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The map label for this gene is atpA

Identifier: 15889879

GI number: 15889879

Start: 2607105

End: 2608634

Strand: Reverse

Name: atpA

Synonym: Atu2624

Alternate gene names: 15889879

Gene position: 2608634-2607105 (Counterclockwise)

Preceding gene: 159185298

Following gene: 15889878

Centisome position: 91.8

GC content: 58.89

Gene sequence:

>1530_bases
ATGGATATCCGCGCCGCGGAAATTTCCGCAATTCTGAAAGATCAAATCAAAAATTTCGGCAACGAGGCGGAAGTCTCGGA
AGTCGGTCAGGTGCTTTCCGTCGGTGACGGTATCGCCCGCGTTTATGGCCTCGACAATGTTCAGGCCGGCGAAATGGTCG
AGTTTCCCGGCGGCATTCGCGGCATGGCGCTCAACCTCGAAGCCGACAACGTCGGTGTGGTTATCTTCGGCTCGGACCGT
TCCATCAAGGAAGGCGACACCGTAAAGCGGACTGGCGCTATCGTTGACGTTCCCGTCGGTCCGGAACTGCTTGGCCGCGT
CGTCGACGCGCTCGGCAACCCGATCGACGGCAAGGGCCCGATCAATGCCGCCAAGCGTTCGCGCGTTGACGTCAAGGCTC
CCGGCATCATTCCGCGCAAGTCGGTCCATGAGCCGATGTCGACCGGCCTCAAGGCCATCGACGCGCTCATCCCGGTTGGC
CGCGGCCAGCGCGAGCTCGTCATCGGCGACCGCCAGACCGGCAAGACCGCCATCATTCTCGACACGATCCTGAACCAGAA
GGCCATTCACGACAATGGTCCTGACGGCGACAAGCTTTATTGCGTCTACGTCGCTATCGGTCAGAAGCGTTCGACCGTTG
CCCAGTTCGTAAAGGTTCTGGAAGAACGCGGTGCGCTGCAGTACTCGATCATCGTTGCCGCAACGGCTTCCGATCCGGCT
CCGATGCAGTACCTCGCTCCGTTTGCCGGTTGCGCCATGGGCGAATATTTCCGTGACAACGGCAAGCACGCTCTCATCGG
TTACGACGACCTTTCCAAGCAGGCCGTTGCCTATCGTCAGATGTCGCTTCTGCTGCGTCGTCCTCCGGGCCGCGAAGCTT
ATCCGGGCGACGTTTTCTACCTTCACTCCCGTCTTCTCGAGCGCGCTGCAAAGCTCTCCGACGAAATGGGCGCTGGTTCG
TTGACGGCACTGCCTGTTATCGAAACCCAGGGTAACGACGTTTCGGCCTTCATTCCGACCAACGTGATCTCGATCACCGA
CGGCCAGATCTTCCTCGAAACCGACCTGTTCTATCAGGGTATCCGTCCGGCTGTTAACGTCGGTCTGTCGGTTTCGCGTG
TTGGTTCCGCCGCTCAGATCAAGGCGATGAAGCAGGTTGCCGGTTCGATCAAGGGTGAACTCGCCCAGTATCGCGAAATG
GCTGCTTTTGCTCAGTTCGGTTCGGACCTTGACGCTTCCACGCAGCGCCTGCTTAACCGCGGTGCCCGCCTGACAGAGCT
TCTGAAGCAGCCGCAGTTCTCTCCGCTCAAGACGGAAGAGCAGGTTGCGGTGATCTTCGCTGGTGTCAACGGTTACCTTG
ACAAGATTCCGGTCGCACAGGTCGGCAAGTTCGAGCAGGGTTTCCTCTCCTACCTCCGCTCGGAAGGTAAGGCGATCCTC
GACACCATCCGCACGGAAAAGGCTATCAGCGACGATACCAAGGGCAAGCTCAAGGGCGCTCTTGATAACTTCGCCAAGTC
TTTCTCTTAA

Upstream 100 bases:

>100_bases
TCCTCGGTGGCCTGATCGTCAAGGTCGGTTCGCGCCAGATCGATACGTCTCTTCGCACCAAACTTTCCACCCTTAAGCTT
GCACTGAAAGAGGTTGGCTG

Downstream 100 bases:

>100_bases
ATCAGGGCTCTTTTACTCGGACGGATAACGGATGCCTTCACTAAAGGATCTGAAAAACCGCATTGCCTCCGTGAAGGCGA
CGCAGAAGATTACCAAGGCG

Product: F0F1 ATP synthase subunit alpha

Products: NA

Alternate protein names: ATP synthase F1 sector subunit alpha; F-ATPase subunit alpha

Number of amino acids: Translated: 509; Mature: 509

Protein sequence:

>509_residues
MDIRAAEISAILKDQIKNFGNEAEVSEVGQVLSVGDGIARVYGLDNVQAGEMVEFPGGIRGMALNLEADNVGVVIFGSDR
SIKEGDTVKRTGAIVDVPVGPELLGRVVDALGNPIDGKGPINAAKRSRVDVKAPGIIPRKSVHEPMSTGLKAIDALIPVG
RGQRELVIGDRQTGKTAIILDTILNQKAIHDNGPDGDKLYCVYVAIGQKRSTVAQFVKVLEERGALQYSIIVAATASDPA
PMQYLAPFAGCAMGEYFRDNGKHALIGYDDLSKQAVAYRQMSLLLRRPPGREAYPGDVFYLHSRLLERAAKLSDEMGAGS
LTALPVIETQGNDVSAFIPTNVISITDGQIFLETDLFYQGIRPAVNVGLSVSRVGSAAQIKAMKQVAGSIKGELAQYREM
AAFAQFGSDLDASTQRLLNRGARLTELLKQPQFSPLKTEEQVAVIFAGVNGYLDKIPVAQVGKFEQGFLSYLRSEGKAIL
DTIRTEKAISDDTKGKLKGALDNFAKSFS

Sequences:

>Translated_509_residues
MDIRAAEISAILKDQIKNFGNEAEVSEVGQVLSVGDGIARVYGLDNVQAGEMVEFPGGIRGMALNLEADNVGVVIFGSDR
SIKEGDTVKRTGAIVDVPVGPELLGRVVDALGNPIDGKGPINAAKRSRVDVKAPGIIPRKSVHEPMSTGLKAIDALIPVG
RGQRELVIGDRQTGKTAIILDTILNQKAIHDNGPDGDKLYCVYVAIGQKRSTVAQFVKVLEERGALQYSIIVAATASDPA
PMQYLAPFAGCAMGEYFRDNGKHALIGYDDLSKQAVAYRQMSLLLRRPPGREAYPGDVFYLHSRLLERAAKLSDEMGAGS
LTALPVIETQGNDVSAFIPTNVISITDGQIFLETDLFYQGIRPAVNVGLSVSRVGSAAQIKAMKQVAGSIKGELAQYREM
AAFAQFGSDLDASTQRLLNRGARLTELLKQPQFSPLKTEEQVAVIFAGVNGYLDKIPVAQVGKFEQGFLSYLRSEGKAIL
DTIRTEKAISDDTKGKLKGALDNFAKSFS
>Mature_509_residues
MDIRAAEISAILKDQIKNFGNEAEVSEVGQVLSVGDGIARVYGLDNVQAGEMVEFPGGIRGMALNLEADNVGVVIFGSDR
SIKEGDTVKRTGAIVDVPVGPELLGRVVDALGNPIDGKGPINAAKRSRVDVKAPGIIPRKSVHEPMSTGLKAIDALIPVG
RGQRELVIGDRQTGKTAIILDTILNQKAIHDNGPDGDKLYCVYVAIGQKRSTVAQFVKVLEERGALQYSIIVAATASDPA
PMQYLAPFAGCAMGEYFRDNGKHALIGYDDLSKQAVAYRQMSLLLRRPPGREAYPGDVFYLHSRLLERAAKLSDEMGAGS
LTALPVIETQGNDVSAFIPTNVISITDGQIFLETDLFYQGIRPAVNVGLSVSRVGSAAQIKAMKQVAGSIKGELAQYREM
AAFAQFGSDLDASTQRLLNRGARLTELLKQPQFSPLKTEEQVAVIFAGVNGYLDKIPVAQVGKFEQGFLSYLRSEGKAIL
DTIRTEKAISDDTKGKLKGALDNFAKSFS

Specific function: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit

COG id: COG0056

COG function: function code C; F0F1-type ATP synthase, alpha subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase alpha/beta chains family

Homologues:

Organism=Homo sapiens, GI50345984, Length=503, Percent_Identity=71.7693836978131, Blast_Score=746, Evalue=0.0,
Organism=Homo sapiens, GI4757810, Length=503, Percent_Identity=71.7693836978131, Blast_Score=746, Evalue=0.0,
Organism=Homo sapiens, GI19913426, Length=355, Percent_Identity=28.169014084507, Blast_Score=112, Evalue=1e-24,
Organism=Homo sapiens, GI19913428, Length=351, Percent_Identity=27.3504273504274, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI32189394, Length=416, Percent_Identity=25, Blast_Score=107, Evalue=3e-23,
Organism=Escherichia coli, GI1790172, Length=520, Percent_Identity=55.3846153846154, Blast_Score=573, Evalue=1e-165,
Organism=Escherichia coli, GI1790170, Length=426, Percent_Identity=25.3521126760563, Blast_Score=111, Evalue=9e-26,
Organism=Escherichia coli, GI1788251, Length=304, Percent_Identity=29.6052631578947, Blast_Score=107, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI71988063, Length=503, Percent_Identity=72.3658051689861, Blast_Score=751, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71988080, Length=503, Percent_Identity=72.3658051689861, Blast_Score=749, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71988074, Length=503, Percent_Identity=66.7992047713718, Blast_Score=680, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17570191, Length=334, Percent_Identity=26.3473053892216, Blast_Score=112, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI17510931, Length=297, Percent_Identity=27.9461279461279, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI25144756, Length=377, Percent_Identity=24.9336870026525, Blast_Score=102, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI71988068, Length=76, Percent_Identity=57.8947368421053, Blast_Score=95, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17509265, Length=50, Percent_Identity=66, Blast_Score=82, Evalue=9e-16,
Organism=Saccharomyces cerevisiae, GI6319370, Length=502, Percent_Identity=71.3147410358566, Blast_Score=747, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6319603, Length=354, Percent_Identity=29.3785310734463, Blast_Score=124, Evalue=4e-29,
Organism=Saccharomyces cerevisiae, GI6322581, Length=404, Percent_Identity=25.2475247524752, Blast_Score=110, Evalue=4e-25,
Organism=Drosophila melanogaster, GI24658560, Length=505, Percent_Identity=72.0792079207921, Blast_Score=749, Evalue=0.0,
Organism=Drosophila melanogaster, GI281361666, Length=340, Percent_Identity=27.6470588235294, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24646341, Length=340, Percent_Identity=27.6470588235294, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI17136796, Length=340, Percent_Identity=27.6470588235294, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24638766, Length=421, Percent_Identity=25.41567695962, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI28574560, Length=415, Percent_Identity=25.7831325301205, Blast_Score=97, Evalue=3e-20,

Paralogues:

None

Copy number: 9,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): ATPA_AGRT5 (Q8UC74)

Other databases:

- EMBL:   AE007869
- PIR:   AG2898
- PIR:   H97673
- RefSeq:   NP_355560.1
- ProteinModelPortal:   Q8UC74
- SMR:   Q8UC74
- STRING:   Q8UC74
- GeneID:   1134662
- GenomeReviews:   AE007869_GR
- KEGG:   atu:Atu2624
- eggNOG:   COG0056
- HOGENOM:   HBG565875
- OMA:   GSDRDIK
- PhylomeDB:   Q8UC74
- ProtClustDB:   PRK09281
- BioCyc:   ATUM176299-1:ATU2624-MONOMER
- HAMAP:   MF_01346
- InterPro:   IPR020003
- InterPro:   IPR000194
- InterPro:   IPR005294
- InterPro:   IPR017458
- InterPro:   IPR018118
- InterPro:   IPR000793
- InterPro:   IPR004100
- PANTHER:   PTHR15184:SF3
- TIGRFAMs:   TIGR00962

Pfam domain/function: PF00006 ATP-synt_ab; PF00306 ATP-synt_ab_C; PF02874 ATP-synt_ab_N; SSF47917 ATPase_a/b_C; SSF50615 ATPase_a/b_N

EC number: =3.6.3.14

Molecular weight: Translated: 54624; Mature: 54624

Theoretical pI: Translated: 6.96; Mature: 6.96

Prosite motif: PS00152 ATPASE_ALPHA_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIRAAEISAILKDQIKNFGNEAEVSEVGQVLSVGDGIARVYGLDNVQAGEMVEFPGGIR
CCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCHHHHHCCCCCCCCCEEECCCCCC
GMALNLEADNVGVVIFGSDRSIKEGDTVKRTGAIVDVPVGPELLGRVVDALGNPIDGKGP
EEEEEEECCCEEEEEECCCCCCCCCCCEECCCCEEECCCCHHHHHHHHHHHCCCCCCCCC
INAAKRSRVDVKAPGIIPRKSVHEPMSTGLKAIDALIPVGRGQRELVIGDRQTGKTAIIL
CCHHHHCCCCCCCCCCCCCHHHCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCEEEEE
DTILNQKAIHDNGPDGDKLYCVYVAIGQKRSTVAQFVKVLEERGALQYSIIVAATASDPA
HHHHCCHHCCCCCCCCCEEEEEEEEECCCHHHHHHHHHHHHHCCCEEEEEEEEEECCCCC
PMQYLAPFAGCAMGEYFRDNGKHALIGYDDLSKQAVAYRQMSLLLRRPPGREAYPGDVFY
CHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHH
LHSRLLERAAKLSDEMGAGSLTALPVIETQGNDVSAFIPTNVISITDGQIFLETDLFYQG
HHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCEEEEECCCEEEEECCEEEEEEHHHHHC
IRPAVNVGLSVSRVGSAAQIKAMKQVAGSIKGELAQYREMAAFAQFGSDLDASTQRLLNR
CCHHHHCCEEHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHC
GARLTELLKQPQFSPLKTEEQVAVIFAGVNGYLDKIPVAQVGKFEQGFLSYLRSEGKAIL
CHHHHHHHHCCCCCCCCCCCCEEEEEECCCCHHHCCCHHHHCCHHHHHHHHHHHCCHHHH
DTIRTEKAISDDTKGKLKGALDNFAKSFS
HHHHHHHHCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDIRAAEISAILKDQIKNFGNEAEVSEVGQVLSVGDGIARVYGLDNVQAGEMVEFPGGIR
CCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCHHHHHCCCCCCCCCEEECCCCCC
GMALNLEADNVGVVIFGSDRSIKEGDTVKRTGAIVDVPVGPELLGRVVDALGNPIDGKGP
EEEEEEECCCEEEEEECCCCCCCCCCCEECCCCEEECCCCHHHHHHHHHHHCCCCCCCCC
INAAKRSRVDVKAPGIIPRKSVHEPMSTGLKAIDALIPVGRGQRELVIGDRQTGKTAIIL
CCHHHHCCCCCCCCCCCCCHHHCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCEEEEE
DTILNQKAIHDNGPDGDKLYCVYVAIGQKRSTVAQFVKVLEERGALQYSIIVAATASDPA
HHHHCCHHCCCCCCCCCEEEEEEEEECCCHHHHHHHHHHHHHCCCEEEEEEEEEECCCCC
PMQYLAPFAGCAMGEYFRDNGKHALIGYDDLSKQAVAYRQMSLLLRRPPGREAYPGDVFY
CHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHH
LHSRLLERAAKLSDEMGAGSLTALPVIETQGNDVSAFIPTNVISITDGQIFLETDLFYQG
HHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCEEEEECCCEEEEECCEEEEEEHHHHHC
IRPAVNVGLSVSRVGSAAQIKAMKQVAGSIKGELAQYREMAAFAQFGSDLDASTQRLLNR
CCHHHHCCEEHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHC
GARLTELLKQPQFSPLKTEEQVAVIFAGVNGYLDKIPVAQVGKFEQGFLSYLRSEGKAIL
CHHHHHHHHCCCCCCCCCCCCEEEEEECCCCHHHCCCHHHHCCHHHHHHHHHHHCCHHHH
DTIRTEKAISDDTKGKLKGALDNFAKSFS
HHHHHHHHCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194