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The map label for this gene is dxs

Identifier: 15888088

GI number: 15888088

Start: 742737

End: 744656

Strand: Reverse

Name: dxs

Synonym: Atu0745

Alternate gene names: 15888088

Gene position: 744656-742737 (Counterclockwise)

Preceding gene: 15888089

Following gene: 159184446

Centisome position: 26.21

GC content: 62.34

Gene sequence:

>1920_bases
TTGACCGGAATGCCACAGACACCATTGCTCGACCGGGTGAATTTTCCCTCCGATCTCAAGGAGATCGATGATCGCGACCT
GCCGGAACTGGCACGGGAACTGCGCGACGAGATGATTGACGCGGTGTCGAAGACCGGTGGCCATCTGGGTGCCGGCCTCG
GTGTGGTGGAACTGACGATTGCCATTCACAAGGTGTTCAACACGCCGGAAGACCGGCTGATCTTCGATGTCGGCCACCAA
TGTTATCCGCACAAAATCCTGACCGGCCGGCGTGACCGCATCCGCACGCTTCGACAGGAAGACGGGCTTTCCGGTTTCAC
GCGGCGGGCCGAAAGCGAATATGACGATTTTGGCGCCGGCCATTCCTCCACCTCCATTTCCGCCGGTCTCGGCATGGCGG
TGGCGGCGGGGCTCGATGGCAGCGACCGCAAGGTCATCGCCGTGATCGGCGACGGTTCAATGTCGGCCGGCATGGCGTTC
GAAGCGCTCAACAATGCCGGTGCACTCGATGCGCGGCTGATCGTCATCCTCAACGATAACGACATGTCGATTGCGCCGCC
GACGGGTGCGATGAGCGCCTATCTGGCGCGGCTGGCCTCCGGCCGCACCTATATGGGCTTTCGCGATTTCGGCAAGAAAC
TGACCGCCTATCTCGGCAAGACCATCGATCGCGCCATTACCCGCGCCGTGACCCATGCCCGCGGTTATGTGACCGGCGGC
ACGCTGTTCGAGGAGCTTGGTTTCTATCACATCGGCCCGATCGACGGTCATTCCTTCGATCACCTTTTGCCGGTGCTTCG
CAATGTGCGCGACAACCAGAAAGGCCCTGTCCTGATCCATGTGGTGACGCAGAAGGGCAAGGGTTACGCCCCGGCGGAAG
CGGCAGCGGACAAATATCACGGCGTCAACAAGTTCGACGTCATCACCGGCGCGCAGGCGAAAGCCAAGCCAAATGCGCCG
AGCTATACCAGCGTGTTTGCCGAAGCGCTGATCCAGGAAGCGACCCTCGACGAGAAGATCATCGGTGTCACCGCTGCCAT
GCCGAATGGTACCGGGCTGGACAAGATGGCCGAGCTTTTCCCGTCCCGCACCTTCGATGTCGGCATTGCCGAGCAACACG
CAGTCACCTTCGCGGCGGGACTTGCGGCCGATGGTTACAAGCCGTTCTGCGCGCTTTATTCCACCTTCCTGCAACGCGGT
TACGACCAGCTGGTGCATGATGTGGCGATCCAGAGCTTGCCCGTGCGTTTCCCCATCGATCGCGCCGGCTTCGTCGGCGC
CGACGGACCGACCCATGCCGGCTCCTTCGACACGACGTTCCTCGCCACCCTGCCCGGCATGGTGGTGATGGCGGCGGCCG
ACGAGGCGGAGCTAAAACATATGGTCCGCACGGCGGCGGCTTACGATGAAGGCCCGATTTCATTCCGTTATCCGCGCGGC
GAAGGTGTCGGCGTCGAAATGCCGGCACGCGGTGAGATTCTCCAGATCGGCAAAGGCCGCATCATCAAGGAAGGCACCAA
GGTTGCCCTCCTCTCCTTCGGAACGCGGCTTGCGGAATGCCTTGCGGCCGCCGAAGATCTCGATGCCGCGGGCCTTTCGA
CTACGGTTGCCGATGCGCGCTTCGCCAAGCCGCTCGATCTCGATCTCATCCGCCAGCTTGCCGCCCATCACGAGGTTCTG
GTAACGATCGAGGAAGGTTCTGTCGGCGGTTTTGGTGCGCATGTGCTGCATTTCATGGCCAGCGCCGGCCTACTCGACCA
TGGCCCGAAGGTTCGGACCCTGACCCTGCCCGACCAGTGGGTGGAGCAGGCCAAGCCTGAGACCATGTATGCCAATGCCG
GCCTCGACCGCGCCGGCATCGTTTCCACCGTGTTTAATGCGCTCGGCCAGCGTCAGGCCGGCGTCGGTTTCGCCGGCTGA

Upstream 100 bases:

>100_bases
CGGAAGGTTGAAATTCTATAGAAGTATACGACATGCAGGGCTCACCCGCCGGCTTTCGTGATAGAGGGCACCCTGCGGAC
CACCAGAAAAGGCCGAACGA

Downstream 100 bases:

>100_bases
CAAGATTGCCGGGACAGGAGGCGGGACTATCCCGCCTCTTTCTCAGGATACAGCGCCATCGAGAAAACCGACGACATTGT
CGATCCGTCCCTCGGTATTG

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS

Number of amino acids: Translated: 639; Mature: 638

Protein sequence:

>639_residues
MTGMPQTPLLDRVNFPSDLKEIDDRDLPELARELRDEMIDAVSKTGGHLGAGLGVVELTIAIHKVFNTPEDRLIFDVGHQ
CYPHKILTGRRDRIRTLRQEDGLSGFTRRAESEYDDFGAGHSSTSISAGLGMAVAAGLDGSDRKVIAVIGDGSMSAGMAF
EALNNAGALDARLIVILNDNDMSIAPPTGAMSAYLARLASGRTYMGFRDFGKKLTAYLGKTIDRAITRAVTHARGYVTGG
TLFEELGFYHIGPIDGHSFDHLLPVLRNVRDNQKGPVLIHVVTQKGKGYAPAEAAADKYHGVNKFDVITGAQAKAKPNAP
SYTSVFAEALIQEATLDEKIIGVTAAMPNGTGLDKMAELFPSRTFDVGIAEQHAVTFAAGLAADGYKPFCALYSTFLQRG
YDQLVHDVAIQSLPVRFPIDRAGFVGADGPTHAGSFDTTFLATLPGMVVMAAADEAELKHMVRTAAAYDEGPISFRYPRG
EGVGVEMPARGEILQIGKGRIIKEGTKVALLSFGTRLAECLAAAEDLDAAGLSTTVADARFAKPLDLDLIRQLAAHHEVL
VTIEEGSVGGFGAHVLHFMASAGLLDHGPKVRTLTLPDQWVEQAKPETMYANAGLDRAGIVSTVFNALGQRQAGVGFAG

Sequences:

>Translated_639_residues
MTGMPQTPLLDRVNFPSDLKEIDDRDLPELARELRDEMIDAVSKTGGHLGAGLGVVELTIAIHKVFNTPEDRLIFDVGHQ
CYPHKILTGRRDRIRTLRQEDGLSGFTRRAESEYDDFGAGHSSTSISAGLGMAVAAGLDGSDRKVIAVIGDGSMSAGMAF
EALNNAGALDARLIVILNDNDMSIAPPTGAMSAYLARLASGRTYMGFRDFGKKLTAYLGKTIDRAITRAVTHARGYVTGG
TLFEELGFYHIGPIDGHSFDHLLPVLRNVRDNQKGPVLIHVVTQKGKGYAPAEAAADKYHGVNKFDVITGAQAKAKPNAP
SYTSVFAEALIQEATLDEKIIGVTAAMPNGTGLDKMAELFPSRTFDVGIAEQHAVTFAAGLAADGYKPFCALYSTFLQRG
YDQLVHDVAIQSLPVRFPIDRAGFVGADGPTHAGSFDTTFLATLPGMVVMAAADEAELKHMVRTAAAYDEGPISFRYPRG
EGVGVEMPARGEILQIGKGRIIKEGTKVALLSFGTRLAECLAAAEDLDAAGLSTTVADARFAKPLDLDLIRQLAAHHEVL
VTIEEGSVGGFGAHVLHFMASAGLLDHGPKVRTLTLPDQWVEQAKPETMYANAGLDRAGIVSTVFNALGQRQAGVGFAG
>Mature_638_residues
TGMPQTPLLDRVNFPSDLKEIDDRDLPELARELRDEMIDAVSKTGGHLGAGLGVVELTIAIHKVFNTPEDRLIFDVGHQC
YPHKILTGRRDRIRTLRQEDGLSGFTRRAESEYDDFGAGHSSTSISAGLGMAVAAGLDGSDRKVIAVIGDGSMSAGMAFE
ALNNAGALDARLIVILNDNDMSIAPPTGAMSAYLARLASGRTYMGFRDFGKKLTAYLGKTIDRAITRAVTHARGYVTGGT
LFEELGFYHIGPIDGHSFDHLLPVLRNVRDNQKGPVLIHVVTQKGKGYAPAEAAADKYHGVNKFDVITGAQAKAKPNAPS
YTSVFAEALIQEATLDEKIIGVTAAMPNGTGLDKMAELFPSRTFDVGIAEQHAVTFAAGLAADGYKPFCALYSTFLQRGY
DQLVHDVAIQSLPVRFPIDRAGFVGADGPTHAGSFDTTFLATLPGMVVMAAADEAELKHMVRTAAAYDEGPISFRYPRGE
GVGVEMPARGEILQIGKGRIIKEGTKVALLSFGTRLAECLAAAEDLDAAGLSTTVADARFAKPLDLDLIRQLAAHHEVLV
TIEEGSVGGFGAHVLHFMASAGLLDHGPKVRTLTLPDQWVEQAKPETMYANAGLDRAGIVSTVFNALGQRQAGVGFAG

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily

Homologues:

Organism=Homo sapiens, GI205277463, Length=533, Percent_Identity=24.577861163227, Blast_Score=89, Evalue=2e-17,
Organism=Homo sapiens, GI4507521, Length=533, Percent_Identity=24.577861163227, Blast_Score=89, Evalue=2e-17,
Organism=Homo sapiens, GI156564403, Length=220, Percent_Identity=24.5454545454545, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1786622, Length=622, Percent_Identity=49.6784565916399, Blast_Score=590, Evalue=1e-169,
Organism=Caenorhabditis elegans, GI17539652, Length=674, Percent_Identity=23.7388724035608, Blast_Score=98, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17538422, Length=239, Percent_Identity=26.7782426778243, Blast_Score=68, Evalue=2e-11,
Organism=Drosophila melanogaster, GI45551847, Length=622, Percent_Identity=24.91961414791, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI45550715, Length=622, Percent_Identity=24.91961414791, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24666278, Length=517, Percent_Identity=26.8858800773694, Blast_Score=99, Evalue=7e-21,
Organism=Drosophila melanogaster, GI24645119, Length=516, Percent_Identity=24.4186046511628, Blast_Score=99, Evalue=9e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXS_AGRT5 (Q8UHD7)

Other databases:

- EMBL:   AE007869
- PIR:   A97450
- PIR:   AC2668
- RefSeq:   NP_353769.1
- ProteinModelPortal:   Q8UHD7
- SMR:   Q8UHD7
- STRING:   Q8UHD7
- GeneID:   1132783
- GenomeReviews:   AE007869_GR
- KEGG:   atu:Atu0745
- eggNOG:   COG1154
- HOGENOM:   HBG571647
- OMA:   QRFPDRY
- PhylomeDB:   Q8UHD7
- ProtClustDB:   PRK05444
- BioCyc:   ATUM176299-1:ATU0745-MONOMER
- HAMAP:   MF_00315
- InterPro:   IPR001017
- InterPro:   IPR005477
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474
- Gene3D:   G3DSA:3.40.50.920
- SMART:   SM00861
- TIGRFAMs:   TIGR00204

Pfam domain/function: PF00676 E1_dh; PF02779 Transket_pyr; PF02780 Transketolase_C; SSF52922 Transketo_C_like

EC number: =2.2.1.7

Molecular weight: Translated: 68116; Mature: 67985

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: PS00801 TRANSKETOLASE_1; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGMPQTPLLDRVNFPSDLKEIDDRDLPELARELRDEMIDAVSKTGGHLGAGLGVVELTI
CCCCCCCCCHHCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHH
AIHKVFNTPEDRLIFDVGHQCYPHKILTGRRDRIRTLRQEDGLSGFTRRAESEYDDFGAG
HHHHHHCCCCCCEEEECCCCCCCCHHHCCCHHHHHHHHHHCCCCHHHHHHHCCHHHCCCC
HSSTSISAGLGMAVAAGLDGSDRKVIAVIGDGSMSAGMAFEALNNAGALDARLIVILNDN
CCCCCHHHCCCHHEEECCCCCCCEEEEEEECCCCCCCHHHHHHCCCCCCCEEEEEEECCC
DMSIAPPTGAMSAYLARLASGRTYMGFRDFGKKLTAYLGKTIDRAITRAVTHARGYVTGG
CCEECCCCHHHHHHHHHHHCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECH
TLFEELGFYHIGPIDGHSFDHLLPVLRNVRDNQKGPVLIHVVTQKGKGYAPAEAAADKYH
HHHHHCCCEEECCCCCCCHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCHHHHHHHHC
GVNKFDVITGAQAKAKPNAPSYTSVFAEALIQEATLDEKIIGVTAAMPNGTGLDKMAELF
CCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHEEEEEECCCCCCHHHHHHHC
PSRTFDVGIAEQHAVTFAAGLAADGYKPFCALYSTFLQRGYDQLVHDVAIQSLPVRFPID
CCCCEECCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
RAGFVGADGPTHAGSFDTTFLATLPGMVVMAAADEAELKHMVRTAAAYDEGPISFRYPRG
CCCCCCCCCCCCCCCCCHHHHHHCCCEEEEECCCHHHHHHHHHHHHHCCCCCCEEECCCC
EGVGVEMPARGEILQIGKGRIIKEGTKVALLSFGTRLAECLAAAEDLDAAGLSTTVADAR
CCCCCCCCCCCCEEECCCCCEEECCCEEEEHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
FAKPLDLDLIRQLAAHHEVLVTIEEGSVGGFGAHVLHFMASAGLLDHGPKVRTLTLPDQW
CCCCCCHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCEEEEECCHHH
VEQAKPETMYANAGLDRAGIVSTVFNALGQRQAGVGFAG
HHHCCCCEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
TGMPQTPLLDRVNFPSDLKEIDDRDLPELARELRDEMIDAVSKTGGHLGAGLGVVELTI
CCCCCCCCHHCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHH
AIHKVFNTPEDRLIFDVGHQCYPHKILTGRRDRIRTLRQEDGLSGFTRRAESEYDDFGAG
HHHHHHCCCCCCEEEECCCCCCCCHHHCCCHHHHHHHHHHCCCCHHHHHHHCCHHHCCCC
HSSTSISAGLGMAVAAGLDGSDRKVIAVIGDGSMSAGMAFEALNNAGALDARLIVILNDN
CCCCCHHHCCCHHEEECCCCCCCEEEEEEECCCCCCCHHHHHHCCCCCCCEEEEEEECCC
DMSIAPPTGAMSAYLARLASGRTYMGFRDFGKKLTAYLGKTIDRAITRAVTHARGYVTGG
CCEECCCCHHHHHHHHHHHCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECH
TLFEELGFYHIGPIDGHSFDHLLPVLRNVRDNQKGPVLIHVVTQKGKGYAPAEAAADKYH
HHHHHCCCEEECCCCCCCHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCHHHHHHHHC
GVNKFDVITGAQAKAKPNAPSYTSVFAEALIQEATLDEKIIGVTAAMPNGTGLDKMAELF
CCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHEEEEEECCCCCCHHHHHHHC
PSRTFDVGIAEQHAVTFAAGLAADGYKPFCALYSTFLQRGYDQLVHDVAIQSLPVRFPID
CCCCEECCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
RAGFVGADGPTHAGSFDTTFLATLPGMVVMAAADEAELKHMVRTAAAYDEGPISFRYPRG
CCCCCCCCCCCCCCCCCHHHHHHCCCEEEEECCCHHHHHHHHHHHHHCCCCCCEEECCCC
EGVGVEMPARGEILQIGKGRIIKEGTKVALLSFGTRLAECLAAAEDLDAAGLSTTVADAR
CCCCCCCCCCCCEEECCCCCEEECCCEEEEHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
FAKPLDLDLIRQLAAHHEVLVTIEEGSVGGFGAHVLHFMASAGLLDHGPKVRTLTLPDQW
CCCCCCHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCEEEEECCHHH
VEQAKPETMYANAGLDRAGIVSTVFNALGQRQAGVGFAG
HHHCCCCEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194