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The map label for this gene is pdxH

Identifier: 15888103

GI number: 15888103

Start: 756990

End: 757610

Strand: Direct

Name: pdxH

Synonym: Atu0760

Alternate gene names: 15888103

Gene position: 756990-757610 (Clockwise)

Preceding gene: 159184452

Following gene: 15888105

Centisome position: 26.64

GC content: 59.26

Gene sequence:

>621_bases
ATGTCGGAAACGGGGTTAACATCCAGTGACTTCACGGAAGAAAATGAACCTTTTGCGCTTTTTGCCGAATGGCTGAAGGA
TGCGACGGCTTCTGAAATCAACGATCCGAACGCGGTGGCGCTCGCGACCGTGGACGAAAATGGCCTGCCGAATGTGCGCA
TGGTGCTGCTGAAAGGTGTCGATGACCGCGGCTTTGTTTTCTACACGAATTTCGAAAGCCAGAAGGGCCAAGAGATTCTC
GGCCAGAAAAAAGCGGCCATGTGTTTCCACTGGAAAAGCCTTCGCCGGCAGGTGCGTCTGCGCGGTGAGGTGGAGATCGT
GAGCGACGAGGAGGCGGATGCCTATTACGCCTCGCGCCCGCGCGGCAGCCGCATAGGCGCCTGGGCTTCCAAACAGTCGC
GGCCGCTGGAAGGCCGTTTCGCGCTGGAAAAAGCGGTGGCCGAATATACCGCCAGATATGCGATCGGCGAAATTCCGCGC
CCGTCCCATTGGTCCGGTTTCCGCATCCGCCCCGTCAGCATCGAATTCTGGCACGACCGCAAGTTTCGCCTGCACGACCG
CATCGAATTCCGTCGCGAGACGCCCGACGGTGCCTGGTCCAAGGTCCGCATGTATCCCTGA

Upstream 100 bases:

>100_bases
AGGCTCTTTGTTCGACTGTTCGACTTTGCTATGACGGTCACCATCTATCGCCAGAGATCATCTCTGGGGTCCAAATCAGC
TCGGGAGCATTTTAGTCAAT

Downstream 100 bases:

>100_bases
ACGCCATCAGGGCAGGCCATCGCGGCCTGCCTATTTCAGCAGCGAATCAAACAGCGGCAGGCCGATCACCGCGGAAATGG
CGATCAGACCGTAGCAGATG

Product: pyridoxamine 5'-phosphate oxidase

Products: NA

Alternate protein names: PNP/PMP oxidase; PNPOx; Pyridoxal 5'-phosphate synthase

Number of amino acids: Translated: 206; Mature: 205

Protein sequence:

>206_residues
MSETGLTSSDFTEENEPFALFAEWLKDATASEINDPNAVALATVDENGLPNVRMVLLKGVDDRGFVFYTNFESQKGQEIL
GQKKAAMCFHWKSLRRQVRLRGEVEIVSDEEADAYYASRPRGSRIGAWASKQSRPLEGRFALEKAVAEYTARYAIGEIPR
PSHWSGFRIRPVSIEFWHDRKFRLHDRIEFRRETPDGAWSKVRMYP

Sequences:

>Translated_206_residues
MSETGLTSSDFTEENEPFALFAEWLKDATASEINDPNAVALATVDENGLPNVRMVLLKGVDDRGFVFYTNFESQKGQEIL
GQKKAAMCFHWKSLRRQVRLRGEVEIVSDEEADAYYASRPRGSRIGAWASKQSRPLEGRFALEKAVAEYTARYAIGEIPR
PSHWSGFRIRPVSIEFWHDRKFRLHDRIEFRRETPDGAWSKVRMYP
>Mature_205_residues
SETGLTSSDFTEENEPFALFAEWLKDATASEINDPNAVALATVDENGLPNVRMVLLKGVDDRGFVFYTNFESQKGQEILG
QKKAAMCFHWKSLRRQVRLRGEVEIVSDEEADAYYASRPRGSRIGAWASKQSRPLEGRFALEKAVAEYTARYAIGEIPRP
SHWSGFRIRPVSIEFWHDRKFRLHDRIEFRRETPDGAWSKVRMYP

Specific function: Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP)

COG id: COG0259

COG function: function code H; Pyridoxamine-phosphate oxidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyridoxamine 5'-phosphate oxidase family

Homologues:

Organism=Homo sapiens, GI8922498, Length=196, Percent_Identity=43.3673469387755, Blast_Score=158, Evalue=3e-39,
Organism=Escherichia coli, GI1787926, Length=191, Percent_Identity=43.455497382199, Blast_Score=166, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI17553712, Length=196, Percent_Identity=40.8163265306122, Blast_Score=138, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6319509, Length=196, Percent_Identity=39.7959183673469, Blast_Score=147, Evalue=8e-37,
Organism=Drosophila melanogaster, GI45551845, Length=188, Percent_Identity=43.0851063829787, Blast_Score=140, Evalue=5e-34,
Organism=Drosophila melanogaster, GI24644901, Length=188, Percent_Identity=43.0851063829787, Blast_Score=140, Evalue=5e-34,
Organism=Drosophila melanogaster, GI24644903, Length=172, Percent_Identity=29.6511627906977, Blast_Score=69, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PDXH_AGRT5 (Q8UHC2)

Other databases:

- EMBL:   AE007869
- PIR:   AB2670
- PIR:   H97451
- RefSeq:   NP_353784.1
- ProteinModelPortal:   Q8UHC2
- SMR:   Q8UHC2
- STRING:   Q8UHC2
- GeneID:   1132798
- GenomeReviews:   AE007869_GR
- KEGG:   atu:Atu0760
- eggNOG:   COG0259
- HOGENOM:   HBG327559
- OMA:   HWSGFRI
- PhylomeDB:   Q8UHC2
- ProtClustDB:   PRK05679
- BioCyc:   ATUM176299-1:ATU0760-MONOMER
- HAMAP:   MF_01629
- InterPro:   IPR000659
- InterPro:   IPR019740
- InterPro:   IPR019576
- InterPro:   IPR011576
- InterPro:   IPR012349
- InterPro:   IPR009002
- Gene3D:   G3DSA:2.30.110.10
- PANTHER:   PTHR10851
- PIRSF:   PIRSF000190
- TIGRFAMs:   TIGR00558

Pfam domain/function: PF10590 PNPOx_C; PF01243 Pyridox_oxidase; SSF50475 FMN_binding

EC number: =1.4.3.5

Molecular weight: Translated: 23721; Mature: 23590

Theoretical pI: Translated: 7.66; Mature: 7.66

Prosite motif: PS01064 PYRIDOX_OXIDASE

Important sites: BINDING 53-53 BINDING 56-56 BINDING 58-58 BINDING 75-75 BINDING 115-115 BINDING 119-119 BINDING 123-123

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSETGLTSSDFTEENEPFALFAEWLKDATASEINDPNAVALATVDENGLPNVRMVLLKGV
CCCCCCCCCCCCCCCCCHHHHHHHHHCCHHHHCCCCCEEEEEEECCCCCCCEEEEEEECC
DDRGFVFYTNFESQKGQEILGQKKAAMCFHWKSLRRQVRLRGEVEIVSDEEADAYYASRP
CCCCEEEEECCCCCCCHHHHCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCEECCCC
RGSRIGAWASKQSRPLEGRFALEKAVAEYTARYAIGEIPRPSHWSGFRIRPVSIEFWHDR
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEEEECCC
KFRLHDRIEFRRETPDGAWSKVRMYP
CEEECCHHHEEECCCCCCCCEEEECC
>Mature Secondary Structure 
SETGLTSSDFTEENEPFALFAEWLKDATASEINDPNAVALATVDENGLPNVRMVLLKGV
CCCCCCCCCCCCCCCCHHHHHHHHHCCHHHHCCCCCEEEEEEECCCCCCCEEEEEEECC
DDRGFVFYTNFESQKGQEILGQKKAAMCFHWKSLRRQVRLRGEVEIVSDEEADAYYASRP
CCCCEEEEECCCCCCCHHHHCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCEECCCC
RGSRIGAWASKQSRPLEGRFALEKAVAEYTARYAIGEIPRPSHWSGFRIRPVSIEFWHDR
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEEEECCC
KFRLHDRIEFRRETPDGAWSKVRMYP
CEEECCHHHEEECCCCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194