BacMap

Definition	Agrobacterium tumefaciens str. C58 chromosome circular, complete sequence.
Accession	NC_003062
Length	2,841,580

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The map label for this gene is ccmA

Identifier: 15889941

GI number: 15889941

Start: 2671192

End: 2671833

Strand: Direct

Name: ccmA

Synonym: Atu2686

Alternate gene names: 15889941

Gene position: 2671192-2671833 (Clockwise)

Preceding gene: 15889937

Following gene: 15889942

Centisome position: 94.0

GC content: 60.9

Gene sequence:

>642_bases
ATGGATTTGACGGCGGAAAATCTCGGCGTGCGACGTGGCGAAGATTTCATATTCATGAACATTTCCTTCAAGTTAAGCGA
CGGAGAGGCACTGGTACTGACCGGCCGCAACGGCTCGGGAAAATCCACGCTTCTGCGCACGGTGGCCGGCCTGCTGCGTC
CCGAACAGGGGCGAGTGAAGATAGCCGGCGAAGGAATAGACGCCGAGATGCGGCCGTCGGAGGCCTTCCATTATCTCGGC
CATCGCAATGCGATGAAAACCGAACTGACCGTCGCGGAAAATCTGCGCTTCTGGAAGGACTTTCTCGGTGATTTTCCCGG
CAGCACGGGCGTGGCCATCGATGAGGCAGCGGCGATCGTCGGTCTCGCCGGCATCACCCACCTGCCCTTCGGTTATCTCT
CGGCCGGCCAGCAGCGGCGTTTTGCCATGGCGAAACTCCTGGTCGCCTGGCGGCCGGTGTGGATTCTCGACGAGCCAACG
GCGGCGCTCGACAGGGCTGCGGACGCCATGTTTACCGATCTCGTGAAAAGCCACCTCGGAAAAGGCGGGATCGTCCTGGC
TGCGACCCATCAGCCTCTGGGACTGGAGAAGGCGCAGGAATTGCAGATGACGGGGTTTGCGGGTGTGGAGACTTGGGCAT
GA

Upstream 100 bases:

>100_bases
TGACACCCATATAGATAATTTCGGAGAAACGTGCCAGACCATTCAACGAAGCTAATCGATTTTTTTATCGAGACGGCGAA
ATCTGAAACGGAATCGCAGC

Downstream 100 bases:

>100_bases
TGGTGATGTGCGCGGAGCCCACCCCCCTCTGCCCTGCAGGGCATCTCCCCCTCAAGGGGGGAGATCGGCAGGAAGCGCTA
CCACCACTTCATTCGCAAAC

Product: cytochrome c biogenesis protein CcmA

Products: NA

Alternate protein names: Heme exporter protein A

Number of amino acids: Translated: 213; Mature: 213

Protein sequence:

>213_residues
MDLTAENLGVRRGEDFIFMNISFKLSDGEALVLTGRNGSGKSTLLRTVAGLLRPEQGRVKIAGEGIDAEMRPSEAFHYLG
HRNAMKTELTVAENLRFWKDFLGDFPGSTGVAIDEAAAIVGLAGITHLPFGYLSAGQQRRFAMAKLLVAWRPVWILDEPT
AALDRAADAMFTDLVKSHLGKGGIVLAATHQPLGLEKAQELQMTGFAGVETWA

Sequences:

>Translated_213_residues
MDLTAENLGVRRGEDFIFMNISFKLSDGEALVLTGRNGSGKSTLLRTVAGLLRPEQGRVKIAGEGIDAEMRPSEAFHYLG
HRNAMKTELTVAENLRFWKDFLGDFPGSTGVAIDEAAAIVGLAGITHLPFGYLSAGQQRRFAMAKLLVAWRPVWILDEPT
AALDRAADAMFTDLVKSHLGKGGIVLAATHQPLGLEKAQELQMTGFAGVETWA
>Mature_213_residues
MDLTAENLGVRRGEDFIFMNISFKLSDGEALVLTGRNGSGKSTLLRTVAGLLRPEQGRVKIAGEGIDAEMRPSEAFHYLG
HRNAMKTELTVAENLRFWKDFLGDFPGSTGVAIDEAAAIVGLAGITHLPFGYLSAGQQRRFAMAKLLVAWRPVWILDEPT
AALDRAADAMFTDLVKSHLGKGGIVLAATHQPLGLEKAQELQMTGFAGVETWA

Specific function: Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system

COG id: COG4133

COG function: function code O; ABC-type transport system involved in cytochrome c biogenesis, ATPase component

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain

Homologues:

Organism=Homo sapiens, GI116734710, Length=172, Percent_Identity=30.2325581395349, Blast_Score=75, Evalue=4e-14,
Organism=Homo sapiens, GI6005701, Length=157, Percent_Identity=29.9363057324841, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI27436953, Length=157, Percent_Identity=29.2993630573248, Blast_Score=68, Evalue=6e-12,
Organism=Homo sapiens, GI27477115, Length=162, Percent_Identity=28.3950617283951, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI215820660, Length=184, Percent_Identity=28.804347826087, Blast_Score=65, Evalue=3e-11,
Organism=Homo sapiens, GI20143975, Length=184, Percent_Identity=28.804347826087, Blast_Score=65, Evalue=3e-11,
Organism=Homo sapiens, GI46592971, Length=184, Percent_Identity=28.2608695652174, Blast_Score=65, Evalue=4e-11,
Organism=Homo sapiens, GI46592964, Length=184, Percent_Identity=28.2608695652174, Blast_Score=65, Evalue=4e-11,
Organism=Homo sapiens, GI46592978, Length=184, Percent_Identity=28.2608695652174, Blast_Score=65, Evalue=4e-11,
Organism=Homo sapiens, GI46592898, Length=184, Percent_Identity=28.2608695652174, Blast_Score=65, Evalue=4e-11,
Organism=Homo sapiens, GI46592956, Length=184, Percent_Identity=28.2608695652174, Blast_Score=65, Evalue=4e-11,
Organism=Homo sapiens, GI46592915, Length=184, Percent_Identity=28.2608695652174, Blast_Score=65, Evalue=4e-11,
Organism=Homo sapiens, GI255708477, Length=195, Percent_Identity=26.1538461538462, Blast_Score=65, Evalue=4e-11,
Organism=Homo sapiens, GI105990541, Length=173, Percent_Identity=27.1676300578035, Blast_Score=65, Evalue=5e-11,
Organism=Homo sapiens, GI42741659, Length=192, Percent_Identity=29.1666666666667, Blast_Score=64, Evalue=7e-11,
Organism=Escherichia coli, GI87082064, Length=199, Percent_Identity=40.2010050251256, Blast_Score=115, Evalue=2e-27,
Organism=Escherichia coli, GI87081709, Length=158, Percent_Identity=30.379746835443, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1786253, Length=176, Percent_Identity=35.7954545454545, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1789672, Length=200, Percent_Identity=30, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1790467, Length=180, Percent_Identity=31.6666666666667, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1788165, Length=173, Percent_Identity=30.0578034682081, Blast_Score=72, Evalue=2e-14,
Organism=Escherichia coli, GI87082267, Length=153, Percent_Identity=32.6797385620915, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI87081782, Length=172, Percent_Identity=28.4883720930233, Blast_Score=71, Evalue=4e-14,
Organism=Escherichia coli, GI1790739, Length=196, Percent_Identity=28.0612244897959, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1790544, Length=190, Percent_Identity=28.9473684210526, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1789991, Length=186, Percent_Identity=30.6451612903226, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI1786698, Length=192, Percent_Identity=28.6458333333333, Blast_Score=67, Evalue=8e-13,
Organism=Escherichia coli, GI87081834, Length=215, Percent_Identity=30.2325581395349, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1788761, Length=168, Percent_Identity=27.9761904761905, Blast_Score=65, Evalue=2e-12,
Organism=Escherichia coli, GI1787105, Length=183, Percent_Identity=27.3224043715847, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1788210, Length=186, Percent_Identity=28.494623655914, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI48994943, Length=170, Percent_Identity=30, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1788897, Length=185, Percent_Identity=31.8918918918919, Blast_Score=64, Evalue=6e-12,
Organism=Escherichia coli, GI48995001, Length=186, Percent_Identity=27.9569892473118, Blast_Score=63, Evalue=1e-11,
Organism=Escherichia coli, GI1787370, Length=185, Percent_Identity=28.1081081081081, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1787029, Length=198, Percent_Identity=28.7878787878788, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1787112, Length=195, Percent_Identity=29.7435897435897, Blast_Score=62, Evalue=2e-11,
Organism=Escherichia coli, GI87081791, Length=176, Percent_Identity=28.4090909090909, Blast_Score=62, Evalue=2e-11,
Organism=Escherichia coli, GI1786345, Length=193, Percent_Identity=30.0518134715026, Blast_Score=62, Evalue=3e-11,
Organism=Escherichia coli, GI1786803, Length=202, Percent_Identity=30.1980198019802, Blast_Score=62, Evalue=4e-11,
Organism=Escherichia coli, GI1786563, Length=172, Percent_Identity=30.8139534883721, Blast_Score=61, Evalue=5e-11,
Organism=Escherichia coli, GI1787041, Length=154, Percent_Identity=33.1168831168831, Blast_Score=60, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI115533608, Length=174, Percent_Identity=25.8620689655172, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71983523, Length=184, Percent_Identity=29.3478260869565, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71983516, Length=184, Percent_Identity=29.3478260869565, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71983510, Length=184, Percent_Identity=29.3478260869565, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI212646699, Length=191, Percent_Identity=28.2722513089005, Blast_Score=66, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71992285, Length=192, Percent_Identity=31.7708333333333, Blast_Score=65, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI25146777, Length=184, Percent_Identity=29.3478260869565, Blast_Score=64, Evalue=5e-11,
Organism=Drosophila melanogaster, GI19920532, Length=188, Percent_Identity=29.7872340425532, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24580930, Length=188, Percent_Identity=29.7872340425532, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI161076682, Length=194, Percent_Identity=30.4123711340206, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI161076684, Length=194, Percent_Identity=30.4123711340206, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24581617, Length=194, Percent_Identity=30.4123711340206, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24581615, Length=194, Percent_Identity=30.4123711340206, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24666092, Length=180, Percent_Identity=27.7777777777778, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI85724864, Length=209, Percent_Identity=30.622009569378, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24580555, Length=209, Percent_Identity=30.622009569378, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI85816269, Length=209, Percent_Identity=30.622009569378, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24580553, Length=209, Percent_Identity=30.622009569378, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI221500365, Length=187, Percent_Identity=26.7379679144385, Blast_Score=64, Evalue=5e-11,
Organism=Drosophila melanogaster, GI116007184, Length=187, Percent_Identity=26.7379679144385, Blast_Score=64, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CCMA_AGRT5 (Q8UC12)

Other databases:

- EMBL:   AE007869
- PIR:   AE2906
- PIR:   F97681
- RefSeq:   NP_355622.1
- ProteinModelPortal:   Q8UC12
- SMR:   Q8UC12
- STRING:   Q8UC12
- GeneID:   1134724
- GenomeReviews:   AE007869_GR
- KEGG:   atu:Atu2686
- eggNOG:   COG4133
- HOGENOM:   HBG758042
- OMA:   SARRGED
- PhylomeDB:   Q8UC12
- ProtClustDB:   PRK13539
- BioCyc:   ATUM176299-1:ATU2686-MONOMER
- HAMAP:   MF_01707
- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR005895
- InterPro:   IPR003593
- PANTHER:   PTHR19222:SF5
- SMART:   SM00382
- TIGRFAMs:   TIGR01189

Pfam domain/function: PF00005 ABC_tran

EC number: =3.6.3.41

Molecular weight: Translated: 23039; Mature: 23039

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: PS00211 ABC_TRANSPORTER_1; PS50893 ABC_TRANSPORTER_2; PS51243 CCMA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLTAENLGVRRGEDFIFMNISFKLSDGEALVLTGRNGSGKSTLLRTVAGLLRPEQGRVK
CCCCCCCCCCCCCCCEEEEEEEEEECCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCEE
IAGEGIDAEMRPSEAFHYLGHRNAMKTELTVAENLRFWKDFLGDFPGSTGVAIDEAAAIV
EEECCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
GLAGITHLPFGYLSAGQQRRFAMAKLLVAWRPVWILDEPTAALDRAADAMFTDLVKSHLG
HHHHHHHCCCHHHCCCCHHHHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHHHHCC
KGGIVLAATHQPLGLEKAQELQMTGFAGVETWA
CCCEEEEECCCCCCCCHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MDLTAENLGVRRGEDFIFMNISFKLSDGEALVLTGRNGSGKSTLLRTVAGLLRPEQGRVK
CCCCCCCCCCCCCCCEEEEEEEEEECCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCEE
IAGEGIDAEMRPSEAFHYLGHRNAMKTELTVAENLRFWKDFLGDFPGSTGVAIDEAAAIV
EEECCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
GLAGITHLPFGYLSAGQQRRFAMAKLLVAWRPVWILDEPTAALDRAADAMFTDLVKSHLG
HHHHHHHCCCHHHCCCCHHHHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHHHHCC
KGGIVLAATHQPLGLEKAQELQMTGFAGVETWA
CCCEEEEECCCCCCCCHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194