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The map label for this gene is edd [H]

Identifier: 15887943

GI number: 15887943

Start: 583195

End: 585015

Strand: Reverse

Name: edd [H]

Synonym: Atu0598

Alternate gene names: 15887943

Gene position: 585015-583195 (Counterclockwise)

Preceding gene: 159184382

Following gene: 159184381

Centisome position: 20.59

GC content: 62.6

Gene sequence:

>1821_bases
ATGTCCGCCGATTCCCGCATTCAGGCCATTACCGCCCGCATCGTCGAACGTTCCAAGCCCTACCGCGAGACCTATCTCGA
GCGGCTGCGGCTGCAGGTTTCGAAGGGCGTTCACCGTTCCGTTCTGTCCTGCGGCAATCTTGCGCATGGATTTGCCGTCT
GTTCCCCCGCCGACAAGGACATCCTTGCCGGCGACCGGGTTCCCAATCTCGGCATTATCACCGCCTATAACGACATGCTG
TCGGCGCACCAGCCCTACGAGACCTTCCCGGCGATCATCCGTGATGCGGCGAAGGAAGCGGGCGGCATCGCGCAGGTAGC
GGGCGCGGTTCCCGCCATGTGCGACGGCGTGACCCAGGGCCAGCCCGGCATGGAGCTTTCGCTGTTTTCCCGCGATGCCA
TTGCCATGGCAGCCGGCATAGGCCTGTCGCACAACATGTTCGACGCCGCCGTCTATCTCGGCGTTTGTGACAAGATCGTG
CCCGGCCTCGTCATCGCCGCGCTCGCCTTTGGCCACCTGCCCGCCGTCTTCGTTCCCGCCGGTCCAATGACATCTGGCCT
GCCGAATGACGAAAAATCCCGCATTCGCCAGCTTTATGCCGAAGGCAAGGTCGGCCGCGCCGAGCTGCTGGAGGCGGAAT
CCAAGTCCTATCACGGCCCCGGCACCTGCACCTTCTACGGCACCGCCAATTCGAACCAGATGCTGATGGAGATCATGGGT
TTCCATATGCCCGGTTCGTCCTTCATCAATCCCGGCACACCGCTGCGTGATGCACTCACCCGTGAAGCAGCCAACCGCGC
GCTGGCGATCACCGCGCAGGGCAATGAATTCACGCCGGCGGGCGAGATGATCGACGAAAGATCCGTCGTCAACGGCGTCG
TCGGCCTGCATGCGACGGGTGGCTCCACCAACCACACCATGCACCTGATCGCCATGGCGCGCGCCGCCGGCATCATTCTC
ACCTGGCAGGATATTTCCGATCTTTCCGACATCGTGCCGCTGCTCGCCCGCGTTTATCCCAACGGGCTTGCCGATGTGAA
CCATTTCCATGCCGCCGGCGGTATGGGCTTCCTCATCAAGCAGCTGCTGAAGCAGGGCTTCGTGCATGATGATGTGCGAA
CCGTCTTCGGACAGGGGCTTTCGGCCTACACCGTCGATGCCATGCTTGACGAGAAGGGTGCAGTCACCCGCCAGCCCTCC
CCCGAACAGAGCCATGACCCGAAGGTTCTGTCCAGCATCGAAACGCCGTTCCAGTCGACCGGCGGCCTGAAGATGCTGAC
CGGCAATCTCGGCAAATCGGTGATCAAGATTTCGGCCGTCAAGCCGGAACGCCACATCATCGAAGCACCGGCGATCGTTT
TCCATGATCAGCAGGAACTTCAAGACGCGTTCAAGGACGGCAAGCTTAACCGTGACTTCATTGCGGTTGTCCGCTTCCAG
GGGCCGAAGGCCAATGGCATGCCGGAACTGCACCGCCTGACGCCGCCGCTCGGCGTGCTGCAGGACCGCGGCTTCAAGGT
GGCGCTGGTGACTGACGGGCGTATGTCTGGCGCATCCGGCAAGGTGCCGGCTGCCATCCATGTCACGCCGGAAGCCTCCG
ATTGCGGCCCGATCTCGCTTATCCGCGATGGCGACATCATCCGTCTCGACGCCATTTCCGGAACGCTGGAAGTGCTGGTT
TCCGCCGCCGAGCTGGCAAAACGTGAACCGGCGCGTGCCGATCTTTCCGGTAATGAATGGGGCATGGGCCGCGAACTTTT
CGCCCCCTTCCGCCGCAATGCCGGCCCGGCCGATCAGGGCGCCAGCGTTCTCTTCCATTGA

Upstream 100 bases:

>100_bases
GCCCGCGACAAGCGCCCGAAGACATGAAGACTGAAACACGACAACCGGCCGCTCACCTCCCGGAACGCTGGTTGCCGACC
AACGAACAGGATGAACGCCC

Downstream 100 bases:

>100_bases
CATCCTGAAAGGCGAAGACCGATGCGGTTTTCGCCTTTCAACCCTGTTTTGCGCATCGTCCGACTGCTCTTTCTTGCCCC
TGACGATCCGGTGCGGAAAC

Product: phosphogluconate dehydratase

Products: NA

Alternate protein names: 6-phosphogluconate dehydratase [H]

Number of amino acids: Translated: 606; Mature: 605

Protein sequence:

>606_residues
MSADSRIQAITARIVERSKPYRETYLERLRLQVSKGVHRSVLSCGNLAHGFAVCSPADKDILAGDRVPNLGIITAYNDML
SAHQPYETFPAIIRDAAKEAGGIAQVAGAVPAMCDGVTQGQPGMELSLFSRDAIAMAAGIGLSHNMFDAAVYLGVCDKIV
PGLVIAALAFGHLPAVFVPAGPMTSGLPNDEKSRIRQLYAEGKVGRAELLEAESKSYHGPGTCTFYGTANSNQMLMEIMG
FHMPGSSFINPGTPLRDALTREAANRALAITAQGNEFTPAGEMIDERSVVNGVVGLHATGGSTNHTMHLIAMARAAGIIL
TWQDISDLSDIVPLLARVYPNGLADVNHFHAAGGMGFLIKQLLKQGFVHDDVRTVFGQGLSAYTVDAMLDEKGAVTRQPS
PEQSHDPKVLSSIETPFQSTGGLKMLTGNLGKSVIKISAVKPERHIIEAPAIVFHDQQELQDAFKDGKLNRDFIAVVRFQ
GPKANGMPELHRLTPPLGVLQDRGFKVALVTDGRMSGASGKVPAAIHVTPEASDCGPISLIRDGDIIRLDAISGTLEVLV
SAAELAKREPARADLSGNEWGMGRELFAPFRRNAGPADQGASVLFH

Sequences:

>Translated_606_residues
MSADSRIQAITARIVERSKPYRETYLERLRLQVSKGVHRSVLSCGNLAHGFAVCSPADKDILAGDRVPNLGIITAYNDML
SAHQPYETFPAIIRDAAKEAGGIAQVAGAVPAMCDGVTQGQPGMELSLFSRDAIAMAAGIGLSHNMFDAAVYLGVCDKIV
PGLVIAALAFGHLPAVFVPAGPMTSGLPNDEKSRIRQLYAEGKVGRAELLEAESKSYHGPGTCTFYGTANSNQMLMEIMG
FHMPGSSFINPGTPLRDALTREAANRALAITAQGNEFTPAGEMIDERSVVNGVVGLHATGGSTNHTMHLIAMARAAGIIL
TWQDISDLSDIVPLLARVYPNGLADVNHFHAAGGMGFLIKQLLKQGFVHDDVRTVFGQGLSAYTVDAMLDEKGAVTRQPS
PEQSHDPKVLSSIETPFQSTGGLKMLTGNLGKSVIKISAVKPERHIIEAPAIVFHDQQELQDAFKDGKLNRDFIAVVRFQ
GPKANGMPELHRLTPPLGVLQDRGFKVALVTDGRMSGASGKVPAAIHVTPEASDCGPISLIRDGDIIRLDAISGTLEVLV
SAAELAKREPARADLSGNEWGMGRELFAPFRRNAGPADQGASVLFH
>Mature_605_residues
SADSRIQAITARIVERSKPYRETYLERLRLQVSKGVHRSVLSCGNLAHGFAVCSPADKDILAGDRVPNLGIITAYNDMLS
AHQPYETFPAIIRDAAKEAGGIAQVAGAVPAMCDGVTQGQPGMELSLFSRDAIAMAAGIGLSHNMFDAAVYLGVCDKIVP
GLVIAALAFGHLPAVFVPAGPMTSGLPNDEKSRIRQLYAEGKVGRAELLEAESKSYHGPGTCTFYGTANSNQMLMEIMGF
HMPGSSFINPGTPLRDALTREAANRALAITAQGNEFTPAGEMIDERSVVNGVVGLHATGGSTNHTMHLIAMARAAGIILT
WQDISDLSDIVPLLARVYPNGLADVNHFHAAGGMGFLIKQLLKQGFVHDDVRTVFGQGLSAYTVDAMLDEKGAVTRQPSP
EQSHDPKVLSSIETPFQSTGGLKMLTGNLGKSVIKISAVKPERHIIEAPAIVFHDQQELQDAFKDGKLNRDFIAVVRFQG
PKANGMPELHRLTPPLGVLQDRGFKVALVTDGRMSGASGKVPAAIHVTPEASDCGPISLIRDGDIIRLDAISGTLEVLVS
AAELAKREPARADLSGNEWGMGRELFAPFRRNAGPADQGASVLFH

Specific function: KEY ENZYME IN THE ENTNER-DOUDOROFF PATHWAY. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI1788157, Length=595, Percent_Identity=62.5210084033613, Blast_Score=767, Evalue=0.0,
Organism=Escherichia coli, GI48994964, Length=553, Percent_Identity=28.75226039783, Blast_Score=194, Evalue=1e-50,
Organism=Escherichia coli, GI2367371, Length=462, Percent_Identity=31.1688311688312, Blast_Score=141, Evalue=9e-35,
Organism=Escherichia coli, GI1786464, Length=498, Percent_Identity=30.3212851405622, Blast_Score=134, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6322476, Length=494, Percent_Identity=29.1497975708502, Blast_Score=171, Evalue=4e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004786
- InterPro:   IPR015928
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.12 [H]

Molecular weight: Translated: 64528; Mature: 64396

Theoretical pI: Translated: 6.73; Mature: 6.73

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSADSRIQAITARIVERSKPYRETYLERLRLQVSKGVHRSVLSCGNLAHGFAVCSPADKD
CCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCEEEECCCCCC
ILAGDRVPNLGIITAYNDMLSAHQPYETFPAIIRDAAKEAGGIAQVAGAVPAMCDGVTQG
CCCCCCCCCCEEEEEEHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHCCHHHHCCCCCC
QPGMELSLFSRDAIAMAAGIGLSHNMFDAAVYLGVCDKIVPGLVIAALAFGHLPAVFVPA
CCCCEEEEECCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECC
GPMTSGLPNDEKSRIRQLYAEGKVGRAELLEAESKSYHGPGTCTFYGTANSNQMLMEIMG
CCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCEEEEEECCCCCHHHHHHHC
FHMPGSSFINPGTPLRDALTREAANRALAITAQGNEFTPAGEMIDERSVVNGVVGLHATG
CCCCCCCCCCCCCCHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHHHEEEEECC
GSTNHTMHLIAMARAAGIILTWQDISDLSDIVPLLARVYPNGLADVNHFHAAGGMGFLIK
CCCCCHHHHEEHHHHCCEEEEECCHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCHHHHHH
QLLKQGFVHDDVRTVFGQGLSAYTVDAMLDEKGAVTRQPSPEQSHDPKVLSSIETPFQST
HHHHHCCCHHHHHHHHHCCCCCEEHHHHHCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCC
GGLKMLTGNLGKSVIKISAVKPERHIIEAPAIVFHDQQELQDAFKDGKLNRDFIAVVRFQ
CCEEEEECCCCCCEEEEEECCCHHHHCCCCEEEECCHHHHHHHHHCCCCCCCEEEEEEEC
GPKANGMPELHRLTPPLGVLQDRGFKVALVTDGRMSGASGKVPAAIHVTPEASDCGPISL
CCCCCCCCHHHHCCCCHHHHHCCCEEEEEEECCCCCCCCCCCCEEEEECCCCCCCCCEEE
IRDGDIIRLDAISGTLEVLVSAAELAKREPARADLSGNEWGMGRELFAPFRRNAGPADQG
EECCCEEEEECCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCC
ASVLFH
CCCCCC
>Mature Secondary Structure 
SADSRIQAITARIVERSKPYRETYLERLRLQVSKGVHRSVLSCGNLAHGFAVCSPADKD
CCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCEEEECCCCCC
ILAGDRVPNLGIITAYNDMLSAHQPYETFPAIIRDAAKEAGGIAQVAGAVPAMCDGVTQG
CCCCCCCCCCEEEEEEHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHCCHHHHCCCCCC
QPGMELSLFSRDAIAMAAGIGLSHNMFDAAVYLGVCDKIVPGLVIAALAFGHLPAVFVPA
CCCCEEEEECCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECC
GPMTSGLPNDEKSRIRQLYAEGKVGRAELLEAESKSYHGPGTCTFYGTANSNQMLMEIMG
CCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCEEEEEECCCCCHHHHHHHC
FHMPGSSFINPGTPLRDALTREAANRALAITAQGNEFTPAGEMIDERSVVNGVVGLHATG
CCCCCCCCCCCCCCHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHHHEEEEECC
GSTNHTMHLIAMARAAGIILTWQDISDLSDIVPLLARVYPNGLADVNHFHAAGGMGFLIK
CCCCCHHHHEEHHHHCCEEEEECCHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCHHHHHH
QLLKQGFVHDDVRTVFGQGLSAYTVDAMLDEKGAVTRQPSPEQSHDPKVLSSIETPFQST
HHHHHCCCHHHHHHHHHCCCCCEEHHHHHCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCC
GGLKMLTGNLGKSVIKISAVKPERHIIEAPAIVFHDQQELQDAFKDGKLNRDFIAVVRFQ
CCEEEEECCCCCCEEEEEECCCHHHHCCCCEEEECCHHHHHHHHHCCCCCCCEEEEEEEC
GPKANGMPELHRLTPPLGVLQDRGFKVALVTDGRMSGASGKVPAAIHVTPEASDCGPISL
CCCCCCCCHHHHCCCCHHHHHCCCEEEEEEECCCCCCCCCCCCEEEEECCCCCCCCCEEE
IRDGDIIRLDAISGTLEVLVSAAELAKREPARADLSGNEWGMGRELFAPFRRNAGPADQG
EECCCEEEEECCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCC
ASVLFH
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10400573; 11481430 [H]