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The map label for this gene is pepA [H]

Identifier: 15887566

GI number: 15887566

Start: 218477

End: 219871

Strand: Reverse

Name: pepA [H]

Synonym: Atu0214

Alternate gene names: 15887566

Gene position: 219871-218477 (Counterclockwise)

Preceding gene: 15887568

Following gene: 15887558

Centisome position: 7.74

GC content: 60.5

Gene sequence:

>1395_bases
ATGGCGCCCTATCAGTTCATCGAACGCCCCACCCCTTTCAGCTCGAAGGCCGGCAGCACATTGCCGGTTTTTGCCGTCAC
GCCAGCCCATATCGAACAGGGTGCCATAGACCCGGTCGCTCTGGACTGGGCGAAAAAGGCGGGGTTCAAGGCGGAAGCCG
GCGCCGTCCTGCTCGTTCCCTCCTCTGATGGATCGCTGGGCGGTGTGCTGCTCGGCCTTGGTGGCAATCCTTCCGAAGTT
CCCTTCATCACCGGGAAACTCGCCCGTGAGCTGCCGGAGGGCGAGTGGCACATCGAAACCGCGCCCCTGACGGCCAATCG
CCTCGCGCTCGGTTTCGGCCTCGGCAGCTACCGCTTCGACAAATACAAGACCACCAAGACCAGCGGGGCAAAGCTTCTCA
TTCCGCAGGACGCTGAAGATGGCGAGATCAAGCGCGTTCTGGCAGGTGTCTTCCTTGCGCGCGACCTCATCAATGTTCCG
GCCAATGACATGGGGCCGGACGAGCTCGAGATTGCCTTCCGAGCGCTTGCCGCCCACTACAAGGCCAAGGTGAACGTTAC
GACGGGCGATGATCTGCTTAAAGAAAACTTCCCGCTCATCCATGCCGTTGGCCGCGCCAGTGAGAGCGCACCGCGCCTTC
TGGAGATGAACTGGGGCAAAAAAGGCAATCCGCGACTGACACTGGTGGGCAAGGGCGTCTGCTTCGACACCGGCGGTCTC
GACATCAAGCCTGCGGCCTCCATGGCATTGATGAAGAAGGATATGGGTGGCGCCGCCAATGTTCTCGGCCTTGCGCTGAT
GATCATGGATGCAAAGCTGCCGGTCGATCTGCGCGTTCTCGTGCCGGCGGTCGAGAACTCCATTTCCGCCAATGCCTTCC
GTCCTGGCGATATCTATAAAAGCCGAAAGGGGCTGACGGTACAGATCGACAATACCGATGCGGAGGGTCGTCTCGTTCTG
GCGGATGCGCTCGCTTATGCCGATGAGGATGCGCCGGACCTGATGATCGACATGGCAACGCTGACGGGTGCCGCGCGTGT
GGCGCTGGGTCCCGATCTGCCGCCCTTCTACACAGATGACGCGGATCTGGCGCATGATATCGCGGAAGCCAGCATCGATA
CGGATGACCCGCTGTGGCGCATGCCGCTTTACATGGGATATGACAAGGATATCCGCTCGCGCGCAGCCGATATCACCAAT
GCGCCTTCAGGCGGCATGGGCGGATCGATCACCGCTGCCCTGTTCCTGAAGCGCTTTGTCACCAATACCAAGCGCTGGGC
GCATTTCGACATCTACGGCTGGTCGCTGAGTGAGCGTCACCATTCGTCGATTGGCGGGGAAGCACAGGGTATCCGCGCGC
TCTTCCATTACATCGCACATCAATTCGCGAAGTAG

Upstream 100 bases:

>100_bases
CACGACAGACTCACATGACGCAACTTTCGCTTAAGCAATAATCTGTTAACCCTAACAGAGCGTTAATCGCACCGATTCTC
GACATTTACGGAAGCATACC

Downstream 100 bases:

>100_bases
TCTGGTGAATCGAGAACAGATTTGAAGGGCGCTTCCTTAACGGGAGCGCCCGGTTGCCTTACACCAGAACCTTCTGTTCC
TTGTGGTCTTCCTCGCCGAA

Product: leucine aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 464; Mature: 463

Protein sequence:

>464_residues
MAPYQFIERPTPFSSKAGSTLPVFAVTPAHIEQGAIDPVALDWAKKAGFKAEAGAVLLVPSSDGSLGGVLLGLGGNPSEV
PFITGKLARELPEGEWHIETAPLTANRLALGFGLGSYRFDKYKTTKTSGAKLLIPQDAEDGEIKRVLAGVFLARDLINVP
ANDMGPDELEIAFRALAAHYKAKVNVTTGDDLLKENFPLIHAVGRASESAPRLLEMNWGKKGNPRLTLVGKGVCFDTGGL
DIKPAASMALMKKDMGGAANVLGLALMIMDAKLPVDLRVLVPAVENSISANAFRPGDIYKSRKGLTVQIDNTDAEGRLVL
ADALAYADEDAPDLMIDMATLTGAARVALGPDLPPFYTDDADLAHDIAEASIDTDDPLWRMPLYMGYDKDIRSRAADITN
APSGGMGGSITAALFLKRFVTNTKRWAHFDIYGWSLSERHHSSIGGEAQGIRALFHYIAHQFAK

Sequences:

>Translated_464_residues
MAPYQFIERPTPFSSKAGSTLPVFAVTPAHIEQGAIDPVALDWAKKAGFKAEAGAVLLVPSSDGSLGGVLLGLGGNPSEV
PFITGKLARELPEGEWHIETAPLTANRLALGFGLGSYRFDKYKTTKTSGAKLLIPQDAEDGEIKRVLAGVFLARDLINVP
ANDMGPDELEIAFRALAAHYKAKVNVTTGDDLLKENFPLIHAVGRASESAPRLLEMNWGKKGNPRLTLVGKGVCFDTGGL
DIKPAASMALMKKDMGGAANVLGLALMIMDAKLPVDLRVLVPAVENSISANAFRPGDIYKSRKGLTVQIDNTDAEGRLVL
ADALAYADEDAPDLMIDMATLTGAARVALGPDLPPFYTDDADLAHDIAEASIDTDDPLWRMPLYMGYDKDIRSRAADITN
APSGGMGGSITAALFLKRFVTNTKRWAHFDIYGWSLSERHHSSIGGEAQGIRALFHYIAHQFAK
>Mature_463_residues
APYQFIERPTPFSSKAGSTLPVFAVTPAHIEQGAIDPVALDWAKKAGFKAEAGAVLLVPSSDGSLGGVLLGLGGNPSEVP
FITGKLARELPEGEWHIETAPLTANRLALGFGLGSYRFDKYKTTKTSGAKLLIPQDAEDGEIKRVLAGVFLARDLINVPA
NDMGPDELEIAFRALAAHYKAKVNVTTGDDLLKENFPLIHAVGRASESAPRLLEMNWGKKGNPRLTLVGKGVCFDTGGLD
IKPAASMALMKKDMGGAANVLGLALMIMDAKLPVDLRVLVPAVENSISANAFRPGDIYKSRKGLTVQIDNTDAEGRLVLA
DALAYADEDAPDLMIDMATLTGAARVALGPDLPPFYTDDADLAHDIAEASIDTDDPLWRMPLYMGYDKDIRSRAADITNA
PSGGMGGSITAALFLKRFVTNTKRWAHFDIYGWSLSERHHSSIGGEAQGIRALFHYIAHQFAK

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=339, Percent_Identity=40.117994100295, Blast_Score=210, Evalue=2e-54,
Organism=Homo sapiens, GI47155554, Length=384, Percent_Identity=30.9895833333333, Blast_Score=134, Evalue=1e-31,
Organism=Escherichia coli, GI87082123, Length=306, Percent_Identity=38.8888888888889, Blast_Score=192, Evalue=4e-50,
Organism=Escherichia coli, GI1790710, Length=337, Percent_Identity=37.0919881305638, Blast_Score=183, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI17556903, Length=286, Percent_Identity=38.1118881118881, Blast_Score=143, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI17565172, Length=215, Percent_Identity=32.093023255814, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24661038, Length=321, Percent_Identity=34.5794392523364, Blast_Score=165, Evalue=5e-41,
Organism=Drosophila melanogaster, GI21355725, Length=321, Percent_Identity=33.6448598130841, Blast_Score=162, Evalue=3e-40,
Organism=Drosophila melanogaster, GI21357381, Length=292, Percent_Identity=34.2465753424658, Blast_Score=138, Evalue=8e-33,
Organism=Drosophila melanogaster, GI221379063, Length=292, Percent_Identity=34.2465753424658, Blast_Score=138, Evalue=9e-33,
Organism=Drosophila melanogaster, GI221379062, Length=292, Percent_Identity=34.2465753424658, Blast_Score=138, Evalue=9e-33,
Organism=Drosophila melanogaster, GI20129969, Length=293, Percent_Identity=27.6450511945392, Blast_Score=116, Evalue=4e-26,
Organism=Drosophila melanogaster, GI19922386, Length=292, Percent_Identity=28.4246575342466, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24646701, Length=217, Percent_Identity=36.405529953917, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24646703, Length=217, Percent_Identity=36.405529953917, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI21358201, Length=217, Percent_Identity=36.405529953917, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI21355645, Length=349, Percent_Identity=25.5014326647564, Blast_Score=108, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24662223, Length=349, Percent_Identity=25.5014326647564, Blast_Score=108, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24662227, Length=294, Percent_Identity=25.8503401360544, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI161077148, Length=290, Percent_Identity=27.9310344827586, Blast_Score=102, Evalue=4e-22,
Organism=Drosophila melanogaster, GI20130057, Length=290, Percent_Identity=27.9310344827586, Blast_Score=102, Evalue=4e-22,
Organism=Drosophila melanogaster, GI20129963, Length=294, Percent_Identity=27.891156462585, Blast_Score=100, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 49693; Mature: 49562

Theoretical pI: Translated: 5.84; Mature: 5.84

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAPYQFIERPTPFSSKAGSTLPVFAVTPAHIEQGAIDPVALDWAKKAGFKAEAGAVLLVP
CCCHHHHCCCCCCCCCCCCCCEEEEECHHHHCCCCCCCHHHHHHHHCCCCCCCCEEEEEE
SSDGSLGGVLLGLGGNPSEVPFITGKLARELPEGEWHIETAPLTANRLALGFGLGSYRFD
CCCCCCCEEEEECCCCCCCCCEEEHHHHHHCCCCCEEEEECCCCCCCEEEEECCCCCCCC
KYKTTKTSGAKLLIPQDAEDGEIKRVLAGVFLARDLINVPANDMGPDELEIAFRALAAHY
CEEECCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHH
KAKVNVTTGDDLLKENFPLIHAVGRASESAPRLLEMNWGKKGNPRLTLVGKGVCFDTGGL
EEEEEEECCHHHHHCCCCEEEEECCCCCCCCCEEEECCCCCCCCEEEEEECCEEEECCCC
DIKPAASMALMKKDMGGAANVLGLALMIMDAKLPVDLRVLVPAVENSISANAFRPGDIYK
CCCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEEEEEEHHHCCCCCCCCCCCHHHH
SRKGLTVQIDNTDAEGRLVLADALAYADEDAPDLMIDMATLTGAARVALGPDLPPFYTDD
CCCCCEEEECCCCCCCEEEEEEHHHHCCCCCCHHEEEHHHHCCCEEEEECCCCCCCCCCC
ADLAHDIAEASIDTDDPLWRMPLYMGYDKDIRSRAADITNAPSGGMGGSITAALFLKRFV
HHHHHHHHHHCCCCCCCCEECCEEECCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHH
TNTKRWAHFDIYGWSLSERHHSSIGGEAQGIRALFHYIAHQFAK
CCCCCEEEEEEEECCCCHHHHHCCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
APYQFIERPTPFSSKAGSTLPVFAVTPAHIEQGAIDPVALDWAKKAGFKAEAGAVLLVP
CCHHHHCCCCCCCCCCCCCCEEEEECHHHHCCCCCCCHHHHHHHHCCCCCCCCEEEEEE
SSDGSLGGVLLGLGGNPSEVPFITGKLARELPEGEWHIETAPLTANRLALGFGLGSYRFD
CCCCCCCEEEEECCCCCCCCCEEEHHHHHHCCCCCEEEEECCCCCCCEEEEECCCCCCCC
KYKTTKTSGAKLLIPQDAEDGEIKRVLAGVFLARDLINVPANDMGPDELEIAFRALAAHY
CEEECCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHH
KAKVNVTTGDDLLKENFPLIHAVGRASESAPRLLEMNWGKKGNPRLTLVGKGVCFDTGGL
EEEEEEECCHHHHHCCCCEEEEECCCCCCCCCEEEECCCCCCCCEEEEEECCEEEECCCC
DIKPAASMALMKKDMGGAANVLGLALMIMDAKLPVDLRVLVPAVENSISANAFRPGDIYK
CCCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEEEEEEHHHCCCCCCCCCCCHHHH
SRKGLTVQIDNTDAEGRLVLADALAYADEDAPDLMIDMATLTGAARVALGPDLPPFYTDD
CCCCCEEEECCCCCCCEEEEEEHHHHCCCCCCHHEEEHHHHCCCEEEEECCCCCCCCCCC
ADLAHDIAEASIDTDDPLWRMPLYMGYDKDIRSRAADITNAPSGGMGGSITAALFLKRFV
HHHHHHHHHHCCCCCCCCEECCEEECCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHH
TNTKRWAHFDIYGWSLSERHHSSIGGEAQGIRALFHYIAHQFAK
CCCCCEEEEEEEECCCCHHHHHCCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA