Click here to switch to the map view.

The map label for this gene is qor [C]

Identifier: 15888339

GI number: 15888339

Start: 992564

End: 993580

Strand: Reverse

Name: qor [C]

Synonym: Atu0996

Alternate gene names: 15888339

Gene position: 993580-992564 (Counterclockwise)

Preceding gene: 15888342

Following gene: 15888335

Centisome position: 34.97

GC content: 62.05

Gene sequence:

>1017_bases
ATGCGCGCCATCGGTTACAAAACCAGCCAGCCCATCACCGCGGCGGATGCCCTCATCGACATCGATCTGGCCCAGCCGGA
AGCCAAGGGGCACGACATTCTGGTGGAGGTGAAGGCGGTTTCGGTGAACCCTGTGGACACCAAGGTGCGCCGCAACCAGT
CGCCGGAAAATGGCGCCACCCGCGTGCTGGGTTTCGACGCTTCGGGTGTAGTAAAGGCCGTCGGCGACAGGGTCTCGCTG
TTCAAGCCGGGCGACGAGGTGTTTTACGCCGGCGTCATCAACCGTCCGGGCTCCAACAGCGAATTCCATCTGGTCGATGA
GCGCATCGTCGGCGCAAAGCCGAAATCACTCAATTTCGAGGAGGCCGCCGCCCTGCCGCTGACAGCGATCACCGCTTACG
AAACGCTGTTCGACCGGCTGCGGGTGAAGGAGCCGGTTCCGGGCGCTGCCAATGCCGTTCTTGTCATCGGCGGTGCCGGC
GGCGTCGGTTCTATCGCCATCCAGCTTCTGCGCGCCCTGACGGATCTCACCGTCATCGCCACGGCATCGCGGCCGGAAAC
CATGGAGTGGGTGAAGGAACTCGGCGCGCATCATGTCGTGGATCACGGCAAGCCGATCGCACCGCAGGTGGAAGCGCTTG
GCCTTGGTGCGCCCGGCTTCGTATTCTCGACCACCCATAGTGATATCCACGCCGCCGACAGCGTGGCGACGATTGCGCCG
CAGGGTCGTTTTGCGCTGATCGACGATCCGGCCGGCGGTTTCGACGTCATGGCCTTCAAGCGCAAATGCGTGTCGATCCA
TTGGGAAATGATGTTCGCCCGCGCGGTTTTCGAGACACCTGACATGATCGAGCAGCACAAATTGCTCAATCACGTCGCGG
AACTGGTCGATGCCGGCAAGATCAGGACGACGCTGACCGAGGTTTTCGGCACCATCAATGCCGCAAACCTCATCAAGGCG
CATGCCCTGATCGAGAGCAACACGGCCAGGGGCAAGATCGTGCTTTCGGGCTTCTGA

Upstream 100 bases:

>100_bases
AGTATCCTTTTTGTATGTATCACCACAAAATGTGCATTCTTGCGATTGATGTTCATATGTATCAAGTAAGAGGCACGCAA
ACAAGCAAAGGAGACTGTTC

Downstream 100 bases:

>100_bases
TCAACGGCGAGGCATCCGCATCGCGGACGTCTTTGCCCCTTAAAGAGATATCCGTGCCGCGCGAAAACCGCGCGGCCGTT
CCATCAATCATCATCAGGAT

Product: zinc-binding dehydrogenase

Products: NADP(+); Semiquinone. [C]

Alternate protein names: NA

Number of amino acids: Translated: 338; Mature: 338

Protein sequence:

>338_residues
MRAIGYKTSQPITAADALIDIDLAQPEAKGHDILVEVKAVSVNPVDTKVRRNQSPENGATRVLGFDASGVVKAVGDRVSL
FKPGDEVFYAGVINRPGSNSEFHLVDERIVGAKPKSLNFEEAAALPLTAITAYETLFDRLRVKEPVPGAANAVLVIGGAG
GVGSIAIQLLRALTDLTVIATASRPETMEWVKELGAHHVVDHGKPIAPQVEALGLGAPGFVFSTTHSDIHAADSVATIAP
QGRFALIDDPAGGFDVMAFKRKCVSIHWEMMFARAVFETPDMIEQHKLLNHVAELVDAGKIRTTLTEVFGTINAANLIKA
HALIESNTARGKIVLSGF

Sequences:

>Translated_338_residues
MRAIGYKTSQPITAADALIDIDLAQPEAKGHDILVEVKAVSVNPVDTKVRRNQSPENGATRVLGFDASGVVKAVGDRVSL
FKPGDEVFYAGVINRPGSNSEFHLVDERIVGAKPKSLNFEEAAALPLTAITAYETLFDRLRVKEPVPGAANAVLVIGGAG
GVGSIAIQLLRALTDLTVIATASRPETMEWVKELGAHHVVDHGKPIAPQVEALGLGAPGFVFSTTHSDIHAADSVATIAP
QGRFALIDDPAGGFDVMAFKRKCVSIHWEMMFARAVFETPDMIEQHKLLNHVAELVDAGKIRTTLTEVFGTINAANLIKA
HALIESNTARGKIVLSGF
>Mature_338_residues
MRAIGYKTSQPITAADALIDIDLAQPEAKGHDILVEVKAVSVNPVDTKVRRNQSPENGATRVLGFDASGVVKAVGDRVSL
FKPGDEVFYAGVINRPGSNSEFHLVDERIVGAKPKSLNFEEAAALPLTAITAYETLFDRLRVKEPVPGAANAVLVIGGAG
GVGSIAIQLLRALTDLTVIATASRPETMEWVKELGAHHVVDHGKPIAPQVEALGLGAPGFVFSTTHSDIHAADSVATIAP
QGRFALIDDPAGGFDVMAFKRKCVSIHWEMMFARAVFETPDMIEQHKLLNHVAELVDAGKIRTTLTEVFGTINAANLIKA
HALIESNTARGKIVLSGF

Specific function: Unknown

COG id: COG0604

COG function: function code CR; NADPH:quinone reductase and related Zn-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily [H]

Homologues:

Organism=Homo sapiens, GI47519420, Length=345, Percent_Identity=31.0144927536232, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI194239676, Length=182, Percent_Identity=37.9120879120879, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI194239674, Length=182, Percent_Identity=37.9120879120879, Blast_Score=102, Evalue=6e-22,
Organism=Homo sapiens, GI13236495, Length=182, Percent_Identity=37.9120879120879, Blast_Score=102, Evalue=6e-22,
Organism=Homo sapiens, GI18379349, Length=192, Percent_Identity=36.4583333333333, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI24308257, Length=308, Percent_Identity=25.974025974026, Blast_Score=77, Evalue=3e-14,
Organism=Escherichia coli, GI1790485, Length=172, Percent_Identity=31.3953488372093, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71987554, Length=171, Percent_Identity=37.4269005847953, Blast_Score=95, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI17507255, Length=241, Percent_Identity=30.2904564315353, Blast_Score=87, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR014182
- InterPro:   IPR011032
- InterPro:   IPR016040
- InterPro:   IPR002364 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.6.5.5 [C]

Molecular weight: Translated: 35977; Mature: 35977

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAIGYKTSQPITAADALIDIDLAQPEAKGHDILVEVKAVSVNPVDTKVRRNQSPENGAT
CCCCCCCCCCCCCHHHHEEEEECCCCCCCCCEEEEEEEEEECCCCHHHHHCCCCCCCCCE
RVLGFDASGVVKAVGDRVSLFKPGDEVFYAGVINRPGSNSEFHLVDERIVGAKPKSLNFE
EEEEECCCCHHHHHCCCEEEECCCCCEEEEEEECCCCCCCCEEEECHHHCCCCCCCCCHH
EAAALPLTAITAYETLFDRLRVKEPVPGAANAVLVIGGAGGVGSIAIQLLRALTDLTVIA
HHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHCEEEEE
TASRPETMEWVKELGAHHVVDHGKPIAPQVEALGLGAPGFVFSTTHSDIHAADSVATIAP
ECCCCHHHHHHHHHCCCEECCCCCCCCCCHHEECCCCCCCEEECCCCCHHCCCCEEEECC
QGRFALIDDPAGGFDVMAFKRKCVSIHWEMMFARAVFETPDMIEQHKLLNHVAELVDAGK
CCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCH
IRTTLTEVFGTINAANLIKAHALIESNTARGKIVLSGF
HHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCEEEEECC
>Mature Secondary Structure
MRAIGYKTSQPITAADALIDIDLAQPEAKGHDILVEVKAVSVNPVDTKVRRNQSPENGAT
CCCCCCCCCCCCCHHHHEEEEECCCCCCCCCEEEEEEEEEECCCCHHHHHCCCCCCCCCE
RVLGFDASGVVKAVGDRVSLFKPGDEVFYAGVINRPGSNSEFHLVDERIVGAKPKSLNFE
EEEEECCCCHHHHHCCCEEEECCCCCEEEEEEECCCCCCCCEEEECHHHCCCCCCCCCHH
EAAALPLTAITAYETLFDRLRVKEPVPGAANAVLVIGGAGGVGSIAIQLLRALTDLTVIA
HHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHCEEEEE
TASRPETMEWVKELGAHHVVDHGKPIAPQVEALGLGAPGFVFSTTHSDIHAADSVATIAP
ECCCCHHHHHHHHHCCCEECCCCCCCCCCHHEECCCCCCCEEECCCCCHHCCCCEEEECC
QGRFALIDDPAGGFDVMAFKRKCVSIHWEMMFARAVFETPDMIEQHKLLNHVAELVDAGK
CCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCH
IRTTLTEVFGTINAANLIKAHALIESNTARGKIVLSGF
HHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.017 {9,10-phenanthrenequinone}} 0.0153 {2,6-dichlorophenolindophenol}} 0.013 {2,6-dichlorophenolindophenol}} 0.065 {1,4-benzoquinone}} 0.007 {NADPH}} 0.0069 {NADPH}} 0.26 {1,4-naphthoquinone}} 0.0024 {1,2-naphthoquinone}} [C]

Substrates: NADPH; Quinone [C]

Specific reaction: NADPH + Quinone = NADP(+) + Semiquinone. [C]

General reaction: Oxidation; Reduction [C]

Inhibitor: 2, 3-Dimercaptopropanol; 2, 5-Dichloro-3, 6-dihydroxy -1, 4-benzoquinone; 4-Hydroxy coumarin; 5, 5'-Dithiobis (2-nitrobenzoate); ADP; Cibacronblue3GA; Coumarin; Cu2+; Dicoumarol warfarin, coumarin; Dithiothreitol preincubation with 9, 10-phenanthrenequino

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA