, Evalue=3e-58,
Organism=Drosophila melanogaster, GI19921920, Length=338, Percent_Identity=39.3491124260355, Blast_Score=222, Evalue=3e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DCUP_AGRT5 (Q8UBL6)

Other databases:

- EMBL:   AE007869
- PIR:   A97699
- PIR:   AB2925
- RefSeq:   NP_355761.1
- ProteinModelPortal:   Q8UBL6
- SMR:   Q8UBL6
- STRING:   Q8UBL6
- GeneID:   1134873
- GenomeReviews:   AE007869_GR
- KEGG:   atu:Atu2835
- eggNOG:   COG0407
- HOGENOM:   HBG628392
- OMA:   AVQLFDS
- PhylomeDB:   Q8UBL6
- ProtClustDB:   PRK00115
- BioCyc:   ATUM176299-1:ATU2835-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00218
- InterPro:   IPR006361
- InterPro:   IPR000257
- PANTHER:   PTHR21091:SF2
- TIGRFAMs:   TIGR01464

Pfam domain/function: PF01208 URO-D

EC number: =4.1.1.37

Molecular weight: Translated: 37174; Mature: 37043

Theoretical pI: Translated: 5.78; Mature: 5.78

Prosite motif: PS00906 UROD_1; PS00907 UROD_2

Important sites: BINDING 43-43 BINDING 74-74 BINDING 149-149 BINDING 204-204 BINDING 319-319

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSERKVMTVLNGKTVTPPPIWLMRQAGRYLPEYRETRKSAGSFLDLCYNPELASEVTLQP
CCCCEEEEEECCCCCCCCHHHHHHHHHHCCHHHHHHHHHHCCHHHHHCCCCHHHHHHHHH
IRRFGLDAAILFSDILVIPDALHRNVSFSEGKGPAMDPIDISGIEKLDASDVMAHLSPVF
HHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHCCHHHHHHHHHHHH
ETVSRLRTSLPDETTLLGFCGAPWTVATYMIAGHGTPDQAPARLFGYQEPAAMEKLLALL
HHHHHHHHCCCCCCEEEEECCCCHHHHHHHHCCCCCCCCCHHHHHCCCCHHHHHHHHHHH
AEVSADYLVAQIDAGADAVQIFDSWAGVLGEKEFEEYAIKPVARIIASVRARRPSAKIIA
HHHHHHHEEEEECCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEE
FAKGAGYLLRDYRRKTGANAIGLDWSVPLSFARDLQKEGPVQGNLDPMLMVAGGKALQDG
EECCCHHHHHHHHHHHCCCEECCCCCCHHHHHHHHHHCCCCCCCCCCEEEEECCHHHHHH
IDAVLQSLGQGPLIFNLGHGITPQADPENVTRLVQRVRSVGGAG
HHHHHHHCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SERKVMTVLNGKTVTPPPIWLMRQAGRYLPEYRETRKSAGSFLDLCYNPELASEVTLQP
CCCEEEEEECCCCCCCCHHHHHHHHHHCCHHHHHHHHHHCCHHHHHCCCCHHHHHHHHH
IRRFGLDAAILFSDILVIPDALHRNVSFSEGKGPAMDPIDISGIEKLDASDVMAHLSPVF
HHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHCCHHHHHHHHHHHH
ETVSRLRTSLPDETTLLGFCGAPWTVATYMIAGHGTPDQAPARLFGYQEPAAMEKLLALL
HHHHHHHHCCCCCCEEEEECCCCHHHHHHHHCCCCCCCCCHHHHHCCCCHHHHHHHHHHH
AEVSADYLVAQIDAGADAVQIFDSWAGVLGEKEFEEYAIKPVARIIASVRARRPSAKIIA
HHHHHHHEEEEECCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEE
FAKGAGYLLRDYRRKTGANAIGLDWSVPLSFARDLQKEGPVQGNLDPMLMVAGGKALQDG
EECCCHHHHHHHHHHHCCCEECCCCCCHHHHHHHHHHCCCCCCCCCCEEEEECCHHHHHH
IDAVLQSLGQGPLIFNLGHGITPQADPENVTRLVQRVRSVGGAG
HHHHHHHCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194