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The map label for this gene is groEL [H]

Identifier: 15888025

GI number: 15888025

Start: 676328

End: 677962

Strand: Reverse

Name: groEL [H]

Synonym: Atu0682

Alternate gene names: 15888025

Gene position: 677962-676328 (Counterclockwise)

Preceding gene: 15888026

Following gene: 159185413

Centisome position: 23.86

GC content: 58.1

Gene sequence:

>1635_bases
ATGGCAGCTAAAGAAGTCAAATTCGGCCGCTCAGCGCGCGAAAAGATGCTCAAGGGCGTCGACATTCTTGCCGATGCAGT
GAAAGTAACCCTCGGCCCGAAGGGCCGTAACGTCGTTATCGACAAGTCCTTCGGCGCTCCGCGCATCACCAAGGACGGCG
TTTCCGTCGCCAAGGAAATCGAACTGGAAGACAAGTTCGAGAACATGGGCGCACAGCTCGTTCGCGAAGTTGCCTCCAAG
ACCAACGACATCGCCGGTGACGGCACCACCACCGCAACGGTTCTGGCCCAGGCCATCGTTCGCGAAGGTGCAAAGGCAGT
TGCTGCCGGCATGAACCCGATGGACCTCAAGCGCGGTATCGATCTGGCCGTTGCTGAAGTCGTCAAGGACCTTCAGGCCA
AGGCCAAGAAGATCAACACGTCTGAAGAAGTTGCACAGGTCGGCACGATCTCTGCAAACGGCGAGCGTCAGATCGGTCTC
GACATTGCTGAAGCAATGCAGCGCGTCGGCAACGAAGGCGTCATCACCGTTGAAGAAGCCAAGACTGCTGAAACCGAACT
CGAAGTCGTCGAAGGCATGCAGTTCGACCGCGGCTACCTGTCGCCTTACTTCGTAACCAACCCGGAAAAGATGGTTGCGG
ACCTCGAAGACGCTTACATCCTTCTGCACGAAAAGAAGCTCTCGAACCTTCAGGCCATGCTGCCTGTTCTCGAAGCCGTC
GTTCAGACCGGCAAGCCGCTCGTCATCATCGCTGAAGACGTCGAAGGCGAAGCTCTTGCAACGCTCGTCGTCAACAAGCT
GCGTGGCGGCCTCAAGATCGCTGCCGTCAAGGCTCCTGGCTTCGGCGATCGCCGCAAGGCCATGCTGGAAGACATCGCCA
TCCTGACCGGTGGTACCGTCATTTCCGAAGACCTCGGCATCAAGCTCGAAAGCGTTACCCTCGACATGCTCGGCAAGTCG
AAGAAGGTTTCGATCTCCAAGGAAAACACCACGATCGTTGACGGTGCCGGCCAGAAGTCCGACATCGAAGGCCGCGTTGC
CCAGATCAAGGCACAGATCGAGGAAACCACTTCCGACTACGACCGCGAAAAGCTGCAGGAACGTCTTGCCAAGCTCGCTG
GCGGCGTTGCCGTGATCCGCGTTGGCGGTTCGACGGAAGTTGAAGTGAAGGAAAAGAAGGACCGCATCGACGACGCTCTC
AACGCGACGCGCGCTGCTGTTCAGGAAGGCATCGTACCGGGCGGCGGCGTTGCCCTGCTGCGTTCTTCCACGAAGATCAC
CGTCAAGGGTGTGAACGACGATCAGGAAGCCGGCATCAACATCGTGCGCAAGGCTCTGCAGTCTCTGGTTCGCCAGATCG
CAGAAAACGCTGGTGATGAAGCTTCCATCGTTGTTGGCAAGATCCTCGACAAGAACGAAGACAACTACGGCTACAACGCC
CAGACCGGCGAATATGGCGATCTGATCGCTCTCGGCATCGTCGACCCGGTCAAGGTTGTACGTACCGCTCTGCAGAACGC
AGCTTCGGTTGCTTCGCTGCTGATCACCACCGAAGCGATGATCGCCGAGCTTCCTAAGAAGGAATCGGCAATGCCGCAGA
TGCCCGGCGGCGGCATGGGCGGCATGGACTTCTAA

Upstream 100 bases:

>100_bases
CGACATCATGGGTATCATCGGCTGATTTTGCCGAACCCATCGTTTCCTTAAATTTCAAGCCGGATCAGTTCCGGCCGTTC
GAAACCAGGAGTTTTGAAAA

Downstream 100 bases:

>100_bases
TCAGTCCTGTCACCGGAATACGAAAGGGCGATCTTCGGATCGCCCTTTTTTCATTGCCGCCCATGCCTTTTTGCGGGTCC
GGCGTCGCAAGCGCACCAGA

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein 1; Protein Cpn60 1 [H]

Number of amino acids: Translated: 544; Mature: 543

Protein sequence:

>544_residues
MAAKEVKFGRSAREKMLKGVDILADAVKVTLGPKGRNVVIDKSFGAPRITKDGVSVAKEIELEDKFENMGAQLVREVASK
TNDIAGDGTTTATVLAQAIVREGAKAVAAGMNPMDLKRGIDLAVAEVVKDLQAKAKKINTSEEVAQVGTISANGERQIGL
DIAEAMQRVGNEGVITVEEAKTAETELEVVEGMQFDRGYLSPYFVTNPEKMVADLEDAYILLHEKKLSNLQAMLPVLEAV
VQTGKPLVIIAEDVEGEALATLVVNKLRGGLKIAAVKAPGFGDRRKAMLEDIAILTGGTVISEDLGIKLESVTLDMLGKS
KKVSISKENTTIVDGAGQKSDIEGRVAQIKAQIEETTSDYDREKLQERLAKLAGGVAVIRVGGSTEVEVKEKKDRIDDAL
NATRAAVQEGIVPGGGVALLRSSTKITVKGVNDDQEAGINIVRKALQSLVRQIAENAGDEASIVVGKILDKNEDNYGYNA
QTGEYGDLIALGIVDPVKVVRTALQNAASVASLLITTEAMIAELPKKESAMPQMPGGGMGGMDF

Sequences:

>Translated_544_residues
MAAKEVKFGRSAREKMLKGVDILADAVKVTLGPKGRNVVIDKSFGAPRITKDGVSVAKEIELEDKFENMGAQLVREVASK
TNDIAGDGTTTATVLAQAIVREGAKAVAAGMNPMDLKRGIDLAVAEVVKDLQAKAKKINTSEEVAQVGTISANGERQIGL
DIAEAMQRVGNEGVITVEEAKTAETELEVVEGMQFDRGYLSPYFVTNPEKMVADLEDAYILLHEKKLSNLQAMLPVLEAV
VQTGKPLVIIAEDVEGEALATLVVNKLRGGLKIAAVKAPGFGDRRKAMLEDIAILTGGTVISEDLGIKLESVTLDMLGKS
KKVSISKENTTIVDGAGQKSDIEGRVAQIKAQIEETTSDYDREKLQERLAKLAGGVAVIRVGGSTEVEVKEKKDRIDDAL
NATRAAVQEGIVPGGGVALLRSSTKITVKGVNDDQEAGINIVRKALQSLVRQIAENAGDEASIVVGKILDKNEDNYGYNA
QTGEYGDLIALGIVDPVKVVRTALQNAASVASLLITTEAMIAELPKKESAMPQMPGGGMGGMDF
>Mature_543_residues
AAKEVKFGRSAREKMLKGVDILADAVKVTLGPKGRNVVIDKSFGAPRITKDGVSVAKEIELEDKFENMGAQLVREVASKT
NDIAGDGTTTATVLAQAIVREGAKAVAAGMNPMDLKRGIDLAVAEVVKDLQAKAKKINTSEEVAQVGTISANGERQIGLD
IAEAMQRVGNEGVITVEEAKTAETELEVVEGMQFDRGYLSPYFVTNPEKMVADLEDAYILLHEKKLSNLQAMLPVLEAVV
QTGKPLVIIAEDVEGEALATLVVNKLRGGLKIAAVKAPGFGDRRKAMLEDIAILTGGTVISEDLGIKLESVTLDMLGKSK
KVSISKENTTIVDGAGQKSDIEGRVAQIKAQIEETTSDYDREKLQERLAKLAGGVAVIRVGGSTEVEVKEKKDRIDDALN
ATRAAVQEGIVPGGGVALLRSSTKITVKGVNDDQEAGINIVRKALQSLVRQIAENAGDEASIVVGKILDKNEDNYGYNAQ
TGEYGDLIALGIVDPVKVVRTALQNAASVASLLITTEAMIAELPKKESAMPQMPGGGMGGMDF

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions [H]

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family [H]

Homologues:

Organism=Homo sapiens, GI41399285, Length=528, Percent_Identity=53.5984848484849, Blast_Score=558, Evalue=1e-159,
Organism=Homo sapiens, GI31542947, Length=528, Percent_Identity=53.5984848484849, Blast_Score=558, Evalue=1e-159,
Organism=Homo sapiens, GI5453607, Length=539, Percent_Identity=22.6345083487941, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI1790586, Length=531, Percent_Identity=67.0433145009416, Blast_Score=702, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17555558, Length=529, Percent_Identity=53.6862003780718, Blast_Score=564, Evalue=1e-161,
Organism=Caenorhabditis elegans, GI193210679, Length=240, Percent_Identity=50.4166666666667, Blast_Score=228, Evalue=4e-60,
Organism=Caenorhabditis elegans, GI17564182, Length=559, Percent_Identity=22.8980322003578, Blast_Score=79, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6323288, Length=526, Percent_Identity=57.4144486692015, Blast_Score=597, Evalue=1e-171,
Organism=Saccharomyces cerevisiae, GI6320393, Length=541, Percent_Identity=24.3992606284658, Blast_Score=79, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6322350, Length=550, Percent_Identity=23.8181818181818, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24641193, Length=528, Percent_Identity=57.0075757575758, Blast_Score=589, Evalue=1e-168,
Organism=Drosophila melanogaster, GI24641191, Length=528, Percent_Identity=57.0075757575758, Blast_Score=589, Evalue=1e-168,
Organism=Drosophila melanogaster, GI45550936, Length=530, Percent_Identity=53.9622641509434, Blast_Score=563, Evalue=1e-160,
Organism=Drosophila melanogaster, GI45550132, Length=530, Percent_Identity=53.9622641509434, Blast_Score=563, Evalue=1e-160,
Organism=Drosophila melanogaster, GI45550935, Length=530, Percent_Identity=53.9622641509434, Blast_Score=563, Evalue=1e-160,
Organism=Drosophila melanogaster, GI17864606, Length=547, Percent_Identity=45.8866544789762, Blast_Score=467, Evalue=1e-132,
Organism=Drosophila melanogaster, GI24584129, Length=537, Percent_Identity=36.1266294227188, Blast_Score=330, Evalue=1e-90,
Organism=Drosophila melanogaster, GI19921262, Length=537, Percent_Identity=36.1266294227188, Blast_Score=330, Evalue=1e-90,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423 [H]

Pfam domain/function: PF00118 Cpn60_TCP1 [H]

EC number: NA

Molecular weight: Translated: 57671; Mature: 57540

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAKEVKFGRSAREKMLKGVDILADAVKVTLGPKGRNVVIDKSFGAPRITKDGVSVAKEI
CCCCCCCCCHHHHHHHHHHHHHHHHHHHEEECCCCCEEEEECCCCCCCCCHHHHHHHHHC
ELEDKFENMGAQLVREVASKTNDIAGDGTTTATVLAQAIVREGAKAVAAGMNPMDLKRGI
CHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCHHHHHCCCCHHHHHHCC
DLAVAEVVKDLQAKAKKINTSEEVAQVGTISANGERQIGLDIAEAMQRVGNEGVITVEEA
HHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCEECCHHHHHHHHCCCCCEEEEECC
KTAETELEVVEGMQFDRGYLSPYFVTNPEKMVADLEDAYILLHEKKLSNLQAMLPVLEAV
CCHHHHHHHHHCCCCCCCCCCCEEECCHHHHHHHHHHHEEEEEHHHHHHHHHHHHHHHHH
VQTGKPLVIIAEDVEGEALATLVVNKLRGGLKIAAVKAPGFGDRRKAMLEDIAILTGGTV
HHCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCEE
ISEDLGIKLESVTLDMLGKSKKVSISKENTTIVDGAGQKSDIEGRVAQIKAQIEETTSDY
EECCCCCEEEEEEHHHCCCCCEEEEECCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHH
DREKLQERLAKLAGGVAVIRVGGSTEVEVKEKKDRIDDALNATRAAVQEGIVPGGGVALL
HHHHHHHHHHHHHCCEEEEEECCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEE
RSSTKITVKGVNDDQEAGINIVRKALQSLVRQIAENAGDEASIVVGKILDKNEDNYGYNA
ECCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHCCCCCCCCCCC
QTGEYGDLIALGIVDPVKVVRTALQNAASVASLLITTEAMIAELPKKESAMPQMPGGGMG
CCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
GMDF
CCCC
>Mature Secondary Structure 
AAKEVKFGRSAREKMLKGVDILADAVKVTLGPKGRNVVIDKSFGAPRITKDGVSVAKEI
CCCCCCCCHHHHHHHHHHHHHHHHHHHEEECCCCCEEEEECCCCCCCCCHHHHHHHHHC
ELEDKFENMGAQLVREVASKTNDIAGDGTTTATVLAQAIVREGAKAVAAGMNPMDLKRGI
CHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCHHHHHCCCCHHHHHHCC
DLAVAEVVKDLQAKAKKINTSEEVAQVGTISANGERQIGLDIAEAMQRVGNEGVITVEEA
HHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCEECCHHHHHHHHCCCCCEEEEECC
KTAETELEVVEGMQFDRGYLSPYFVTNPEKMVADLEDAYILLHEKKLSNLQAMLPVLEAV
CCHHHHHHHHHCCCCCCCCCCCEEECCHHHHHHHHHHHEEEEEHHHHHHHHHHHHHHHHH
VQTGKPLVIIAEDVEGEALATLVVNKLRGGLKIAAVKAPGFGDRRKAMLEDIAILTGGTV
HHCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCEE
ISEDLGIKLESVTLDMLGKSKKVSISKENTTIVDGAGQKSDIEGRVAQIKAQIEETTSDY
EECCCCCEEEEEEHHHCCCCCEEEEECCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHH
DREKLQERLAKLAGGVAVIRVGGSTEVEVKEKKDRIDDALNATRAAVQEGIVPGGGVALL
HHHHHHHHHHHHHCCEEEEEECCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEE
RSSTKITVKGVNDDQEAGINIVRKALQSLVRQIAENAGDEASIVVGKILDKNEDNYGYNA
ECCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHCCCCCCCCCCC
QTGEYGDLIALGIVDPVKVVRTALQNAASVASLLITTEAMIAELPKKESAMPQMPGGGMG
CCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
GMDF
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA