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The map label for this gene is gcvT [H]

Identifier: 15888944

GI number: 15888944

Start: 1617734

End: 1620247

Strand: Reverse

Name: gcvT [H]

Synonym: Atu1632

Alternate gene names: 15888944

Gene position: 1620247-1617734 (Counterclockwise)

Preceding gene: 159184847

Following gene: 159184846

Centisome position: 57.02

GC content: 59.55

Gene sequence:

>2514_bases
ATGAAGACACATGCACGGGCGGTGGTGATCGGTGGCGGCGTTGTCGGCGTCTCGACGCTTTATCATCTTGCCAAAAAGGG
CTGGAGCGACAGCGTTCTCATCGAGCGCAAGGAGCTGACCTCCGGTTCCACCTGGCATGCGGCAGGCCTCTTGCCGCTGT
TCAACATGAGCTATTCGGTTGGCCAGATCCACAAATATTCCGTGAAGTTCTACGAGGAGCTTCAGGAAGAGACCGGCATG
AATGTCGGCTTCTCCAAGGTTTCGAATATCCGTCTCGCCCGTACCAAGGATCGCTGGGACGAATATATGTATTATGCCGG
CATTGCCGAGACCATCGGTGTGCGCGTCAACATGCTGACGCCGGAGCAGGTGAAGGAAATCTGGCCGCTCTGCGAAACCG
ACGGTCTGCTCGGCGCCATCCAGCATCCTGACGACGGTTATATCCAGCCCGCCGACCTGACACAGGCTCTCGCCAAGGGC
GCGCGTGACCGTGGGGCGACGATCTATCGCAACACGACAGTTACCGCCATCGAGCAGCTGGAAGACGGTCACTGGAAGGT
GACGACGGACAAGGGCGAGATCATCGCCGAACATATCATCTCCTGCACCGGCAACTTCGCCCGCAAGACCGGCGAGATGG
TTGGCATCGATATTCCGGTCATCCCGGTCGAGCATCAATATATCGTCACTGAGCCGCATCCGGCCATTCTGGAGCGCCGC
CGTCAGGGGCTGCCGGAAATGGGCGTCCTGCGTGAATCGGACTCTGCCTGGTACATGCGCGAGGAAGCGGGCGGCCTGAT
CCTCGGTCCGTATGAAGTCGGCGCGCCGGTCTGTTATGTCGATGGTCCCTCCGACGACAGCGAATATGAGCTGTTCCAGG
AAGAACTCGACCGCTTGATGCCGCATATCGAAACGGCAATGGTGCGCGTTCCGGCCTTTGGCGAAGTGGGCATCAAGAAG
GTTTATAATGGCGCGATCGCCTATACGCCTGACGGTAACCCGATCGTCGGCCCTGCGCCGGGCCTCAAGAATTTCTGGCT
GAACGAGGGCCATTCCTTCGGCATCACCGCCGCCGGCGGCGCCGGCTGGCAGCTGGCCGAATGGATCGTCGATGGCGAAC
CGACGCTCGACCTGATGGGTGTCGATCCGCGTCGTTTCGGACCGCACGCTACGGAAGGTTACCTCATTGCCAAGAACGAG
GAAGCCTATGCCAACGTCTTCACCATGCATTATCCTGATGAAGAGCGTTCCGCCGCTCGTCCCTTGAAGACGACGCCGGT
TTACGACCGCCTGAAAAAGCTCGGCGGCGTGTTCGGCTCCGTTTACGGTTGGGAGCGCGCCAACTGGTATGCGCCGGAAG
GTTATGCGCTGCGGGAAGAAGACCTCGGCGTCGGCGCCGATGTCATCACCAGCCACAATTACGCGCCGCCGCTGGACGAT
GGCCGTATCGTCGAGAAATGGTCGTTCCGCCGCTCGAACTATTTCGAACATGTCGGCAACGAGGTGAAGAACGTCACGAA
CAATGTCGGCGTGCTTGATATGTCGGCCTTCGCCAAGATGGAGGTTTCCGGCCCCGGCGCGCGTGCGTGGCTGGACAGTA
TTCTGGCCAATATCGTGCCGAAGAAGCGCGGTCGTATTGCGCTGACACATCTTCTGACGCCGAATGGCGGTGTGAAGATT
GAGTTCACTGTTTATGAATGGGCGCCTGGCCGGTTCTACATGGTTTCGGCAGGCGGTCTTGAGGCACATGACCATGACGT
TCTGCGCCGTCTTGCACCCACCGACGGTTCCGTGGTGCTGCAGCCGATCACCCAGAAATACGGCGTGCTGGTGCTGGCCG
GTCCGAAGTCGCGCGATCTCCTGAAGAAGCTGACCCGCACCAGCCTCGAGAACAAGGATTTCCCCTGGCTCACCGGCAAG
CAGATTTCCGTTGGCGTGGCGACGGCGCATGCGCTACGCGTCAACTTCGTGGGCGAGTTGGGCTGGGAGCTGCACCATCC
GATCGAGATGCAGAATTACATCTTCGACCGGCTGATGGAAGCGGGTGCGGAATTCGGCATCAAGCCGTTCGGCATCCGGG
CCATGGTGTCGATGTCGCTCGAAAAGTCCTATCGCAACATGGGCCGCGAGCTTTCGGTGGAATATAACGCCTATGAATCC
GGTCTCGACCGCTTCCTGCGGCCGGAAAAATCCTTCATCGGCCGCGATGCGCTGGTAGCCTATAAGGAAGCCGGGCTGAA
GTCGGTGTTTTCGACGCTGACCGTGTCGGGCAATACGGATGTCGATGCCCGCGGGTCGGAAGCGATTTCGGATGAAAACG
GCGTTCTTGCCGGTCGTGTCACCAGCGGCGGCTTCGGTTGGCGCATCGGCAAGTCGATTGCACTTGCCATGCTCAAACCG
GAATATGCGGCGGTTGGCACGAAGCTGAAGATCCGCATTCTCGGTACGCTTTATGATGCCGAGGTGGTGGAAGAAAGCCC
GTTCGACACGGAAAATGCGCTGCTGCGCGCATAA

Upstream 100 bases:

>100_bases
GTCGCAATCAGGCGGCTGAACGGCAGGCAAGCGCTTCATATTCCTCCCATCCAATGTCGGCGGAATAAGGCGAGGCCGGC
GCTTTTCAGGGGTTCTGTAA

Downstream 100 bases:

>100_bases
GATCATTCCCTCCCAAAGCTGGAATACGGCCCCTCGCGGGCCGTATTTCCGTTTAGGTAAGCATATGCCCGCATTCCTTG
CTGGCAAAAGTGCTATTAAT

Product: dimethylglycine dehydrogenase

Products: NA

Alternate protein names: Glycine cleavage system T protein [H]

Number of amino acids: Translated: 837; Mature: 837

Protein sequence:

>837_residues
MKTHARAVVIGGGVVGVSTLYHLAKKGWSDSVLIERKELTSGSTWHAAGLLPLFNMSYSVGQIHKYSVKFYEELQEETGM
NVGFSKVSNIRLARTKDRWDEYMYYAGIAETIGVRVNMLTPEQVKEIWPLCETDGLLGAIQHPDDGYIQPADLTQALAKG
ARDRGATIYRNTTVTAIEQLEDGHWKVTTDKGEIIAEHIISCTGNFARKTGEMVGIDIPVIPVEHQYIVTEPHPAILERR
RQGLPEMGVLRESDSAWYMREEAGGLILGPYEVGAPVCYVDGPSDDSEYELFQEELDRLMPHIETAMVRVPAFGEVGIKK
VYNGAIAYTPDGNPIVGPAPGLKNFWLNEGHSFGITAAGGAGWQLAEWIVDGEPTLDLMGVDPRRFGPHATEGYLIAKNE
EAYANVFTMHYPDEERSAARPLKTTPVYDRLKKLGGVFGSVYGWERANWYAPEGYALREEDLGVGADVITSHNYAPPLDD
GRIVEKWSFRRSNYFEHVGNEVKNVTNNVGVLDMSAFAKMEVSGPGARAWLDSILANIVPKKRGRIALTHLLTPNGGVKI
EFTVYEWAPGRFYMVSAGGLEAHDHDVLRRLAPTDGSVVLQPITQKYGVLVLAGPKSRDLLKKLTRTSLENKDFPWLTGK
QISVGVATAHALRVNFVGELGWELHHPIEMQNYIFDRLMEAGAEFGIKPFGIRAMVSMSLEKSYRNMGRELSVEYNAYES
GLDRFLRPEKSFIGRDALVAYKEAGLKSVFSTLTVSGNTDVDARGSEAISDENGVLAGRVTSGGFGWRIGKSIALAMLKP
EYAAVGTKLKIRILGTLYDAEVVEESPFDTENALLRA

Sequences:

>Translated_837_residues
MKTHARAVVIGGGVVGVSTLYHLAKKGWSDSVLIERKELTSGSTWHAAGLLPLFNMSYSVGQIHKYSVKFYEELQEETGM
NVGFSKVSNIRLARTKDRWDEYMYYAGIAETIGVRVNMLTPEQVKEIWPLCETDGLLGAIQHPDDGYIQPADLTQALAKG
ARDRGATIYRNTTVTAIEQLEDGHWKVTTDKGEIIAEHIISCTGNFARKTGEMVGIDIPVIPVEHQYIVTEPHPAILERR
RQGLPEMGVLRESDSAWYMREEAGGLILGPYEVGAPVCYVDGPSDDSEYELFQEELDRLMPHIETAMVRVPAFGEVGIKK
VYNGAIAYTPDGNPIVGPAPGLKNFWLNEGHSFGITAAGGAGWQLAEWIVDGEPTLDLMGVDPRRFGPHATEGYLIAKNE
EAYANVFTMHYPDEERSAARPLKTTPVYDRLKKLGGVFGSVYGWERANWYAPEGYALREEDLGVGADVITSHNYAPPLDD
GRIVEKWSFRRSNYFEHVGNEVKNVTNNVGVLDMSAFAKMEVSGPGARAWLDSILANIVPKKRGRIALTHLLTPNGGVKI
EFTVYEWAPGRFYMVSAGGLEAHDHDVLRRLAPTDGSVVLQPITQKYGVLVLAGPKSRDLLKKLTRTSLENKDFPWLTGK
QISVGVATAHALRVNFVGELGWELHHPIEMQNYIFDRLMEAGAEFGIKPFGIRAMVSMSLEKSYRNMGRELSVEYNAYES
GLDRFLRPEKSFIGRDALVAYKEAGLKSVFSTLTVSGNTDVDARGSEAISDENGVLAGRVTSGGFGWRIGKSIALAMLKP
EYAAVGTKLKIRILGTLYDAEVVEESPFDTENALLRA
>Mature_837_residues
MKTHARAVVIGGGVVGVSTLYHLAKKGWSDSVLIERKELTSGSTWHAAGLLPLFNMSYSVGQIHKYSVKFYEELQEETGM
NVGFSKVSNIRLARTKDRWDEYMYYAGIAETIGVRVNMLTPEQVKEIWPLCETDGLLGAIQHPDDGYIQPADLTQALAKG
ARDRGATIYRNTTVTAIEQLEDGHWKVTTDKGEIIAEHIISCTGNFARKTGEMVGIDIPVIPVEHQYIVTEPHPAILERR
RQGLPEMGVLRESDSAWYMREEAGGLILGPYEVGAPVCYVDGPSDDSEYELFQEELDRLMPHIETAMVRVPAFGEVGIKK
VYNGAIAYTPDGNPIVGPAPGLKNFWLNEGHSFGITAAGGAGWQLAEWIVDGEPTLDLMGVDPRRFGPHATEGYLIAKNE
EAYANVFTMHYPDEERSAARPLKTTPVYDRLKKLGGVFGSVYGWERANWYAPEGYALREEDLGVGADVITSHNYAPPLDD
GRIVEKWSFRRSNYFEHVGNEVKNVTNNVGVLDMSAFAKMEVSGPGARAWLDSILANIVPKKRGRIALTHLLTPNGGVKI
EFTVYEWAPGRFYMVSAGGLEAHDHDVLRRLAPTDGSVVLQPITQKYGVLVLAGPKSRDLLKKLTRTSLENKDFPWLTGK
QISVGVATAHALRVNFVGELGWELHHPIEMQNYIFDRLMEAGAEFGIKPFGIRAMVSMSLEKSYRNMGRELSVEYNAYES
GLDRFLRPEKSFIGRDALVAYKEAGLKSVFSTLTVSGNTDVDARGSEAISDENGVLAGRVTSGGFGWRIGKSIALAMLKP
EYAAVGTKLKIRILGTLYDAEVVEESPFDTENALLRA

Specific function: The glycine cleavage system catalyzes the degradation of glycine [H]

COG id: COG0404

COG function: function code E; Glycine cleavage system T protein (aminomethyltransferase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family [H]

Homologues:

Organism=Homo sapiens, GI24797151, Length=839, Percent_Identity=38.7365911799762, Blast_Score=554, Evalue=1e-157,
Organism=Homo sapiens, GI197927446, Length=869, Percent_Identity=31.5304948216341, Blast_Score=398, Evalue=1e-110,
Organism=Homo sapiens, GI21361378, Length=869, Percent_Identity=31.5304948216341, Blast_Score=398, Evalue=1e-110,
Organism=Homo sapiens, GI194306651, Length=810, Percent_Identity=28.1481481481481, Blast_Score=339, Evalue=7e-93,
Organism=Escherichia coli, GI1789272, Length=368, Percent_Identity=25.5434782608696, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71994045, Length=827, Percent_Identity=30.229746070133, Blast_Score=314, Evalue=2e-85,
Organism=Caenorhabditis elegans, GI71994052, Length=834, Percent_Identity=29.9760191846523, Blast_Score=311, Evalue=1e-84,
Organism=Caenorhabditis elegans, GI32563613, Length=856, Percent_Identity=26.7523364485981, Blast_Score=258, Evalue=1e-68,
Organism=Drosophila melanogaster, GI20130091, Length=859, Percent_Identity=30.151338766007, Blast_Score=349, Evalue=5e-96,
Organism=Drosophila melanogaster, GI28571104, Length=864, Percent_Identity=28.3564814814815, Blast_Score=329, Evalue=6e-90,
Organism=Drosophila melanogaster, GI20129441, Length=341, Percent_Identity=24.3401759530792, Blast_Score=70, Evalue=6e-12,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903 [H]

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C [H]

EC number: =2.1.2.10 [H]

Molecular weight: Translated: 92443; Mature: 92443

Theoretical pI: Translated: 5.74; Mature: 5.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTHARAVVIGGGVVGVSTLYHLAKKGWSDSVLIERKELTSGSTWHAAGLLPLFNMSYSV
CCCCCEEEEEECCHHHHHHHHHHHHCCCCCCEEEEEHHCCCCCCEEHHCCHHHHCCCCCC
GQIHKYSVKFYEELQEETGMNVGFSKVSNIRLARTKDRWDEYMYYAGIAETIGVRVNMLT
CCHHHHHHHHHHHHHHHCCCCCCHHHHCCEEEEECHHHHHHHHHHHCHHHHHCEEEEEEC
PEQVKEIWPLCETDGLLGAIQHPDDGYIQPADLTQALAKGARDRGATIYRNTTVTAIEQL
HHHHHHHCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHCCCCCCCCEEEECCHHHHHHHH
EDGHWKVTTDKGEIIAEHIISCTGNFARKTGEMVGIDIPVIPVEHQYIVTEPHPAILERR
CCCCEEEECCCHHHHHHHHHHHCCHHHHHCCCEEEEEEEEEECCCEEEEECCCHHHHHHH
RQGLPEMGVLRESDSAWYMREEAGGLILGPYEVGAPVCYVDGPSDDSEYELFQEELDRLM
HHCCCCCCCEECCCCCEEEEECCCCEEECCHHHCCCEEEECCCCCCHHHHHHHHHHHHHH
PHIETAMVRVPAFGEVGIKKVYNGAIAYTPDGNPIVGPAPGLKNFWLNEGHSFGITAAGG
HHHHHHHEECCCCCCCCHHHHHCCEEEECCCCCEECCCCCCCCHHHCCCCCEEEEEECCC
AGWQLAEWIVDGEPTLDLMGVDPRRFGPHATEGYLIAKNEEAYANVFTMHYPDEERSAAR
CCCCHHHEEECCCCCEEEEECCHHHCCCCCCCCEEEEECCCCEEEEEEEECCCCHHHHCC
PLKTTPVYDRLKKLGGVFGSVYGWERANWYAPEGYALREEDLGVGADVITSHNYAPPLDD
CCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEECCCCCCCCCHHHCCCCCCCCCCC
GRIVEKWSFRRSNYFEHVGNEVKNVTNNVGVLDMSAFAKMEVSGPGARAWLDSILANIVP
CCEEHHHHCHHHHHHHHHHHHHHHHHCCCCEEEEHHHEEEEECCCCHHHHHHHHHHHHCC
KKRGRIALTHLLTPNGGVKIEFTVYEWAPGRFYMVSAGGLEAHDHDVLRRLAPTDGSVVL
CCCCCEEEEEEECCCCCEEEEEEEEEECCCEEEEEECCCCCCHHHHHHHHHCCCCCCEEE
QPITQKYGVLVLAGPKSRDLLKKLTRTSLENKDFPWLTGKQISVGVATAHALRVNFVGEL
EECHHHCCEEEEECCCCHHHHHHHHHHCCCCCCCCEECCCEEEEEEEEEEEEEEEEHHHC
GWELHHPIEMQNYIFDRLMEAGAEFGIKPFGIRAMVSMSLEKSYRNMGRELSVEYNAYES
CCCCCCCHHHHHHHHHHHHHCCHHCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEECHHHH
GLDRFLRPEKSFIGRDALVAYKEAGLKSVFSTLTVSGNTDVDARGSEAISDENGVLAGRV
HHHHHHCCCHHHCCCHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCCCCCEEEEEE
TSGGFGWRIGKSIALAMLKPEYAAVGTKLKIRILGTLYDAEVVEESPFDTENALLRA
ECCCCCEEHHHHEEEEEECCHHHHCCCEEEEEEEEEEHHHHHHCCCCCCCCHHHCCC
>Mature Secondary Structure
MKTHARAVVIGGGVVGVSTLYHLAKKGWSDSVLIERKELTSGSTWHAAGLLPLFNMSYSV
CCCCCEEEEEECCHHHHHHHHHHHHCCCCCCEEEEEHHCCCCCCEEHHCCHHHHCCCCCC
GQIHKYSVKFYEELQEETGMNVGFSKVSNIRLARTKDRWDEYMYYAGIAETIGVRVNMLT
CCHHHHHHHHHHHHHHHCCCCCCHHHHCCEEEEECHHHHHHHHHHHCHHHHHCEEEEEEC
PEQVKEIWPLCETDGLLGAIQHPDDGYIQPADLTQALAKGARDRGATIYRNTTVTAIEQL
HHHHHHHCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHCCCCCCCCEEEECCHHHHHHHH
EDGHWKVTTDKGEIIAEHIISCTGNFARKTGEMVGIDIPVIPVEHQYIVTEPHPAILERR
CCCCEEEECCCHHHHHHHHHHHCCHHHHHCCCEEEEEEEEEECCCEEEEECCCHHHHHHH
RQGLPEMGVLRESDSAWYMREEAGGLILGPYEVGAPVCYVDGPSDDSEYELFQEELDRLM
HHCCCCCCCEECCCCCEEEEECCCCEEECCHHHCCCEEEECCCCCCHHHHHHHHHHHHHH
PHIETAMVRVPAFGEVGIKKVYNGAIAYTPDGNPIVGPAPGLKNFWLNEGHSFGITAAGG
HHHHHHHEECCCCCCCCHHHHHCCEEEECCCCCEECCCCCCCCHHHCCCCCEEEEEECCC
AGWQLAEWIVDGEPTLDLMGVDPRRFGPHATEGYLIAKNEEAYANVFTMHYPDEERSAAR
CCCCHHHEEECCCCCEEEEECCHHHCCCCCCCCEEEEECCCCEEEEEEEECCCCHHHHCC
PLKTTPVYDRLKKLGGVFGSVYGWERANWYAPEGYALREEDLGVGADVITSHNYAPPLDD
CCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEECCCCCCCCCHHHCCCCCCCCCCC
GRIVEKWSFRRSNYFEHVGNEVKNVTNNVGVLDMSAFAKMEVSGPGARAWLDSILANIVP
CCEEHHHHCHHHHHHHHHHHHHHHHHCCCCEEEEHHHEEEEECCCCHHHHHHHHHHHHCC
KKRGRIALTHLLTPNGGVKIEFTVYEWAPGRFYMVSAGGLEAHDHDVLRRLAPTDGSVVL
CCCCCEEEEEEECCCCCEEEEEEEEEECCCEEEEEECCCCCCHHHHHHHHHCCCCCCEEE
QPITQKYGVLVLAGPKSRDLLKKLTRTSLENKDFPWLTGKQISVGVATAHALRVNFVGEL
EECHHHCCEEEEECCCCHHHHHHHHHHCCCCCCCCEECCCEEEEEEEEEEEEEEEEHHHC
GWELHHPIEMQNYIFDRLMEAGAEFGIKPFGIRAMVSMSLEKSYRNMGRELSVEYNAYES
CCCCCCCHHHHHHHHHHHHHCCHHCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEECHHHH
GLDRFLRPEKSFIGRDALVAYKEAGLKSVFSTLTVSGNTDVDARGSEAISDENGVLAGRV
HHHHHHCCCHHHCCCHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCCCCCEEEEEE
TSGGFGWRIGKSIALAMLKPEYAAVGTKLKIRILGTLYDAEVVEESPFDTENALLRA
ECCCCCEEHHHHEEEEEECCHHHHCCCEEEEEEEEEEHHHHHHCCCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]