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The map label for this gene is pgi

Identifier: 15887753

GI number: 15887753

Start: 398432

End: 400057

Strand: Reverse

Name: pgi

Synonym: Atu0404

Alternate gene names: 15887753

Gene position: 400057-398432 (Counterclockwise)

Preceding gene: 15887754

Following gene: 159184285

Centisome position: 14.08

GC content: 60.58

Gene sequence:

>1626_bases
ATGCAGGCCACCATCGAAAAACTGAAAGCAACGGCAAGCAGCACAGCCGCAACCGATCTGCGCGCCGCTTTTGCGGCCGA
CGACCAGAGATTCAGCCGTTTCAGCGTCAAATTCGATGACCTGCTGATGGATTACTCCAAATGTGCCGTCAACGAAGAGA
TCGTCACGCTTCTCGAACAGCTCGCGCGCGAAGGCGGTGTCGAGGCCAAGCGCGAGGAGATGTTCTCCGGCAAGGCCATC
AACTTCACCGAAGACCGCGCCGTGCTGCATACCGCCCTGCGCAATCGTTCCAACACGCCCGTTCTCGTTGATGACAAGGA
CGTGATGCCTGATGTGAACGGCGTTCTGGCAGCCATGGGCAAGTTTGCCGATGCGATCCGTTCCGGCTCCCTGAAAGGTG
CGACCGGGAAAAAGATTACCGACGTCGTCAATATTGGTATTGGCGGTTCCGATCTCGGCCCTGTTATGGCGACGCTGGCG
CTTGCGCCCTTCCATGACGGCCCGCGTGCGCATTTCGTTTCCAATATCGACGGCGCGCATATTGCCGATACGCTGAAGCT
TCTCGATCCGGAAACCTCTCTCTTCATCATCGCATCGAAGACCTTCACCACCATCGAGACGATGACGAATGCCGCCACCG
CGCGCCGTTTCATCGCCGAAAAGCTGGGCGAAGGCGCCGTCAAGCATCACTTCGCCGCCGTCTCCACCGCGCTGGACAAG
GTCGCCGCCTTCGGTATCGAAAGCGACCGCATCTTCGGTTTCTGGGACTGGGTGGGCGGACGTTATTCGATCTGGTCGGC
CATCGGCCTGCCGCTGATGATCGCCATCGGGCCTGACAATTTCGGCAAGTTCCTGGATGGCGCGCATGCCATGGATCGCC
ACTTCCGCGAGGCGCCGATCCGCGAAAACCTGCCGATGCTACTCGGCCTCATCGGCTTCTATAACCGTAACGTGCTGGAC
TATCCGACACGCGCGATCCTGCCCTATGACCAGCGCCTGTCGCGTTTCCCGGCCTATCTTCAGCAGCTCGACATGGAATC
GAACGGCAAGGGTGTGACCATCGACGGCACGCCGGTCGAAGGCCAGTCCGGTCCGGTCGTCTGGGGCGAGCCCGGCACCA
ATGGCCAGCACGCCTTCTACCAGCTGATCCATCAGGGCACGAGCGTCATTCCGGCCGAATTCATGATCGCCGCCAATGGC
TTTGAGCCCGAACTGCGCCATCAGCACCAGCTTCTTATCGCTAATTGCCTGGCGCAGTCGGAAGCGCTGATGAAGGGACG
TACGCTTGCCGAAGCGAAGGCCCAGCTCACCTCCAAGGGCATGGAAGACAGCCAAGCCGATTTCATCGCGCCGCACCGTG
TCTTCACCGGCAATCGCCCCTCCATCACCTTCGTTTACGACAAGCTGACGCCCTTTGCGCTCGGCCGGCTCATCGCGCTC
TATGAACATCGCGTTTTCGTGGAAGGTGTGCTGTTCCGCATCAACTCCTTTGATCAGTGGGGCGTGGAGCTTGGCAAGGA
ACTGGCCACCGGCCTGCTTCCCGTCGTGGAAGGCAAGGAGAGCGCCGCCGGCCATGACAGCTCGACACAAGGGCTGGTGA
AGGCGCTGGCGGGTCTCGCCGGCTGA

Upstream 100 bases:

>100_bases
TCTTTTCTCCCGGCCCTTTTCTTTTATCGAAGTCGCCTTGATTTGGCCGCCGGAAAAAGAATAGTTTCCTCATCCTTCCA
CGGAAGCCGAGGAGCATAAG

Downstream 100 bases:

>100_bases
GGCTATCCTTTAAAAAAAAGCCGGAGCTGTCTCCGGCTTTTTTAATGCGCTTCGCTCAAATATAAAGTGCCGCCATCTTC
CGCCACGCACCGGCACGATG

Product: glucose-6-phosphate isomerase

Products: NA

Alternate protein names: GPI; Phosphoglucose isomerase; PGI; Phosphohexose isomerase; PHI

Number of amino acids: Translated: 541; Mature: 541

Protein sequence:

>541_residues
MQATIEKLKATASSTAATDLRAAFAADDQRFSRFSVKFDDLLMDYSKCAVNEEIVTLLEQLAREGGVEAKREEMFSGKAI
NFTEDRAVLHTALRNRSNTPVLVDDKDVMPDVNGVLAAMGKFADAIRSGSLKGATGKKITDVVNIGIGGSDLGPVMATLA
LAPFHDGPRAHFVSNIDGAHIADTLKLLDPETSLFIIASKTFTTIETMTNAATARRFIAEKLGEGAVKHHFAAVSTALDK
VAAFGIESDRIFGFWDWVGGRYSIWSAIGLPLMIAIGPDNFGKFLDGAHAMDRHFREAPIRENLPMLLGLIGFYNRNVLD
YPTRAILPYDQRLSRFPAYLQQLDMESNGKGVTIDGTPVEGQSGPVVWGEPGTNGQHAFYQLIHQGTSVIPAEFMIAANG
FEPELRHQHQLLIANCLAQSEALMKGRTLAEAKAQLTSKGMEDSQADFIAPHRVFTGNRPSITFVYDKLTPFALGRLIAL
YEHRVFVEGVLFRINSFDQWGVELGKELATGLLPVVEGKESAAGHDSSTQGLVKALAGLAG

Sequences:

>Translated_541_residues
MQATIEKLKATASSTAATDLRAAFAADDQRFSRFSVKFDDLLMDYSKCAVNEEIVTLLEQLAREGGVEAKREEMFSGKAI
NFTEDRAVLHTALRNRSNTPVLVDDKDVMPDVNGVLAAMGKFADAIRSGSLKGATGKKITDVVNIGIGGSDLGPVMATLA
LAPFHDGPRAHFVSNIDGAHIADTLKLLDPETSLFIIASKTFTTIETMTNAATARRFIAEKLGEGAVKHHFAAVSTALDK
VAAFGIESDRIFGFWDWVGGRYSIWSAIGLPLMIAIGPDNFGKFLDGAHAMDRHFREAPIRENLPMLLGLIGFYNRNVLD
YPTRAILPYDQRLSRFPAYLQQLDMESNGKGVTIDGTPVEGQSGPVVWGEPGTNGQHAFYQLIHQGTSVIPAEFMIAANG
FEPELRHQHQLLIANCLAQSEALMKGRTLAEAKAQLTSKGMEDSQADFIAPHRVFTGNRPSITFVYDKLTPFALGRLIAL
YEHRVFVEGVLFRINSFDQWGVELGKELATGLLPVVEGKESAAGHDSSTQGLVKALAGLAG
>Mature_541_residues
MQATIEKLKATASSTAATDLRAAFAADDQRFSRFSVKFDDLLMDYSKCAVNEEIVTLLEQLAREGGVEAKREEMFSGKAI
NFTEDRAVLHTALRNRSNTPVLVDDKDVMPDVNGVLAAMGKFADAIRSGSLKGATGKKITDVVNIGIGGSDLGPVMATLA
LAPFHDGPRAHFVSNIDGAHIADTLKLLDPETSLFIIASKTFTTIETMTNAATARRFIAEKLGEGAVKHHFAAVSTALDK
VAAFGIESDRIFGFWDWVGGRYSIWSAIGLPLMIAIGPDNFGKFLDGAHAMDRHFREAPIRENLPMLLGLIGFYNRNVLD
YPTRAILPYDQRLSRFPAYLQQLDMESNGKGVTIDGTPVEGQSGPVVWGEPGTNGQHAFYQLIHQGTSVIPAEFMIAANG
FEPELRHQHQLLIANCLAQSEALMKGRTLAEAKAQLTSKGMEDSQADFIAPHRVFTGNRPSITFVYDKLTPFALGRLIAL
YEHRVFVEGVLFRINSFDQWGVELGKELATGLLPVVEGKESAAGHDSSTQGLVKALAGLAG

Specific function: Involved in glycolysis and in gluconeogenesis. [C]

COG id: COG0166

COG function: function code G; Glucose-6-phosphate isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GPI family

Homologues:

Organism=Homo sapiens, GI18201905, Length=523, Percent_Identity=55.8317399617591, Blast_Score=599, Evalue=1e-171,
Organism=Homo sapiens, GI296080693, Length=523, Percent_Identity=51.8164435946463, Blast_Score=542, Evalue=1e-154,
Organism=Escherichia coli, GI1790457, Length=520, Percent_Identity=54.2307692307692, Blast_Score=578, Evalue=1e-166,
Organism=Caenorhabditis elegans, GI71996703, Length=517, Percent_Identity=55.1257253384913, Blast_Score=578, Evalue=1e-165,
Organism=Caenorhabditis elegans, GI71996708, Length=517, Percent_Identity=55.1257253384913, Blast_Score=578, Evalue=1e-165,
Organism=Saccharomyces cerevisiae, GI6319673, Length=536, Percent_Identity=49.6268656716418, Blast_Score=525, Evalue=1e-150,
Organism=Drosophila melanogaster, GI24651916, Length=541, Percent_Identity=53.2347504621072, Blast_Score=592, Evalue=1e-169,
Organism=Drosophila melanogaster, GI24651914, Length=541, Percent_Identity=53.2347504621072, Blast_Score=592, Evalue=1e-169,
Organism=Drosophila melanogaster, GI17737445, Length=541, Percent_Identity=53.2347504621072, Blast_Score=592, Evalue=1e-169,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): G6PI_AGRT5 (Q8UI94)

Other databases:

- EMBL:   AE007869
- PIR:   AC2626
- PIR:   B97408
- RefSeq:   NP_353434.1
- ProteinModelPortal:   Q8UI94
- SMR:   Q8UI94
- STRING:   Q8UI94
- GeneID:   1132442
- GenomeReviews:   AE007869_GR
- KEGG:   atu:Atu0404
- HOGENOM:   HBG352954
- OMA:   GPKIVSQ
- PhylomeDB:   Q8UI94
- ProtClustDB:   PRK00179
- BioCyc:   ATUM176299-1:ATU0404-MONOMER
- GO:   GO:0005737
- GO:   GO:0006094
- GO:   GO:0006096
- HAMAP:   MF_00473
- InterPro:   IPR001672
- InterPro:   IPR023096
- InterPro:   IPR018189
- Gene3D:   G3DSA:1.10.1390.10
- PANTHER:   PTHR11469
- PRINTS:   PR00662

Pfam domain/function: PF00342 PGI

EC number: =5.3.1.9

Molecular weight: Translated: 58710; Mature: 58710

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: PS00765 P_GLUCOSE_ISOMERASE_1; PS00174 P_GLUCOSE_ISOMERASE_2; PS51463 P_GLUCOSE_ISOMERASE_3

Important sites: ACT_SITE 346-346 ACT_SITE 377-377 ACT_SITE 506-506

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQATIEKLKATASSTAATDLRAAFAADDQRFSRFSVKFDDLLMDYSKCAVNEEIVTLLEQ
CCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHH
LAREGGVEAKREEMFSGKAINFTEDRAVLHTALRNRSNTPVLVDDKDVMPDVNGVLAAMG
HHHHCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCEEECCCCCCCCHHHHHHHHH
KFADAIRSGSLKGATGKKITDVVNIGIGGSDLGPVMATLALAPFHDGPRAHFVSNIDGAH
HHHHHHHCCCCCCCCCCCEEHHEEECCCCCCHHHHHHHHHHCCCCCCCCHHHCCCCCCHH
IADTLKLLDPETSLFIIASKTFTTIETMTNAATARRFIAEKLGEGAVKHHFAAVSTALDK
HHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
VAAFGIESDRIFGFWDWVGGRYSIWSAIGLPLMIAIGPDNFGKFLDGAHAMDRHFREAPI
HHHHCCCCCCEEEEECCCCCCHHHHHHCCCCEEEEECCCHHHHHHCCHHHHHHHHHHCCC
RENLPMLLGLIGFYNRNVLDYPTRAILPYDQRLSRFPAYLQQLDMESNGKGVTIDGTPVE
CCCHHHHHHHHHHHCCCCCCCCCHHCCCHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCC
GQSGPVVWGEPGTNGQHAFYQLIHQGTSVIPAEFMIAANGFEPELRHQHQLLIANCLAQS
CCCCCEEECCCCCCCHHHHHHHHHCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHH
EALMKGRTLAEAKAQLTSKGMEDSQADFIAPHRVFTGNRPSITFVYDKLTPFALGRLIAL
HHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCEEECCCCCCEEEEECCCCHHHHHHHHHH
YEHRVFVEGVLFRINSFDQWGVELGKELATGLLPVVEGKESAAGHDSSTQGLVKALAGLA
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHCCCCCCCCCCCCCHHHHHHHHHHCC
G
C
>Mature Secondary Structure
MQATIEKLKATASSTAATDLRAAFAADDQRFSRFSVKFDDLLMDYSKCAVNEEIVTLLEQ
CCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHH
LAREGGVEAKREEMFSGKAINFTEDRAVLHTALRNRSNTPVLVDDKDVMPDVNGVLAAMG
HHHHCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCEEECCCCCCCCHHHHHHHHH
KFADAIRSGSLKGATGKKITDVVNIGIGGSDLGPVMATLALAPFHDGPRAHFVSNIDGAH
HHHHHHHCCCCCCCCCCCEEHHEEECCCCCCHHHHHHHHHHCCCCCCCCHHHCCCCCCHH
IADTLKLLDPETSLFIIASKTFTTIETMTNAATARRFIAEKLGEGAVKHHFAAVSTALDK
HHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
VAAFGIESDRIFGFWDWVGGRYSIWSAIGLPLMIAIGPDNFGKFLDGAHAMDRHFREAPI
HHHHCCCCCCEEEEECCCCCCHHHHHHCCCCEEEEECCCHHHHHHCCHHHHHHHHHHCCC
RENLPMLLGLIGFYNRNVLDYPTRAILPYDQRLSRFPAYLQQLDMESNGKGVTIDGTPVE
CCCHHHHHHHHHHHCCCCCCCCCHHCCCHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCC
GQSGPVVWGEPGTNGQHAFYQLIHQGTSVIPAEFMIAANGFEPELRHQHQLLIANCLAQS
CCCCCEEECCCCCCCHHHHHHHHHCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHH
EALMKGRTLAEAKAQLTSKGMEDSQADFIAPHRVFTGNRPSITFVYDKLTPFALGRLIAL
HHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCEEECCCCCCEEEEECCCCHHHHHHHHHH
YEHRVFVEGVLFRINSFDQWGVELGKELATGLLPVVEGKESAAGHDSSTQGLVKALAGLA
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHCCCCCCCCCCCCCHHHHHHHHHHCC
G
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194