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The map label for this gene is lpxK

Identifier: 15888041

GI number: 15888041

Start: 695709

End: 696755

Strand: Direct

Name: lpxK

Synonym: Atu0697

Alternate gene names: 15888041

Gene position: 695709-696755 (Clockwise)

Preceding gene: 15888040

Following gene: 15888044

Centisome position: 24.48

GC content: 62.75

Gene sequence:

>1047_bases
ATGGTTTCTGAAGCGCCGCCCTTCTGGTGGCAGAAAGCAGGTTGGCAGGCATGGCTCCTGTCACCTTTTTCGCTTCTTTA
TGGCAAGGTCGCCGGCCGGCGCATGCGCACGGCAAAACGGGCAAACGTTCCCGTTCCGGTCATCTGCATCGGCAATTTCA
CGGTCGGCGGGGCAGGCAAGACACCGACGGCGATAGCCATCGCCAGAGCCGCCGTCGCACGGGGAATGAAGCCCGGCTTC
CTCAGCCGCGGTTATGGCGGCACGCTTGACGTCACCACTCTTGTGGATGCGCAGCACCATCGCGCCGCCGCTGTCGGAGA
TGAACCTCTTCTCCTGGCGCGCGAGGCGGTAACGGTCATTTCGCGCAGACGCGTGGAGGGCGCACACCGGCTGGTAAAGG
AAGGCGTCAATCTCATCATCATGGATGACGGGTTCCAGAGCGCCCGCCTGACGCTGGATTACGCGCTCGTTGTTATTGAT
ACGGTGCGCGGCATCGGCAATGGCCATCTCGTGCCCGGCGGCCCGGTGAGGGCGCCGCTGGCAGAACAGATGCGGCAGAT
GACCGGACTGCTGAAGGTCGGCAAGGGCCACGCGGCCGATCCGCTGGTGAGGCAGGCGGCAAAGGCCGCCAAACCCGTCT
TCGTCGCCGCGATCATGCCGCAGGAGCCGGAGGATTTCAGGGGAAAGCGCGTGCTGGCTTTCGCCGGTATCGCCGATCCG
GCGAAATTCTATCGCACCGTCGAGGCGCTTGGCGGCGACATCGTGCTGAGCCGCTCCTTTCCGGATCATCATCATTTCAG
CGATGATGAAATCGACGATCTCCTCAAGGATGCCCGCAAGGAGAATTTGCAGCTGGTGACGACCGCCAAGGATGCGGTGC
GGCTCAACGGACATCACGGCCGGGCGGAAGAGCTGCTGTGGAACAGTCAGGTGATCGAAATCGACATGGTATTCGACGAT
CCCAATGCGGCCGGAACTGTTATCGAGACGGCGGTGGTGAACTGCCGCGCGCGCCTGCTGCGGGACAACGCACGGTCGTC
AACTTAG

Upstream 100 bases:

>100_bases
TATTCCATTTTTGCAATTTACGGTTTTTTCTGGCAAACAACCTCCCAGATGTGAATAGCGAACGGAATGCCGTGGGCGAC
GCGGCCGGGAGCAGGAATAG

Downstream 100 bases:

>100_bases
AGCCCGACTGAGGCCGGCAAATCGCCAGCCTTCCGCTCCGCCTCCAGCGAAGCCGCCGCGTCCACATAGGCCTCCTGACG
CGCCACGCTCCAGTAGCGCA

Product: tetraacyldisaccharide 4'-kinase

Products: NA

Alternate protein names: Lipid A 4'-kinase

Number of amino acids: Translated: 348; Mature: 348

Protein sequence:

>348_residues
MVSEAPPFWWQKAGWQAWLLSPFSLLYGKVAGRRMRTAKRANVPVPVICIGNFTVGGAGKTPTAIAIARAAVARGMKPGF
LSRGYGGTLDVTTLVDAQHHRAAAVGDEPLLLAREAVTVISRRRVEGAHRLVKEGVNLIIMDDGFQSARLTLDYALVVID
TVRGIGNGHLVPGGPVRAPLAEQMRQMTGLLKVGKGHAADPLVRQAAKAAKPVFVAAIMPQEPEDFRGKRVLAFAGIADP
AKFYRTVEALGGDIVLSRSFPDHHHFSDDEIDDLLKDARKENLQLVTTAKDAVRLNGHHGRAEELLWNSQVIEIDMVFDD
PNAAGTVIETAVVNCRARLLRDNARSST

Sequences:

>Translated_348_residues
MVSEAPPFWWQKAGWQAWLLSPFSLLYGKVAGRRMRTAKRANVPVPVICIGNFTVGGAGKTPTAIAIARAAVARGMKPGF
LSRGYGGTLDVTTLVDAQHHRAAAVGDEPLLLAREAVTVISRRRVEGAHRLVKEGVNLIIMDDGFQSARLTLDYALVVID
TVRGIGNGHLVPGGPVRAPLAEQMRQMTGLLKVGKGHAADPLVRQAAKAAKPVFVAAIMPQEPEDFRGKRVLAFAGIADP
AKFYRTVEALGGDIVLSRSFPDHHHFSDDEIDDLLKDARKENLQLVTTAKDAVRLNGHHGRAEELLWNSQVIEIDMVFDD
PNAAGTVIETAVVNCRARLLRDNARSST
>Mature_348_residues
MVSEAPPFWWQKAGWQAWLLSPFSLLYGKVAGRRMRTAKRANVPVPVICIGNFTVGGAGKTPTAIAIARAAVARGMKPGF
LSRGYGGTLDVTTLVDAQHHRAAAVGDEPLLLAREAVTVISRRRVEGAHRLVKEGVNLIIMDDGFQSARLTLDYALVVID
TVRGIGNGHLVPGGPVRAPLAEQMRQMTGLLKVGKGHAADPLVRQAAKAAKPVFVAAIMPQEPEDFRGKRVLAFAGIADP
AKFYRTVEALGGDIVLSRSFPDHHHFSDDEIDDLLKDARKENLQLVTTAKDAVRLNGHHGRAEELLWNSQVIEIDMVFDD
PNAAGTVIETAVVNCRARLLRDNARSST

Specific function: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)

COG id: COG1663

COG function: function code M; Tetraacyldisaccharide-1-P 4'-kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxK family

Homologues:

Organism=Escherichia coli, GI1787144, Length=307, Percent_Identity=30.9446254071661, Blast_Score=126, Evalue=2e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXK_AGRT5 (Q8UHI5)

Other databases:

- EMBL:   AE007869
- PIR:   AC2662
- PIR:   B97444
- RefSeq:   NP_353722.1
- STRING:   Q8UHI5
- GeneID:   1132735
- GenomeReviews:   AE007869_GR
- KEGG:   atu:Atu0697
- eggNOG:   COG1663
- HOGENOM:   HBG663914
- OMA:   VILMDDG
- PhylomeDB:   Q8UHI5
- ProtClustDB:   PRK00652
- BioCyc:   ATUM176299-1:ATU0697-MONOMER
- HAMAP:   MF_00409
- InterPro:   IPR003758
- TIGRFAMs:   TIGR00682

Pfam domain/function: PF02606 LpxK

EC number: =2.7.1.130

Molecular weight: Translated: 37691; Mature: 37691

Theoretical pI: Translated: 10.03; Mature: 10.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSEAPPFWWQKAGWQAWLLSPFSLLYGKVAGRRMRTAKRANVPVPVICIGNFTVGGAGK
CCCCCCCCHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCEEECCCCC
TPTAIAIARAAVARGMKPGFLSRGYGGTLDVTTLVDAQHHRAAAVGDEPLLLAREAVTVI
CCHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEECCCHHHHHHCCCCCHHHHHHHHHHH
SRRRVEGAHRLVKEGVNLIIMDDGFQSARLTLDYALVVIDTVRGIGNGHLVPGGPVRAPL
HHHHHHHHHHHHHCCCCEEEEECCCCCCEEEHHHHHHHHHHHHCCCCCCCCCCCCCCCHH
AEQMRQMTGLLKVGKGHAADPLVRQAAKAAKPVFVAAIMPQEPEDFRGKRVLAFAGIADP
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCEEEEEECCCCCCCCCCCEEEEEECCCCH
AKFYRTVEALGGDIVLSRSFPDHHHFSDDEIDDLLKDARKENLQLVTTAKDAVRLNGHHG
HHHHHHHHHCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHCCEEEEEECCCCEEECCCCC
RAEELLWNSQVIEIDMVFDDPNAAGTVIETAVVNCRARLLRDNARSST
CHHHHHCCCEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MVSEAPPFWWQKAGWQAWLLSPFSLLYGKVAGRRMRTAKRANVPVPVICIGNFTVGGAGK
CCCCCCCCHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCEEECCCCC
TPTAIAIARAAVARGMKPGFLSRGYGGTLDVTTLVDAQHHRAAAVGDEPLLLAREAVTVI
CCHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEECCCHHHHHHCCCCCHHHHHHHHHHH
SRRRVEGAHRLVKEGVNLIIMDDGFQSARLTLDYALVVIDTVRGIGNGHLVPGGPVRAPL
HHHHHHHHHHHHHCCCCEEEEECCCCCCEEEHHHHHHHHHHHHCCCCCCCCCCCCCCCHH
AEQMRQMTGLLKVGKGHAADPLVRQAAKAAKPVFVAAIMPQEPEDFRGKRVLAFAGIADP
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCEEEEEECCCCCCCCCCCEEEEEECCCCH
AKFYRTVEALGGDIVLSRSFPDHHHFSDDEIDDLLKDARKENLQLVTTAKDAVRLNGHHG
HHHHHHHHHCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHCCEEEEEECCCCEEECCCCC
RAEELLWNSQVIEIDMVFDDPNAAGTVIETAVVNCRARLLRDNARSST
CHHHHHCCCEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194