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The map label for this gene is pleC [H]

Identifier: 15889187

GI number: 15889187

Start: 1867187

End: 1868722

Strand: Direct

Name: pleC [H]

Synonym: Atu1888

Alternate gene names: 15889187

Gene position: 1867187-1868722 (Clockwise)

Preceding gene: 15889182

Following gene: 15889190

Centisome position: 65.71

GC content: 59.64

Gene sequence:

>1536_bases
ATGAGTAAAAGCGTCAGCACGTCCACCGACAAGATCATCGTCGACCGATCGAAGAAACACCGCAACAAGGCGGTTTTCGA
CACGGTGAAGACGACGCGTGAACGCCTGCAGCAGGGTGCCGGCGGAAACGAAGCCTATGAACGCGAAATGCTGACCATGC
ACATCGCCGAAGCCCTGCAGGGCGCGATGATCATGCCGCTTTTCATCGTGCTTGCCTCCATCATCGGCCTTTACATCACC
GGCGATATCAGCCTGATCATCTGGTCGCTGATTGCGCTGAGTTTTCACGCCATGTCGCTGGTGCTGGCGAAACGGGCCGC
CAAACAGGCGATCACCGACGACAATCTCCAGCATTGGAAAAACCTCTTTCTCGGCATGCAGATCCTCATCGGCTGCGCCT
GGGCCATGTTCGCACTGGCCGAACCGGTGCGCAACGACCCGACGCTCGTTCTTTTCTTCAAGGGATCGACGCTGCTGATC
GCCCTTTCGCTGACCGCCATGGCCAACTTCATGCTGCGGCGGGCAACCTTCATGACCTTCCTGCCGGTGCTGGCGGCGCT
GTGCATAACCTCGGCGATTTCGCGCGATCCCTTCGATGTCGGTCTGGCGCTGATGTTCGGCATGGCGATCCTCTTCTGTC
ATCGCATCACCAGCCGGCTTTACCAGACCAGCATCAAGCTCCTGTCCTCTCAGACGGAAAAGGACGACCTGATCGCCGAA
CTCGAGGTCGCCAATTCCGTGTCCGACGAAGCGCGGCGACGTGCTGAAGAGGCCAATCTGGCGAAATCGCGTTTTCTCGC
TTCCATGTCGCACGAGCTGCGCACGCCGCTCAACGCCATTCTCGGCTTTTCCGAGGTCATGTCGTCAGAGGTGCTCGGTC
CGCTCAACAACCCGCTCTACAAGGAATATTCCGGCGATATCCACCGCTCCGGCCAGCATCTGCTCGATCTCATCAACGAA
ATCCTCGACCTCTCACGCATCGAGGCCGGCCGCTACGATCTCAACGAGGAATCCATCTCCATGCTGGAAATCGCCGAGGA
TTGCATCGGCATGATCCAGCTGCGCGCCCGCGCCAAGAACATCAGGATTTCCCAGCAGTTCGAAGCCAGTCTGCCGCAAG
TCTGGGCCGATGAGAAATCCATCCGCCAGGTCATACTCAACCTGCTCTCCAATGCCGTGAAATTCACCCCGCAGGGCGGC
GAGATTCTCGTGAAGGCGGGCTGGACGGCGGGCGGTGGGCAATATGTGTCGATCAGGGATAACGGCCCCGGCATTCCGGA
AGATGAAATCCCCGTGGTGCTCTCGGCCTTCGGCCAGGGATCGATCGCGATCAAGAGCGCGGAACAGGGAACGGGCCTTG
GCCTGCCCATCGTTCAGGCCATTCTCGCCAAGCACGACGGCCAGTTCATCCTGAAATCGAAGTTGCGCGAAGGCACCGAA
GGCATCGCCATCCTGCCGGCAAAACGCGTTCTGCAAAGCCTGCCGGCGGTGGAAGAAACTCACGCCATCCAGCCGCGCCG
GCGGTCTTTCGCCTAG

Upstream 100 bases:

>100_bases
CAAACCCTTGTCAGAAATGGCAAACAAATCCTTTCACGGCAGCATCTTCTTAAGATTTTGGGCGTAGCCTGCAAGGGTTC
ATGTCACCTGCGTTGTAACA

Downstream 100 bases:

>100_bases
AGCGCACCAAAGCTCAGAAGAACAGCGTCGTCACCAGCGAATACAGCACGAAAAATCCGTTCGCCAGCAACAGACAGAAG
ACGGCAAAGGAGCCGAGATC

Product: two component sensor kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 511; Mature: 510

Protein sequence:

>511_residues
MSKSVSTSTDKIIVDRSKKHRNKAVFDTVKTTRERLQQGAGGNEAYEREMLTMHIAEALQGAMIMPLFIVLASIIGLYIT
GDISLIIWSLIALSFHAMSLVLAKRAAKQAITDDNLQHWKNLFLGMQILIGCAWAMFALAEPVRNDPTLVLFFKGSTLLI
ALSLTAMANFMLRRATFMTFLPVLAALCITSAISRDPFDVGLALMFGMAILFCHRITSRLYQTSIKLLSSQTEKDDLIAE
LEVANSVSDEARRRAEEANLAKSRFLASMSHELRTPLNAILGFSEVMSSEVLGPLNNPLYKEYSGDIHRSGQHLLDLINE
ILDLSRIEAGRYDLNEESISMLEIAEDCIGMIQLRARAKNIRISQQFEASLPQVWADEKSIRQVILNLLSNAVKFTPQGG
EILVKAGWTAGGGQYVSIRDNGPGIPEDEIPVVLSAFGQGSIAIKSAEQGTGLGLPIVQAILAKHDGQFILKSKLREGTE
GIAILPAKRVLQSLPAVEETHAIQPRRRSFA

Sequences:

>Translated_511_residues
MSKSVSTSTDKIIVDRSKKHRNKAVFDTVKTTRERLQQGAGGNEAYEREMLTMHIAEALQGAMIMPLFIVLASIIGLYIT
GDISLIIWSLIALSFHAMSLVLAKRAAKQAITDDNLQHWKNLFLGMQILIGCAWAMFALAEPVRNDPTLVLFFKGSTLLI
ALSLTAMANFMLRRATFMTFLPVLAALCITSAISRDPFDVGLALMFGMAILFCHRITSRLYQTSIKLLSSQTEKDDLIAE
LEVANSVSDEARRRAEEANLAKSRFLASMSHELRTPLNAILGFSEVMSSEVLGPLNNPLYKEYSGDIHRSGQHLLDLINE
ILDLSRIEAGRYDLNEESISMLEIAEDCIGMIQLRARAKNIRISQQFEASLPQVWADEKSIRQVILNLLSNAVKFTPQGG
EILVKAGWTAGGGQYVSIRDNGPGIPEDEIPVVLSAFGQGSIAIKSAEQGTGLGLPIVQAILAKHDGQFILKSKLREGTE
GIAILPAKRVLQSLPAVEETHAIQPRRRSFA
>Mature_510_residues
SKSVSTSTDKIIVDRSKKHRNKAVFDTVKTTRERLQQGAGGNEAYEREMLTMHIAEALQGAMIMPLFIVLASIIGLYITG
DISLIIWSLIALSFHAMSLVLAKRAAKQAITDDNLQHWKNLFLGMQILIGCAWAMFALAEPVRNDPTLVLFFKGSTLLIA
LSLTAMANFMLRRATFMTFLPVLAALCITSAISRDPFDVGLALMFGMAILFCHRITSRLYQTSIKLLSSQTEKDDLIAEL
EVANSVSDEARRRAEEANLAKSRFLASMSHELRTPLNAILGFSEVMSSEVLGPLNNPLYKEYSGDIHRSGQHLLDLINEI
LDLSRIEAGRYDLNEESISMLEIAEDCIGMIQLRARAKNIRISQQFEASLPQVWADEKSIRQVILNLLSNAVKFTPQGGE
ILVKAGWTAGGGQYVSIRDNGPGIPEDEIPVVLSAFGQGSIAIKSAEQGTGLGLPIVQAILAKHDGQFILKSKLREGTEG
IAILPAKRVLQSLPAVEETHAIQPRRRSFA

Specific function: Member of the two-component regulatory system involved in the regulation of polar organelle development. PleC functions as a membrane-associated protein kinase that transfers phosphate to the response regulator pleD, leading to its activation [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1789149, Length=247, Percent_Identity=34.0080971659919, Blast_Score=134, Evalue=2e-32,
Organism=Escherichia coli, GI1788713, Length=277, Percent_Identity=32.129963898917, Blast_Score=112, Evalue=6e-26,
Organism=Escherichia coli, GI87081816, Length=214, Percent_Identity=36.9158878504673, Blast_Score=111, Evalue=1e-25,
Organism=Escherichia coli, GI48994928, Length=232, Percent_Identity=31.8965517241379, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1786912, Length=290, Percent_Identity=29.6551724137931, Blast_Score=104, Evalue=2e-23,
Organism=Escherichia coli, GI145693157, Length=294, Percent_Identity=29.5918367346939, Blast_Score=102, Evalue=5e-23,
Organism=Escherichia coli, GI1786600, Length=231, Percent_Identity=29.4372294372294, Blast_Score=102, Evalue=5e-23,
Organism=Escherichia coli, GI87082128, Length=210, Percent_Identity=30, Blast_Score=94, Evalue=3e-20,
Organism=Escherichia coli, GI1788549, Length=271, Percent_Identity=25.4612546125461, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1790300, Length=240, Percent_Identity=26.6666666666667, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI1790436, Length=240, Percent_Identity=24.5833333333333, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1788393, Length=240, Percent_Identity=25.8333333333333, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1786783, Length=237, Percent_Identity=27.0042194092827, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1790551, Length=224, Percent_Identity=27.6785714285714, Blast_Score=67, Evalue=4e-12,
Organism=Escherichia coli, GI1788279, Length=205, Percent_Identity=26.3414634146341, Blast_Score=65, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6322044, Length=148, Percent_Identity=33.1081081081081, Blast_Score=63, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 56214; Mature: 56083

Theoretical pI: Translated: 7.66; Mature: 7.66

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKSVSTSTDKIIVDRSKKHRNKAVFDTVKTTRERLQQGAGGNEAYEREMLTMHIAEALQ
CCCCCCCCCCEEEEECCHHHCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHC
GAMIMPLFIVLASIIGLYITGDISLIIWSLIALSFHAMSLVLAKRAAKQAITDDNLQHWK
CHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
NLFLGMQILIGCAWAMFALAEPVRNDPTLVLFFKGSTLLIALSLTAMANFMLRRATFMTF
HHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCEEHHHHHHHHHHHHHHHHHHHHH
LPVLAALCITSAISRDPFDVGLALMFGMAILFCHRITSRLYQTSIKLLSSQTEKDDLIAE
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
LEVANSVSDEARRRAEEANLAKSRFLASMSHELRTPLNAILGFSEVMSSEVLGPLNNPLY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
KEYSGDIHRSGQHLLDLINEILDLSRIEAGRYDLNEESISMLEIAEDCIGMIQLRARAKN
HHHCCCHHCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHC
IRISQQFEASLPQVWADEKSIRQVILNLLSNAVKFTPQGGEILVKAGWTAGGGQYVSIRD
CCCHHHHHHCCCHHHCCHHHHHHHHHHHHHHHHEECCCCCEEEEEECCCCCCCEEEEEEC
NGPGIPEDEIPVVLSAFGQGSIAIKSAEQGTGLGLPIVQAILAKHDGQFILKSKLREGTE
CCCCCCCCCCCHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHCCCCHHHHHHHHCCCC
GIAILPAKRVLQSLPAVEETHAIQPRRRSFA
CEEECCHHHHHHHCCCHHHHHCCCCHHHCCC
>Mature Secondary Structure 
SKSVSTSTDKIIVDRSKKHRNKAVFDTVKTTRERLQQGAGGNEAYEREMLTMHIAEALQ
CCCCCCCCCEEEEECCHHHCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHC
GAMIMPLFIVLASIIGLYITGDISLIIWSLIALSFHAMSLVLAKRAAKQAITDDNLQHWK
CHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
NLFLGMQILIGCAWAMFALAEPVRNDPTLVLFFKGSTLLIALSLTAMANFMLRRATFMTF
HHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCEEHHHHHHHHHHHHHHHHHHHHH
LPVLAALCITSAISRDPFDVGLALMFGMAILFCHRITSRLYQTSIKLLSSQTEKDDLIAE
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
LEVANSVSDEARRRAEEANLAKSRFLASMSHELRTPLNAILGFSEVMSSEVLGPLNNPLY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
KEYSGDIHRSGQHLLDLINEILDLSRIEAGRYDLNEESISMLEIAEDCIGMIQLRARAKN
HHHCCCHHCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHC
IRISQQFEASLPQVWADEKSIRQVILNLLSNAVKFTPQGGEILVKAGWTAGGGQYVSIRD
CCCHHHHHHCCCHHHCCHHHHHHHHHHHHHHHHEECCCCCEEEEEECCCCCCCEEEEEEC
NGPGIPEDEIPVVLSAFGQGSIAIKSAEQGTGLGLPIVQAILAKHDGQFILKSKLREGTE
CCCCCCCCCCCHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHCCCCHHHHHHHHCCCC
GIAILPAKRVLQSLPAVEETHAIQPRRRSFA
CEEECCHHHHHHHCCCHHHHHCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8421698; 11259647 [H]