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The map label for this gene is argD

Identifier: 15887775

GI number: 15887775

Start: 424029

End: 425228

Strand: Direct

Name: argD

Synonym: Atu0428

Alternate gene names: 15887775

Gene position: 424029-425228 (Clockwise)

Preceding gene: 15887774

Following gene: 15887776

Centisome position: 14.92

GC content: 62.17

Gene sequence:

>1200_bases
ATGGCCGAAGCCGCCGCGCCATTGTTCGATACGTTTGCAAGAGCCCCCCTGCGCTTTGAGCGAGGCGAGGGCGTCTGGCT
TTTCACGGAAAGCGGCGAGCGATATCTGGATTTTGCGGCCGGCGTTGCGGTCAACTCGCTGGGCCACGCCCACCCGCACC
TCGTGGAAGCGATCAAGACCCAGGCCGAGAAGGTCTGGCACGTCTCCAACCTCTATGAAGTGCCCGGACAGGAAAAGCTT
GCAAAGCGACTGACGGAAGCGACATTTGCGGACAAGGTCTTTTTCACCAATTCCGGCGCGGAAGCGCTGGAATGCGCGAT
CAAGACCGCGCGCCGTTACCATTATTCCAAGGGACATCCGGAAAAGTTCCGCATCATCACATTTGAAGGCGCCTTCCATG
GCCGCACGCTGGCGACGATCGCCGCCGGCGGCCAGCAGAAATATCTCGAAGGTTTCGGTCCCAAGGTCGAAGGTTTTGAC
CAGGTGCCGTTCGGTGATGTCGATGCGCTGAAGGCTGCCATCACGGCCGAGACGGCCGCACTTCTGATCGAGCCCATTCA
GGGCGAGGGCGGCATCCGCGCGCCGGCCAAGGAATTCCTGCAGCTGCTGCGGTCGCTTTGTGATGAGCACGACCTGCTCC
TGATTTTCGATGAGGTCCAGACCGGCGTTGGCCGCACGGGCAAATTTTTTGCCTATGAGCAGACTGGTGTCGCGCCTGAC
ATCATGGCGGTTGCCAAGGGTATCGGCGGCGGTTTCCCGCTCGGCGCGTGCCTTGCAACGGCGGATGCCGCTTCCGGCAT
GACGGCCGGCGTGCACGGCACCACCTATGGCGGCAATCCGCTGGCCATGGCGGTCGGCAATGCCGTGCTCGACGTCGTTC
TCGCTGACGGCTTTCTCGAAAAGGTCCGTGATGTCGCACTGGTTTTCCGCCAGGGGCTTGCCTCGCTGAAGGATCGTTAT
CCCGATGTCATCGAGGAAATTCGCGGCGAAGGCCTGCTGCTTGGCATCAAGGCCAGAGTTCCCTCGGGTGAGCTGCTGCA
GGCCATGCGTGCGGAACATCTGCTCGGCGTACCGGCGGGAGACAACGTCATCCGCCTTCTGCCGCCACTCGTTACGACGG
CGGAAGAGGCTCGCGAAGGGTTGGCACGCGTGGAAGCGGCAGCCGCATCCCTGACCGCCAAGCAGGCGAAAATCGCCTGA

Upstream 100 bases:

>100_bases
GCCGCCGCAAGGCGGCATTTTTGATTTTCAGGCGAGGGATAACCCTCAGAGCCTATTGACAACCGTCTGACAGCGCGTCC
GCGCAAGGAGTGATACAGCC

Downstream 100 bases:

>100_bases
GGAAACAATAAAAGCGGGCCTCTTCCTGGAGGCTCGCGAGCATGGGATAGTTTGAAATGGCTTCACCTAAACATTTTCTC
GACCTGTCGGCCGTTGGCCC

Product: acetylornithine transaminase protein

Products: NA

Alternate protein names: ACOAT

Number of amino acids: Translated: 399; Mature: 398

Protein sequence:

>399_residues
MAEAAAPLFDTFARAPLRFERGEGVWLFTESGERYLDFAAGVAVNSLGHAHPHLVEAIKTQAEKVWHVSNLYEVPGQEKL
AKRLTEATFADKVFFTNSGAEALECAIKTARRYHYSKGHPEKFRIITFEGAFHGRTLATIAAGGQQKYLEGFGPKVEGFD
QVPFGDVDALKAAITAETAALLIEPIQGEGGIRAPAKEFLQLLRSLCDEHDLLLIFDEVQTGVGRTGKFFAYEQTGVAPD
IMAVAKGIGGGFPLGACLATADAASGMTAGVHGTTYGGNPLAMAVGNAVLDVVLADGFLEKVRDVALVFRQGLASLKDRY
PDVIEEIRGEGLLLGIKARVPSGELLQAMRAEHLLGVPAGDNVIRLLPPLVTTAEEAREGLARVEAAAASLTAKQAKIA

Sequences:

>Translated_399_residues
MAEAAAPLFDTFARAPLRFERGEGVWLFTESGERYLDFAAGVAVNSLGHAHPHLVEAIKTQAEKVWHVSNLYEVPGQEKL
AKRLTEATFADKVFFTNSGAEALECAIKTARRYHYSKGHPEKFRIITFEGAFHGRTLATIAAGGQQKYLEGFGPKVEGFD
QVPFGDVDALKAAITAETAALLIEPIQGEGGIRAPAKEFLQLLRSLCDEHDLLLIFDEVQTGVGRTGKFFAYEQTGVAPD
IMAVAKGIGGGFPLGACLATADAASGMTAGVHGTTYGGNPLAMAVGNAVLDVVLADGFLEKVRDVALVFRQGLASLKDRY
PDVIEEIRGEGLLLGIKARVPSGELLQAMRAEHLLGVPAGDNVIRLLPPLVTTAEEAREGLARVEAAAASLTAKQAKIA
>Mature_398_residues
AEAAAPLFDTFARAPLRFERGEGVWLFTESGERYLDFAAGVAVNSLGHAHPHLVEAIKTQAEKVWHVSNLYEVPGQEKLA
KRLTEATFADKVFFTNSGAEALECAIKTARRYHYSKGHPEKFRIITFEGAFHGRTLATIAAGGQQKYLEGFGPKVEGFDQ
VPFGDVDALKAAITAETAALLIEPIQGEGGIRAPAKEFLQLLRSLCDEHDLLLIFDEVQTGVGRTGKFFAYEQTGVAPDI
MAVAKGIGGGFPLGACLATADAASGMTAGVHGTTYGGNPLAMAVGNAVLDVVLADGFLEKVRDVALVFRQGLASLKDRYP
DVIEEIRGEGLLLGIKARVPSGELLQAMRAEHLLGVPAGDNVIRLLPPLVTTAEEAREGLARVEAAAASLTAKQAKIA

Specific function: Involved In Both The Arginine And Lysine Biosynthetic Pathways. [C]

COG id: COG4992

COG function: function code E; Ornithine/acetylornithine aminotransferase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily

Homologues:

Organism=Homo sapiens, GI4557809, Length=384, Percent_Identity=34.1145833333333, Blast_Score=230, Evalue=2e-60,
Organism=Homo sapiens, GI284507298, Length=303, Percent_Identity=35.6435643564356, Blast_Score=187, Evalue=1e-47,
Organism=Homo sapiens, GI13994255, Length=452, Percent_Identity=29.646017699115, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI37574042, Length=410, Percent_Identity=29.2682926829268, Blast_Score=141, Evalue=1e-33,
Organism=Homo sapiens, GI24119277, Length=425, Percent_Identity=27.2941176470588, Blast_Score=132, Evalue=4e-31,
Organism=Homo sapiens, GI226442705, Length=410, Percent_Identity=28.2926829268293, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI226442709, Length=375, Percent_Identity=28.5333333333333, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI188536080, Length=411, Percent_Identity=24.330900243309, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI38679950, Length=411, Percent_Identity=24.330900243309, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI38679946, Length=411, Percent_Identity=24.330900243309, Blast_Score=97, Evalue=3e-20,
Organism=Escherichia coli, GI1789759, Length=376, Percent_Identity=45.7446808510638, Blast_Score=330, Evalue=1e-91,
Organism=Escherichia coli, GI1788044, Length=391, Percent_Identity=44.7570332480818, Blast_Score=328, Evalue=4e-91,
Organism=Escherichia coli, GI145693181, Length=398, Percent_Identity=34.6733668341709, Blast_Score=220, Evalue=1e-58,
Organism=Escherichia coli, GI1789016, Length=401, Percent_Identity=34.4139650872818, Blast_Score=205, Evalue=4e-54,
Organism=Escherichia coli, GI1787560, Length=386, Percent_Identity=35.2331606217617, Blast_Score=180, Evalue=2e-46,
Organism=Escherichia coli, GI1786991, Length=397, Percent_Identity=30.7304785894207, Blast_Score=149, Evalue=4e-37,
Organism=Escherichia coli, GI1786349, Length=313, Percent_Identity=32.5878594249201, Blast_Score=128, Evalue=6e-31,
Organism=Caenorhabditis elegans, GI25144271, Length=370, Percent_Identity=32.7027027027027, Blast_Score=213, Evalue=2e-55,
Organism=Caenorhabditis elegans, GI32564660, Length=421, Percent_Identity=29.9287410926366, Blast_Score=174, Evalue=9e-44,
Organism=Caenorhabditis elegans, GI25144274, Length=270, Percent_Identity=32.962962962963, Blast_Score=157, Evalue=7e-39,
Organism=Caenorhabditis elegans, GI71992977, Length=414, Percent_Identity=28.0193236714976, Blast_Score=122, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI17541228, Length=431, Percent_Identity=25.2900232018561, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI71981843, Length=154, Percent_Identity=32.4675324675325, Blast_Score=87, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6324432, Length=398, Percent_Identity=36.6834170854271, Blast_Score=252, Evalue=9e-68,
Organism=Saccharomyces cerevisiae, GI6323470, Length=391, Percent_Identity=33.7595907928389, Blast_Score=211, Evalue=1e-55,
Organism=Saccharomyces cerevisiae, GI6324386, Length=394, Percent_Identity=25.1269035532995, Blast_Score=101, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6321456, Length=375, Percent_Identity=25.6, Blast_Score=95, Evalue=2e-20,
Organism=Drosophila melanogaster, GI21357415, Length=382, Percent_Identity=32.9842931937173, Blast_Score=217, Evalue=1e-56,
Organism=Drosophila melanogaster, GI161085790, Length=430, Percent_Identity=31.3953488372093, Blast_Score=185, Evalue=5e-47,
Organism=Drosophila melanogaster, GI28574759, Length=421, Percent_Identity=31.353919239905, Blast_Score=184, Evalue=1e-46,
Organism=Drosophila melanogaster, GI21356575, Length=421, Percent_Identity=31.353919239905, Blast_Score=148, Evalue=6e-36,
Organism=Drosophila melanogaster, GI281366494, Length=421, Percent_Identity=24.2280285035629, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24667139, Length=421, Percent_Identity=24.2280285035629, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24667143, Length=421, Percent_Identity=24.2280285035629, Blast_Score=100, Evalue=3e-21,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): ARGD_AGRT5 (Q8UI71)

Other databases:

- EMBL:   AE007869
- PIR:   AB2629
- PIR:   H97410
- RefSeq:   NP_353456.1
- ProteinModelPortal:   Q8UI71
- SMR:   Q8UI71
- STRING:   Q8UI71
- GeneID:   1132466
- GenomeReviews:   AE007869_GR
- KEGG:   atu:Atu0428
- eggNOG:   COG4992
- HOGENOM:   HBG725944
- OMA:   VALVFRQ
- PhylomeDB:   Q8UI71
- ProtClustDB:   PRK01278
- BioCyc:   ATUM176299-1:ATU0428-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01107
- InterPro:   IPR004636
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PANTHER:   PTHR11986
- PANTHER:   PTHR11986:SF19
- TIGRFAMs:   TIGR00707

Pfam domain/function: PF00202 Aminotran_3; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.11

Molecular weight: Translated: 42478; Mature: 42347

Theoretical pI: Translated: 5.64; Mature: 5.64

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: BINDING 132-132 BINDING 135-135 BINDING 274-274 BINDING 275-275

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEAAAPLFDTFARAPLRFERGEGVWLFTESGERYLDFAAGVAVNSLGHAHPHLVEAIKT
CCCCHHHHHHHHHCCCCEEECCCEEEEEECCCCHHHHHHHHHHHHHCCCCCHHHHHHHHH
QAEKVWHVSNLYEVPGQEKLAKRLTEATFADKVFFTNSGAEALECAIKTARRYHYSKGHP
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCEEEEECCCHHHHHHHHHHHHHHCCCCCCC
EKFRIITFEGAFHGRTLATIAAGGQQKYLEGFGPKVEGFDQVPFGDVDALKAAITAETAA
CEEEEEEEECCCCCCEEEEEECCCHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
LLIEPIQGEGGIRAPAKEFLQLLRSLCDEHDLLLIFDEVQTGVGRTGKFFAYEQTGVAPD
HEEEECCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEEHHHHCCCCCCCEEEEECCCCCHH
IMAVAKGIGGGFPLGACLATADAASGMTAGVHGTTYGGNPLAMAVGNAVLDVVLADGFLE
HHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
KVRDVALVFRQGLASLKDRYPDVIEEIRGEGLLLGIKARVPSGELLQAMRAEHLLGVPAG
HHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCCC
DNVIRLLPPLVTTAEEAREGLARVEAAAASLTAKQAKIA
CCHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AEAAAPLFDTFARAPLRFERGEGVWLFTESGERYLDFAAGVAVNSLGHAHPHLVEAIKT
CCCHHHHHHHHHCCCCEEECCCEEEEEECCCCHHHHHHHHHHHHHCCCCCHHHHHHHHH
QAEKVWHVSNLYEVPGQEKLAKRLTEATFADKVFFTNSGAEALECAIKTARRYHYSKGHP
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCEEEEECCCHHHHHHHHHHHHHHCCCCCCC
EKFRIITFEGAFHGRTLATIAAGGQQKYLEGFGPKVEGFDQVPFGDVDALKAAITAETAA
CEEEEEEEECCCCCCEEEEEECCCHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
LLIEPIQGEGGIRAPAKEFLQLLRSLCDEHDLLLIFDEVQTGVGRTGKFFAYEQTGVAPD
HEEEECCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEEHHHHCCCCCCCEEEEECCCCCHH
IMAVAKGIGGGFPLGACLATADAASGMTAGVHGTTYGGNPLAMAVGNAVLDVVLADGFLE
HHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
KVRDVALVFRQGLASLKDRYPDVIEEIRGEGLLLGIKARVPSGELLQAMRAEHLLGVPAG
HHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCCC
DNVIRLLPPLVTTAEEAREGLARVEAAAASLTAKQAKIA
CCHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194