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The map label for this gene is lldA [H]

Identifier: 15889595

GI number: 15889595

Start: 2296021

End: 2297169

Strand: Direct

Name: lldA [H]

Synonym: Atu2318

Alternate gene names: 15889595

Gene position: 2296021-2297169 (Clockwise)

Preceding gene: 159185156

Following gene: 159185157

Centisome position: 80.8

GC content: 60.84

Gene sequence:

>1149_bases
GTGAAGGCTTTATCCATGGGCAAAATCCTGACCATAGCGGACCTGAAGCAACAGGCTCAGCGTCGTGTGCCGAAAATGTT
CTTCGACTATGCCGATAGCGGCGCGTGGACGGAAAGCACCTACCGCGCCAATGAGGATGATTTTGCCAAGATAAAGCTGC
GCCAGCGCGTGCTGGTGGATATGACTGACCGGTCGCTGGCCACAGAAATGGTTGGCGAGAAGGTTTCGATGCCGGTCGCG
CTCTCCCCCACCGGGCTCACCGGCATGCAGCACGCCGATGGCGAAATGCTGGCCGCAAAAGCGGCGGAGGAATTCGGCGT
GCCCTTCACGCTCTCCACCATGAGCATCTGCTCCATCGAGGATGTCGCCTCGGTCACGTCAAAACCCTTCTGGTTCCAGC
TTTACGTGATGAAGGACCGCGACTTCGTCAATAATCTCATCGACCGCGCCAAGGCAGCGGGATGCTCGGCGCTGGTGCTG
ACGCTCGACCTGCAAATCCTCGGCCAGCGCCACAAGGATTTGCGCAACGGCCTGTCCGCGCCGCCGAAATTCACCCCCAA
ACATATCTGGCAGATGGCGACCCGGCCGCAATGGTGCATGGACATGGCGCGCACCAAGCGCCGCAGCTTCGGCAATATCG
TCGGCCATGCGAAAAACGTGTCCGACCTTTCATCGCTCTCCACCTGGACGGCCGAACAATTCGATCCGCGCCTGTCCTGG
CAGGACGTCGAATGGATCAAGCAACGCTGGGGCGGCAAGCTGATCCTCAAGGGTATCCTTGACGAGGAAGATGCCCGCGC
CGCGATCGATACCGGCGCCGATGCCATCATCGTCTCCAACCATGGCGGCCGCCAGCTCGACGGCGCCCATTCCTCCATCG
CCATGCTGCCGAAGATCGTCGATGCCGTTGGTGACAGGATCGAAGTGCACATGGATGGTGGCATCCGCTCCGGCCAGGAT
GTGTTGAAGGCGGTCGCACTTGGTGCCAGGGGCACCTATATCGGCCGCCCCTTCCTCTACGGCCTTGGCGCCGGCGGAAA
ACAGGGCGTGACAACGGCGCTCGAGATCATTCGCAAGGAACTGGATATCAGCATGGCGCTCTGCGGCAAGCGGCTGATCA
CGGATGTGGACCGCAGCATTCTGGCTTGA

Upstream 100 bases:

>100_bases
CTCTGATTTCTAGATACAAGCGATTCAAAAAACCCTAAAACTACGATCGACGAACTCGCGCATCCAAATAGAATATGCTA
GGTGAAGCCATCATTCAAAT

Downstream 100 bases:

>100_bases
TGGTGACGTGGAGTAGATGGGCAGGGCCTCAGAGCCGATGCGCCATAAAGTCCCGCCCTGCGCTGCCTCCCTCATCCCTG
TGCCTGTCACAGGGATCCAG

Product: L-lactate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 382; Mature: 382

Protein sequence:

>382_residues
MKALSMGKILTIADLKQQAQRRVPKMFFDYADSGAWTESTYRANEDDFAKIKLRQRVLVDMTDRSLATEMVGEKVSMPVA
LSPTGLTGMQHADGEMLAAKAAEEFGVPFTLSTMSICSIEDVASVTSKPFWFQLYVMKDRDFVNNLIDRAKAAGCSALVL
TLDLQILGQRHKDLRNGLSAPPKFTPKHIWQMATRPQWCMDMARTKRRSFGNIVGHAKNVSDLSSLSTWTAEQFDPRLSW
QDVEWIKQRWGGKLILKGILDEEDARAAIDTGADAIIVSNHGGRQLDGAHSSIAMLPKIVDAVGDRIEVHMDGGIRSGQD
VLKAVALGARGTYIGRPFLYGLGAGGKQGVTTALEIIRKELDISMALCGKRLITDVDRSILA

Sequences:

>Translated_382_residues
MKALSMGKILTIADLKQQAQRRVPKMFFDYADSGAWTESTYRANEDDFAKIKLRQRVLVDMTDRSLATEMVGEKVSMPVA
LSPTGLTGMQHADGEMLAAKAAEEFGVPFTLSTMSICSIEDVASVTSKPFWFQLYVMKDRDFVNNLIDRAKAAGCSALVL
TLDLQILGQRHKDLRNGLSAPPKFTPKHIWQMATRPQWCMDMARTKRRSFGNIVGHAKNVSDLSSLSTWTAEQFDPRLSW
QDVEWIKQRWGGKLILKGILDEEDARAAIDTGADAIIVSNHGGRQLDGAHSSIAMLPKIVDAVGDRIEVHMDGGIRSGQD
VLKAVALGARGTYIGRPFLYGLGAGGKQGVTTALEIIRKELDISMALCGKRLITDVDRSILA
>Mature_382_residues
MKALSMGKILTIADLKQQAQRRVPKMFFDYADSGAWTESTYRANEDDFAKIKLRQRVLVDMTDRSLATEMVGEKVSMPVA
LSPTGLTGMQHADGEMLAAKAAEEFGVPFTLSTMSICSIEDVASVTSKPFWFQLYVMKDRDFVNNLIDRAKAAGCSALVL
TLDLQILGQRHKDLRNGLSAPPKFTPKHIWQMATRPQWCMDMARTKRRSFGNIVGHAKNVSDLSSLSTWTAEQFDPRLSW
QDVEWIKQRWGGKLILKGILDEEDARAAIDTGADAIIVSNHGGRQLDGAHSSIAMLPKIVDAVGDRIEVHMDGGIRSGQD
VLKAVALGARGTYIGRPFLYGLGAGGKQGVTTALEIIRKELDISMALCGKRLITDVDRSILA

Specific function: Unknown

COG id: COG1304

COG function: function code C; L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FMN hydroxy acid dehydrogenase domain [H]

Homologues:

Organism=Homo sapiens, GI11068137, Length=377, Percent_Identity=36.3395225464191, Blast_Score=267, Evalue=1e-71,
Organism=Homo sapiens, GI54234014, Length=374, Percent_Identity=36.096256684492, Blast_Score=234, Evalue=1e-61,
Organism=Homo sapiens, GI7705393, Length=374, Percent_Identity=36.096256684492, Blast_Score=234, Evalue=1e-61,
Organism=Escherichia coli, GI1790033, Length=374, Percent_Identity=46.524064171123, Blast_Score=356, Evalue=2e-99,
Organism=Caenorhabditis elegans, GI193208036, Length=373, Percent_Identity=36.9973190348526, Blast_Score=236, Evalue=1e-62,
Organism=Caenorhabditis elegans, GI32566217, Length=290, Percent_Identity=33.7931034482759, Blast_Score=155, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6323587, Length=387, Percent_Identity=32.2997416020672, Blast_Score=200, Evalue=3e-52,
Organism=Drosophila melanogaster, GI78707188, Length=374, Percent_Identity=36.096256684492, Blast_Score=241, Evalue=7e-64,
Organism=Drosophila melanogaster, GI281363140, Length=374, Percent_Identity=36.096256684492, Blast_Score=241, Evalue=7e-64,
Organism=Drosophila melanogaster, GI78707190, Length=374, Percent_Identity=36.096256684492, Blast_Score=241, Evalue=7e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012133
- InterPro:   IPR000262
- InterPro:   IPR008259
- InterPro:   IPR020920 [H]

Pfam domain/function: PF01070 FMN_dh [H]

EC number: =1.1.2.3 [H]

Molecular weight: Translated: 42027; Mature: 42027

Theoretical pI: Translated: 8.87; Mature: 8.87

Prosite motif: PS00557 FMN_HYDROXY_ACID_DH ; PS00141 ASP_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKALSMGKILTIADLKQQAQRRVPKMFFDYADSGAWTESTYRANEDDFAKIKLRQRVLVD
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHC
MTDRSLATEMVGEKVSMPVALSPTGLTGMQHADGEMLAAKAAEEFGVPFTLSTMSICSIE
CCHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCHHHHHHHHHHHCCCEEECCHHHHHHH
DVASVTSKPFWFQLYVMKDRDFVNNLIDRAKAAGCSALVLTLDLQILGQRHKDLRNGLSA
HHHHHHCCCEEEEEEEECCHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHCCCCC
PPKFTPKHIWQMATRPQWCMDMARTKRRSFGNIVGHAKNVSDLSSLSTWTAEQFDPRLSW
CCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCC
QDVEWIKQRWGGKLILKGILDEEDARAAIDTGADAIIVSNHGGRQLDGAHSSIAMLPKIV
CHHHHHHHHCCCEEEEEECCCCCHHHHHHCCCCCEEEEECCCCCCCCCCHHHHHHHHHHH
DAVGDRIEVHMDGGIRSGQDVLKAVALGARGTYIGRPFLYGLGAGGKQGVTTALEIIRKE
HHCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCCCCHHHEECCCCCCCHHHHHHHHHHHH
LDISMALCGKRLITDVDRSILA
HHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKALSMGKILTIADLKQQAQRRVPKMFFDYADSGAWTESTYRANEDDFAKIKLRQRVLVD
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHC
MTDRSLATEMVGEKVSMPVALSPTGLTGMQHADGEMLAAKAAEEFGVPFTLSTMSICSIE
CCHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCHHHHHHHHHHHCCCEEECCHHHHHHH
DVASVTSKPFWFQLYVMKDRDFVNNLIDRAKAAGCSALVLTLDLQILGQRHKDLRNGLSA
HHHHHHCCCEEEEEEEECCHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHCCCCC
PPKFTPKHIWQMATRPQWCMDMARTKRRSFGNIVGHAKNVSDLSSLSTWTAEQFDPRLSW
CCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCC
QDVEWIKQRWGGKLILKGILDEEDARAAIDTGADAIIVSNHGGRQLDGAHSSIAMLPKIV
CHHHHHHHHCCCEEEEEECCCCCHHHHHHCCCCCEEEEECCCCCCCCCCHHHHHHHHHHH
DAVGDRIEVHMDGGIRSGQDVLKAVALGARGTYIGRPFLYGLGAGGKQGVTTALEIIRKE
HHCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCCCCHHHEECCCCCCCHHHHHHHHHHHH
LDISMALCGKRLITDVDRSILA
HHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA