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The map label for this gene is kefB [H]

Identifier: 15888035

GI number: 15888035

Start: 688740

End: 690572

Strand: Reverse

Name: kefB [H]

Synonym: Atu0692

Alternate gene names: 15888035

Gene position: 690572-688740 (Counterclockwise)

Preceding gene: 159184422

Following gene: 15888031

Centisome position: 24.3

GC content: 61.54

Gene sequence:

>1833_bases
ATGACCGAGCACGACGCTCTCTTTTCCGAACCATTGCTGCTTCTGGCCGGCGCGGTCATCGCGGCCTCCGTTTTCCGCAA
GCTAGGTCTTGGCACCGTGCTCGGTTATCTGGTGGCCGGCATCATCATCGGGCCGTTCCTGCATCTCGTCACGGATGCGA
AGGACATCTTCAATGTCTCGGAACTCGGCGTGGTTTTCCTGCTCTTCATCATCGGGCTGGAACTGAAACCCTCGCGCATC
TGGCAGATGCGGCGCGATATTTTGGGCCTCGGGCTGGCGCAGGTGCTGGTGACGGGTAGCGCGCTGGCGGCGATTGCCTG
GTGGGCGGGGCTGATCGACGCGCGGGGAAGCGTGGTTGCGGGTTTCGGCCTTGCGCTTTCCTCCACCGCTTTTGCGCTGC
AGATTCTGGAAGACGACGGCGACATGAATACGCGCCACGGCAACCGTTCCTTCTCGATCCTGCTGTTTCAGGATCTTGCC
ATCGTGCCGCTTCTGGCGCTCGTGACCATTCTCTCCAACCGGCCGGATGTGCCGACGGATTCGATGGCTTACGATCTCGT
CGCCTCGGTCGTTGCGGTGGCAGGCATGGTGCTGGCCGGACGCTTCCTGCTGACGCCGATGTTCCAGATCATCGCCCGCA
CGGGTGCGCGCGAAGTGATGATCGCGGCCGCCCTTTTTGTCGTCATCGGCGCGGCCGCCATTATGGAGATGGTGGGCCTG
TCGATGGGCATGGGTGCGCTGCTGGCAGGGCTGATGCTGTCGGAATCCTCTTACCGGCATGAGCTGGAGGCCGATATCGA
GCCGTTTCGCGGGTTGTTCCTGGCGCTGTTCTTCATGGCCGTCGGCATGTCGCTGCATATCAATATCGTCTACGAGCACA
TCGTCCTCATCCTCATCGCCGTGCCTGTCATGATGGCGGTGAAGGCGGCCCTGATCTATGGTCTTTGCCGCATTGCCGGT
TCGTCGCGTTATGCGTCGAGCCGCATCGCGCTGCTTCTGGCGCAGGGCGGCGAATTCGGTTTCGTGCTTTTCACCACGGC
CGCCGCGTCCGGCCTGTTTCCGCAGGCCACGGCCTCGATCCTCGTCGCCGTCGTCACGCTCTCCATGGCGCTGACGCCGG
TTCTGGCAGTGATTTCGCGGCGGCTGACCGCGGAGGATGCGGAAGAGGACAAGCTGGAAGAGGATTTCGACGGGGCGGGT
GCGGATGTGCTGATGATCGGCTTTTCCCGCTTCGGCCAGATCGCCTCGCAGATCCTTCTTGCTGGCGGCCGCGACGTGAC
TGTCATCGACAGTTCGGCCGACCGTGTGCGTCAGGCCGCCCGTTTCGGGTTCCGCATCTTTTTCGGCGATGGCACCCGCA
AGGATGTGCTGATCGCAGCCGGTATCGAACGCGCCGATCTGGTGGCGGTCTGCACCCACAAGAAGGAGGTCACCGACCGT
ATCATCGACATGATCCAGTCGGAATTTCCAAGCGTGCGCATCTATGCCCGCTCCTATGACCGCATTCATTCCCTCGACCT
CAGGAAAAAGGGCGTGGAATATGAAATCCGAGAGACGCTGGAATCCGGCCTGCTGTTCGGCAGGCGCATTCTGGAAGGGC
TGGATATGGACGCTGAAAGGGCACTTGCCATTTCCGACGACATCCGCGAACGCGACGAACAGCGACTGGAGCTTCAGGCC
GTCGAAGGCCTCGCGGCCGGACGGCAGATGCTGCACAACAAACCCGTGCGCGAAGTGAAGCCGGAACCGCTGATGAAGCC
GAAGAACAAGGCGGAGAAGCGGGAGGAGGAAGAAGAGGATATGGAGGAAAGCGAGACGGAAGTTTTACTGTAG

Upstream 100 bases:

>100_bases
CCTGTTCCATTTATTGTGCCAGCAACCCTGCATCAAGGGCGAAACGCCGCTTTCTCCATTCAGACGGCTCCATCGCCACC
CTATTTGAAAGTCCGCCCGC

Downstream 100 bases:

>100_bases
TGTCAAATAAGCGGCCCCCGCTCGGCTTCCTATTCAGGGTGTAACGCTCAAGCCTCCACGCCCTGCCCGCGGTGAAACAA
CTCCACCTGCATCTCGATCT

Product: glutathione-regulated potassium-efflux system protein

Products: Proton [Cytoplasm]; K (I) [Periplasm] [C]

Alternate protein names: K(+)/H(+) antiporter [H]

Number of amino acids: Translated: 610; Mature: 609

Protein sequence:

>610_residues
MTEHDALFSEPLLLLAGAVIAASVFRKLGLGTVLGYLVAGIIIGPFLHLVTDAKDIFNVSELGVVFLLFIIGLELKPSRI
WQMRRDILGLGLAQVLVTGSALAAIAWWAGLIDARGSVVAGFGLALSSTAFALQILEDDGDMNTRHGNRSFSILLFQDLA
IVPLLALVTILSNRPDVPTDSMAYDLVASVVAVAGMVLAGRFLLTPMFQIIARTGAREVMIAAALFVVIGAAAIMEMVGL
SMGMGALLAGLMLSESSYRHELEADIEPFRGLFLALFFMAVGMSLHINIVYEHIVLILIAVPVMMAVKAALIYGLCRIAG
SSRYASSRIALLLAQGGEFGFVLFTTAAASGLFPQATASILVAVVTLSMALTPVLAVISRRLTAEDAEEDKLEEDFDGAG
ADVLMIGFSRFGQIASQILLAGGRDVTVIDSSADRVRQAARFGFRIFFGDGTRKDVLIAAGIERADLVAVCTHKKEVTDR
IIDMIQSEFPSVRIYARSYDRIHSLDLRKKGVEYEIRETLESGLLFGRRILEGLDMDAERALAISDDIRERDEQRLELQA
VEGLAAGRQMLHNKPVREVKPEPLMKPKNKAEKREEEEEDMEESETEVLL

Sequences:

>Translated_610_residues
MTEHDALFSEPLLLLAGAVIAASVFRKLGLGTVLGYLVAGIIIGPFLHLVTDAKDIFNVSELGVVFLLFIIGLELKPSRI
WQMRRDILGLGLAQVLVTGSALAAIAWWAGLIDARGSVVAGFGLALSSTAFALQILEDDGDMNTRHGNRSFSILLFQDLA
IVPLLALVTILSNRPDVPTDSMAYDLVASVVAVAGMVLAGRFLLTPMFQIIARTGAREVMIAAALFVVIGAAAIMEMVGL
SMGMGALLAGLMLSESSYRHELEADIEPFRGLFLALFFMAVGMSLHINIVYEHIVLILIAVPVMMAVKAALIYGLCRIAG
SSRYASSRIALLLAQGGEFGFVLFTTAAASGLFPQATASILVAVVTLSMALTPVLAVISRRLTAEDAEEDKLEEDFDGAG
ADVLMIGFSRFGQIASQILLAGGRDVTVIDSSADRVRQAARFGFRIFFGDGTRKDVLIAAGIERADLVAVCTHKKEVTDR
IIDMIQSEFPSVRIYARSYDRIHSLDLRKKGVEYEIRETLESGLLFGRRILEGLDMDAERALAISDDIRERDEQRLELQA
VEGLAAGRQMLHNKPVREVKPEPLMKPKNKAEKREEEEEDMEESETEVLL
>Mature_609_residues
TEHDALFSEPLLLLAGAVIAASVFRKLGLGTVLGYLVAGIIIGPFLHLVTDAKDIFNVSELGVVFLLFIIGLELKPSRIW
QMRRDILGLGLAQVLVTGSALAAIAWWAGLIDARGSVVAGFGLALSSTAFALQILEDDGDMNTRHGNRSFSILLFQDLAI
VPLLALVTILSNRPDVPTDSMAYDLVASVVAVAGMVLAGRFLLTPMFQIIARTGAREVMIAAALFVVIGAAAIMEMVGLS
MGMGALLAGLMLSESSYRHELEADIEPFRGLFLALFFMAVGMSLHINIVYEHIVLILIAVPVMMAVKAALIYGLCRIAGS
SRYASSRIALLLAQGGEFGFVLFTTAAASGLFPQATASILVAVVTLSMALTPVLAVISRRLTAEDAEEDKLEEDFDGAGA
DVLMIGFSRFGQIASQILLAGGRDVTVIDSSADRVRQAARFGFRIFFGDGTRKDVLIAAGIERADLVAVCTHKKEVTDRI
IDMIQSEFPSVRIYARSYDRIHSLDLRKKGVEYEIRETLESGLLFGRRILEGLDMDAERALAISDDIRERDEQRLELQAV
EGLAAGRQMLHNKPVREVKPEPLMKPKNKAEKREEEEEDMEESETEVLL

Specific function: Transport system that facilitate potassium-efflux, possibly by potassium-proton antiport [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK N-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI157388921, Length=388, Percent_Identity=26.2886597938144, Blast_Score=91, Evalue=4e-18,
Organism=Escherichia coli, GI1789749, Length=557, Percent_Identity=41.2926391382406, Blast_Score=384, Evalue=1e-107,
Organism=Escherichia coli, GI1786232, Length=563, Percent_Identity=39.4316163410302, Blast_Score=370, Evalue=1e-103,
Organism=Escherichia coli, GI1786685, Length=500, Percent_Identity=28.6, Blast_Score=154, Evalue=1e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771
- InterPro:   IPR016040
- InterPro:   IPR003148 [H]

Pfam domain/function: PF00999 Na_H_Exchanger; PF02254 TrkA_N [H]

EC number: NA

Molecular weight: Translated: 66225; Mature: 66094

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEHDALFSEPLLLLAGAVIAASVFRKLGLGTVLGYLVAGIIIGPFLHLVTDAKDIFNVS
CCCCHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHH
ELGVVFLLFIIGLELKPSRIWQMRRDILGLGLAQVLVTGSALAAIAWWAGLIDARGSVVA
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
GFGLALSSTAFALQILEDDGDMNTRHGNRSFSILLFQDLAIVPLLALVTILSNRPDVPTD
HHHHHHHHHHHEEEEEECCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHCCCCCCCCH
SMAYDLVASVVAVAGMVLAGRFLLTPMFQIIARTGAREVMIAAALFVVIGAAAIMEMVGL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
SMGMGALLAGLMLSESSYRHELEADIEPFRGLFLALFFMAVGMSLHINIVYEHIVLILIA
HCCHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHHHHHHHCCHHHEEHHHHHHHHHHHHH
VPVMMAVKAALIYGLCRIAGSSRYASSRIALLLAQGGEFGFVLFTTAAASGLFPQATASI
HHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCEEEEEEEHHHHCCCCHHHHHHH
LVAVVTLSMALTPVLAVISRRLTAEDAEEDKLEEDFDGAGADVLMIGFSRFGQIASQILL
HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHH
AGGRDVTVIDSSADRVRQAARFGFRIFFGDGTRKDVLIAAGIERADLVAVCTHKKEVTDR
CCCCEEEEECCCHHHHHHHHHCCEEEEECCCCCCCEEEEECCCHHHHHHHHHCHHHHHHH
IIDMIQSEFPSVRIYARSYDRIHSLDLRKKGVEYEIRETLESGLLFGRRILEGLDMDAER
HHHHHHHCCCCEEEEECHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHH
ALAISDDIRERDEQRLELQAVEGLAAGRQMLHNKPVREVKPEPLMKPKNKAEKREEEEED
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCCHHHHHHHHHHH
MEESETEVLL
HHHHHCCCCC
>Mature Secondary Structure 
TEHDALFSEPLLLLAGAVIAASVFRKLGLGTVLGYLVAGIIIGPFLHLVTDAKDIFNVS
CCCHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHH
ELGVVFLLFIIGLELKPSRIWQMRRDILGLGLAQVLVTGSALAAIAWWAGLIDARGSVVA
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
GFGLALSSTAFALQILEDDGDMNTRHGNRSFSILLFQDLAIVPLLALVTILSNRPDVPTD
HHHHHHHHHHHEEEEEECCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHCCCCCCCCH
SMAYDLVASVVAVAGMVLAGRFLLTPMFQIIARTGAREVMIAAALFVVIGAAAIMEMVGL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
SMGMGALLAGLMLSESSYRHELEADIEPFRGLFLALFFMAVGMSLHINIVYEHIVLILIA
HCCHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHHHHHHHCCHHHEEHHHHHHHHHHHHH
VPVMMAVKAALIYGLCRIAGSSRYASSRIALLLAQGGEFGFVLFTTAAASGLFPQATASI
HHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCEEEEEEEHHHHCCCCHHHHHHH
LVAVVTLSMALTPVLAVISRRLTAEDAEEDKLEEDFDGAGADVLMIGFSRFGQIASQILL
HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHH
AGGRDVTVIDSSADRVRQAARFGFRIFFGDGTRKDVLIAAGIERADLVAVCTHKKEVTDR
CCCCEEEEECCCHHHHHHHHHCCEEEEECCCCCCCEEEEECCCHHHHHHHHHCHHHHHHH
IIDMIQSEFPSVRIYARSYDRIHSLDLRKKGVEYEIRETLESGLLFGRRILEGLDMDAER
HHHHHHHCCCCEEEEECHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHH
ALAISDDIRERDEQRLELQAVEGLAAGRQMLHNKPVREVKPEPLMKPKNKAEKREEEEED
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCCHHHHHHHHHHH
MEESETEVLL
HHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Cytoplasm] = Proton [Cytoplasm] + K (I) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]