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The map label for this gene is pbpB1 [H]

Identifier: 15889384

GI number: 15889384

Start: 2065236

End: 2066978

Strand: Reverse

Name: pbpB1 [H]

Synonym: Atu2100

Alternate gene names: 15889384

Gene position: 2066978-2065236 (Counterclockwise)

Preceding gene: 159185047

Following gene: 159185046

Centisome position: 72.74

GC content: 61.79

Gene sequence:

>1743_bases
ATGTCTTTCCTTTCCCGTGTCATGGTCCTGAAGAGCAAGGCTCACTTTTCCGCCAGCACCACCGGTGTCTATACCGACCA
CGCTGCTTTTGAGGGCGCCCGCAAGAAGCGCGCTGCCCAGGCGAAAAGCCGCGTCGGCCTTCTCATTTTCGGTTTCATCG
CCTTTTATGCCGTCGTCGGTGGTCGTCTGGTGCAATATGGCATGGCGGAACAGGAAACGGTGTCGAGCATCGCGCCCGCA
GACCGGCTGATGGCGTCGCGCCCCGATCTCCTCGACCGCAACGGCGAGGTGCTGGCCACCGATATCCGCACCGTCTCGCT
GTTTGCCGAGCCGCATCGCATTGTCGATATCGACGAGGCCATCGAAAAGCTGCGCACCGTGCTGCCTGACCTCGACCAGC
GCGGCACCTATCAGAAGCTCACCTCCAATTCGCGTTTCCAGTGGCTGCGCCGTCAGCTGACGCCGAAGCAGCAGAGCCAG
ATTCTGGCGCTCGGCATTCCCGGCGTCGGGTTCCGCCCGGAAAAGCGTCGCTTTTATCCCGGTGGGCCGACCGCCGCCCA
TGTCGTCGGCCACGTCAACATCGACAATCGCGGTGTTGCCGGCATGGAACGTTACGTCGACAGCCAGGGGCTGGCCGATC
TGACGGCGCTCGGCATGACCAGCGACCAGCCGCTGGAACCGGTGAAGCTTTCGATCGATCTGCGCGTGCAGTCCATCGTG
CGTGAAGTCGTGACGGCGGCGATCGCCAAGTTCCAGGCGATCGGTGCGGGTGCCGTGGTTCTGGATGTGCATACCGGTGA
AGTTCTCGCCATGGCCTCGGTGCCGGATTACGATCCGAACAACCCGGCCGAAGGCGCCAAGGAAGGCTGGCTCAACCGCA
TGTCGAACGGCACGTTCGAAATGGGGTCCACCTTCAAGTCCTTCACGATTGCCATGGGTCTCGATTCGGGCCGCGTCCGT
CTCGGTGATATGTTCGATGCGCGTTATCCGATCCGCATCGGCGGCTTCACCATCAAGGACTTCCACGGCAAGGGCCGGAT
GCTTTCGGTGCCGGAAATCTTCCAGTTTTCTTCGAATATCGGTACGGCCAAGATCGCCGACACCGTTGGTACCGAAGGCC
ACAAGGAATTCCTGACGCGGCTTGGCCTCCTGACCCGCATGCAGACCGAACTGCCGGAAGTGGCGTTGCCGTCGCAGCCG
CGCGAATGGAAGAAGATCAACTCCATCACCATTTCCTTCGGTCACGGTGTTTCCACGACACCGCTGCAGACGGCGGTTGC
CGGTGCGGCGCTCGTCAATGGTGGCAAGCTGATCGAGCCGACATTCCTGCCGCGTACCCGCGAACAGGCGGATCAGGTGG
CGAAACAGGTTCTGAAGCCTGGCGCCAGCAAGGATATGCGTTTCCTGTTCGAGTGGAACGGCGTCAACGGTTCCGGCCGC
AATGCGCGCGTCGACGGCTTCAACGTCGGCGGCAAGACCGGCACGGCTGATAAGGTCGTCAACGGACGTTACGTGCACGA
CAAGAACTTCAACGCTTTCCTGTCGGCCTTCCCGATGGATGACCCGCAATATGTGGTGCTGTCCTTCATCGATGAGCCGA
AGACGGACAAGGGCAACGGCGCGGCGCTTGCCGGCACGTCCGCAGCACCGATGGTGCACGACATCATCACCCGCACGGCG
GCGGTGCTGGGCGTGAAGCCGAAGTTCGGCAAGGATGGCTCGGCCTTGCTCGTGTCTTATTGA

Upstream 100 bases:

>100_bases
GTCCGGCGCCGGCGCCGACACCTGTACCGGTTGCCTCCGCCACCGCTGGCGATGAAACCGGCGAGATGGATGAAACCATA
ACAGGATCGGTGAACCGCTG

Downstream 100 bases:

>100_bases
TTGTTAGCTTATGATGTTCCGGCGATTCGCGCCGGGGGGACAAGACGGACACAGTCGATGAATTTGCGAGATATATCCGG
AAATGCGTTTCCGGAATTGA

Product: penicillin binding protein 2

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 580; Mature: 579

Protein sequence:

>580_residues
MSFLSRVMVLKSKAHFSASTTGVYTDHAAFEGARKKRAAQAKSRVGLLIFGFIAFYAVVGGRLVQYGMAEQETVSSIAPA
DRLMASRPDLLDRNGEVLATDIRTVSLFAEPHRIVDIDEAIEKLRTVLPDLDQRGTYQKLTSNSRFQWLRRQLTPKQQSQ
ILALGIPGVGFRPEKRRFYPGGPTAAHVVGHVNIDNRGVAGMERYVDSQGLADLTALGMTSDQPLEPVKLSIDLRVQSIV
REVVTAAIAKFQAIGAGAVVLDVHTGEVLAMASVPDYDPNNPAEGAKEGWLNRMSNGTFEMGSTFKSFTIAMGLDSGRVR
LGDMFDARYPIRIGGFTIKDFHGKGRMLSVPEIFQFSSNIGTAKIADTVGTEGHKEFLTRLGLLTRMQTELPEVALPSQP
REWKKINSITISFGHGVSTTPLQTAVAGAALVNGGKLIEPTFLPRTREQADQVAKQVLKPGASKDMRFLFEWNGVNGSGR
NARVDGFNVGGKTGTADKVVNGRYVHDKNFNAFLSAFPMDDPQYVVLSFIDEPKTDKGNGAALAGTSAAPMVHDIITRTA
AVLGVKPKFGKDGSALLVSY

Sequences:

>Translated_580_residues
MSFLSRVMVLKSKAHFSASTTGVYTDHAAFEGARKKRAAQAKSRVGLLIFGFIAFYAVVGGRLVQYGMAEQETVSSIAPA
DRLMASRPDLLDRNGEVLATDIRTVSLFAEPHRIVDIDEAIEKLRTVLPDLDQRGTYQKLTSNSRFQWLRRQLTPKQQSQ
ILALGIPGVGFRPEKRRFYPGGPTAAHVVGHVNIDNRGVAGMERYVDSQGLADLTALGMTSDQPLEPVKLSIDLRVQSIV
REVVTAAIAKFQAIGAGAVVLDVHTGEVLAMASVPDYDPNNPAEGAKEGWLNRMSNGTFEMGSTFKSFTIAMGLDSGRVR
LGDMFDARYPIRIGGFTIKDFHGKGRMLSVPEIFQFSSNIGTAKIADTVGTEGHKEFLTRLGLLTRMQTELPEVALPSQP
REWKKINSITISFGHGVSTTPLQTAVAGAALVNGGKLIEPTFLPRTREQADQVAKQVLKPGASKDMRFLFEWNGVNGSGR
NARVDGFNVGGKTGTADKVVNGRYVHDKNFNAFLSAFPMDDPQYVVLSFIDEPKTDKGNGAALAGTSAAPMVHDIITRTA
AVLGVKPKFGKDGSALLVSY
>Mature_579_residues
SFLSRVMVLKSKAHFSASTTGVYTDHAAFEGARKKRAAQAKSRVGLLIFGFIAFYAVVGGRLVQYGMAEQETVSSIAPAD
RLMASRPDLLDRNGEVLATDIRTVSLFAEPHRIVDIDEAIEKLRTVLPDLDQRGTYQKLTSNSRFQWLRRQLTPKQQSQI
LALGIPGVGFRPEKRRFYPGGPTAAHVVGHVNIDNRGVAGMERYVDSQGLADLTALGMTSDQPLEPVKLSIDLRVQSIVR
EVVTAAIAKFQAIGAGAVVLDVHTGEVLAMASVPDYDPNNPAEGAKEGWLNRMSNGTFEMGSTFKSFTIAMGLDSGRVRL
GDMFDARYPIRIGGFTIKDFHGKGRMLSVPEIFQFSSNIGTAKIADTVGTEGHKEFLTRLGLLTRMQTELPEVALPSQPR
EWKKINSITISFGHGVSTTPLQTAVAGAALVNGGKLIEPTFLPRTREQADQVAKQVLKPGASKDMRFLFEWNGVNGSGRN
ARVDGFNVGGKTGTADKVVNGRYVHDKNFNAFLSAFPMDDPQYVVLSFIDEPKTDKGNGAALAGTSAAPMVHDIITRTAA
VLGVKPKFGKDGSALLVSY

Specific function: Synthesis of cross-linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786272, Length=510, Percent_Identity=29.6078431372549, Blast_Score=192, Evalue=4e-50,
Organism=Escherichia coli, GI1786854, Length=500, Percent_Identity=25, Blast_Score=91, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 62859; Mature: 62728

Theoretical pI: Translated: 10.05; Mature: 10.05

Prosite motif: PS00146 BETA_LACTAMASE_A

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFLSRVMVLKSKAHFSASTTGVYTDHAAFEGARKKRAAQAKSRVGLLIFGFIAFYAVVG
CCHHHHHHHHHHHCCCCCCCCCEEECHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHC
GRLVQYGMAEQETVSSIAPADRLMASRPDLLDRNGEVLATDIRTVSLFAEPHRIVDIDEA
CHHHHHCCCHHHHHHHHCCHHHHHHCCCCHHCCCCCEEEEEEEEEEEEECCCEEEEHHHH
IEKLRTVLPDLDQRGTYQKLTSNSRFQWLRRQLTPKQQSQILALGIPGVGFRPEKRRFYP
HHHHHHHHCCCCCCCCHHHHHCCHHHHHHHHHCCCCHHCCEEEEECCCCCCCCCCCCCCC
GGPTAAHVVGHVNIDNRGVAGMERYVDSQGLADLTALGMTSDQPLEPVKLSIDLRVQSIV
CCCCEEEEEEEEECCCCCCHHHHHHHCCCCCHHHHHCCCCCCCCCCCEEEEEEHHHHHHH
REVVTAAIAKFQAIGAGAVVLDVHTGEVLAMASVPDYDPNNPAEGAKEGWLNRMSNGTFE
HHHHHHHHHHHHHCCCCEEEEEEECCCEEEEECCCCCCCCCCCCHHHHHHHHHHCCCCCC
MGSTFKSFTIAMGLDSGRVRLGDMFDARYPIRIGGFTIKDFHGKGRMLSVPEIFQFSSNI
CCCCCEEEEEEEECCCCCEEECCCCCCCCCEEECCEEEEEECCCCCEECCHHHHHHHCCC
GTAKIADTVGTEGHKEFLTRLGLLTRMQTELPEVALPSQPREWKKINSITISFGHGVSTT
CCEEHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCEEEEEECCCCCCC
PLQTAVAGAALVNGGKLIEPTFLPRTREQADQVAKQVLKPGASKDMRFLFEWNGVNGSGR
HHHHHHHHHHHCCCCCEECCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCC
NARVDGFNVGGKTGTADKVVNGRYVHDKNFNAFLSAFPMDDPQYVVLSFIDEPKTDKGNG
CEEECCEECCCCCCCHHHCCCCEEEECCCCCHHEEECCCCCCCEEEEEECCCCCCCCCCC
AALAGTSAAPMVHDIITRTAAVLGVKPKFGKDGSALLVSY
CEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEC
>Mature Secondary Structure 
SFLSRVMVLKSKAHFSASTTGVYTDHAAFEGARKKRAAQAKSRVGLLIFGFIAFYAVVG
CHHHHHHHHHHHCCCCCCCCCEEECHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHC
GRLVQYGMAEQETVSSIAPADRLMASRPDLLDRNGEVLATDIRTVSLFAEPHRIVDIDEA
CHHHHHCCCHHHHHHHHCCHHHHHHCCCCHHCCCCCEEEEEEEEEEEEECCCEEEEHHHH
IEKLRTVLPDLDQRGTYQKLTSNSRFQWLRRQLTPKQQSQILALGIPGVGFRPEKRRFYP
HHHHHHHHCCCCCCCCHHHHHCCHHHHHHHHHCCCCHHCCEEEEECCCCCCCCCCCCCCC
GGPTAAHVVGHVNIDNRGVAGMERYVDSQGLADLTALGMTSDQPLEPVKLSIDLRVQSIV
CCCCEEEEEEEEECCCCCCHHHHHHHCCCCCHHHHHCCCCCCCCCCCEEEEEEHHHHHHH
REVVTAAIAKFQAIGAGAVVLDVHTGEVLAMASVPDYDPNNPAEGAKEGWLNRMSNGTFE
HHHHHHHHHHHHHCCCCEEEEEEECCCEEEEECCCCCCCCCCCCHHHHHHHHHHCCCCCC
MGSTFKSFTIAMGLDSGRVRLGDMFDARYPIRIGGFTIKDFHGKGRMLSVPEIFQFSSNI
CCCCCEEEEEEEECCCCCEEECCCCCCCCCEEECCEEEEEECCCCCEECCHHHHHHHCCC
GTAKIADTVGTEGHKEFLTRLGLLTRMQTELPEVALPSQPREWKKINSITISFGHGVSTT
CCEEHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCEEEEEECCCCCCC
PLQTAVAGAALVNGGKLIEPTFLPRTREQADQVAKQVLKPGASKDMRFLFEWNGVNGSGR
HHHHHHHHHHHCCCCCEECCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCC
NARVDGFNVGGKTGTADKVVNGRYVHDKNFNAFLSAFPMDDPQYVVLSFIDEPKTDKGNG
CEEECCEECCCCCCCHHHCCCCEEEECCCCCHHEEECCCCCCCEEEEEECCCCCCCCCCC
AALAGTSAAPMVHDIITRTAAVLGVKPKFGKDGSALLVSY
CEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3126399 [H]